University Of Calgary

This study is testing different doses of the clot-busting drug tenecteplase in 4,000 people who have had a stroke caused by a blood clot. The goal is to find the safest and most effective dose to help patients recover with less disability. The trial also looks at whether giving t…

This study tests a wellness program for adults waiting for a kidney or liver transplant. The program includes exercise, nutrition, stress reduction, and sleep support before and after surgery. Researchers want to see if it improves fitness, quality of life, and reduces hospital v…

This study tests whether a virtual home hospital program, which includes remote monitoring and digital tools, can help adults with acute kidney injury recover at home instead of staying in the hospital. About 354 participants will be randomly assigned to either the virtual care p…

This study is testing whether taking a prebiotic fiber supplement for 6 months can help people with type 1 diabetes have fewer low blood sugar episodes and better overall blood sugar control. The study involves 144 people recently diagnosed with type 1 diabetes. Participants will…

This study tests a stem cell transplant for children with sickle cell disease who have a family donor with a different blood type. The goal is to see if a milder treatment before transplant can reduce serious complications like red blood cell failure. Up to 12 children will take …

This study tests whether giving children with a severe E. coli infection extra fluids through an IV can prevent kidney damage. About 1,040 children will be randomly assigned to either high-volume fluids or standard care. The goal is to see if this simple approach reduces the need…

This study tests whether a small, hand-held biosensor can accurately measure a brain injury marker in the blood of adults with concussion. Researchers will compare the device's results to standard lab tests and track symptoms over 12 weeks. The goal is to provide a fast, affordab…

This study looks at whether giving fluids through an IV before and during a procedure called ERCP can prevent pancreatitis, a common complication. Researchers want to find a short, practical hydration plan that works for patients who go home the same day. About 13,000 adults havi…

This study looks at whether regular aerobic exercise (like brisk walking or cycling) can help prevent Alzheimer's and other dementias in older adults who are at higher risk. Researchers will compare a 6-month aerobic exercise program to a stretching-and-toning program in 264 inac…

This study tests if giving IV fluids for a short time around an ERCP procedure can prevent pancreatitis, a common and serious side effect. About 505 adults aged 18-75 who need an ERCP will receive different fluid plans. The goal is to find a simple, practical way to lower the ris…

This study tests whether a large dose of IV saline (about 4 cups) can improve thinking speed and memory in people with Long COVID or POTS who experience brain fog. Researchers will compare the effects of the full dose to a tiny placebo dose in 100 adults. The goal is to see if th…

This study tests whether a custom mouthpiece that gently moves the lower jaw forward during sleep can improve sleep quality, heart rate patterns, and blood oxygen levels. Twenty-four healthy adults aged 40-65 will wear both the active device and a placebo device for several weeks…

This study tests if transcranial magnetic stimulation (TMS) can reduce anxiety and depression in 120 children and teens aged 6 to 18. Participants have a doctor's diagnosis and active symptoms. The treatment uses magnetic pulses to stimulate the brain, and researchers will measur…

This study tests whether breathing small amounts of carbon dioxide can raise blood pressure and improve symptoms in people with neurogenic orthostatic hypotension (NOH), a condition where blood pressure drops sharply upon standing. Researchers will compare the effects of differen…

This study is testing whether a robotic walking trainer, called the Trexo, can help children and adults with walking problems (like those with cerebral palsy or brain injury) improve their mobility. Researchers want to see if a structured program using this robot in a hospital is…

This study tests a simple device that lets people rebreathe some of their own exhaled carbon dioxide to raise blood pressure. It is for adults with neurogenic orthostatic hypotension, a condition where standing causes a big drop in blood pressure and fainting. Researchers will me…

This study looks at whether eating more salt can help people with POTS, a condition that causes a fast heart rate and dizziness when standing. Researchers will compare a high-salt diet to a normal-salt diet over 3 months in 50 adults. The goal is to see if extra salt reduces symp…

This study tests if botulinum injections can reduce leg pain during sport in people with chronic exertional compartment syndrome. 50 adults with confirmed diagnosis will receive either the injection or a placebo. Researchers will track pain levels and leg function over 24 weeks.

This study tests whether probenecid, a safe drug already used for gout, can reduce withdrawal symptoms in people with chronic pain who are voluntarily lowering their opioid dose. Withdrawal symptoms often make it hard to stop or reduce opioids. The trial will enroll 40 adults and…

This study looks at how much walking practice on a special treadmill (split-belt) with virtual reality stroke survivors can handle in early recovery. About 72 people who had their first stroke within the past three months will try different amounts of training to find the safest …

This study tests whether cannabis can help prevent chronic migraines. About 72 adults with frequent headaches will take either a low or high dose of CBD (a cannabis compound) or a placebo pill for several months. Researchers will track changes in the number of headache days to se…

This study tests whether a non-invasive brain stimulation technique called theta burst rTMS can reduce ADHD symptoms like poor attention and impulsivity. Researchers will enroll 30 children aged 9-15 with ADHD. The goal is to see if this approach can ease symptoms without the sid…

This study tests whether wearing compression garments (like tight waist-high stockings or abdominal shapewear) during everyday activities can lower heart rate and ease symptoms in adults with Postural Orthostatic Tachycardia Syndrome (POTS). About 30 participants will wear the ga…

This study is testing an 8 to 12 week exercise program for people who have or had cancer. The program includes supervised exercise classes, either online or in person, to help improve physical activity and reduce cancer-related symptoms. About 740 adults across Canada will take p…

This study tests a safe, non-invasive device that sends mild electrical pulses through the ear to stimulate the vagus nerve, which helps control pain and stress. Researchers want to see if this treatment can reduce neck pain, disability, and anxiety in 40 adults with chronic whip…

This study compares a topical diclofenac gel to oral ibuprofen for children aged 6-18 with recent ankle or knee injuries. The goal is to see if the gel works as well or better at reducing pain, and whether a larger study is possible. Participants will use the assigned treatment t…

This study looks at whether therapeutic cuddling (like kangaroo care or comfort holding) can reduce pain, agitation, and delirium in children in the pediatric intensive care unit (PICU). About 112 children expected to stay more than 48 hours will be randomly assigned to receive c…

This study tests whether using a person's genetic information can help doctors pick the best antidepressant for teenagers aged 12-17 with anxiety or depression. About 452 teens will be randomly assigned to either standard prescribing or gene-guided prescribing for 12 weeks. The g…

This early-stage study tests whether psilocybin (the active ingredient in magic mushrooms) combined with talk therapy can safely help people aged 18-65 with concussion symptoms lasting over 3 months. Forty participants will receive either a high or low dose of psilocybin, plus we…

This study tests a program that lets cancer patients report symptoms from home using a digital questionnaire. A nurse then gives tailored advice. The goal is to see if this improves quality of life and reduces emergency visits. About 1055 adults with cancer will take part.

This study looks at the health and well-being of girls and women with and without ADHD, from age 10 onward. Researchers want to understand how hormones, life stages, and childhood experiences affect mental health. Participants fill out surveys about their ADHD, mood, and overall …

This study looks at how changing heart rate changes blood flow to the brain. Researchers will use temporary pacemakers in 20 adults already scheduled for heart procedures to speed up their hearts, then measure brain blood flow with ultrasound. The goal is to better understand the…

This study tests whether a smartphone app called ICanWALK can teach people to use walking aids like crutches, canes, and walkers more safely. About 52 adults with leg injuries or conditions like stroke or multiple sclerosis will use the app or receive standard care. The goal is t…

This study is creating a detailed database of 6,000 adults who undergo ERCP, a procedure used to diagnose and treat bile duct and pancreas issues. Researchers are collecting information before, during, and after the procedure to track complications like pancreatitis or bleeding. …

This study looks at whether donor breast milk can help restore healthy gut bacteria in full-term babies born by C-section who need extra feeding. About 90 mothers and their infants will take part, with some babies getting donor milk and others getting formula. The goal is to see …

This study looks at whether a fine needle biopsy can provide the same molecular information as a larger surgical sample for people with papillary thyroid cancer. Researchers will compare results from the Thyroid GuidePx test on both sample types. The goal is to see if the less in…

This study looks at better ways to diagnose bile duct stones, which can be dangerous if missed. Current methods often lead to unnecessary procedures. Researchers will test if changes in liver enzyme levels can improve accuracy. About 2000 adults with suspected stones will take pa…

This study looks at how different heart rates and body positions change the amount of blood the heart pumps. Researchers will safely adjust the heart rates of 25 people who already have pacemakers. The goal is to better understand fainting (vasovagal syncope) and improve future t…

This study looks at how different types of iron supplements affect iron levels, exercise performance, and gut health in young female athletes who have low iron stores. Participants will take one of three iron supplements every other day for 12 weeks and complete fitness tests, bl…

This study follows 825 pregnant women who need blood thinners for blood clots. Researchers want to see how different treatment plans around childbirth affect bleeding risks. The goal is to find the safest way to manage these medications for both mother and baby.

This study tests whether brain computer interfaces (BCI) can be used at home by children aged 5-18 with severe physical disabilities, such as cerebral palsy or brain injury. The goal is to see if BCI helps them achieve personal life participation goals, like communicating or play…

This study tests a new, non-invasive method to measure how well the heart and blood vessels work in adults with and without heart failure. Participants will squeeze a device with their hand for 2 minutes while sensors track their heart function. The goal is to see if this simple …

This study watches 90 adults with Crohn's disease who are starting a drug called guselkumab. Researchers use intestinal ultrasound and blood protein tests to see who responds well over one year. The goal is to find better ways to measure treatment success without invasive procedu…

This study aims to understand why people with Postural Tachycardia Syndrome (POTS) get dizzy and have a fast heartbeat when standing. Researchers will compare blood samples from 125 people with and without POTS to see if certain antibodies are more common in POTS patients. No tre…

This study looks at how blood flow in the brain affects breathing stability during sleep, especially when oxygen levels are low. Researchers will test 12 healthy adults in a controlled setting to measure changes in breathing reflexes and blood markers. The goal is to better under…

This study looks at whether increasing carbon dioxide (CO2) levels in the blood can lower heart rate and reduce symptoms in people with Postural Orthostatic Tachycardia Syndrome (POTS) when they stand up. Researchers will test different CO2 concentrations to find the best one. Ab…

This study looks at why some children and teens get agitated or restless when taking common antidepressants (SSRIs). Researchers will collect saliva samples from 120 participants aged 6 to 24 with depression, anxiety, or OCD to see if certain genes are linked to this side effect.…

This study looks at how a robotic walking trainer called Trexo helps people with conditions like cerebral palsy who have trouble walking. Researchers want to understand why it works and how to use it best. About 50 participants will try different settings on the robot to see how …

This study looks at how sleep quality and physical activity are linked to memory in people living in assisted-living facilities. Researchers will measure sleep using monitors and questionnaires, and assess physical function and memory with simple tasks. The goal is to find factor…

This study tests an online decision aid called 'My Heart Care and CKD' for people with both chronic kidney disease and heart disease. The tool helps patients and doctors understand the risks and benefits of heart procedures like angiograms or surgery, which can be riskier for kid…

This study explores how a child's genetic makeup influences their response to a common ADHD medication called methylphenidate. Researchers will track symptom changes and side effects in 400 participants aged 6 to 24 across Western Canada. The goal is to learn which genetic profil…

This study looks at whether the intense, mind-altering experience caused by psilocybin (the active ingredient in magic mushrooms) is necessary for its positive after-effects. Healthy volunteers will receive psilocybin along with either a placebo or risperidone, a drug that blocks…

This study tests a new online survey tool that lets patients with coronary artery disease report their symptoms and quality of life before doctor visits. The results are shared with their cardiologist to improve communication and care. About 200 patients and their doctors will tr…

This study looks at how well different first aid methods (like back blows and abdominal thrusts) work for adults and children over age 2 who are choking. Researchers in Alberta, Canada will collect information from real choking incidents to see which treatments are safest and mos…

This study aims to see if a smartphone app can help track recovery in 800 sarcoma patients after surgery. Participants will fill out health questionnaires and let the app monitor their steps and activity for a year. The goal is to better understand how patients heal and improve f…

This study looks at how well different first aid techniques work for infants (up to 2 years old) who are choking. Researchers in Alberta, Canada will collect information from real-life choking incidents to see which treatments are safest and most effective. The goal is to improve…