University Of Cincinnati

This study tests a new drug called AM3101 to see if it helps meniscus tears heal better after surgical repair. About 74 people aged 18 to 40 with a torn meniscus will receive either AM3101 or a placebo injection during surgery. The goal is to improve healing and reduce the chance…

This study is for people whose head and neck cancer has come back after previous treatment. It tests whether giving a type of immunotherapy (pembrolizumab) along with either standard or proton radiation before surgery is safe and helps shrink tumors more than surgery alone. About…

This study compares two types of metal plates used to fix a broken hip socket (acetabular fracture) after a hip dislocation. The goal is to see if a newer 'rim plate' with screws through it holds the bone better than the standard 'buttress plate', leading to less arthritis and be…

This study looks at whether a procedure called endovascular thrombectomy (EVT) can help people who have a stroke but already had a moderate-to-severe disability before the stroke. About 1,060 adults with a large blood vessel blockage in the brain will be randomly assigned to get …

This study looks at whether using a continuous passive motion (CPM) machine after surgery for certain leg fractures can lower pain and the need for strong painkillers. About 100 adults who had surgery for a broken hip, thigh, or shin bone will be split into two groups: one gets s…

This study compares two standard numbing methods for breast cancer patients having a mastectomy. One method is done before surgery, the other during surgery. The goal is to see which approach reduces pain and the need for opioid painkillers after the operation. About 100 adults w…

This study tests whether starting pelvic floor physical therapy soon after radiation treatment can reduce bowel and bladder control problems in women with cervical cancer. Twenty-eight women who are getting pelvic radiation will receive the therapy and be checked for incontinence…

This study looks at whether a supplement called N-acetylcysteine (NAC) and mindfulness-based therapy can help young people aged 15 to 24 with mild depression. Researchers will measure changes in brain chemicals and connections linked to emotion and attention. The goal is to see i…

This study tests a new device called VirtuaCare™ that gives patients real-time feedback on their at-home exercises after shoulder surgery. The goal is to see if it helps people do their prescribed physical therapy more consistently. About 60 adults who had shoulder replacement or…

This study tests a special type of radiation called lattice therapy for people with large, hard-to-treat tumors. The goal is to see if it can shrink tumors better than standard radiation and help people feel better. About 37 adults with advanced solid tumors will receive this tre…

This study tests whether a daily probiotic called Pendulum Glucose Control (PGC) can safely reduce stomach and bowel side effects in people receiving radiation for pelvic cancers (like prostate, rectal, or cervical cancer). About 20 adults will take the probiotic during their rad…

This study looks at whether moderate or high-intensity walking exercise is better for improving walking in people who had a stroke at least 6 months ago. Participants will do 45-minute walking sessions with a physical therapist three times a week for 12 weeks. The goal is to see …

This study tests whether a tongue endurance exercise program can improve swallowing in adults who have trouble swallowing after a stroke. About 70 people will be randomly assigned to do either the tongue exercises or a sham therapy at home for 8 weeks. Researchers will measure ch…

This early-phase study looks at whether a natural protein called C-peptide can help the liver produce more glucose during insulin-induced low blood sugar in people with type 1 diabetes. The goal is to understand how this protein might reduce the risk of severe hypoglycemic episod…

This study explores whether mild electrical stimulation of the spine can change how the brain processes body signals, which may be disrupted in major depression. Researchers will test different stimulation levels in 67 adults with depression to see if it affects brain activity an…

This study looks at why walking is harder for people after a stroke. Researchers will test a new method to measure walking efficiency in 18 adults who have had a stroke. Participants will walk on a treadmill for three 5-minute sessions to compare this new measure with standard en…

This study looks at how hormones like insulin and glucagon change after a meal in people with cystic fibrosis. Researchers want to find links to blood sugar problems common in this group. About 61 adults aged 18-45 with cystic fibrosis will take part. No treatment is given—only b…

This study looks at whether brain scans and electrical tests done soon after a stroke can predict how well a person will recover arm movement. Researchers will collect data from 657 adults who had a stroke and have arm weakness. The goal is to create a large dataset to help desig…

This study looks at how brain activity changes as people recover from a moderate to severe traumatic brain injury (TBI). It also tests whether giving a gentle electrical stimulation to the brain (called anodal transcranial electrical stimulation) early after injury can improve th…

This study uses brain imaging to see how language therapy affects the brains of preschoolers with Developmental Language Disorder (DLD), a condition that makes it hard to learn grammar. Researchers will scan the brains of 100 children aged 4 to 6 years, both with and without DLD,…

This study looks at whether monitoring specific brain wave patterns (called spreading depolarizations) in real time can help doctors choose treatments to calm the brain after severe traumatic brain injury. About 72 people who need emergency brain surgery will be enrolled. The goa…

This early-phase study tests whether letrozole, a drug typically used for breast cancer, can penetrate the blood-brain barrier and concentrate in brain tumors. About 39 adults with recurrent high-grade gliomas will receive letrozole alongside standard therapy. The main goal is to…

This study compares two forms of DHA (a healthy fat) to see which one gets into the brain more effectively. Researchers will give 153 older adults with early memory problems either a special DHA (LPC-DHA) or standard DHA for 24 weeks. They will measure DHA levels in spinal fluid …