Medical University Of Vienna

This study tests whether using a patient's own tumor cells to find the best drugs can improve survival in people with a newly diagnosed, aggressive brain cancer called glioblastoma. About 240 adults will either receive standard treatment or have their tumor cells tested in a lab …

This study tests a combination of drugs given in low, frequent doses to slow or stop the growth of recurrent brain tumors in children. The goal is to extend survival while maintaining quality of life. About 232 children with medulloblastoma, ependymoma, ATRT, or other rare CNS tu…

This study tests a simple injection of mashed parathyroid tissue into the forearm during thyroid surgery. The goal is to prevent permanent low calcium levels that require lifelong medication. About 100 adults having thyroid surgery will receive this injection, and researchers wil…

This study is testing whether a drug-coated balloon can replace the usual stent in emergency procedures for people having a severe type of heart attack (STEMI). The balloon delivers medication to open the blocked artery without leaving a permanent implant. Researchers will track …

This study looks at whether routinely inflating the balloon a second time after placing a new heart valve (TAVI) helps the valve open more evenly and work better. About 146 people with severe aortic stenosis will take part. The goal is to see if this extra step improves valve fun…

This study tests a drug called datopotamab-deruxtecan in 20 people with triple-negative breast cancer that has spread to the brain. The goal is to see if the drug can shrink brain tumors. Participants must have newly diagnosed or worsening brain metastases. The trial is currently…

This study compares two different stent systems used to repair a weakened area in the main artery (aortic aneurysm). About 126 adults will be randomly assigned to receive either the BeFlared or the VBX stent during a minimally invasive procedure. The goal is to see which device t…

This study tests a special add-on lens placed behind the eye's iris to correct high astigmatism in people who have had a cornea transplant and cataract surgery. About 40 participants aged 45-90 will get the lens and be followed for up to 7 months to see if it reduces blurring and…

This study tests a new drug called BT200 in 4-6 adults with type 2B von Willebrand disease who have low platelets and a history of bleeding. The drug is designed to raise von Willebrand factor and platelet levels, which may reduce bleeding episodes. Participants receive both BT20…

This study checks whether standard devices that measure blood flow and fluid needs work correctly in patients on ECMO, a machine that pumps and oxygenates blood outside the body. Researchers will compare three different monitoring methods in 30 adults on ECMO. The goal is to impr…

This study checks how well standard devices measure blood flow in patients on ECMO, a machine that adds oxygen to blood outside the body. About 30 adults on ECMO will have their blood flow measured using different methods, including ultrasound and a leg-raising test. The goal is …

This study looks at whether playing music that patients choose themselves during the start and end of anesthesia can lower anxiety and improve comfort. About 100 adults having eye surgery will be randomly assigned to either hear music or not. Researchers will measure anxiety leve…

This study tests whether taking a daily lactobacillus probiotic can reduce symptoms of overactive bladder in women. One hundred women with the condition will take either the probiotic or a placebo for six months. Researchers will track symptom changes and check the bacteria in th…

This study is testing several types of approved artificial lenses used in cataract surgery to find out which one gives the clearest vision at different distances. About 461 people with age-related cataracts will receive a different lens in each eye and have their vision tested af…

This study tests whether a 6-week outpatient pulmonary rehabilitation program helps people with post-PE syndrome (lingering symptoms after a pulmonary embolism) walk farther and breathe better. About 48 adults who had a pulmonary embolism 12 to 36 weeks earlier will be randomly a…

This pilot study is testing whether a low dose of radiation to the jaw joint can reduce pain from arthritis. Ten adults over age 50 with temporomandibular joint arthritis will receive the treatment and report their pain levels and any side effects. The goal is to see if this appr…

This study tests whether psilocybin, the active ingredient in magic mushrooms, can improve the ability to feel pleasure (anhedonia) in people with depression. 85 participants will receive psilocybin in two sessions—one with a drug that blocks the psychedelic effects—and undergo b…

This study tests whether a small device that gently stimulates a nerve in the ear can help people with long-term back pain. 48 adults will either get the ear stimulation plus standard rehab, or rehab alone, for 3 weeks. The goal is to see if the device improves daily function and…

This study tests a new treatment called transcranial pulse stimulation (TPS) for people with Post-COVID syndrome who suffer from fatigue, memory problems, or low mood. About 102 adults who had COVID-19 at least 12 months ago will receive either real TPS or a sham (fake) treatment…

This study looks at whether a new cyclosporin eye drop (Vevizye®) can reduce inflammation and dryness in people with moderate to severe dry eye disease who still have symptoms after using artificial tears. About 25 adults with chronic dry eye and visible eye redness will use the …

This study looks at how the bones and soft tissues of the face change when the upper jaw is widened using a custom-made expander anchored to small temporary screws. About 38 people with a narrow upper jaw and crossbite will take part. The goal is to measure these changes precisel…

This study looks at whether using a tablet for video interpreting helps emergency doctors talk with patients who don't speak the same language. 50 awake adult patients with language barriers will take part. The goal is to see if the technology works, is easy to use, and changes h…

This study follows 5,000 adults who spent more than 72 hours in the ICU to understand long-term problems with thinking, physical health, and emotions. Researchers will collect data during the hospital stay and for up to five years after discharge. The goal is to identify risk fac…

This study looks at how a protein called NaV1.8, found in pain-sensing nerves, contributes to different kinds of pain. Healthy volunteers receive tiny, safe doses of a drug that blocks NaV1.8 directly into their skin, then undergo brief pain tests (like heat, cold, or pressure). …

This study is testing a new approach to personalize treatment for people with a fast-growing brain tumor called glioblastoma. Researchers will use a lab test on tumor cells to see which drugs might work best for each patient. The goal is to find out if this method can help more p…

This study looks back at data from 100 adults with cardiogenic shock who received an Impella 5.5 heart pump. Researchers aim to build a computer tool that uses pump and ICU data to predict whether a patient's heart will recover or if complications may arise. The goal is to help d…

This study follows 10,000 people with advanced chronic liver disease to track their health over time. Researchers will collect medical data and samples like blood, urine, and tissue to better understand how cirrhosis progresses. The goal is to learn more about the disease, not to…

This study looks at whether performing chest compressions affects how well medical professionals can recall a patient's medical history. 38 trained rescuers will either do CPR while hearing a history or just listen without any other task. Their memory is then tested to see if mul…

This study aims to understand how electroconvulsive therapy (ECT) works in the brain for people with severe depression. Researchers will use MRI scans, blood, and spinal fluid tests before and after ECT in 30 adults. The goal is to find markers that can predict which patients wil…

This study looks at whether special eye and brain monitors can help doctors predict brain recovery very early in patients placed on a heart-lung machine after cardiac arrest. About 45 adults will be tested before and after the machine starts. The goal is to see if these tools wor…

This study is looking for ways to predict postoperative delirium—a state of confusion that can happen after surgery in older adults. Researchers will measure certain substances in the blood of 1,170 patients aged 65 and older before and after major surgery. They hope to find a re…

This study is a registry that will follow 500 adults with primary biliary cholangitis (PBC) in Austria to learn how the disease changes over time. Researchers will collect medical data and optional blood or liver samples to study biomarkers and complications. The goal is to bette…

This study looks at how high-dose hormone therapy for transgender individuals (male-to-female and female-to-male) changes heart function, fat buildup in the liver and heart, and insulin levels. Researchers will use MRI scans and glucose tests before and after 6 months of treatmen…

This observational study will follow 1,300 critically ill patients in intensive care to see if a blood marker called anti-factor Xa activity is linked to dangerous blood clots (deep vein thrombosis or pulmonary embolism). Researchers will also track bleeding risks, survival, and …

This study follows 60 transgender men and women who have been on gender-affirming hormone therapy for 2 years, tracking changes in heart function, fat in the heart, liver, and pancreas, insulin system, and mental health at 2, 5, and 10 years. Using advanced MRI scans, blood tests…

This study watches how different hospitals help ICU patients start moving early. Researchers will track 6,000 adults to see which rehab methods lead to better physical function and quality of life. No new treatments are tested—only routine care is recorded.

This study looks at how the retina (the light-sensitive part of the eye) uses oxygen as people age. Researchers will measure oxygen extraction in 50 healthy nonsmokers aged 18 to 80 using special eye cameras. They will also test what happens when participants breathe pure oxygen.…

This study looks at whether using a video laryngoscope helps doctors place a breathing tube through the nose more successfully on the first try in babies under 1 year old with congenital heart disease who are having heart surgery. About 60 infants will be randomly assigned to eit…

This study looks at how certain diabetes medications (like Ozempic and Mounjaro) change blood flow and oxygen use in the eyes of people with diabetes. Researchers will measure these effects in 20 adults before and after starting the drugs. The goal is to understand whether these …

This study looks at 20 adults with hypertrophic obstructive cardiomyopathy (HOCM) to see if changes in heart blood flow, measured by MRI, relate to how far they can walk in six minutes. Participants are already on standard medications and will have a follow-up MRI and walking tes…