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127426 trials found · Page 6367 of 6372
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A dose-escalation, dose-extension and efficacy-extension, phase I/II clinical study to evaluate the safety, tolerability, pharmacokinetic profile and preliminary efficacy of AP-L1898 capsule for the treatment of the patients with locally advanced or metastatic non-small cell lung cancer
Stopped earlyThis is a phase I/II, open-label, first-in-human clinical study designed to evaluate the safety, tolerability, PK profile and efficacy of JS111 for patients with Non-small cell lung cance. This study is divided into 3 periods: dose escalation stage, dose extension stage, and effi…
Phase 1/2 • Sponsor: Suzhou Junjing BioSciences Co., Ltd.
Last updated Sep 10, 2026 15:00 UTC
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Feasibility and preliminary effects of yoghurt supplementation on the gut microbiome and systemic inflammation in critically ill adults: a pilot randomized controlled trial
CompletedThis pilot randomized controlled trial tested the feasibility of yoghurt supplementation (400 mL/day for 3 days) in critically ill adults receiving nasogastric feeds. Twelve patients were enrolled, with high adherence and no safety concerns reported. Yoghurt intake was associated…
Sponsor: All India Institute of Medical Sciences, Bhubaneswar
Last updated Sep 10, 2026 15:00 UTC
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Evaluation of advanced HIV disease differentiated care model in malawi: a mixed methods non-randomized cluster study
CompletedThis study will evaluate the implementation of an enhanced package of care, CD4 and tuberculosis lipoarabinomannan (TB-LAM) tests and the initiation of patients on TB prophylaxis \[TPT and CPT\], on retention in care and viral suppression ((\<50 copies/ml) at 6 and 12 months afte…
Sponsor: Elizabeth Glaser Pediatric AIDS Foundation
Last updated Sep 10, 2026 15:00 UTC
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A Six-Week randomized, parallel design study to compare the effects of philips sonicare 9900 prestige versus an Oscillating-Rotating power toothbrush on plaque and gum health
CompletedThe goal of this clinical trial is to learn if powered toothbrushing with a side-to-side motion is more effective than powered toothbrushing with oscillating-rotation motion in removing dental plaque. It will also learn about the safety of power toothbrushing with both products. …
Sponsor: Philips Clinical & Medical Affairs Global
Last updated Sep 10, 2026 15:00 UTC
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An open-label, single-arm, multi-center, phase II clinical study of MRG003 in the treatment of patients with EGFR-positive unresectable, locally advanced or metastatic biliary tract cancer
CompletedThe objective of this study is to assess the safety, efficacy, pharmacokinetics, and immunogenicity of MRG003 as single agent in EGFR-positive unresectable locally advanced or metastatic biliary tract cancer patients who have progressed during or relapsed after at least one prior…
Phase 2 • Sponsor: Lepu Biopharma Co., Ltd.
Last updated Sep 10, 2026 15:00 UTC
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Phase 3, randomized, Placebo-Controlled, efficacy and safety study of VERU-111 for the treatment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in patients at high risk for acute respiratory distress syndrome (ARDS).
CompletedTo demonstrate the efficacy of VERU-111 in the treatment of SARS-Cov-2 Infection by assessing its effect on the proportion of patients who die on study (prior to Day 60).
Phase 3 • Sponsor: Veru Inc.
Last updated Sep 10, 2026 15:00 UTC
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Development of a haemophiLia PHysiotherapy INtervention for optimum musculoskeletal health in children (DOLPHIN-II) - a randomised controlled trial
Completed"Being able to participate in games and activities with their friends" is one of the things that matters most to boys with haemophilia. At present, there is a lack of robust evidence to determine whether muscle strengthening exercise can improve or negatively affect outcomes for …
Sponsor: East Kent Hospitals University NHS Foundation Trust
Last updated Sep 10, 2026 15:00 UTC
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Non-ablative oligofractionated radiation therapy before surgical transplantation as radiovaccination
Recruiting nowThis is a prospective phase I study to determine the safety and feasibility of non-ablative oligofractionated radiation therapy (NORT) before lung transplantation for patients with underlying pulmonary malignancy. We hypothesize that heterogeneous dose distributions could generat…
Sponsor: Marc de Perrot
Last updated Sep 10, 2026 15:00 UTC
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An Open-Label, single arm, Multi-Center phase II clinical study to evaluate the efficacy and safety of MRG003 in patients with recurrent or metastatic squamous cell carcinoma of head and neck.
CompletedThe objective of this study is to assess the safety, efficacy, pharmacokinetics, and immunogenicity of MRG003 and the combination of MRG003 and HX008 in patients with recurrent or metastatic squamous cell carcinoma of head and neck.
Phase 2 • Sponsor: Lepu Biopharma Co., Ltd.
Last updated Sep 10, 2026 15:00 UTC
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An Open-Label, Multi-Cohort, multi-center, Non-Randomized, phase II clinical study to evaluate the efficacy and safety of MRG003 in patients with EGFR-Positive advanced Non-Small cell lung cancer
CompletedThe objective of this study is to assess the efficacy, safety of MRG003 as single agent in EGFR-positive advanced non-small cell lung cancer
Phase 2 • Sponsor: Lepu Biopharma Co., Ltd.
Last updated Sep 10, 2026 15:00 UTC
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Evaluation of prevalence, molecular and genetic backgrounds of Calcium-Based stones among patients with renal calcular disease in mansoura urology and nephrology center
CompletedEvaluation of Prevalence, Molecular and Genetic Backgrounds of Calcium-Based stones among Patients with Renal Calcular Disease in Mansoura Urology and Nephrology Center
Sponsor: Mansoura University
Last updated Sep 10, 2026 15:00 UTC
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A "Physician & patient-powered" cohort registry
Recruiting nowThe aim of this observational study is the creation of a national multiple myeloma registry to monitor the current routine clinical practice in Italy and describe the standard of care adopted for the diagnosis and treatment of patients with multiple myeloma in the different Itali…
Sponsor: Fondazione EMN Italy Onlus
Last updated Sep 10, 2026 15:00 UTC
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The impact of video-based cardiac rehabilitation education in patients with cardiovascular implantable electronic Devices(CIEDs)- a randomized controlled trial
CompletedCardiac rehabilitation has the beneficial effects of secondary prevention and social psychological and physical health status in patients with cardiovascular diseases. International and clinical guidelines currently recommend exercise training and rehabilitation for heart failure…
Sponsor: National Taiwan University Hospital Hsin-Chu Branch
Last updated Sep 10, 2026 15:00 UTC
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A person-centred approach to pictorial support in care for children (PicPecc)
CompletedIntroduction: Person-centred care is based on the assumption that every person has resources that should be used in the care situation. In order for this to happen the patient has to be able to effectively communicate his/her symptoms. This protocol describes the analysis of a di…
Sponsor: Göteborg University
Last updated Sep 10, 2026 15:00 UTC
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Change in brain perfusion during induction of general anesthesia: relationship between transcranial doppler, bispectral index and cerebral oximetry : a prospective observational study CERVO2
Stopped earlyArterial hypotension during general anesthesia remains a factor of poor outcomes, increases the risk of myocardial infarction, acute kidney injury and 1-year mortality. Furthermore, arterial hypotension may also decrease cerebral perfusion contributing to worsen neurological outc…
Sponsor: Assistance Publique - Hôpitaux de Paris
Last updated Sep 10, 2026 15:00 UTC
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Program evaluation: eggs hatching hope. providing egg vouchers to women with young children in rural honduras.
Recruiting nowThe study is a prospective community-cluster non-randomized trial that will evaluate the effectiveness of a program that will provide 30-day egg vouchers to mothers of 6 to 24 month-old children living in rural areas of Intibucá, Honduras.
Sponsor: Georgia Southern University
Last updated Sep 10, 2026 15:00 UTC
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Adaptations from a telehealth stretching exercise program on painful conditions, depression, sleep and functionality of women with fibromyalgia during the Covid-19 pandemic: a randomized clinical trial
CompletedThis study is a randomized, single-blinded, parallel, superiority, controlled trial. The main objective is to verify the effects of a telehealth stretching exercise program on pain, depression, sleep parameters and functionality of women with fibromyalgia, during the Covid-19 pan…
Sponsor: Federal University of Pelotas
Last updated Sep 10, 2026 15:00 UTC
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Phase ib clinical study of toripalimab combined with gemcitabine and cisplatin neoadjuvant chemotherapy in patients with resectable locally advanced head and neck squamous cell carcinoma
OngoingHead and Neck Squamous Cell Carcinoma (HNSCC) is the most common malignant tumor of the head and neck, accounting for 90% of head and neck malignancies, and 16% to 40% of systemic malignancies. There are 60,000 new cases reported annually worldwide, and the incidence and mortalit…
Phase 1 • Sponsor: Fifth Affiliated Hospital, Sun Yat-Sen University
Last updated Sep 10, 2026 15:00 UTC
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VIGIP-SEP2: evaluation of the impact of the training of patients by nurses on the adverse drug reaction reporting by RRMS patient via a mobile application: a randomized real-life study
CompletedThe patient's reporting of adverse drug reactions (ADRs) is recognized as being of interest for post-marketing safety monitoring, but is still underdeveloped in France, with an average lower than the European average. A multidisciplinary team of the University Hospital of Caen, c…
Sponsor: University Hospital, Caen
Last updated Sep 10, 2026 15:00 UTC
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Intra-arterial neuroprotective strategy for ischemic STroke patients with no reperfusion therapy (INSIST-NRT): one single center, safety and feasibility study
Recruiting nowTo explore the safety and feasibility of intra-arterial neuroprotective strategy in acute ischemic stroke patients who missed recanalization operation.
Sponsor: Hui-Sheng Chen
Last updated Sep 10, 2026 15:00 UTC