University Hospital, Strasbourg, France

This study tests if freezing the tumor (cryoablation) works better than standard drugs for people with desmoid tumors that have grown after a period of monitoring. About 150 participants aged 13 and older will be randomly assigned to one of the two treatments. The goal is to see …

This study looks at whether reducing immunosuppressive medications can help kidney transplant patients recover faster from life-threatening infections in the intensive care unit (ICU). About 212 adult kidney transplant recipients who are in the ICU with septic shock or severe bre…

This study looks at whether using one antibiotic or a combination of two antibiotics works better for a serious bloodstream infection caused by Enterococcus faecalis. The infection can be deadly, with a 15-25% death rate. Researchers will track 700 adults to see which approach lo…

This study looks at 830 people with relapsing-remitting multiple sclerosis (MS) that started after age 50. Researchers compare two treatment strategies: starting with a moderately effective drug versus starting with a highly effective drug. The goal is to see which approach bette…

This study looks at how well a non-surgical endoscopic procedure works for repairing bile duct injuries that happen during gallbladder or liver surgery. Researchers will track 220 adults to see how many have successful treatment right away and again after 3 months. The goal is to…

This study looks at whether replacing an infected hip or knee joint in just one surgery works as well as the usual two-surgery approach for rare Candida fungal infections. Researchers will track 16 adults who already had this one-stage procedure to see if the infection clears up.…

This study is testing whether the antibiotic clindamycin works as well as other antibiotics for treating strep infections that occur around artificial joints (like hip or knee replacements). The researchers will compare success rates in 260 adults who had surgery for the infectio…

This study looks at two versions of a surgery (Nuss technique) to fix a sunken chest in teenagers. Researchers will compare operation time, pain control, hospital stay, and cosmetic results between the classic and modified methods. The goal is to find which approach leads to bett…

This study tests if eating gradually increasing amounts of raw apple can reduce mouth itching and swelling in people allergic to both birch pollen and apples. About 110 participants will receive either raw apple or a placebo over 9 months. The goal is to see if they can tolerate …

This study looks at 550 adults having heart procedures through the wrist to see if giving heparin (a blood thinner) before inserting the tube reduces the chance of wrist artery blockage compared to giving it after. The main goal is to check for blockages one day later using ultra…

This study aims to see how well specially trained dogs can detect bladder cancer by smelling urine samples. About 340 adults who are scheduled for bladder surgery will provide urine samples for the dogs to sniff. The goal is to measure the dogs' accuracy in identifying cancer, wh…

This study looks at whether two checklists (PERC score and YEARS algorithm) can safely reduce the number of CT scans needed to diagnose a blood clot in the lungs. Researchers will review records of 500 adults who visited the emergency room and had both a D-dimer blood test and ch…

This study looks at whether a simple decision-making flowchart can help general practitioners diagnose vertigo more accurately. Vertigo is a common but tricky condition, and many doctors lack experience in handling it. The tool is designed to guide them toward the right specialis…

This study compares a new blood test, Cryocheck HexLA, with current tests to see if it better detects lupus anticoagulant, a substance that can increase blood clot risk. Researchers will analyze samples from 200 adults already having routine testing. The goal is to find a more ac…

This study looks at whether giving pregnant women free organic vegetables and healthy-eating workshops can lower their exposure to harmful pesticides. Researchers will compare urine pesticide levels in women who receive the organic food with those who eat as usual. The goal is to…

This study tests whether a personalized facial rehabilitation program can reduce mouth disability in people with systemic sclerosis, a rare autoimmune disease that tightens facial skin and makes it hard to open the mouth, eat, and speak. About 60 adults with facial involvement wi…

This study looks at a new way to fix a common elbow fracture in children using anchors with sutures instead of screws or pins. The goal is to reduce problems like hardware irritation and the need for a second surgery to remove implants. Nine children under 15 with displaced fract…

This study examines real-life cases where adults with psychotic disorders, who are stable on long-term antipsychotics, try to reduce or stop their medication. The goal is to understand when and how this can be done safely, and what challenges arise. By sharing these experiences, …

This study looks at children under 4 who had extra genetic testing (exome sequencing) during pregnancy because of ultrasound findings. Researchers want to see if a negative result truly means no genetic problems, or if current tests miss some issues. The goal is to better underst…

This study looks at how doctors at Strasbourg University Hospital treat severe stomach or intestinal bleeding in patients taking direct oral anticoagulants (blood thinners). Researchers will review the records of 250 adults to see how often a drug called prothrombin complex conce…

This study looks back at how often and why antithrombin—a blood protein that helps prevent clots—was given to patients in intensive care or during surgery at Strasbourg University Hospitals over one year. Researchers will review records of 160 adults who received it to see if pre…

This study looks back at how doctors currently screen for and treat obstructive sleep apnea (OSA) in children with Down syndrome. Researchers will review medical records of 30 children to see what works and what doesn't. The goal is to create a standard guide to improve care acro…

This study looks at how occupational health doctors and nurses in France identify police officers who may be struggling with mental health issues like depression, anxiety, or PTSD, and how they refer them to specialized care. About 200 health professionals who work with national …

This study looks at why some people with advanced bladder cancer receive older platinum-based chemotherapy instead of newer drug combinations. Researchers will review the medical records of 50 adults treated since October 2024. The goal is to understand patient characteristics an…

This study looks at whether having total knee replacement surgery as an outpatient (going home the same day) leads to similar recovery as staying in the hospital overnight. Researchers will compare recovery scores from 440 patients who had the surgery between 2020 and 2023 at a F…

This study looks at chest CT scans from 80 patients with a rare but serious fungal lung infection called pulmonary mucormycosis. Researchers want to see if certain patterns on the scans can predict whether a patient will get better or worse. The goal is to help doctors tailor fol…

This study looks at families where more than one person has systemic scleroderma, a rare autoimmune disease. By studying these families, researchers hope to find clues about how the disease progresses and identify targets for new treatments. The study will involve 20 adults with …

This study looks at whether common blood thinners (heparins) can mess up lab tests for another blood thinner called argatroban. Researchers will check blood samples from 70 adults already taking heparin to see if the test overestimates argatroban's activity. The goal is to improv…

This study looks back at 100 cases of human babesiosis, a rare tick-borne disease, diagnosed in France between 2000 and 2024. Researchers aim to describe who gets sick, what symptoms they have, and how they are treated. No new treatments are tested; the goal is simply to learn mo…

This study reviews medical records of 221 people with advanced melanoma who received immunotherapy between 2013 and 2021. The goal is to find new clues that predict who will have a complete response, meaning all signs of cancer disappear. By understanding these factors, doctors m…

This study looks at why some women feel pain during a C-section even with spinal anesthesia. Researchers will review the records of about 2,450 women who gave birth at Strasbourg University Hospital between 2021 and 2022. The goal is to find risk factors and improve how this pain…

This study examines how patients who have had a transient ischemic attack (TIA), or mini-stroke, are diagnosed and treated in the emergency department. Researchers will review records of 300 adults to see if care matches their risk level. The goal is to find gaps in current pract…

This study looks at whether teaching delivery room staff how to better find and repair tears in the anal muscles during childbirth can lower the number of women who later have trouble controlling gas or stool. About 1,000 women who gave birth vaginally at a French hospital will b…

This study looks at whether certain medications that alter gut bacteria can influence how well immunotherapy works in people with advanced lung cancer. Researchers will review medical records from 800 adults with stage III-C or IV non-small cell lung cancer who received immunothe…

This study tests a special MRI technique to spot tiny brain changes in professional soccer players near retirement. Researchers will compare their scans to people who never played contact sports. The goal is to catch early signs of chronic traumatic encephalopathy (CTE) and impro…

This study looks at whether a tool called the HScore can accurately diagnose hemophagocytic lymphohistiocytosis (HLH) in intensive care patients with liver failure or cirrhosis. Researchers will review medical records of 100 adults admitted to one hospital over 10 years who had c…

This study uses questionnaires to find out what teenage girls (ages 11-18) with hypogonadism and their parents know about hormone replacement therapy. The goal is to identify gaps in understanding so that better educational programs can be created to help patients stick with thei…

This study looks at a painless, non-invasive technique called liver elastography to measure liver scarring (fibrosis) in children and young adults with type III glycogen storage disease. The goal is to see if this gentle scan can replace the need for a liver biopsy, which is more…

This study looks at people 75 and older who come to the emergency room with a medical problem and need to be admitted to the hospital. It compares those sent directly to a regular hospital ward versus those who first spend time in a short-stay unit. The main goal is to see if the…

This study looks at whether people who are more physically active before incisional hernia surgery have fewer problems afterward. Researchers will track 100 adults who already had the surgery and see if their activity level relates to complications. The goal is to understand if b…

This study explores how the way doctors talk about breech birth influences a mother's decision to have a vaginal delivery or a C-section. Researchers will survey 200 women who gave birth to a breech baby in 2024 at French university hospitals, along with their doctors. The goal i…

This study surveys 100 doctors and trainees in France to see how much they know about tick-borne encephalitis, a rare but serious disease spread by ticks. The goal is to find gaps in knowledge so that diagnosis and prevention can be improved. No treatment is given; it is purely a…

This study surveys 50 pregnant women at the CMCO to understand their interest and worries about ambulatory (walking) epidural anesthesia for labor. The goal is to learn what patients expect and fear, so the hospital can better introduce this option. No treatment is given—just a q…

This study looks at how fast blood thinners start working in ICU patients with serious lung clots (pulmonary embolism). Researchers will review records from 100 adults treated between 2014 and 2023 to see how quickly effective anticoagulation is reached and whether delays affect …

This study looks at the quality of life of people who survived acute mesenteric ischemia, a life-threatening blockage of blood flow to the intestine. Researchers will ask 100 adults treated between 2010 and 2022 at a French hospital to fill out a questionnaire about their digesti…

This study tests whether a special CT scan (dual-energy CT) can be as good as MRI for staging mouth and throat cancers. If it works, patients may need fewer scans, get treatment faster, and free up MRI machines for others. The study involves 30 adults with confirmed oral or throa…

This study looks at how sleep helps or hurts memory in children with certain types of epilepsy. Researchers will test memory in 95 children with different epilepsy severities and compare them to children without epilepsy. The goal is to see if epileptic brain activity during slee…

This study looks back at the medical records of 30 immunocompromised patients (like organ transplant recipients or those on immune-suppressing drugs) who had toxoplasmosis. The goal is to understand how many are affected and how to better diagnose, treat, and prevent this infecti…

This study looks at how a stay in the intensive care unit (ICU) affects a person's quality of life and mental health after leaving the hospital. Researchers will ask 40 adults who spent more than 48 hours in the ICU to fill out questionnaires about their experience and current we…

This study surveys 100 French dentists who treat children to understand how they handle baby teeth with irreversible pulpitis or pulp necrosis. The goal is to collect information on whether they choose extraction, pulpectomy, or other methods, and what factors influence their dec…

This study looks at whether medical students in their final year of training accept a new course on how to confirm a death and tell the family. Many new doctors feel unprepared for these duties. The study will survey 20 students in Strasbourg to see if they think this training is…

This study looks at how well people recover after total knee replacement surgery depending on whether they had spinal or general anesthesia. Researchers will review medical records of 500 adults who had the surgery between 2020 and 2023. The goal is to see if one type of anesthes…

This study looks back at 100 adults treated at Strasbourg University Hospital for aerodigestive fistulas—abnormal openings between the airway and digestive tract. These rare conditions can cause coughing or life-threatening infections. Researchers aim to learn how different treat…

This study looks at one adult with severe hemophilia A who is taking long-term blood thinners (anticoagulation). Researchers want to see how well the blood clots and if new clotting factor treatments can make blood thinners safer. The goal is to learn more about balancing bleedin…

This study will survey 100 adults with cystic fibrosis to find out how many smoke or vape. Researchers want to understand the current situation so they can improve tobacco prevention and see how smoking might affect newer treatments like Kaftrio. Participants must be 18 or older …

This study looks at cases of recurrent borreliosis, a bacterial infection spread by ticks or lice, that have been diagnosed in France. Researchers will describe the symptoms, where patients got infected, which Borrelia species caused it, and how it was diagnosed and treated. The …

This study is looking at 100 women with polycystic ovary syndrome (PCOS) in Alsace, France. The goal is to better understand the different types of PCOS and why diagnosis is often delayed. Researchers will measure things like obesity rates and insulin resistance. No new treatment…

This study looks at whether measuring the amount of Aspergillus fumigatus (a fungus) in blood or lung fluid can help predict outcomes in patients with a serious lung infection called invasive aspergillosis. Researchers will track 100 patients to see if changes in PCR levels durin…

This study looks at testing newborns for cytomegalovirus (CMV) infection if they fail a hearing screening. CMV is a common infection that can cause hearing loss and other health issues. Researchers want to see how often CMV is found in these babies and improve how they are monito…

This study looks at how different types of platelets change in adults who need ECMO (a machine that helps the heart and lungs). Researchers want to see if these changes can explain bleeding or clotting problems. The study will follow 75 patients in the ICU for one week after star…

This study looks at whether taking metformin before being admitted to the intensive care unit (ICU) affects survival in people with type 2 diabetes who develop severe lactic acidosis. Researchers will review records of 100 adult patients admitted to a French hospital between 2014…

This study looks at whether surgical or medical abortion is safer for women between 14 and 16 weeks of pregnancy. Researchers will measure heavy bleeding (over 500 cc) in 50 adult women. The goal is to help doctors and patients choose the method with the lowest risk.

This study looks at how often physical restraints are used properly in the emergency departments of Strasbourg University Hospital. Researchers will check if doctors and nurses follow official best practice guidelines from 2021. They will also study which patients are most at ris…

This study tests a new training method for brain surgeons using donated human placentas to practice repairing intracranial aneurysms. The placenta's blood vessels closely resemble those in the brain, offering a realistic and low-cost alternative to animal or computer models. Abou…

This study looks at whether a special MRI scoring system called O-RADS can accurately predict if an ovarian mass in girls under 16 is cancerous or not. Researchers will review the MRI results of 100 girls who had surgery for ovarian masses. The goal is to help surgeons choose the…

This study looks at how fatigue and muscle function are connected in people with axial spondyloarthritis, a type of inflammatory arthritis. Researchers will measure exercise capacity and muscle strength in 122 adults who are starting a new targeted therapy. The goal is to better …

This study looks at the medical records of 115 transgender people who started medical support before turning 18 at Strasbourg University Hospital. The goal is to describe their care and experiences. No new treatments are being tested.

This study looks at whether a rectal swab can help predict which intensive care patients will get infections from hard-to-treat bacteria. Researchers will test 1,000 adults in the ICU and track who later develops an infection. The goal is to see if a negative swab reliably means …

This study surveys healthcare professionals in European dialysis centers to understand how they measure intraperitoneal pressure (belly pressure) in children with kidney failure who are on peritoneal dialysis. The goal is to learn about current practices and improve how dialysis …

This study is testing a simple symptom score questionnaire to see if it helps doctors and patients track allergic rhinitis (hay fever) severity during ear, nose, and throat (ENT) visits. About 30 adults with allergic rhinitis will use the score to rate their symptoms. The goal is…

This study follows 93 women with Turner Syndrome who wanted to become parents. Researchers will track how many succeed through natural pregnancy, egg donation, or adoption. The goal is to understand the real-world success rate of parenthood in this group.

This study looks back at medical records of 100 adults in Alsace, France, who had a confirmed anaplasmosis infection. The goal is to learn more about the disease's symptoms, complications, and outcomes in this region. No new treatments are being tested; the aim is simply to gathe…

This study looks back at medical records of 60 adults treated for adrenal cortex carcinoma, a rare cancer, at a French hospital. Researchers want to learn how the disease progresses and what affects survival. No new treatments are given; the goal is to gather information to impro…

This study observes 100 patients in France who developed severe Lyme disease after receiving anti-CD20 treatment. Researchers will describe the symptoms, severity, and progression of the infection. The goal is to better understand how Lyme disease behaves in people with weakened …

This study looks at what helps or hinders creating care plans for vulnerable patients in palliative care who live in medicalized residential facilities. Researchers will interview staff and others to understand the organizational and human factors involved. About 100 adults in Al…

This study looks back at the medical records of 400 full-term newborns who had very low cord blood pH (a sign of severe oxygen shortage during birth). Researchers want to find specific heart rate patterns that show when a baby is struggling and needs help. The goal is to help doc…

This study looks at a rare condition called panniculitis, which is inflammation of the fat under the skin, in people who already have dermatomyositis. Researchers want to describe how it looks and acts, both on the skin and under a microscope, to better tell it apart from similar…

This study reviews medical records of 400 adults hospitalized with a serious strep blood infection (Streptococcus anginosus). The goal is to identify factors linked to death within 28 days. No new treatments are tested; instead, researchers hope to learn what makes this infection…

This study looks at whether continuously monitoring oxygen levels while moving patients from the operating room to the recovery area can prevent drops in oxygen. About 30 adults having surgery will take part. Researchers will compare oxygen readings taken at the start and end of …

This study looks at blood clotting (hemostasis) in 1,000 premature infants born before 37 weeks. Researchers want to find out what normal clotting values are from birth to 18 months, and whether they differ from full-term babies. The goal is to help doctors better understand and …

This study looks back at medical records of 50 adults recently diagnosed with HIV to find out if doctors missed signs during earlier visits. The goal is to understand why testing didn't happen sooner and how to improve early detection. No new treatments are tested; instead, resea…

This study aims to better understand Lewy body disease, a brain disorder causing thinking and behavior problems. Researchers will analyze EEG recordings from 40 adults to see if unusual brain activity patterns can help diagnose the disease. The goal is to learn more about how the…

This study is observing 100 children under 18 who come to the emergency room with visible blood in their urine. The goal is to find out what causes this symptom and how doctors currently manage it. By learning more, researchers hope to create a standard care plan for this common …

This study tests a new DNA reading technology (long-read sequencing) to find genetic causes of dystonia in 150 people whose standard genetic tests came back normal. Dystonia causes involuntary muscle contractions, and many cases remain unexplained. If successful, this approach co…

This study collects information from 1,300 people with rare diseases to better understand mouth and tooth problems that often come with these conditions. Researchers will look at dental history, family patterns, and genes to improve how these problems are diagnosed and treated. T…

This study looks at 50 adults with unexplained bleeding to see if low levels of serotonin in their platelets are linked to their symptoms. Researchers will use a standard bleeding questionnaire to measure severity. No new treatments are tested; the goal is to better understand th…

This study looks back at how well a particular type of knee replacement (a fixed polyethylene cemented prosthesis) performed in 960 adults who had surgery between 2013 and 2024. Researchers will check pain, movement, stability, and walking ability at least one year after surgery,…

This study looks at whether high-speed centrifugation (spinning blood very fast) can remove fat from blood samples so doctors can accurately measure anti-Xa activity, a test used to monitor blood thinners. About 150 adults on anticoagulants will have their blood samples tested. T…

This study looks at whether nutrition is linked to better outcomes in adults with gastroenteropancreatic neuroendocrine tumors, a slow-growing cancer. Researchers will check 100 patients for weight loss and other signs of malnutrition. The goal is to see if improving nutrition co…

This study interviews 12 general practitioners in the Bas-Rhin region of France to find out what makes it easier or harder for them to care for terminally ill patients at home. Many people wish to die at home, but family doctors face challenges like heavy workloads and emotional …

This study tests a simple questionnaire called AT HARM 10 to help identify when a hospital visit is caused by a medication problem. Researchers will enroll 100 adults over 65 in the emergency department to see how well the tool works. The goal is to improve treatment and prevent …

This study looks at medical records of 20 adults who had bariatric surgery and later received treatment for alcohol use disorder. Researchers want to understand if and how the surgery was considered during addiction follow-up. The goal is to improve care for people with both cond…

This study looks at whether giving parents an easy-to-understand information sheet after their child's first simple febrile seizure can lower anxiety and reduce unnecessary emergency room visits. About 100 children aged 9 months to 5 years will be included. The goal is to see if …

This study aims to understand why families refuse organ donation when asked, even though most people in France support it. Researchers will interview relatives of 100 brain-dead patients in a Strasbourg hospital to learn the reasons behind opposition. The goal is to reduce refusa…

This study surveys 100 healthcare professionals and students in Alsace, France, to understand their training, knowledge, and experience with organ donation. The goal is to identify gaps in education that may contribute to low donation rates. No treatments or interventions are inv…

This study looks at whether sleep disorders make vertigo worse for people with Ménière's disease, a condition that causes hearing loss, ringing in the ears, and dizziness. Researchers will track 100 adults to see if those with more severe vertigo also have more sleep problems. Th…

This study surveys 269 healthcare professionals in Alsace, France—including psychiatrists, midwives, and general practitioners—to understand how they handle eating disorders during pregnancy and the postpartum period. The goal is to identify gaps in knowledge and care practices. …

This study looks at a newer method called cryobiopsy, which uses extreme cold to take tissue samples from the lungs. The goal is to see how safe and accurate it is for diagnosing conditions like lung cancer, scarring, and swollen lymph nodes. About 30 adults who need this procedu…

This study looks at how blood cells work and signs of stress in the blood to see if they can help doctors detect and predict the course of a lung condition called pre-capillary pulmonary hypertension. Researchers will collect blood samples from 120 patients during regular visits …

This study looks at 36 adults with type 1 diabetes who have received a pancreatic islet transplant. Researchers want to see if a continuous glucose monitor (CGM) can detect early loss of the transplant's function. They will track a measure called "Time in Tight Range" (blood suga…

This study looks at how to better choose antibiotics for people who say they are allergic to beta-lactam drugs (like penicillin) before orthopedic surgery. Many people think they are allergic, but only a few actually are. Researchers will use a simple questionnaire called the PEN…