Gustave Roussy, Cancer Campus, Grand Paris

This study tests a drug called ASP3082 in people with advanced lung or pancreatic cancer that has a specific gene change (KRAS G12D). About 60 participants will receive the drug intravenously to see if it shrinks tumors and how long that lasts. Researchers will also collect blood…

This study tests whether adding a drug called ATRA (a form of vitamin A) to targeted radiation therapy can prevent a drop in immune cells (lymphocytes) in adults with solid tumors that have spread to a few spots. About 58 participants will receive radiation to all visible tumors,…

This study tests a hormone-blocking drug called elacestrant, given alone or with a drug that stops ovarian function, in premenopausal women with early-stage ER+/HER2- breast cancer. The goal is to see if the drug can slow tumor growth before surgery. About 140 women will take the…

This study tests whether adding a precise, high-dose X-ray treatment (contact X-ray brachytherapy) to standard chemotherapy can help people with intermediate-stage rectal cancer avoid removal of the rectum. About 212 adults with tumors 3.1 to 6 cm in size will be enrolled. The go…

This study tests a drug called valemetostat in people with advanced solid tumors that have specific gene changes (SWI/SNF defects). The drug aims to reactivate protective genes and slow cancer growth. About 900 adults will take the drug daily for up to 2 years, with regular check…

This study is for people with non-small cell lung cancer that has spread to a few spots (up to 5 in 3 organs). It tests whether adding local ablative treatments (like radiation or heat to destroy tumors) to first-line immunotherapy-based standard care can improve overall survival…

This study looks at how older adults (70+) with advanced kidney cancer handle a combination of two drugs, cabozantinib and nivolumab. The goal is to see what doses work best and how often side effects cause treatment breaks. About 50 participants will be followed for a year to tr…

This phase 3 trial tests whether the drug ONC201 works better than everolimus for children with DIPG, a rare and aggressive brain tumor. About 433 participants will receive one of the two drugs, and can switch if their disease gets worse. The goal is to see which drug slows tumor…

This study tests a vaccine designed to help the immune system fight HPV-positive oropharyngeal cancer. It is for adults who have completed surgery or chemoradiation and show no signs of remaining cancer. The goal is to find the safest and most effective dose by measuring immune r…

This study tests an experimental drug called tarlatamab in 40 adults with advanced small-cell lung cancer or other poorly differentiated neuroendocrine cancers. The drug is given intravenously to see if it can shrink tumors and control the disease. Researchers will also collect b…

This study tests whether two common drugs—aspirin and a cholesterol-lowering statin—can help men with a certain type of advanced prostate cancer live longer. About 1,210 men whose cancer has stopped responding to hormone therapy will take one or both drugs alongside their usual t…

This study tests whether taking a daily targeted therapy pill (olaparib) for one year after standard chemoradiation can help prevent endometrial cancer from coming back in people with a specific genetic subtype (p53abn). About 554 participants will be randomly assigned to receive…

This study tests whether a fecal transplant (MaaT033) combined with the immunotherapy drug cemiplimab can help people with advanced lung cancer whose prior immunotherapy stopped working after antibiotic use. About 162 participants will either get the combination or standard care.…

This study tests an experimental drug called patritumab deruxtecan in people with advanced breast cancer that no longer responds to hormone therapy. About 99 participants will receive the drug every three weeks to see if it shrinks tumors. Researchers will also study how the drug…

This study tests a new imaging technique that uses a special dye and a camera to help surgeons see tiny bits of cancer that might be left behind during head and neck cancer surgery. About 65 adults with oral or throat cancer will take part. The goal is to see if this method can f…

This study tests if shining a special low-level laser inside the mouth before chemotherapy can prevent severe mouth sores in children and young adults aged 4 to 25. Participants receive either real laser treatment or a fake (placebo) treatment. The goal is to see if the laser red…

This study tests if a smartphone app can help people at high risk of cancer eat less ultra-processed foods and improve their overall diet. About 170 participants will either get the app plus nutrition education or just education alone. The goal is to see if the app helps them mak…

This study tests three different online programs designed to help people with cancer manage their fatigue. 372 adults with cancer who feel moderate to severe tiredness will be randomly assigned to one of the programs or standard care. The goal is to see which approach best reduce…

This study tests whether a mobile app can improve quality of life for people with early-stage breast cancer who are taking hormone therapy. The app provides education and self-care tips alongside standard medical care. 180 participants will be randomly assigned to use the app or …

This study aims to analyze the DNA of tumors from 20,000 adults with cancer to identify genetic changes that can be targeted with specific drugs. By using advanced genetic testing, researchers hope to learn how many patients have a treatable genetic alteration. The goal is to imp…

This study is for people at higher risk of developing cancer. Researchers will collect body fluids like blood or urine and test them to see if they can spot cancer earlier than usual. The goal is to find cancers within three years of the test, which could lead to faster treatment…

This study is collecting blood and bone marrow samples from 5,000 adults with chronic myelomonocytic leukemia (CMML) to better understand the disease. Researchers aim to improve diagnosis, predict how the disease will progress, and identify new treatment options. Participants pro…

This study aims to understand why some ovarian cancers stop responding to chemotherapy. Researchers will collect tumor, blood, and other samples from 350 patients over time to look for genetic markers and changes that predict treatment success or failure. The goal is to improve f…

This study collects real-world data on how well new cancer drugs work in children, teens, and young adults up to age 25 who have relapsed or stopped responding to treatment and cannot join a clinical trial. Researchers will track safety and effectiveness of targeted therapies, im…

This study is for children whose cancer has come back or not responded to standard treatments. Researchers will use advanced genetic testing of each child's tumor to match them with a targeted drug or drug combination. The goal is to find the safest dose and see if the treatment …

This study aims to create immune organoids—tiny lab-grown models of the immune system—using cells from children and young adults with brain tumors, kidney tumors, neuroblastoma, or sarcoma. Researchers will mix these organoids with tumor cells to see how they interact. The goal i…

This study is testing a new way to provide supportive care to cancer patients. It will include 700 adults with any type or stage of cancer. The main goal is to see if this approach reduces patient distress and meets their needs within 12 weeks.