Wake Forest University Health Sciences

This study looks at whether lung cancer patients who are less fit (performance status 2) can get the same benefits and safety from a standard chemo/immunotherapy combination as fitter patients (performance status 0-1). About 105 adults with advanced non-small cell lung cancer who…

This study tests whether a personalized, gradual start to dialysis is safer and improves quality of life compared to the standard fixed schedule. It involves 350 adults with end-stage kidney disease who recently started dialysis. Researchers will track hospital visits, overall he…

This study tests a high dose of the chemotherapy drug methotrexate given through a vein in people with breast cancer that has spread to the lining of the brain. The goal is to see if it helps patients live longer. The trial includes 16 adults with specific types of breast cancer …

This study tests whether adding omeprazole (a common heartburn medicine) to standard chemotherapy can help control advanced prostate cancer that has stopped responding to other treatments. About 50 men with castration-resistant prostate cancer will receive either omeprazole plus …

This study looks for the best ways to prevent bone loss when older adults lose weight. It involves 900 participants who are overweight or have low bone mass. They will try different combinations of exercise, medication, and diet changes over two years.

This early-stage trial tests a vaginal implant made from a woman's own cells for those born without a vagina (vaginal aplasia). The implant is created from a small tissue biopsy and aims to create a functional vagina. The study will enroll 10 women aged 15-45 and primarily check …

This study looks at two medications, levetiracetam and lacosamide, to see which one better prevents seizures in the first week after a traumatic brain injury. Researchers will also check which drug causes fewer side effects like agitation. The study involves 600 adults with moder…

This study looks at whether helping people with high blood pressure who also struggle to get enough food can improve their health. Researchers will test different types of food support to see which works best for lowering blood pressure and helping people take their medications a…

This study compares managing chronic high blood pressure during pregnancy using telehealth visits and home blood pressure monitoring versus standard in-person clinic visits. Pregnant women aged 18-45 with chronic hypertension can join. The goal is to see if this approach is safe …

This early-stage study tests whether a lab-grown urethral tube can safely repair narrowed or injured urethras in adult men. Doctors take a small sample of the patient's own bladder cells, grow them into a new tissue tube, and implant it to replace the damaged section. The main go…

This study looks at whether a program where parents and children work together can help them lose weight and be healthier. About 90 families will join a weight management program that focuses on healthy eating, physical activity, and positive communication. The goal is to see if …

This study compares two surgical methods for treating severe heel fractures. The standard approach is to fix the broken bone, while the experimental approach adds a subtalar fusion (joining two bones in the ankle) during the same surgery. The goal is to see if the fusion reduces …

This study tests a custom leg brace (called IDEO) combined with a high-intensity rehab program for adults with lower leg injuries. The goal is to see if the brace and rehab improve walking, stair climbing, and daily activities. About 370 participants will be tested before, during…

This study tests whether rinsing with virgin coconut oil can prevent severe mouth sores in children and young adults (ages 7-26) undergoing high-dose chemotherapy before a bone marrow transplant. Participants will either use standard mouth rinses or add coconut oil to their routi…

This study looks at whether giving the immunotherapy drug Durvalumab within two weeks of finishing chemotherapy and radiation is safe and practical for people with stage III lung cancer that cannot be removed by surgery. About 28 participants will receive Durvalumab early, and re…

This study looks at whether taking vitamin D supplements during standard chemotherapy can help more tumors disappear in people with triple negative breast cancer who are low in vitamin D. About 50 participants will either get vitamin D plus chemo or just chemo. The goal is to see…

This pilot study is for adults with type 2 diabetes who have trouble affording healthy food. Participants will receive culturally appropriate food bundles and easy-to-read recipes and cooking guides. The goal is to see if this support improves cooking habits, nutrition knowledge,…

This study looks at how not having enough food (food insecurity) affects the heart health of people with HIV. Researchers will test a program where trained peers and a mobile app help participants get better access to food and support. The goal is to see if this can lower the ris…

This study tests a new way to treat fecal incontinence (uncontrolled bowel leakage) by injecting small pieces of the patient's own muscle into the anal sphincter. The goal is to help the muscle grow stronger and improve control. The trial involves 10 adults who have not been help…

This study tests whether starting cholesterol-lowering care in the emergency department can help prevent heart attacks and strokes. It involves 130 adults aged 40-75 who are at risk for heart disease but not yet on treatment. Participants will receive guideline-based care during …

This study compares two smartphone apps designed to help people living with HIV quit smoking. Over 6 months, 314 participants will use one of the apps along with nicotine patches and gum. The goal is to see which app works better at helping people stay smoke-free, with regular ch…

This study tests whether the targeted drug cetuximab can shrink tumors in people with advanced head and neck cancer whose prior immunotherapy stopped working or caused side effects. About 38 adults will receive cetuximab alone, and doctors will measure how many patients see their…

This study tests a new approach to improve rotator cuff healing. A small piece of chest muscle is taken, broken into tiny fragments, and injected into the shoulder muscle during surgery. Researchers hope this will increase muscle size and strength. The study involves 20 adults ag…

This study tests whether home blood pressure monitoring with extra support from a pharmacist and a community health worker works better than usual clinic care for Black patients with uncontrolled high blood pressure. About 864 Black adults aged 21-85 with high blood pressure will…

This study tests a procedure called Round Spermatid Injection (ROSI) for couples where the male partner cannot produce mature sperm. Doctors will collect immature cells from the testicles and use them to fertilize eggs, similar to IVF. The goal is to see if this method can safely…

This study compares two radiation schedules for head and neck cancer patients who start treatment more than 6 weeks after surgery. One group gets standard radiation 5 days a week; the other gets an accelerated schedule of 6 days a week. The goal is to see if the faster schedule b…

This study tests whether a monthly pill called risedronate can reduce bone and muscle loss that often happens after weight-loss surgery. About 200 people who have had sleeve gastrectomy will take either the drug or a placebo for 6 months and be followed for a year. The goal is to…

This study tests whether giving two FDA-approved chemotherapy drugs in a specific order can shrink pancreatic tumors enough to allow complete surgical removal. About 64 adults with borderline resectable or locally advanced pancreatic cancer will receive gemcitabine plus nab-pacli…

This study looks at how well different treatments work for Central Centrifugal Cicatricial Alopecia (CCCA), a type of scarring hair loss that mainly affects African-American women. Researchers will take photos of the scalp before and after treatment to compare results. About 250 …

This study tests whether offering financial rewards through a smartphone app can help people with opioid or cocaine use disorder stay abstinent. Researchers will compare two reward schedules: one that increases rewards over time and one that decreases them. The goal is to find th…

This study tests whether adding the diabetes drug metformin to standard cancer therapy helps people with advanced soft tissue sarcoma live longer. About 50 adults whose cancer has spread or cannot be removed will receive metformin alongside their first-line treatment. The main go…

This study looks at whether a DNA-based urine test (called Next Generation Sequencing) can find bacteria that standard urine cultures miss. It involves 100 women with UTI symptoms but low bacteria counts on the usual test. The goal is to see if the DNA test leads to better treatm…

This study tests a computer model that predicts whether a person has COPD, a lung disease that is often missed or misdiagnosed. Researchers will enroll 500 adults aged 40 and older who have had a lung function test in the past 5 years. The goal is to see if the tool can correctly…

This study offers free mobile low-dose CT scans to people aged 40-54 who have smoked heavily (30 pack-years or more) and live in North or South Carolina. The goal is to see if screening at a younger age can catch lung cancer earlier, when it's more treatable. Participants will ge…

This study is testing whether an AI tool called Belle.ai can help doctors correctly identify common skin diseases. About 400 people visiting a dermatology clinic will have three photos taken of their skin condition. The AI will then suggest a diagnosis, which will be compared to …

This study aims to create a computer program that can predict how easy or hard it will be to place a breathing tube by analyzing digital photos of a patient's face. Researchers will take pictures from three angles and use them to develop an algorithm that provides a consistent, o…

This study aims to find multiple myeloma at its earliest, precancerous stage (MGUS) in people at higher risk, including Black adults and close relatives of patients with plasma cell disorders. Researchers will screen up to 1,665 volunteers with a simple blood test. The goal is to…

This study tests a program called Walk On! to see if it helps prevent falls in older adults (60+) who have trouble moving or feel lonely. Participants join group walks twice a week for 12 weeks. Researchers will check if the program reduces falls and boosts confidence.

This study combines peer navigation (trained community members) with a mobile health app to help gay, bisexual, and transgender women in rural Appalachia access HIV, STI, and hepatitis C testing and prevention services. About 141 participants will be randomly assigned to receive …

This study tests an enhanced version of the National Diabetes Prevention Program (NDPP-NextGen) designed for young women aged 18-39 who are overweight and may become pregnant within two years. Participants will either join online group classes for 12 months or receive standard he…

This study tests whether a daily low-dose aspirin can prevent dangerous blood clots in people with advanced germ cell tumors (including testicular cancer) who are receiving standard chemotherapy. About 35 participants will take aspirin alongside their chemo for 26 weeks. The goal…

This study tests whether placing an antibiotic depot (calcium sulfate with antibiotics) inside the bone during surgery can prevent infections after severe open tibia fractures. About 497 adults with type II or III open fractures will be randomly assigned to receive either the ant…

This study is for adults with a severe open break of the shinbone (tibia). It tests whether a metal rod (nail) coated with antibiotics can prevent deep bone infections better than the standard uncoated rod. About 484 participants will be randomly assigned to one of the two treatm…

This study tests a program called COACH that teaches youth football coaches how to plan safer practices to reduce head impacts and concussions. About 880 young athletes will take part, and researchers will measure head impacts, thinking skills, and balance before and after the se…

This study tests whether using a single Perclose device to close the large blood-vessel entry point after TAVR works as well as the usual two-device method. About 300 adults having TAVR through the leg will be randomly assigned to one or two devices. The main goal is to see if on…

This study tests a short group therapy program (Dialectical Behavior Therapy) to help cancer patients reduce or stop smoking. Sixteen adults with cancer who smoke daily will try the program. The goal is to see if it's practical and helpful, not to cure cancer.

This study looks at whether teaching cancer patients about taste changes caused by chemotherapy and giving them self-management tools can help reduce those symptoms and maintain healthy eating. About 400 adults starting chemotherapy will be split into two groups: one gets standar…

This study compares two types of catheters (SpeediCath and Luja) in 17 women who regularly use catheters to empty their bladder. The goal is to see which one lets urine flow faster and which one women prefer. Participants will have one visit and a follow-up phone call a week late…

This study tests whether a single dose of intravenous (IV) magnesium can safely and effectively slow a dangerously fast heart rate in people with atrial fibrillation or atrial flutter. Researchers will compare two different doses (2 grams and 4 grams) against a placebo in 153 adu…

This study tests if orthopedic surgeons can safely screen for depression in patients with broken bones and start treatment with antidepressant medication. About 100 adults who have had surgery for a broken bone and show signs of depression will be offered medication or no medicat…

This study tests whether a cheaper mix of pain medicines (R.E.C.K) works as well as a more expensive drug (Exparel) for controlling pain after robotic kidney surgery. About 170 adults having their kidney removed will be randomly assigned to one of the two treatments. Researchers …

This study tests whether a custom 3D-printed mouth splint can help burn patients who have difficulty opening their mouths (microstomia). Ten participants will use the splint and be measured for changes in mouth opening and quality of life. The goal is to improve function and ease…

This study looks at whether physical therapy wound care methods, like pulsed water cleaning and electrical stimulation, can help heal pressure sores (bedsores) in people with spinal cord injuries. About 40 adults in a rehab hospital will try one of three treatments. The goal is t…

This study is testing whether a yoga program is practical and helpful for people with functional dyspepsia or gastroparesis—conditions that cause nausea, vomiting, and stomach pain. Ten adults will try yoga sessions and report how they feel. The goal is to see if yoga can provide…

This study tests a new, no-stitch device to hold surgical drains in place after surgery. The goal is to see if it improves patient comfort and reduces complications compared to the usual stitch method. About 140 adults having plastic or reconstructive surgery will take part. Resu…

This study looks at different ways doctors close the skin after a cesarean section (C-section) to find which method leads to the best-looking scar and fewest wound problems. About 52 women having scheduled C-sections will take part. Researchers will take photos of scars and have …

This study tests a short program to help children and their caregivers manage post-traumatic stress and depression after a serious injury like a burn or car accident. About 24 child-caregiver pairs will take part. The goal is to see if the program reduces emotional distress and i…

This study tests whether an internet-based pain coping skills program can help cancer survivors with ongoing pain. About 456 participants will either receive the online program plus enhanced usual care, or enhanced usual care alone. The goal is to see if the program reduces pain …

This early-phase study is testing whether inhaled nitric oxide (iNO) is safe for people having emergency clot removal after a stroke. Researchers will enroll 36 adults to find the highest safe dose and watch for bleeding in the brain. The goal is to see if iNO can be used alongsi…

This study looks at whether a mobile app can help young women (ages 18-45) with breast cancer feel less distressed. About 120 participants will use the app for 26 weeks, and researchers will check if distress scores improve. The goal is to see if the app is a useful tool for mana…

This study tests whether taking a fisetin supplement can lessen fatigue in older adults who have survived cancer. About 60 people who finished cancer treatment more than a year ago will take fisetin or a placebo. Researchers will measure changes in fatigue levels using a standard…

This study looks at whether a simple exercise routine—30 minutes of activity, five days a week—can help children and young adults (ages 2-25) with newly diagnosed cancer maintain their physical abilities and feel better emotionally during chemotherapy. About 60 participants will …

This study is testing whether oxytocin, given as a nasal spray or through an IV, can reduce pain from heat. About 24 healthy adults will rate their pain after a small heater is placed on their skin. Researchers will also check if age, weight, or sex affect how well oxytocin works…

This study is testing whether a low dose of clonidine, a drug usually used for high blood pressure, can improve sleep and reduce PTSD symptoms in military veterans. About 32 veterans with PTSD will take the drug and be monitored for 6 weeks. The goal is to see if this safe, affor…

This study compares two different remote support programs to see which one helps women feel better after surgery for suspected gynecological cancer. About 160 women will participate, and researchers will measure pain, mood, and sleep quality. The goal is to find better ways to su…

This study tests a telehealth program for caregivers of people with cancer who are about to have major surgery. The program aims to help caregivers find resources to reduce stress, depression, and financial strain. Researchers will enroll 50 caregivers to see if the program is he…

This study tests whether freezing certain nerves (cryoablation) during surgery to fix broken ribs can help control pain better than surgery alone. About 80 adults with multiple broken ribs will be randomly assigned to receive either the standard surgery or surgery plus nerve free…

This study compares two non-drug virtual programs designed to help people with migraines feel better and have less disability. About 286 adults with migraines will take part in 8 weekly online sessions while continuing their usual medications. The goal is to see which program wor…

This study is testing a new, standardized speech therapy treatment for people who feel a constant lump in their throat (globus pharyngeus). Ten adults with this sensation will receive the therapy to see if it reduces their symptoms. The goal is to create a proven treatment plan t…

This study explores whether virtual reality (VR) can reduce phantom limb pain in people who have lost an arm or hand. About 20 adults with phantom pain will use VR experiences to see if it lowers their pain and improves quality of life. The goal is to find a drug-free way to mana…

This study tests whether giving IV lidocaine during paraesophageal hernia surgery can reduce pain and speed recovery. About 50 adults having elective laparoscopic hernia repair will receive either lidocaine or a placebo alongside standard pain management. Researchers will measure…

This study compares two skin-resurfacing techniques—microneedling and dermabrasion—to see which one improves the look of early surgical scars on the face. About 30 adults with a vertical scar on the upper third of their face will be treated and followed for 6 months. The goal is …

This small pilot study tests whether a special red LED cap can improve symptoms and slow hair loss in women with central centrifugal cicatricial alopecia (CCCA), a scarring hair loss that mainly affects middle-aged Black women. Five women with confirmed CCCA will use the cap dail…

This study looks at whether giving magnesium along with the usual migraine drug prochlorperazine can better ease migraine pain in the emergency department. About 100 adults with migraines will receive either the combination or the drug alone. Researchers will measure pain changes…

This study tests a new, flexible hearing aid that sticks on the skin like a patch to help people with conductive hearing loss hear better. It uses tiny vibrating actuators to send sound through the skin to the inner ear. The study will include 200 children and adults with this ty…

This study tests whether wearing a virtual reality (VR) headset during radiation therapy can help manage anxiety in cancer patients. Researchers will enroll 54 adults with prostate, breast, lung, or head and neck cancer who are scheduled for at least 15 treatments. The goal is to…

This study tests whether a tailored physical activity program helps lymphoma and breast cancer patients preserve their exercise capacity, heart function, memory, and quality of life during treatment. About 110 adults aged 18-85 will be randomly assigned to either health education…

This study looks at whether injecting Xeomin® into the upper arm can improve walking and mobility in adults who have had a stroke. About 20 people with arm and leg stiffness will be tested before and 4-6 weeks after the injection using simple walking tests. The goal is to see if …

This study tests whether regular supportive phone calls from a care team can improve quality of life for adults with posttraumatic epilepsy who also have anxiety or depression. About 56 participants will either receive these calls over 24 weeks or continue with usual neurology ca…

This study is testing a device called Cereset Research to see if it can help people who feel stressed, anxious, or have trouble sleeping. The device listens to your heartbeat and brain signals and plays back tones to help your body relax. About 200 adults with these symptoms will…

This study compares two diets—a low-carb (ketogenic) diet and a low-fat diet—in 120 adults with mild memory problems (mild cognitive impairment). Participants follow their assigned diet for 16 weeks, then return to normal eating for 8 more weeks. Researchers will check if the die…

This study looks at two surgical methods for fixing certain types of broken thigh bones near the knee. About 144 adults will be randomly assigned to get either one or two metal implants during surgery. The main goal is to see which approach helps people get back to work and every…

This study tests a 24-week collaborative care program for 60 adults with epilepsy who also have anxiety or depression. The program adds extra support from a care manager to usual neurology care, aiming to improve emotional well-being and quality of life. Researchers will compare …

This study tests a non-invasive brain relaxation method called Cereset in 20 caregivers of people with dementia. Participants will attend up to three 60-minute sessions per week for 4 weeks. The goal is to see if it improves heart rate variability (a sign of stress) and reduces f…

This study looks at whether wearing a functional brace after ACL reconstruction helps people feel more ready to return to sports. About 96 people aged 14 to 39 with a complete ACL tear who want to get back to sports will take part. Half will wear a brace and half will not, and re…

This study is testing a new group exercise program combined with remote activity monitoring for older adults with heart failure with preserved ejection fraction (HFpEF). The goal is to see if this approach can improve exercise habits, quality of life, and physical function better…

This study looks at two common bowel treatments—oral senna and a rectal bisacodyl suppository—to see which helps women have their first bowel movement sooner after vaginal surgery for pelvic organ prolapse. About 88 women will take part, and their satisfaction with the treatment …

This study is testing whether a low-frequency pulsed electromagnetic field (PEMF) device can safely reduce pelvic pain and urinary symptoms in women with Interstitial Cystitis/Bladder Pain Syndrome. About 75 female adults will use the device at home and report their pain levels o…

This study tests whether using a virtual reality (VR) headset during a bone marrow biopsy can lower pain and anxiety. About 160 adults with blood cancers will be randomly assigned to use VR or standard care. The goal is to see if VR offers a simple, drug-free way to improve the p…

This study tests whether a 12-week high-velocity resistance training program is safe and doable for 30 older adults with advanced chronic kidney disease. Participants will either do the strength exercises or attend weekly healthy lifestyle group sessions. The goal is to see if th…

This study looks at how oxytocin, a natural hormone, affects pupil changes as a way to measure nervous system activity. Researchers will give oxytocin or a placebo injection to 38 people with chronic knee pain and healthy volunteers. The goal is to see if pupil measurements can r…

This study looks at how very low nicotine cigarettes change heart rate and heart rate variability in people who smoke daily or occasionally. Researchers will compare three types of cigarettes with different nicotine levels. The goal is to understand the heart effects of reducing …

This study looks at whether PET scans and blood tests can predict how a person's memory and thinking might change after radiation therapy for high-grade glioma. Most people experience at least mild memory or attention problems after radiation. The study will involve 16 adults wit…

This study looks at whether suctioning out stomach contents before taking heart images during cardiac surgery leads to clearer pictures. About 200 adults having heart surgery with a special ultrasound probe in the esophagus will take part. Researchers will compare image quality b…

This study looks at how a non-invasive brain stimulation technique called TMS affects brain activity in people who drink heavily and those who don't. Researchers will use a special brain scanner (MEG) to measure these effects. The goal is to gather information to plan future stud…

This study looks at whether firefighters' exposure to dangerous chemicals on the job raises their risk of developing blood cancers. Researchers will test blood samples from 300 firefighters aged 40-49 with at least 5 years of service to look for early signs of pre-cancerous chang…

This study looks at whether older adults with advanced colorectal cancer who have low muscle mass experience more severe side effects from chemotherapy. Researchers will follow 300 participants to track toxicities and survival. The goal is to better understand risks and improve t…

This study looks at how certain natural chemicals in the body affect high blood pressure and related heart and kidney damage in children. Researchers will follow 125 children aged 7-18 with newly diagnosed high blood pressure, plus healthy kids, for two years. They will collect b…

This study aims to create better survey questions to measure quality of life in adolescents and young adults (ages 15-39) with cancer and their caregivers. Researchers will test questions about body image, fertility concerns, and financial burden with 3,000 participants across th…

This study looks at whether requiring labor and delivery staff to complete a simulation training for cervical exams leads to fewer exams for patients and more consistent results between different examiners. Over 1,100 healthcare providers and pregnant women will be observed befor…

This study surveys 500 surgeons and advanced practice providers to see how often they prescribe blood clot prevention medication after abdominal or pelvic cancer surgery. The goal is to understand current practices and improve adherence to guidelines. No patients are treated dire…

This study looks at whether a flexible, step-by-step food support program can help pregnant women who struggle to afford enough food. About 60 pregnant women in their first trimester will receive different levels of help based on their needs. The goal is to see if this approach i…

This study is tracking 2000 adults with newly diagnosed breast, colorectal, lung, melanoma, or lymphoma cancer who are getting chemotherapy or immunotherapy. Researchers want to see if using cannabis or cannabinoids helps with symptoms like pain, nausea, or fatigue, and whether i…

This study aims to understand cancer-related fatigue in 20 adults with non-small cell lung cancer who are receiving immunotherapy. Researchers will conduct interviews and surveys to learn about fatigue patterns, daily life impacts, and patients' views on physical activity. The go…

This study follows 200 people who have broken their pelvis or hip socket to understand how they recover over time. Researchers will track pain, physical function, and how soon patients return to work or daily activities. The goal is to learn what recovery looks like for different…

This study looks at why people with a JAK2 mutation have a higher risk of dangerous blood clots compared to those with a CALR mutation. Researchers will collect blood samples from 35 adults with CALR-mutated myeloproliferative neoplasms to measure immune markers and inflammatory …

This study is testing different ways to give weekly feedback to people trying to lose weight. Researchers want to see which type of message helps people lose the most weight. About 300 adults who are overweight or obese will take part. The study does not test a new drug or treatm…

This study looks at whether a comprehensive genetic test (microarray PGx) can find more drug-gene interactions than the standard single-gene test in 120 adults with cancer who are about to receive chemotherapy. The goal is to see if this broader test gives doctors extra informati…

This study explores why many people with pancreatic cancer develop severe muscle wasting, called cachexia. Researchers will collect blood samples from 100 patients to look for genetic differences that may be linked to this condition. The goal is to better understand cachexia and …

This study compares pain reports from younger (45 and under) and older women receiving pegfilgrastim (a drug that helps white blood cell recovery) during chemotherapy for non-metastatic breast cancer. Researchers want to see if younger women experience more frequent or intense pa…

This study looks at whether a nurse-led support program helps new mothers and babies in five rural North Carolina counties get better care after childbirth. About 1,300 women who deliver at a specific hospital and live in those counties will be randomly assigned to the program or…

This study looks at whether patients who talk to an EMS doctor on the phone are more likely to agree to go to the hospital by ambulance. About 250 adults who want to refuse transport will be included. The goal is to see if a doctor's advice can reduce refusal rates and improve ca…

This study looks at how many opioid pain pills patients take after surgery for bladder, kidney, or prostate cancer. About 684 adults will report their opioid use 30 days after leaving the hospital. The study also tests if a simple pamphlet helps people safely dispose of leftover …

This study looks at whether people with chest pain who are at moderate risk for a heart attack can be safely evaluated as outpatients instead of being admitted to the hospital. About 500 adults with chest pain will be randomly assigned to either a rapid outpatient evaluation or s…

This study looks at families who struggle to get enough food while their child is in the hospital. Researchers want to find out whether delivering meals or giving grocery gift cards works better. About 30 caregivers of hospitalized children in Forsyth County, North Carolina, will…

This study looks at how 3-4 rounds of chemotherapy before surgery affects frailty in adults over 55 with advanced ovarian or endometrial cancer. Researchers will track changes in a frailty score using medical records. The goal is to learn whether this treatment approach helps or …

This study looks at how myotonic dystrophy type 2 (DM2) changes the brain and thinking skills. About 100 adults with DM2 or DM1 and healthy volunteers will get brain MRIs, thinking and movement tests, and blood draws. Some will also have a spinal tap. The goal is to find brain me…

This study asks 300 young adults (ages 15-39) who have or had cancer to fill out surveys about what they were taught regarding exercise, sexual health, fertility, finances, and other key topics. The goal is to identify gaps in education so that hospitals can better support future…

This study watches 600 children under 10 years old to see what helps them breathe well after their breathing tube is removed during IV-only anesthesia. The goal is to find better ways to predict a smooth recovery and avoid problems like low oxygen or airway blockages. Results may…

This study is creating a program called CERCA to help families of children with cancer get support for basic needs like food, housing, and transportation. Researchers will work with doctors, community groups, and families to design the program. The goal is to make sure families g…

This study tests a new way to help smokers in rural areas who are not yet ready to quit. Paramedics will refer participants to a text-message program designed to motivate them to stop smoking. The goal is to see if this approach can reach more people and help them eventually quit…

This study tests a program called COACH-APP, which provides education and mentorship to advanced practice providers (like nurse practitioners and physician assistants) in community cancer clinics. The goal is to boost their confidence and skills in participating in clinical resea…

This study looks at how belly pressure changes during a heart procedure called pulsed field ablation (PFA) for atrial fibrillation or atrial flutter. Researchers will use a special monitoring system to measure pressure in the abdomen and compare it based on whether patients recei…

This study looks at whether extra financial help (called financial navigation) can reduce money-related stress and improve quality of life for people being treated for acute myeloid leukemia (AML). About 120 adults aged 18-64 starting intensive chemotherapy will be split into two…

This study looks at how well the immune system works in children who have finished cancer treatment. It also tests starting routine vaccinations earlier than usual—just 3 months after therapy ends—to see if a single booster or a full series of shots works better to restore protec…

This study collects blood and tissue samples from 20,000 people with suspected solid tumors. The samples are stored in a central bank for researchers to use in future cancer studies. Participants must be scheduled for a biopsy or surgery. No direct treatment is given, but the sam…

This study looks at how to better support adults aged 65 and older during chemotherapy. Researchers will use a frailty score to create personalized care plans and track how well participants handle treatment. The goal is to see if this approach improves resilience and reduces hos…

This study is collecting basic survival and complication information from 2000 people receiving stem cell transplants for blood cancers or immune diseases. The goal is to build a database that helps doctors and researchers better understand long-term outcomes and improve future t…

This study looks at whether oxytocin, a natural hormone, can change how nerves send pain signals after a small area of skin is heated. Sixty healthy adults will receive either oxytocin or a placebo through an IV, and researchers will measure nerve activity and pain ratings. The g…

This study looks at whether wearable devices (like a smartwatch) combined with personal wellness coaching can help first-year medical students stay healthy and avoid burnout. About 49 students will track their heart rate, sleep, and stress levels over time. The goal is to see if …

This study is for people with leukemia who are getting a blood stem cell transplant. It aims to understand how genetics and drug levels affect the risk of graft-versus-host disease (GVHD), a serious complication. Researchers will study 120 participants to find ways to personalize…

This study looks at how chronic marijuana use changes brain inflammation and thinking abilities in people with HIV. Researchers will use brain scans and blood tests to measure brain health in 220 adults. The goal is to understand the effects, not to test a new treatment.

This pilot study looks at whether giving older adults (65+) an antidepressant called duloxetine right after surgery for a broken leg can help prevent depression. About 100 participants will take the medicine daily for a year and be screened monthly for depression. The main goal i…

This study looks at how cancer survivors talk about their fatigue. Researchers want to understand the different ways people describe this tiredness. They will use this information to create a poster that helps patients and doctors discuss fatigue more easily. The goal is to help …

This study looks at how salt in the diet affects blood pressure in young adults who were born prematurely. Researchers will compare their responses to those born full-term and test whether a drug called allopurinol can reduce salt sensitivity. The goal is to better understand why…

This study is testing whether wearable activity trackers (like a Fitbit) can be used by people with pancreatic or breast cancer to track fatigue during treatment. About 46 participants will wear the device for 14 days and share their heart rate data. The goal is to see if patient…

This study is looking at how a breast cancer medicine called an aromatase inhibitor changes the bacteria in your gut. Researchers will collect stool and blood samples from 25 women before and after starting the drug to see if these changes affect estrogen levels. The goal is to b…

This study looks at whether using telehealth can help primary care doctors better manage children with very rare, complex health conditions that require care from many specialists. About 909 children under 18 with multiple chronic conditions will take part. The goal is to see if …

This study follows 850 adults with normal memory or mild cognitive issues to find early signs of Alzheimer's. Researchers focus on how the body handles sugar and insulin, as these may affect brain health. Participants undergo yearly memory tests and optional scans or spinal taps …

This study looks at how well people with atopic dermatitis (eczema) follow their topical medication routine. About 30 participants will be split into groups: standard care, a demonstration, or a mobile app. Researchers will measure how much cream is used, how often it's applied, …

This study measures the normal pressure inside the brain's veins in 10 people who are already having a brain angiogram for other reasons. The goal is to collect baseline data to better understand Idiopathic Intracranial Hypertension (IIH), a condition that causes severe headaches…

This study is developing advanced muscle imaging techniques to better measure disease progression in myotonic dystrophy, a condition causing muscle weakness and disability. Researchers will scan the leg muscles of 75 adults (ages 18-65) with the disease and compare them to health…

This study looks at whether regular MRI scans of the brain after radiation therapy can find cancer that has spread to the brain before it causes symptoms. About 60 adults with stage III non-squamous lung cancer will get MRI scans at set times. The goal is to see if this monitorin…

This study is testing a blood test called a liquid biopsy to see if it can find tiny bits of tumor DNA in people with sarcoma (a type of bone or soft tissue cancer). Researchers will collect blood samples from 300 participants before, during, and after treatment to see how well t…

This study aims to see if a program created by local community members can help people adopt behaviors that reduce virus transmission. Researchers will enroll 546 adults from specific areas in North Carolina who have not had COVID-19. The program is developed through a crowdsourc…

This study explores how a person's genetic makeup influences side effects and treatment success when using azacitidine and venetoclax for newly diagnosed acute myeloid leukemia. Researchers will enroll 50 adults and track severe side effects like infections and low blood counts, …

This study aims to identify frailty in people aged 50 and older living with HIV. Researchers will measure physical performance and quality of life to better understand the challenges of healthy aging. The study involves 100 participants from a specialty clinic and does not test a…

This study compares different outreach methods to see which works best for getting people at high risk for lung cancer to complete a screening CT scan. It includes 27,000 participants, focusing on racial/ethnic minorities and rural residents. The goal is to find the most effectiv…

This study looks at how chronic stress changes brain and immune function in people with HIV who use stimulants. Researchers will use brain scans and interviews to understand these changes, with the goal of finding better ways to treat depression and reduce stimulant use. The stud…