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This is a Phase 2 study randomized, quadruple-masked, multi-center trial with an open-label extension (OLE), designed to investigate the efficacy and safety of BPL-003 in patients with treatment resistant depression (TRD).

Phase 2 • Sponsor: Beckley Psytech Limited

Last updated Sep 10, 2026 14:00 UTC

A randomized controlled trail to examine the efficacy of tai chi for the prophylaxis of episodic migraine compared with standard prophylactic medication in chinese women and a pre-post neuroimaging and laboratory-based study to explore the mechanism of tai Chi's intervention effect

The proposed study aims to examine the clinical efficacy of 24-week Tai Chi training in the prophylaxis of episodic migraine comparing with standard prophylactic medication in Hong Kong Chinese women, and to explore the mechanism of Tai Chi's intervention effect by examining the …

Sponsor: The Hong Kong Polytechnic University

Last updated Sep 10, 2026 14:00 UTC

Prevention of thromboembolism using apixaban vs enoxaparin following spinal cord injury

Currently, Enoxaparin is the usual prophylactic anticoagulant treatment at the acute and sub-acute phases of spinal cord injury (SCI). Patients at the sub-acute phase of SCI (rehabilitation) will be given either Enoxaparin 40 mg/day (control) or Apixaban 2.5-5 mg twice a day. Api…

Sponsor: Loewenstein Hospital

Last updated Sep 10, 2026 14:00 UTC

Eradication of helicobacter pylori: a comparative randomized controlled trial of bismuth quadruple therapy and bismuth add-on to clarithromycin triple therapy

The primary objective of the study is to compare the efficacy of 2 different regimens of treatment of gastric bacteria (H pylori) these are: quadruple bismuth therapy and clarithromycin triple therapy with add-on bismuth, in eradicating H. pylori. The secondary objective of the …

Phase 3 • Sponsor: Reham Abdelkader Elkhouly

Last updated Sep 10, 2026 14:00 UTC

Evaluation of the impact of experimentally induced fatigability on motor and cognitive functions. effect of high intensity training on motor and cognitive functions:a pilot randomized controlled trial

Fatigability is one of the most prevalent disorder in MS followed by walking, balance and cognitive disorders. However, there are few experimental studies on the effects of fatigability on balance and gait hampering the knowledge of causal fatigue-related changes of walking, bal…

Sponsor: Fondazione Don Carlo Gnocchi ETS

Last updated Sep 10, 2026 14:00 UTC

Complex lifestyle modification in the treatment of non-alcoholic fatty liver disease

The project will study the impact of individually tailored lifestyle counselling compared to standard care on the parameters of NAFLD/NASH in patients with metabolic syndrome. The factors affecting the outcome (including clinical and laboratory parameters and microbiome profiling…

Sponsor: General University Hospital, Prague

Last updated Sep 10, 2026 14:00 UTC

A prospective imaging study of target definition and radiation planning workflows on the integrated TrueBeam-HyperSight system for patients receiving radiation therapy

Cone beam computed tomography (CBCT) images are routinely used in radiation treatment delivery workflows to align patients with the treatment beam. Conventional CBCT image quality is sufficient for this task but not good enough for other radiotherapy-related tasks, such as contou…

Sponsor: Varian, a Siemens Healthineers Company

Last updated Sep 10, 2026 14:00 UTC

A double-blinded, randomized, placebo-controlled phase II trial to assess extended safety and tolerability of subcutaneous CAP256V2LS and VRC07-523LS in HIV negative women

A double blinded, Randomized, Placebo- controlled phase II trial to assess extended safety and tolerability of subcutaneous CAP256V2LS and VRC07-523LS in HIV- negative women

Phase 2 • Sponsor: Centre for Infectious Disease Research in Zambia

Last updated Sep 10, 2026 14:00 UTC

Drug-eluting stenting versus medical treatment alone for patients with extracranial vertebral artery stenosis: the VISTA trial

Posterior circulation stroke accounts for 20% of all ischemic stroke. Approximately one quarter of posterior circulation strokes are due to stenosis in the vertebral artery and basilar artery. Two previous randomized controlled trials focusing on vertebral artery stenting, the V…

Sponsor: Xuanwu Hospital, Beijing

Last updated Sep 10, 2026 14:00 UTC

Comparing decision on match of expectations and aesthetics using a conventional versus a cloud-based healthcare platform approach in breast cancer patients proposed for locoregional treatment: a prospective randomized trial

Breast cancer is the most commonly diagnosed cancer, with an estimated 2.3 million new cases per year globally. Approximately 90% of these patients will undergo breast surgery with/without radiation (locoregional treatment). Different surgical techniques can be offered to the pat…

Sponsor: Fundacao Champalimaud

Last updated Sep 10, 2026 14:00 UTC

A clinical study of CS1-Targeted CAR-T cells in Relapsed/Refractory multiple myeloma

This investigator-initiated, exploratory clinical trial is designed to evaluate the feasibility, safety, and preliminary antitumor activity of autologous CS1-targeted chimeric antigen receptor T (CAR-T) cells in adults with relapsed or refractory multiple myeloma (MM). Multiple …

Phase 1 • Sponsor: Qi Junyuan

Last updated Sep 10, 2026 14:00 UTC

Hospital-to-Home transitional cardiac rehabilitation as a transition from Centre-Based cardiac rehabilitation after cardiac surgery: a Single-Blind randomised controlled trial

Cardiac rehabilitation (CR) improves outcomes after cardiac surgery, but is usually delivered on a fixed centre-based schedule that requires repeated daytime hospital attendance. A hybrid model, in which supervised training begins in hospital and then transitions to monitored hom…

Sponsor: Cheng-Hsin General Hospital

Last updated Sep 10, 2026 14:00 UTC

Investigating the effects of Full-Spectrum medicinal cannabis plant extract 0.08% THC (NTI164) on paediatric acute-onset neuropsychiatric syndrome (PANS)

This study investigates the effectiveness of a medicinal cannabis extract (NTI164) with 0.08% THC in treating children with pediatric acute-onset neuropsychiatric syndrome (PANS) over a period of 18 to 54 weeks. Participants, aged 18 to 54, will start with a daily dose of 5mg/kg,…

Phase 1/2 • Sponsor: Fenix Innovation Group

Last updated Sep 10, 2026 14:00 UTC

A prospective, single arm clinical study to evaluate efficacy and safety of lenvatinib combined with tislelizumab in the first line treatment of patients with locally advanced or metastastic fumarate hydratase deficient renal cell carcinoma

FHRCC is a rare kind of renal cell carcinoma with a morbidity of 1/2000000 per year.Although several combination therapies demonstrated possible efficacy in this population. No standard treatment has been approved. The purpose of this study is to evaluate the efficacy and safety …

Phase 2 • Sponsor: RenJi Hospital

Last updated Sep 10, 2026 14:00 UTC

A randomized, wait List-Controlled, clinical trial of IBD strong peer for Self-Management of psychological distress by persons living with inflammatory bowel diseases (IBD)

Psychological distress (PD) as a result of inflammatory bowel disease (IBD) is prevalent and associated with worse disease-related outcomes. IBD-associated psychological distress (IBD-PD) is particularly common at initial diagnosis, during disease flares, before surgery, and duri…

Sponsor: Jennifer Jones

Last updated Sep 10, 2026 14:00 UTC

Understanding changes in the gut microbiome in patients with gallstone disease and its impact on patient outcomes

The goal of this prospective observational study is to explore the role of the gut microbiome in patients with gallstone disease. The main question\[s\] it aims to answer are: * if there is a relationship between the gut microbiome and the development of complications associate…

Sponsor: East Kent Hospitals University NHS Foundation Trust

Last updated Sep 10, 2026 14:00 UTC

A multi-center, phase II study to evaluate efficacy and safety of perioperative chemotherapy with fluorouracil, leucovorin, oxaliplatin, docetaxel (FLOT) and trastuzumab in combination with toripalimab in patients with HER2 positive locally advanced gastric or esophagogastric junction adenocarcinoma

This study is a prospective, single arm, multi-center phase II clinical trial designed to evaluate the efficacy and safety of perioperative chemotherapy with FLOT regimen and trastuzumab in combination with toripalimab in participants with resectable HER2 positive locally advance…

Phase 2 • Sponsor: Yu jiren

Last updated Sep 10, 2026 14:00 UTC

Evaluating the impact of including virtual dietary education within an electronic irritable bowel syndrome pathway

Irritable bowel syndrome is a functional bowel disorder that affects many Canadians. The syndrome involves abdominal pain and change in frequency or form of bowel movements, and these symptoms can lead to a decreased quality of life for patients. Primary care physicians are dissa…

Sponsor: Nova Scotia Health Authority

Last updated Sep 10, 2026 14:00 UTC

Timing and facilitation effects of Theta-Burst stimulation in the reading and language systems