Shanghai Zhongshan Hospital

This study tests whether adding surgery to a combination of immunotherapy and chemotherapy (with or without targeted therapy) helps people with stomach cancer that has spread to a few other places in the body. About 84 adults aged 18-79 with a specific type of stomach cancer will…

This study is testing whether giving chemotherapy plus immunotherapy before endoscopic removal can safely shrink esophageal cancer and allow patients to keep their esophagus instead of having major surgery. About 60 adults with early-stage esophageal cancer will receive two or mo…

This early study tests a new treatment for people with early-stage type 1 diabetes. The therapy uses specially engineered immune cells (CAR-T cells) from a donor to target and calm the immune attack that destroys insulin-making cells. The goal is to see if it is safe and can help…

This study looks at how well the drug surufatinib works for people with advanced neuroendocrine tumors (a rare type of cancer). About 350 adults will take the drug by mouth daily, either alone or with other treatments, as part of their regular care. Researchers will track tumor s…

This study tests whether a continuous 24-hour intravenous infusion of lidocaine, a common local anesthetic, can lower the risk of serious lung complications (like pneumonia or needing a breathing machine) in adults undergoing emergency abdominal surgery for an intra-abdominal inf…

This study tests whether combining two types of drugs—immunotherapy (anti-PD-1/PD-L1) and a drug that blocks blood vessel growth (anti-VEGF)—is safe and effective for people with advanced liver cancer that cannot be removed by surgery. About 50 adults will take part. The goal is …

This study tests if a special fluid called balanced gelatin is better than the standard fluid for people with sepsis who need emergency abdominal surgery. Sepsis causes dangerous fluid loss, and this gelatin fluid may help keep blood pressure stable. About 318 adults will take pa…

This study looks at two ways to treat severe calcium buildup in heart arteries: a drug-coated balloon and a drug-eluting stent. About 656 adults with hard, calcified blockages will first get their calcium broken up with special tools, then receive one of the two treatments. Resea…

This early-stage study tests a personalized cell therapy (BTC-Ag-T) for people with advanced bile duct or gallbladder cancer that has not responded to standard treatments. The therapy uses the patient's own immune cells, modified to better recognize and attack cancer. The main go…

This study tests whether montelukast, an asthma drug, can reduce heart damage and improve recovery in 512 adults having a severe type of heart attack (anterior STEMI). Participants will receive montelukast or a placebo alongside standard emergency treatment. The goal is to see if…

This early study tests a new treatment called HN2301 for people with Graves' disease that hasn't improved with standard therapy. HN2301 works by turning the body's own immune cells into special cells that target the overactive thyroid. Five participants will receive several doses…

This study tests whether indobufen (a newer blood thinner) works better and causes fewer bleeding problems than aspirin in people over 65 who have had a heart attack or unstable angina and received a stent. About 2,800 participants will take either indobufen plus ticagrelor or as…

This study tests whether asiaticoside, a compound from the herb Centella asiatica, can help adults with overweight or obesity lose weight. Researchers will measure changes in metabolic rate and body weight over 12 weeks. The study involves 30 participants and aims to see if this …

This early-phase trial tests a new treatment called RD06-05, which uses specially engineered immune cells (CAR-T cells) to target and calm the overactive immune response in people with refractory Graves' disease. The goal is to see if a single infusion can safely restore normal t…

This study is for people with advanced bile duct cancer that cannot be removed by surgery. It tests whether adding immunotherapy drugs (anti-PD-1/PD-L1 antibodies) to standard chemotherapy (gemcitabine and cisplatin) can help shrink tumors and delay cancer growth. The study will …

This study tests a powerful mix of treatments—tumor destruction (ablation), chemotherapy beads (TACE), an immunotherapy drug (tislelizumab), and a targeted therapy (lenvatinib)—for people with liver cancer that cannot be removed by surgery. About 17 adults with advanced liver can…

This study looks at the best way to maintain weight loss after losing weight with a high dose of the drug mazdutide. Researchers will compare a year of intensive lifestyle changes, a lower weekly dose of mazdutide (3.0 mg), or both together. The goal is to find a safe and effecti…

This study tests a new combination of drugs (chidamide, chemotherapy, and immunotherapy) as a first treatment for people with advanced intrahepatic cholangiocarcinoma, a type of liver cancer that cannot be removed by surgery. About 35 adults will receive the treatment in 21-day c…

This study tests a new drug called envafolimab combined with standard chemotherapy given before surgery for people with a type of esophageal cancer that can be removed. The goal is to see if this combination can shrink the tumor more effectively, potentially leading to better lon…

This study tests whether a new chemotherapy combination (NALIRIFOX) plus targeted therapy works better than the standard combination (FOLFOX) plus targeted therapy for people with metastatic colorectal cancer that cannot be removed by surgery. About 144 adults who have not had pr…

This study tests a new drug called HEC88473 in 30 women with polycystic ovary syndrome (PCOS). The drug targets two systems (GLP-1 and FGF21) to improve hormone levels, menstrual regularity, and weight. Participants will receive the drug for 24 weeks, and researchers will measure…

This study tests whether giving a powerful cholesterol-lowering drug (PCSK9 inhibitor) very soon after a heart attack can reduce the chance of another heart attack, stroke, or death over the next year. About 1,500 adults who have had a recent heart attack and have blockages in mu…

This study compares two types of stomach removal surgery for people with advanced stomach cancer. About 1,018 participants will be randomly assigned to either laparoscopic (small incisions) or open (large incision) surgery. The main goal is to see which approach leads to longer o…

This study looks at whether a new imaging technique called µQFR can accurately detect blocked blood flow in side branches of heart arteries after a single stent is placed. About 290 adults with coronary artery disease and complex artery branch points will be enrolled. The goal is…

This study compares two ways of giving oxygen during a sedated stomach exam (gastroscopy) in people with visceral obesity (excess belly fat). The goal is to see if a high-flow nasal cannula works better than a standard face mask at preventing low oxygen levels. About 200 adults w…

This study is testing whether fecal microbiota transplantation (FMT) can help people with irritable bowel syndrome (IBS) who haven't gotten better with standard treatments. About 102 adults will receive FMT through capsules or a tube once a month for three months, then be followe…

This study follows 6,000 people who had a heart attack and were treated with emergency angioplasty (a procedure to open blocked heart arteries). Researchers will collect information on their health during the hospital stay and for up to two years after. The goal is to track serio…

This observational study looks at whether combining information from CT scans, blood tests, and pathology reports can more accurately predict how pancreatic cancer will progress. Researchers will collect data from medical records of about 1,030 participants who had surgery for pa…

This study follows about 1,400 people with liver-related high blood pressure that causes enlarged veins in the esophagus and stomach. Researchers compare those who get endoscopic treatment (using a scope) with those who receive other treatments like medication or surgery. The goa…

This study will test a new, high-speed CT scanner to see if it can measure heart artery plaque stiffness and blood flow without invasive procedures. About 500 adults with suspected or known coronary artery disease will get this scan, and results will be compared with standard tes…

This study is testing whether a non-invasive blood pressure monitor can accurately detect blockages in the heart's main pumping chamber in people with hypertrophic cardiomyopathy (HCM). Researchers will compare blood pressure readings with standard invasive measurements in 800 ad…

This study collects blood, tissue, and medical images from 1,000 people with portal hypertension (high blood pressure in the liver) to create a biobank. The goal is to use advanced technologies like genetics and AI to better predict and manage life-threatening variceal bleeding. …

This study looks at how an 8-week exercise program affects the metabolism of 40 overweight or obese adults with prediabetes. Researchers will measure changes in body weight, fat, blood sugar, and other lab values, and use advanced cell analysis to find potential biomarkers. The g…

This study follows 189 adults who experienced delirium in the ICU to understand their main recovery challenges after moving to a regular hospital ward. Researchers will assess physical abilities, thinking skills, and mental health using simple questionnaires. The goal is to ident…

This study looks at whether images from a standard heart X-ray (angiogram) can accurately diagnose disease in the tiny blood vessels of the heart, avoiding the need for a special wire. About 192 adults with chest pain or suspected heart disease will have their angiogram images ta…

This study involves 1,516 adults with diabetes and coronary heart disease. Researchers will use a special camera (NIRS-OCT) to look at fatty plaques inside heart arteries. The goal is to find which plaques are dangerous and could cause heart attacks, so doctors can better prevent…

This study follows 1500 people with cirrhosis and varices who also have a blood clot in the portal vein (the main vein to the liver). Researchers want to see what factors help the clot dissolve over time. The goal is to better understand the disease and guide future care.

This study looks at why some people with coronary heart disease continue to have plaque buildup in their arteries even when they are on intensive cholesterol-lowering therapy. Researchers will follow 900 adults aged 18 to 75 who have had a stent placed and have mild blockages nea…