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127426 trials found · Page 6358 of 6372
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Project QUIT+: adapting and testing a smoking cessation intervention for transgender and gender expansive individuals
Stopped earlySmoking remains the leading preventable cause of death in the United States, and there are persistent and significant disparities in tobacco use among transgender and gender diverse (TGD) individuals. Stigma, discrimination, gender dysphoria, and other gender minority stressors l…
Sponsor: Massachusetts General Hospital
Last updated Sep 10, 2026 15:00 UTC
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A single arm, open label, dose-escalation phase i and dose-expansion phase IIa clinical study to evaluate the feasibility, safety, and efficacy of allogeneic chimeric antigen receptor (CAR) Gamma-Delta t cells CAR001 in subjects with Relapsed/Refractory solid tumors
Recruiting nowThis study is composed of phase I and IIa parts. The dose-escalation phase I part aims to find the maximum tolerated dose (MTD) and to identify the safety of CAR001 in subjects with relapsed/refractory solid tumor; the dose-expansion phase IIa part aims to evaluate the potential …
Phase 1/2 • Sponsor: Ever Supreme Bio Technology Co., Ltd.
Last updated Sep 10, 2026 15:00 UTC
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CRS questionnaire validation project
Recruiting nowThe 'CRS validation project' consists of a joint effort of 32 medical centers in Europe, the USA, and South Africa to carry out the validation of 2 novel questionnaires designated to measure self-perceived severity and control of Chronic Rhinosinusitis (with or without nasal poly…
Sponsor: The European Forum for Research and Education in Allergy and Airway Diseases
Last updated Sep 10, 2026 15:00 UTC
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Radiofrequency using the fistura® procedure for the treatment of complex anal fistulas: assessing healing rate and anal incontinence up to 1 year follow-up
Recruiting nowThis study aims to evaluate the healing rate of complex fistulas using radiofrequency (Fistura® procedure), in a prospective, interventional, monocenter, single-arm design.
Sponsor: F Care Systems NV
Last updated Sep 10, 2026 15:00 UTC
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Health effects of cottonseed oil versus matched composition diets in humans
Recruiting nowCardiovascular disease risk factors, including higher BMIs and poor cholesterol profiles, are on the rise and contribute to the United States' growing disease burden. Cottonseed oil (CSO) is found readily in the food supply, and the investigator's previous studies have demonstrat…
Sponsor: University of Georgia
Last updated Sep 10, 2026 15:00 UTC
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Radiofrequency ablation via catheter and transpapillary access in patients with cholangiocarcinoma
Recruiting nowThe goal of this clinical trial is to learn about radiofrequency ablation in patients with unresectable bile duct cancer who receive systemic chemotherapy and bile duct stenting. The main questions it aims to answer are: * Does radiofrequency ablation of tumorous bile duct occlu…
Sponsor: Universitätsklinikum Hamburg-Eppendorf
Last updated Sep 10, 2026 15:00 UTC
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Prevention of lifestyle-related disorders with early examinations of health and function and individualised functional profiles - a randomised controlled trial
OngoingThe goal of this randomised controlled trial is to examine the effects of functional examinations and feedback/support on healthy 40-year-olds. The main questions it aims to answer are: • Does feedback and motivational interviewing after testing physical function motivate inactiv…
Sponsor: Lena Bornhoft
Last updated Sep 10, 2026 15:00 UTC
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Electrolyte imbalance in surgical and Non-Surgical geriatric brain injury patients
CompletedInvestigators invite you to the research titled "Evaluation of Serum Electrolyte Imbalance in Geriatric Patients Undergoing Brain Surgery: A Prospective Randomized Observational Study" conducted by Specialist Nurse Tülin KURT ALKAN. Before participant decide whether or not to par…
Sponsor: Zonguldak Bulent Ecevit University
Last updated Sep 10, 2026 15:00 UTC
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A randomized, Double-Blind, placebo-controlled, Single-Ascending-Dose and Multiple-Ascending-Dose study to evaluate the safety, tolerability and pharmacokinetics of RNV-166 in healthy male volunteers
CompletedThis Phase 1 first-in-human clinical study evaluated the safety, tolerability, and pharmacokinetics of RNV-166 following single ascending dose (SAD) and multiple ascending dose (MAD) administration in healthy participants. Single oral doses of RNV-166 ranging from 200 mg to 1600 …
Phase 1 • Sponsor: InVitro Research Solutions Private Limited
Last updated Sep 10, 2026 15:00 UTC
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"Effect of an intervention based in acceptance and commitment therapy (ACT) to increase psychological flexibility and reduce anxiety in medical students of the health sciences university center"
CompletedObjective: To evaluate the association between ACT-process with negative psychological variables in a cross-sectional design, and to evaluate the effect of an ACT-based intervention to diminish anxiety in a sample of medical students. Methods: An ACT-based intervention was desig…
Sponsor: University of Guadalajara
Last updated Sep 10, 2026 15:00 UTC
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Neuromodulation with transcranial pulse stimulation of the anterior insula cortex and dorsal anterior cingulate cortex in healthy adults: a randomized, single-blind, three-arm, sham-controlled, pilot trial
CompletedTranscranial pulse stimulation (TPS) is a newly developed non-invasive brain stimulation (NIBS) technique from Austria \& Germany with highly promising applicability in neuropsychiatric disorders. Clinical trials have shown a beneficial effect of TPS in patients with Alzheime…
Sponsor: The Hong Kong Polytechnic University
Last updated Sep 10, 2026 15:00 UTC
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The bad berka heart rhythm registry (2B2R) is a prospective, single-center observational cohort evaluating safety, efficacy, and outcomes in patients undergoing arrhythmia therapy or CIED implantation at the heart center bad berka
Recruiting nowThe Bad Berka Heart Rhythm Registry (2B2R) is a prospective, single-center observational cohort designed to systematically collect and analyze data of patients undergoing cardiac arrhythmia therapy as well as implantation of cardiac electronic devices (CIEDs) at the Heart Center …
Sponsor: Zentralklinik Bad Berka
Last updated Sep 10, 2026 15:00 UTC
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The effect of adding ketamine to propofol for drug-induced sleep endoscopy in adult patients with obstructive sleep apnea a randomized controlled study
CompletedThe investigator compared the sedative effects of propofol alone and ketamine added to propofol in drug induced sleep endoscopy
Phase 4 • Sponsor: Zagazig University
Last updated Sep 10, 2026 15:00 UTC
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Effect of the use of dapagliflozin in diuresis, natriuresis and in ultrafiltration and peritoneal elimination of sodium, in patients with refractory heart failure
OngoingCross-over, 2-sequence, 2-treatment, 2-period single-centre, phase IV, randomized, open label study.
Phase 4 • Sponsor: Fundación para la Investigación del Hospital Clínico de Valencia
Last updated Sep 10, 2026 15:00 UTC
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Early detrusor chemodenervation to preserve bladder compliance and longevity after spinal cord injury
By invitation onlyThe investigators would like to improve our understanding of how early intervention with the use of bladder chemodenervation can preserve bladder function in those with a new SCI. Although detrimental cystometric and tissue changes are known to occur, often within 3 months after …
Early phase 1 • Sponsor: University of Washington
Last updated Sep 10, 2026 15:00 UTC
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Fibrinogen to albumin ratio (FAR) as a risk factor for type 2 diabetic Nephropathy(DN)
CompletedAimed to investigate the association of fibrinogen to albumin ratio (FAR) with DKD type 2 and to prove its possible role as a novel biomarker to predict and prevent DKD progression.
Sponsor: Assiut University
Last updated Sep 10, 2026 15:00 UTC
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Transcutaneous vagus nerve stimulation (tVNS) for improved recovery after exertion in patients with Long/Post-COVID.
OngoingWidespread infection with SARS-CoV-2 has resulted in millions of people having Post-COVID. Post-COVID is a complex, non-monolithic disease with diverse clinical manifestations. Symptoms range from fatigue, brain fog, muscle aches and shortness of breath, affecting multiple organ …
Sponsor: University Hospital Tuebingen
Last updated Sep 10, 2026 15:00 UTC
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A Block-and-Replace therapy with osilodrostat and concomitant glucocorticoid replacement
Recruiting nowThe major goal of this study is to determine the incidence of adrenal insufficiency in patients with endogenous Cushing syndrome receiving osilodrostat treatment combined with a replacement of glucocorticoid (block-and-replace approach). The investigators are also evaluating new…
Sponsor: University of Michigan
Last updated Sep 10, 2026 15:00 UTC
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A single-arm, multi-center, prospective clinical study of mitoxantrone hydrochloride liposome injection-based CMOP±R regimen in the treatment of newly diagnosed Non-Hodgkin's lymphoma
Recruiting nowThis is a prospective, single arm, multicenter study to evaluate the safety and efficacy of CMOP±R in patients with newly diagnosed non-Hodgkin's lymphoma.
Phase 2 • Sponsor: The First Affiliated Hospital of Soochow University
Last updated Sep 10, 2026 15:00 UTC
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Prospective clinical study to assess the safety and efficacy of versius, in urological procedures in paediatrics
OngoingThis is prospective, multi-phase, single arm, multi-centre, multi-surgeon feasibility clinical trial to provide proof of concept and clinical evidence regarding the safety and efficacy of Versius (robotic surgery medical device) in Urological Procedures in Paediatric population. …
Sponsor: CMR Surgical Ltd
Last updated Sep 10, 2026 15:00 UTC