Tianjin Medical University Cancer Institute And Hospital

This study tests whether a mix of chemotherapy, immunotherapy, targeted therapy, and radiation can shrink advanced liver tumors enough to allow surgery. About 30 adults with liver cancer that cannot be removed at first will receive these treatments in sequence. The goal is to see…

This study tests a new treatment for people with advanced non-small cell lung cancer that no longer responds to PD-1 inhibitors. The treatment combines special immune cells (WAST cells) with a chemotherapy drug called docetaxel. The goal is to see if this combination can shrink t…

This study looks at two treatment options for people with a type of esophageal cancer that shrank after initial chemo-immunotherapy. One group will have surgery to remove the tumor, while the other will receive chemoradiotherapy (chemo plus radiation) instead. The goal is to see …

This study tests whether the drug anlotinib can help prevent lung cancer from returning in patients who still had cancer cells after surgery and chemotherapy. About 64 adults with stage IIA-IIIA non-small cell lung cancer will take anlotinib capsules. The main goal is to see how …

This study tests a combination of four drugs (sintilimab, ipilimumab, cetuximab, and dabrafenib) in people with a specific type of advanced colorectal cancer that has a BRAF V600E mutation and is microsatellite stable. About 49 participants will receive the treatment to see if it…

This study tests a combination of two drugs (Sacituzumab Tirumotecan and Furmonertinib) in people with advanced non-squamous non-small cell lung cancer that has gotten worse after standard treatments. The goal is to see if the combination can slow or stop cancer growth. About 25 …

This study tests a new treatment combination for people with advanced non-small cell lung cancer whose cancer got worse after initial immunotherapy and chemotherapy. The treatment includes a procedure called microwave ablation (which uses heat to destroy tumors) plus two drugs: t…

This study tests whether adding the drug serplulimab to standard chemoradiotherapy after cervical cancer surgery can help prevent the cancer from returning. It includes 134 women aged 18-65 with certain types of cervical cancer and multiple risk factors. Participants will receive…

This study tests whether adding a drug called iparomlimab after standard chemoradiation can help older adults (70+) with advanced esophageal cancer live longer without the cancer growing. Iparomlimab boosts the immune system to fight cancer. The trial involves 52 participants and…

This study tests a combination of three drugs (chidamide, rituximab, and polatuzumab vedotin) in elderly patients aged 70 and older (or 60-69 with frailty) who have a specific type of untreated lymphoma called double-positive DLBCL. The goal is to see how many patients achieve co…

This study tests a new type of radiation called lattice radiation therapy (LRT) combined with immunotherapy for people with advanced solid tumors that have stopped responding to standard treatments. LRT delivers high-dose radiation to small spots inside the tumor while giving low…

This study tests a combination of four drugs (ipilimumab, sintilimab, bevacizumab biosimilar, and chemotherapy into the liver artery) in 43 adults with advanced liver cancer that cannot be surgically removed. The goal is to shrink the tumors enough so that surgery becomes possibl…

This study is testing a combination of three drugs (liposomal irinotecan, capecitabine, and enlonstobart) plus a short course of radiation before surgery for people with locally advanced rectal cancer. The goal is to see if this approach can make tumors disappear completely or le…

This study tests whether adding an immunotherapy drug (sintilimab) to short-course radiation and chemotherapy can improve long-term survival in people with a common type of locally advanced rectal cancer (MSS type). About 130 adults with stage II/III rectal cancer will be randoml…

This study tests a mix of four drugs (iparomlimab, tuvonralimab, chidamide, and chemo) as a first treatment for people with metastatic pancreatic cancer that has spread. The goal is to see if the combination can shrink tumors and help people live longer. About 33 adults who have …

This early-stage trial is testing a new cell therapy called GK01, given alone or with chemotherapy, for people with advanced solid tumors like pancreatic or stomach cancer. The main goal is to check if the treatment is safe and to see how it affects the body. Only 15 participants…

This study tests two surgical approaches for bile duct cancer that has spread to nearby lymph nodes. One method removes the bile duct completely to clear all lymph nodes, while the other preserves the bile duct but may leave some lymph tissue behind. The goal is to see which appr…

This study tests whether women with certain aggressive breast cancers (triple negative or HER2-positive) can safely avoid breast surgery if their tumors disappear completely after a combination of chemotherapy and radiation. About 200 participants will receive the non-surgical tr…

This study tests a new way to treat lung cancer that has spread to the brain. It combines a targeted drug (osimertinib) with a special type of whole-brain radiation that tries to protect the memory center (hippocampus). The goal is to see if this approach can control brain tumors…

This study tests a combination of three treatments—a targeted pill (furmonertinib), chemotherapy injected into the spinal fluid, and precise radiation—as a first treatment for people with a specific type of lung cancer (EGFR mutation) that has spread to the brain and spinal cord.…

This study tests whether ongoing immune therapy can help prevent head and neck cancer from returning in patients who already had a strong response to initial treatment. About 268 adults aged 18 to 80 with locally advanced head and neck cancer will receive immune maintenance thera…

This study tests a two-step treatment for people with advanced esophageal cancer that cannot be removed by surgery. First, patients receive two cycles of immunotherapy plus chemotherapy. Then, based on how well the tumor responds, they get either the same drugs with radiation or …

This study tests whether adding two drugs (serplulimab and nimotuzumab) to standard chemoradiation before surgery can improve outcomes for people with a type of esophageal cancer. About 46 adults with locally advanced but removable tumors will receive the combination treatment, t…

This study tests a new treatment for people with a type of lung cancer (non-small cell lung cancer) who had surgery but still had cancer cells left. The treatment combines a special cell therapy (L-TIL) made from the patient's own tumor-fighting cells with an immunotherapy drug (…

This study tests whether adding the drug serplulimab to standard chemoradiotherapy helps people with locally advanced cervical cancer live longer without the disease getting worse. About 216 women aged 18-75 with untreated cervical cancer will take part. The main goal is to see i…

This study is testing whether a special nurse-led care plan can help people recover better after head and neck cancer surgery. The plan includes extra support from nurses, dietitians, and counselors to reduce complications and improve quality of life. About 80 adults having surge…

This study tests whether a dexmedetomidine nasal spray can help women feel relaxed and reduce anxiety during breast-conserving surgery for breast cancer. About 394 women will receive either the nasal spray or a placebo before surgery. Researchers will measure sedation levels, awa…

This study looks at whether a special belly press device can reduce lung tumor movement during radiation therapy for lung cancer. About 50 people with early-stage lung cancer will use the device during treatment. The goal is to see if it helps make radiation more accurate by keep…

This study looks at 400 people having surgery for advanced stomach cancer. Doctors want to find the best area to remove lymph nodes (called No.4sb) to see where cancer spreads most often. The goal is to make surgery more precise and effective.

This study looks at how bacteria inside tumors might help predict whether cancer treatments will work. Researchers will collect tumor samples from 90 people with stomach, colon, pancreas, or esophageal cancer before they start treatment. The goal is to find bacterial patterns tha…

This study looks at how well CDK4/6 inhibitors work for people with a common type of advanced breast cancer (HR+/HER2-). It will follow 245 patients to see how long the treatment controls the cancer and what options work best if the cancer stops responding. The goal is to gather …