The First Affiliated Hospital Of Soochow University

This study tests if a new chemotherapy combination (TmBU) works better than the standard one (mBUCY) before a stem cell transplant in people with high-risk or relapsed acute leukemia. About 48 adults aged 65 or younger will be randomly assigned to one of the two regimens. The mai…

This study tests a combination of three drugs (anti-PD-1 antibody, lenalidomide, and azacitidine) in people with a type of lymphoma that has not responded to or has returned after standard treatment. The goal is to see if this combination can shrink tumors and control the disease…

This study tests a combination of three drugs (venetoclax, azacytidine, and chidamide) for people newly diagnosed with a specific type of leukemia called acute monocytic leukemia. Participants are those who cannot receive intensive chemotherapy due to age or other health issues. …

This study tests whether fecal microbiota transplantation (FMT) can safely treat gut graft-versus-host disease (GVHD), a serious complication after stem cell transplants. Researchers will track changes in stool frequency and volume in 50 participants aged 10 to 60. The goal is to…

This early-phase study tests a new treatment called CT0596 CAR-T cells for people with multiple myeloma or plasma cell leukemia that has come back or stopped responding to standard therapies. The main goals are to check safety, find the best dose, and see how well it works. About…

This study tests whether the drug gilteritinib works better than sorafenib at keeping leukemia from coming back after a stem cell transplant. About 594 adults and teens with a specific genetic mutation (FLT3-ITD) will be randomly assigned to take one of the two drugs for up to 2 …

This study tests a sequence of two immunotherapy drugs (blinatumomab and inotuzumab ozogamicin) in people with B-cell acute lymphoblastic leukemia. It includes newly diagnosed patients who are older or too frail for standard chemo, as well as those whose leukemia has returned or …

This study tests a new combination of three drugs (zeprumetostat, azacitidine, and mitoxantrone hydrochloride liposome) in about 26 adults whose peripheral T-cell lymphoma has come back or stopped responding to prior treatments. The goal is to see if this combo can shrink tumors …

This early-stage trial tests a new treatment called U69 (CXCR4 CCR9 CAR-T) for people with T-cell acute lymphoblastic leukemia or lymphoma that has come back or not responded to standard therapy. The treatment uses a patient's own immune cells, modified to better find and attack …

This study tests whether a maintenance drug (HMA) can help prevent relapse in people with favorable-risk acute myeloid leukemia (AML) who are already in remission after initial treatment. About 77 adults aged 16 and older will receive the drug and be followed to see how long they…

This study tests whether a once-weekly injection (romiplostim) helps platelets recover faster and safer than a daily injection (rhTPO) after a donor stem cell transplant. It includes 66 adults with MDS or severe aplastic anemia. The goal is to reduce bleeding risk and transfusion…

This study tests a weekly injection called romiplostim in 60 adults with immune thrombocytopenia (ITP) whose platelet counts stayed low despite taking oral medications. The goal is to see if the shot can safely raise platelet levels and reduce bleeding over 24 weeks. Participants…

This early-phase trial tests an experimental oral drug called BY002 in about 18 adults whose acute leukemia has returned or not responded to prior treatments. The study focuses on safety and finding the right dose, while also checking if the drug can shrink or control the cancer.…

This study is for people newly diagnosed with a rare and aggressive form of T-cell leukemia called ETP-ALL. The trial tests a combination of five drugs (venetoclax, azacitidine, chidamide, vindesine, and dexamethasone) to see if it can improve remission rates and survival. About …

This study tests whether combining two drugs—romiplostim and rituximab—can safely raise platelet counts in adults with primary immune thrombocytopenia (ITP) who did not respond to standard oral treatments. About 30 participants will receive weekly injections of romiplostim and fo…

This study tests a combination of three drugs (venetoclax, hypomethylating agents, and low-dose cytarabine) in adults newly diagnosed with a specific genetic type of acute myeloid leukemia (CEBPA-mutated) who are not fit for intensive chemotherapy. The goal is to see if this trea…

This study tests whether combining venetoclax with azacitidine can help people with newly diagnosed T-cell acute lymphoblastic leukemia (T-ALL) achieve remission. About 28 participants aged 15 and older will receive the drug combination for up to two 21-day cycles. The main goal …

This study looks at whether menin inhibitors can help prevent leukemia from coming back after a stem cell transplant. About 20 people with certain genetic types of acute leukemia will take these drugs as part of their regular care. Researchers will track how long patients stay ca…

This study tests a combination of three treatments (PD-1 inhibitor, azacitidine, and low-dose donor lymphocyte infusion) for people whose acute myeloid leukemia has come back after a stem cell transplant. The goal is to see if this approach can control the cancer and improve surv…

This study tests a new drug combination called VABu given before a stem cell transplant in people aged 60 and older with acute myeloid leukemia (AML). The goal is to see if this approach can better control the disease and improve survival. About 20 participants will receive the V…

This early-phase study tests a new treatment plan for adults with B-cell acute lymphoblastic leukemia (B-ALL) who cannot or choose not to have a donor stem cell transplant. The approach uses the drug blinatumomab before and after an autologous (using the patient's own cells) stem…

This study compares four different drug combinations for adults newly diagnosed with acute myeloid leukemia (AML) who are not healthy enough for strong chemotherapy or choose not to have it. About 172 participants will be randomly assigned to one of four treatment groups to see w…

This study tests a new approach for people newly diagnosed with a fast-growing lymphoma (DLBCL) that has a specific genetic change (TP53 mutation). Instead of standard chemotherapy, doctors will choose treatments based on the tumor's genetic subtype. The goal is to see if this pe…

This study tests whether adding umbilical cord blood to a half-matched stem cell transplant can help people with aplastic anemia, a serious condition where the bone marrow stops making enough blood cells. About 224 participants aged 14 and older will receive either the combined t…

This study tests a new drug combination (venetoclax plus other medicines) that avoids traditional strong chemotherapy for adults with a specific genetic type of acute myeloid leukemia (CBFβ::MYH11-positive). The goal is to see if this gentler approach can put the cancer into remi…

This study is testing a combination of three drugs (venetoclax, cladribine, and low-dose cytarabine) in people aged 15-70 with relapsed or treatment-resistant Philadelphia chromosome-negative B-cell acute lymphoblastic leukemia. The goal is to see how well the treatment works and…

This study tests a 4-week treatment combining zanubrutinib (a targeted pill) and rituximab (an antibody infusion) for people with B-cell lymphoma who develop a dangerous immune overreaction called hemophagocytic lymphohistiocytosis (HLH). About 40 adults aged 14-80 will receive t…

This study tests a new treatment plan for people with a slow-growing lymphoma called marginal zone lymphoma. After a short course of standard chemo, patients who respond well will get a targeted drug (Orelabrutinib) to keep the cancer under control for up to two years. The goal i…

This study tests a new treatment plan for adults with a type of blood cancer called B-cell acute lymphoblastic leukemia (B-ALL). The plan combines a reduced dose of chemotherapy with an immunotherapy drug called blinatumomab, and for some patients, a CAR-T cell therapy or a stem …

This study tests a new combination of drugs (cladribine, lisaftolax, and busulfan) given before a stem cell transplant in 30 patients aged 50 and older with relapsed or refractory acute myeloid leukemia (AML) or myelodysplastic syndromes (MDS). The goal is to make the transplant …

This study tests a three-drug combination (chidamide, venetoclax, azacitidine) in 32 adults with acute myeloid leukemia whose cancer did not improve after one round of standard two-drug therapy. The goal is to see if adding chidamide can help more patients achieve remission. Part…

This study tests a personalized cell therapy (CAR T-cells) for people with B-cell acute lymphoblastic leukemia that has not responded to standard treatments or has come back. The therapy uses the patient's own immune cells, modified to target and kill cancer cells. The goal is to…

This study tests a combination of three drugs (pirtobrutinib, lisaftoclax, and rituximab) in adults with diffuse large B-cell lymphoma that has come back or not responded to at least one prior treatment. The goal is to see if this combination can shrink or eliminate tumors. About…

This study is for people aged 16 to 70 with acute myeloid leukemia (AML) that has returned or not improved after standard treatment. Researchers are testing a combination of three drugs (venetoclax, cladribine, and low-dose cytarabine) to see if it can shrink or eliminate the can…

This study is developing an artificial intelligence (AI) model to help doctors detect early gastric (stomach) cancer during endoscopic exams. The AI combines different types of images and patient data to improve accuracy and explain its reasoning. Researchers will enroll 100 adul…

This study looks at whether a highly sensitive blood test can accurately diagnose systemic mastocytosis, a rare disease where too many mast cells build up in the body. Currently, diagnosis requires an invasive bone marrow biopsy. Researchers will compare the blood test results to…

This study is testing new types of MRI scans to see if they can more accurately find and grade prostate cancer without using contrast dye. Researchers will compare these new scans with standard MRI results and tissue samples from surgery or biopsy. About 300 people with suspected…

This study tests whether giving the antiviral drug letermovir for a longer period (up to 28 weeks) can prevent cytomegalovirus (CMV) infection in 330 Chinese adults who are at high risk after a stem cell transplant. Participants must be CMV-positive before transplant and have ris…

This study tests whether giving patients their own fecal bacteria can prevent acute graft-versus-host disease (GVHD) after a half-matched stem cell transplant. About 100 bone marrow transplant patients will receive either standard care or an autologous fecal bacteria transplant. …

This study tests a single infusion of amimestrocel, made from human umbilical cord cells, to prevent severe mouth and gut sores in 22 adults receiving a stem cell transplant. Patients get the infusion 1-2 days before transplant, and researchers will track mouth sores, pain, and s…

This study tests whether using virtual reality for mindfulness-based therapy can help adults with long-term low back pain feel better and move easier. About 214 people aged 20-70 with pain lasting at least 3 months will either get 8 weeks of VR therapy plus usual care or just usu…

This study tests whether low-frequency magnetic pulses to a specific brain area can reduce chronic belly pain in people with irritable bowel syndrome with diarrhea (IBS-D). 42 adults will be randomly assigned to receive either real or fake (sham) stimulation for two weeks. The go…

This study tests whether a non-invasive brain stimulation technique called rTMS can reduce abdominal pain and diarrhea in people with diarrhea-predominant irritable bowel syndrome (IBS-D). Researchers will enroll 46 adults aged 18-60 and track symptom changes over 21 days. They w…

This early-stage study tests the safety of a new drug called IBI3002 in adults with asthma. About 12 to 27 participants will receive either the drug or a placebo by injection over 12 weeks. The goal is to see if the drug is safe and how it behaves in the body, not yet to prove it…

This study looks at the nutritional health of 200 people who have had a hematopoietic stem cell transplant. Researchers will measure body composition, food intake, and blood albumin levels over six months to see how nutrition affects survival and recovery. The goal is to understa…

This study looks at how the body breaks down certain carbohydrates (FODMAPs) in the gut and whether that affects a condition called graft-versus-host disease (GVHD) after a bone marrow transplant. Researchers will follow 100 transplant patients to track when and how severe GVHD o…

This study looks at whether warming the numbing medicine used in epidurals can lower the chance of fever during childbirth. About 424 women giving birth vaginally will get either room-temperature or body-temperature medicine. Researchers will track fevers, pain levels, and health…