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The Bad Berka Heart Rhythm Registry (2B2R) is a prospective, single-center observational cohort designed to systematically collect and analyze data of patients undergoing cardiac arrhythmia therapy as well as implantation of cardiac electronic devices (CIEDs) at the Heart Center …

Sponsor: Zentralklinik Bad Berka

Last updated Sep 09, 2026 17:00 UTC

Effect of the use of dapagliflozin in diuresis, natriuresis and in ultrafiltration and peritoneal elimination of sodium, in patients with refractory heart failure

Cross-over, 2-sequence, 2-treatment, 2-period single-centre, phase IV, randomized, open label study.

Phase 4 • Sponsor: Fundación para la Investigación del Hospital Clínico de Valencia

Last updated Sep 09, 2026 17:00 UTC

Early detrusor chemodenervation to preserve bladder compliance and longevity after spinal cord injury

By invitation only

The investigators would like to improve our understanding of how early intervention with the use of bladder chemodenervation can preserve bladder function in those with a new SCI. Although detrimental cystometric and tissue changes are known to occur, often within 3 months after …

Early phase 1 • Sponsor: University of Washington

Last updated Sep 09, 2026 17:00 UTC

Fibrinogen to albumin ratio (FAR) as a risk factor for type 2 diabetic Nephropathy(DN)

Aimed to investigate the association of fibrinogen to albumin ratio (FAR) with DKD type 2 and to prove its possible role as a novel biomarker to predict and prevent DKD progression.

Sponsor: Assiut University

Last updated Sep 09, 2026 17:00 UTC

Transcutaneous vagus nerve stimulation (tVNS) for improved recovery after exertion in patients with Long/Post-COVID.

Widespread infection with SARS-CoV-2 has resulted in millions of people having Post-COVID. Post-COVID is a complex, non-monolithic disease with diverse clinical manifestations. Symptoms range from fatigue, brain fog, muscle aches and shortness of breath, affecting multiple organ …

Sponsor: University Hospital Tuebingen

Last updated Sep 09, 2026 17:00 UTC

A Block-and-Replace therapy with osilodrostat and concomitant glucocorticoid replacement

The major goal of this study is to determine the incidence of adrenal insufficiency in patients with endogenous Cushing syndrome receiving osilodrostat treatment combined with a replacement of glucocorticoid (block-and-replace approach). The investigators are also evaluating new…

Sponsor: University of Michigan

Last updated Sep 09, 2026 17:00 UTC

A single-arm, multi-center, prospective clinical study of mitoxantrone hydrochloride liposome injection-based CMOP±R regimen in the treatment of newly diagnosed Non-Hodgkin's lymphoma

This is a prospective, single arm, multicenter study to evaluate the safety and efficacy of CMOP±R in patients with newly diagnosed non-Hodgkin's lymphoma.

Phase 2 • Sponsor: The First Affiliated Hospital of Soochow University

Last updated Sep 09, 2026 17:00 UTC

An equity focused intervention to improve utilization of guideline concordant extended venous thromboembolism prophylaxis after major cancer surgery

While blood clots after major cancer surgery are common and harmful to patients, the medications to decrease blood clot risk are seldom used after patients leave the hospital despite the recommendation of multiple professional medical societies. The reason why these medications a…

Sponsor: Medical University of South Carolina

Last updated Sep 09, 2026 17:00 UTC

Colorectal anastomosis outcomes using the novel powered circular stapler compared with manual circular staplers. a randomized multicentre controlled trial.

Patients whom meet all eligibility criteria will be assigned random 1:1 to one of the following arms: * ECPS group: Echelon Circular™ Powered Stapler (n=270) * MCS Group: manual circular staplers (n=270) Patients will be followed during 30 days in order to evaluate the primary e…

Sponsor: Fundación para la Investigación del Hospital Clínico de Valencia

Last updated Sep 09, 2026 17:00 UTC

The promoting resilience in stress Management-Social needs (PRISM-SN) intervention for adolescents and young adults with cancer: a randomized controlled trial

The goal of this study is to establish feasibility, acceptability, and proof-of-concept of an psychosocial intervention adapted to address social health needs of adolescents and young adults (AYAs) newly diagnosed with cancer. The aims of this study are to: 1. Determine if the P…

Sponsor: Seattle Children's Hospital

Last updated Sep 09, 2026 17:00 UTC

The effects of external nasal dilator strips on sleep and cardiovascular health

The goal of this interventional study is to learn if wearing an external nasal dilator strip while sleeping changes objective and perceived sleep quality, immediate post-waking blood pressure, and immediate-post waking heart rate variability.

Sponsor: Florida State University

Last updated Sep 09, 2026 17:00 UTC

Early REmote rehabilitation to improve health of the elderly after CARDiac surgery. (RECARD trial). a bi-center, prospective, randomized, open-label, blinded evaluation (PROBE) trial

An increasing number of older patients undergo heart surgery. Despite seemingly successful outcomes, these vulnerable patients may face prolonged decreased functional capacity, reduced self-efficacy, and impaired quality of life after discharge. Early engagement in physical activ…

Sponsor: Ivy susanne Modrau, MD

Last updated Sep 09, 2026 17:00 UTC

Analgesic requirement for Post-Operative pain control in elective 1-3 level transforaminal lumbar interbody fusion: comparison of thoracolumbar interfascial plane block with exparel to bupivacaine HCl

By invitation only

The goal of this clinical trail is to to compare the efficacy of thoracolumbar interfascial plane block with Exparel vs with standard of care 0.25% Bupivacaine HCl in patients undergoing 1-3 level elective transforaminal lumbar interbody fusion. The investigators hypothesize that…

Phase 2/3 • Sponsor: Foundation for Orthopaedic Research and Education

Last updated Sep 09, 2026 17:00 UTC

Feasibility and safety of home blood count measurement and transfusions by systematically educated patients with acute myeloid leukemia

The aim is to investigate the feasibility, safety, and complication rates of patient's self-measurement of CBC and self-administration of blood and platelet transfusions at home and examine the performance of patients conducting at-home monitoring of their blood pressure, pulse r…

Sponsor: Rigshospitalet, Denmark

Last updated Sep 09, 2026 17:00 UTC

Cardiovascular, cerebral, and performance responses to Q-Collar™ use in a 5-km cycling time trial

This study examined the effects of wearing the Q-Collar during high-intensity cycling exercise. Eleven recreationally trained male participants completed two 5-kilometer cycling time trials: one while wearing the Q-Collar and one without the Q-Collar. During and after each trial,…

Sponsor: University of Northern Iowa

Last updated Sep 09, 2026 17:00 UTC

Subcutaneous tranexamic acid in nasal mohs local flap reconstruction: perioperative bleeding, edema, and ecchymosis

This study will be a prospective randomized control trial to evaluate the effects of subcutaneously administered TXA among patients undergoing nasal Mohs reconstruction with local flaps at VUMC.

Phase 2 • Sponsor: Vanderbilt University Medical Center

Last updated Sep 09, 2026 17:00 UTC

Identification of cellular and molecular mechanisms involved in the pathophysiology of alcohol use disorder by examination of cerebrospinal fluid

BACKGROUND The brain and spinal cord are enveloped by cerebrospinal fluid (CSF), which extends down to the base of the spine, a few centimeters below the termination of the spinal cord. Here, it can be collected through a minor needle puncture. This procedure enables the gatheri…

Sponsor: Vastra Gotaland Region

Last updated Sep 09, 2026 17:00 UTC

Deep learning for automatic segmentation of bone sequestra on orthopantomographs: a UNet-Based approach

This study developed and evaluated a UNet-based deep learning model for automatic segmentation of bone sequestra on orthopantomographs (OPGs), with the goal of improving diagnostic efficiency and reducing inter-observer variability in osteomyelitis, osteoradionecrosis, and medica…

Sponsor: Izmir Katip Celebi University

Last updated Sep 09, 2026 17:00 UTC

Safety and performance of the biphasic plate distal femur: a multicenter case series