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Up to: Syndromic disease · Hypoxanthine-guanine phosphoribosyltransferase deficiency
Lesch-Nyhan syndrome
Lesch-Nyhan syndrome (LNS) is the most severe form of hypoxanthine-guanine phosphoribosyltransferase (HPRT) deficiency, a hereditary disorder of purine metabolism, and is associated with uric acid overproduction (UAO), neurological troubles, and behavioral problems.