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127005 trials found · Page 6347 of 6351
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A phase i study to evaluate the safety and immunogenicity of 3D189 in patients with hematologic malignancies
CompletedTo assess the safety, immunogenicity and preliminary efficacy of 3D189 in patients with hematological malignancies.
Phase 1 • Sponsor: 3D Medicines
Last updated Sep 09, 2026 15:00 UTC
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A phase 2/3, multicenter, Double-Blind, randomized study to determine the efficacy and safety of tividenofusp alfa (DNL310) vs idursulfase in pediatric and young adult participants with neuronopathic or Non-Neuronopathic mucopolysaccharidosis type II
OngoingThis is a Phase 2/3, multiregional, two-arm, double-blind, randomized, active (standard-of-care)-controlled study of the efficacy and safety of tividenofusp alfa (DNL310), an investigational central nervous system (CNS)-penetrant enzyme-replacement therapy (ERT) for mucopolysacch…
Phase 2/3 • Sponsor: Denali Therapeutics Inc.
Last updated Sep 09, 2026 15:00 UTC
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Personalized ultrasonic brain stimulation for depression: a pilot study of target engagement and mood effects
CompletedThis study will evaluate a new form of non-invasive brain stimulation for individuals with depression. Personalized low-intensity transcranial focused ultrasound stimulation will first be delivered using a range of stimulation parameters during psychological and physiological mon…
Phase 1/2 • Sponsor: University of Utah
Last updated Sep 09, 2026 15:00 UTC
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A placebo-controlled, proof-of-concept study to evaluate the safety and efficacy of lanifibranor alone and in combination with the sodium-glucose transport protein 2 (SGLT2) inhibitor EmpaGliflozin in patiEnts with non-alcoholic steatohepatitis (NASH) and type 2 diabetes mellitus (T2DM)
CompletedThe study in the T2DM population is intended to confirm the lanifibranor effect versus placebo on glycemic control and assess a positive effect of the combination of lanifibranor with an SGLT2 inhibitor on glycemic control.
Phase 2 • Sponsor: Inventiva Pharma
Last updated Sep 09, 2026 15:00 UTC
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PRIME study: precision radiotherapy using MR-linac for pancreatic neuroendocrine tumours in MEN1 patients
OngoingPatients with the Multiple Endocrine Neoplasia type 1 (MEN1) syndrome are genetically predisposed for developping multiple pancreatic neuro-endocrine tumours (pNET). The management of small (pNET) in both MEN1 and sporadic cases, pose a major clinical challenge. At present, pancr…
Sponsor: J.M. de Laat
Last updated Sep 09, 2026 15:00 UTC
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Randomized, delayed start, double blind, parallel group, placebo controlled, multicenter study of piromelatine 20 mg in participants with mild dementia due to Alzheimer's disease
Stopped earlyRandomized efficacy and safety study of piromelatine 20 mg versus placebo in participants with mild dementia due to Alzheimer's disease (AD) who are 2:107,510,000-107,540,000 polymorphism non-carriers with the primary objective to compare the effect of piromelatine to that of pla…
Phase 2/3 • Sponsor: Neurim Pharmaceuticals Ltd.
Last updated Sep 09, 2026 15:00 UTC
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A phase i, randomized, Single-Blind, placebo-controlled study to assess the safety, tolerability, pharmacokinetics, and pharmacodynamics of AZD0780 following single and multiple ascending dose administration to healthy subjects with or without elevated LDL-C levels
CompletedThis study will assess the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of AZD0780 following single and multiple dose administration to healthy subjects with or without elevated Low-Density Lipoprotein-Cholesterol (LDL-C) levels. This study will consist…
Phase 1 • Sponsor: AstraZeneca
Last updated Sep 09, 2026 15:00 UTC
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Evaluate and compare the effectiveness of a novel toothbrush, Ortho-Buddy, designed specifically for patients undergoing orthodontic treatment with a standard toothbrush
CompletedThe goal of this clinical trial is to learn whether the Ortho-Buddy toothbrush can improve plaque removal in adolescents undergoing orthodontic treatment with fixed appliances. The main question it aims to answer is: Does using the Ortho-Buddy toothbrush, alone or together with …
Sponsor: Rutgers, The State University of New Jersey
Last updated Sep 09, 2026 15:00 UTC
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Phase 2, randomized, parallel-group, double-blind, placebo-controlled study of sonelokimab in patients with active moderate to severe hidradenitis suppurativa
CompletedThis is a study to demonstrate the clinical efficacy and safety of the nanobody® sonelokimab administered subcutaneously (sc) compared with placebo in the treatment of adult participants with moderate to severe hidradenitis suppurativa.
Phase 2 • Sponsor: MoonLake Immunotherapeutics AG
Last updated Sep 09, 2026 15:00 UTC
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Reproducibility of photobiomodulation induced changes in local skin blood flow in healthy subjects
CompletedThis study investigated whether near-infrared photobiomodulation (PBM), a non-invasive light therapy, can consistently increase blood flow in the skin of healthy adults. Participants attended two identical study sessions in which they received both active PBM treatment and a plac…
Sponsor: Norwegian University of Science and Technology
Last updated Sep 09, 2026 15:00 UTC
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Safety study of tivanisiran to treat dry eye
CompletedThis study will examine the safety of tivanisiran sodium eye drops versus vehicle when dosed once daily for 1 year in subjects with signs and symptoms of dry eye disease (DED).
Phase 3 • Sponsor: Sylentis, S.A.
Last updated Sep 09, 2026 15:00 UTC
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Assessment of flecainide to lower the patent foramen ovale closure risk of atrial arrhythmia or tachycardia
OngoingAbout 30% of ischemic strokes are cryptogenic. Patent Foramen Ovale (PFO) is present in about 25% of the general population. In cryptogenic strokes, PFO has been shown to be overrepresented and recent intervention studies have confirmed that PFO has a causal link with stroke. In …
Phase 3 • Sponsor: Assistance Publique - Hôpitaux de Paris
Last updated Sep 09, 2026 15:00 UTC
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Neoadjuvant low-dose radiotherapy, tislelizumab, combined with albumin-bound paclitaxel and cisplatin in resectable locally advanced head and neck squamous cell carcinoma (NeoRTPC02): an open label, single-arm, phase II clinical trial
OngoingThis is an open-label, single-arm, phase II clinical trial to explore the efficacy and safety of neoadjuvant low-dose radiotherapy combined with chemoimmunotherapy in resectable locally advanced head and neck squamous cell carcinoma. The eligible patients are scheduled to adminis…
Phase 2 • Sponsor: Fifth Affiliated Hospital, Sun Yat-Sen University
Last updated Sep 09, 2026 15:00 UTC
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Glutathione, brain metabolism and inflammation in Alzheimer's disease
OngoingAlzheimer's disease (AD) is associated with significant, progressive cognitive decline. Key defects in mitochondrial fuel metabolism insulin resistance, inflammation and decreased brain glucose uptake are linked to AD. This trial will investigate the effects of supplementing glyc…
Early phase 1 • Sponsor: Baylor College of Medicine
Last updated Sep 09, 2026 15:00 UTC
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A randomized clinical trial of early empiric Anti-Mycobacterium tuberculosis therapy for sepsis in Sub-Saharan africa
CompletedIn sub-Saharan Africa, tuberculosis (TB) is the etiology of 25-50% of bloodstream infections (BSIs) and the leading cause of sepsis among people living with HIV. TB BSI is associated with 20-50% mortality, and 20-25% of deaths occur within five days of admission. TB BSI is diffic…
Phase 3 • Sponsor: University of Virginia
Last updated Sep 09, 2026 15:00 UTC
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Effects of gastrocnemius kinesiology taping on postural control during Single-Leg stance in healthy adults
CompletedThe objective of this study was to investigate the immediate effects of activation- and inhibition-oriented gastrocnemius kinesiology taping on static balance control during an eyes-closed single-leg stance task in healthy young adults.
Sponsor: University of St. Augustine for Health Sciences
Last updated Sep 09, 2026 15:00 UTC
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Postoperative upper limb edema and dysfunction generated by axillary nodes excision differs due to the ratio of axillary lymphatic and axillary vein reflux in breast cancer patients: a prospective cohort study
CompletedThe purpose of this study is to compare the difference in the incidence of upper limb edema and dysfunction between the Preponderant lymphatic reflux group (high ratio of axillary lymphatic reflux to axillary vein reflux) and the Preponderant venous reflux group (low ratio of axi…
Sponsor: Xiangyun Zong
Last updated Sep 09, 2026 15:00 UTC
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A phase II clinical study to evaluate the efficacy and safety of MRG003 in EGFR-Positive, HER2-Negative advanced gastric cancer.
Stopped earlyThe objective of this study is to assess the safety, efficacy, pharmacokinetics, and immunogenicity of MRG003 in patients with EGFR-positive, HER2-negative, inoperable locally advanced or metastatic gastric cancer.
Phase 2 • Sponsor: Lepu Biopharma Co., Ltd.
Last updated Sep 09, 2026 15:00 UTC
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Role of self-focused attention in depression
CompletedUsing a task measuring the tracking of eye movements, the aim of this study is to demonstrate that individuals suffering from depression focus their attention more on their reflection in the screen after recalling a failure (and this all the more so as their depressive symptomato…
Sponsor: Centre Hospitalier Henri Laborit
Last updated Sep 09, 2026 15:00 UTC
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Prevention of fall injury in military settings through the use of body awareness.
CompletedThe POSITION project aims to investigate the cognitive mechanism of postural body awareness as a risk factor for injury and as a target for a primary prevention strategy based on the Resource Optimization of Armed Forces (ROAF) method.
Sponsor: Direction Centrale du Service de Santé des Armées
Last updated Sep 09, 2026 15:00 UTC