University Hospital, Tours

This study follows 150 children aged 3 to 10 who need surgery for a spine problem called hemivertebra. The goal is to see how well the surgery straightens the spine and whether problems like nerve damage or poor healing occur. Researchers will check the children for up to 6 month…

This study tests whether a structured diet and exercise program can help adults with cystic fibrosis increase their lean muscle mass. All participants are already taking the drug Trikafta (elexacaftor-tezacaftor-ivacaftor). The program combines dietary advice with adapted physica…

This study tests whether using water pills (diuretics) as the second blood pressure medication works better than usual care for people with moderate-to-severe chronic kidney disease and uncontrolled high blood pressure. About 720 adults will be randomly assigned to either a diure…

This study tests if lying face down (prone positioning) while awake can help adults with severe pneumonia avoid needing a breathing tube. Researchers will compare this approach to standard care in 1078 ICU patients. The goal is to see if this simple position change reduces the ne…

This study aims to find out if proteins and fats in tears can be used to diagnose Alzheimer's disease. Researchers will collect tear samples from 90 participants (people with Alzheimer's and healthy volunteers) and compare the levels of certain biomarkers. If successful, this cou…

This study tests whether a quick, non-invasive lung ultrasound can detect interstitial lung disease in people with rheumatoid arthritis. About 280 adults with RA and risk factors for lung disease will get an ultrasound, and results will be compared to standard chest CT scans. If …

This study tests a new type of talk therapy called dissociation-focused cognitive behavior therapy (DF-CBT) for people with dissociative disorders, such as depersonalization or dissociative identity disorder. The goal is to see if DF-CBT reduces dissociative symptoms better than …

This study tests whether using hypnosis during a screening colonoscopy helps people complete the procedure with less anxiety and pain. About 600 adults getting a routine colonoscopy for colorectal cancer detection will be randomly assigned to receive either standard care or hypno…

This study tests whether serving food in easy-to-grip, bite-sized pieces (finger foods) helps elderly residents in care homes eat more, gain weight, and feel more independent. About 30 people over 75 who are undernourished or losing weight will take part. Researchers will check i…

This study tests whether giving a water pill (furosemide) and extra fluids during laser kidney stone surgery helps clear out tiny leftover fragments. About 374 adults who need this surgery will be randomly assigned to receive either the water pill plus fluids or standard care. Th…

This study tests a new high-tech device that uses eye-tracking to help patients in the intensive care unit (ICU) who are on breathing machines communicate with their caregivers. Many of these patients are awake but cannot speak due to a tube in their throat, which can be frustrat…

This study looks at two ways to start labor in pregnant women whose cervix hasn't opened enough after 24 hours of preparation. One method uses the hormone oxytocin, the other uses prostaglandins (another hormone). The goal is to see which approach leads to fewer C-sections and fa…

This study looks at 100 adults with sickle cell disease who are in intensive care for severe pain crises and receiving morphine. Researchers want to see if faster kidney filtration (common in sickle cell patients) causes morphine to be cleared too quickly, leading to underdosing …

This study aims to improve how doctors manage a type of stroke called intracerebral hemorrhage (ICH), which is a bleed inside the brain. About 600 adults admitted to a hospital in France will be followed to see if using a special care plan reduces death and long-term disability. …

This study will gather information from 10,000 people who have a spontaneous brain bleed (intracerebral hemorrhage). Researchers will collect medical history, brain scans, and blood samples to learn more about the condition and find ways to improve diagnosis and treatment. The go…

This study examines specific immune cells (iNKT cells and monocytes) in people with lupus to see how they differ between those with active disease and those with stable disease. Researchers will measure certain receptors on these cells using blood samples. The goal is to better u…

This study looks at how genes and body chemistry are linked in adults with phenylketonuria (PKU) who were treated early in life. Researchers will analyze blood and saliva samples from 149 participants to find patterns. The goal is to better understand PKU, not to test a new treat…

This study uses ultrasound to measure tiny brain movements in 300 people with mild or major cognitive disorders. Researchers want to see if these brain pulses differ between groups and can predict who will get worse over time. The goal is to better understand the disease, not to …

This study looks at the bone marrow of children with acute leukemia to understand why some cases relapse or resist treatment. Researchers will compare cells from 40 children with leukemia to those without blood diseases. No new treatment is tested; the goal is to gather knowledge…

This study is testing whether a blood-based model can predict how well rheumatoid arthritis patients will respond to a lower dose of the drug rituximab. Researchers will enroll 30 adults who already respond well to standard-dose rituximab and switch them to a single 1000 mg infus…

This study looks at whether patients in intensive care with severe breathing problems can safely eat or drink before being placed on a ventilator. Normally, patients must fast to prevent food from entering the lungs, but this can cause hunger, thirst, and weakness. The researcher…

This study looks at how mucus from the airways of people with bronchiectasis (a chronic lung condition) affects a new inhaled antibody treatment. Researchers will collect sputum samples from 30 adults with stable bronchiectasis and test how well the antibodies can reach and bind …

This study aims to improve how doctors diagnose Alzheimer's disease by using a new memory test that considers emotions and personal experiences. Researchers will enroll 150 adults aged 50 and older with mild memory problems. The goal is to see if this test can better distinguish …