Fudan University

This study tests a personalized vaccine (Neo-DC) made from a patient's own immune cells to target unique markers on their advanced solid tumor. The vaccine aims to teach the immune system to attack the cancer. The trial enrolls 9 adults with advanced solid tumors who have not res…

This study explores whether a simple blood test that tracks tumor DNA (ctDNA) can help doctors decide the best treatment for people with HER2-negative metastatic breast cancer. About 122 participants will receive antibody-drug conjugate therapy, and those whose cancer does not wo…

This study tests whether a combination of three drugs (RC48, sintilimab, and SOX) can shrink advanced stomach cancer enough to allow surgical removal. It involves 30 adults with a specific type of HER2-positive cancer that cannot be removed initially. Participants receive the dru…

This study tests a combination of HRS-4642 with adebrelimab (and possibly other drugs) in people with advanced pancreatic cancer that has not responded to standard treatments. The goal is to see if the combination is safe and can shrink tumors or slow the disease. About 130 adult…

This study looks at whether giving another round of antibody-drug conjugates (ADCs) can help people with advanced breast cancer whose disease has progressed after prior ADC treatment. About 160 adults with metastatic breast cancer will receive the same or a different ADC to see i…

This study looks at two radiation therapy approaches for women with early-stage breast cancer that has spread to 1-2 lymph nodes. The goal is to see if giving radiation only to the nearby armpit area works as well as treating a larger region, while possibly causing fewer side eff…

This study tests new drug combinations for people with advanced pancreatic cancer that has spread or cannot be removed. Researchers want to see if these targeted therapies are safe and shrink tumors. About 160 adults aged 18-75 with good organ function can join.

This study tests whether a blood test that looks for tumor DNA can help doctors decide which high-risk stage II colorectal cancer patients need stronger chemotherapy after surgery. About 340 participants will be enrolled, and those with a positive blood test one month after surge…

This study tests whether giving personalized chemotherapy before surgery (neoadjuvant therapy) can improve outcomes for people with early-stage breast cancer. Researchers will use detailed tumor typing to match each participant with the most promising drug combination. The trial …

This early study tests a new cell therapy called RGL-305 in 12 adults with lymphoma who still have small amounts of cancer cells after standard treatment. The main goal is to see if the therapy is safe and how the cells behave in the body. Participants will receive one infusion o…

This study tests two drugs together for people with a rare and aggressive type of thyroid cancer that cannot be removed by surgery or has spread. The drugs are MRG003, which targets a protein called EGFR on cancer cells, and pucotenlimab, which helps the immune system attack the …

This study looks at whether giving radiation therapy after completely removing a type of chest tumor called thymoma (stages II or III) can help people live longer without the cancer coming back. About 238 adults aged 18-75 who had surgery within the last 3 months will be randomly…

This study tests whether adding immunotherapy to a special type of radiation (that spares tumor-draining lymph nodes) plus chemotherapy works better than the radiation and chemo alone for adults with advanced esophageal squamous cell cancer. About 432 participants will receive ei…

This study tests whether matching treatments to the specific molecular subtype of triple-negative breast cancer can help people whose cancer has not responded to standard therapies. About 120 women with advanced or recurrent TNBC will receive targeted drugs based on their tumor's…

This study tests two different treatment plans for people with locally advanced rectal cancer that has not spread. One plan uses longer radiation followed by chemotherapy, while the other uses shorter radiation plus chemotherapy, an immunotherapy drug, and an anti-inflammatory pi…

This study tests two different radiation schedules (long-course vs short-course) combined with chemotherapy (CAPOX), an immunotherapy drug (PD-1 inhibitor), and a COX-2 inhibitor in people with a specific type of advanced rectal cancer (MSS type). The goal is to see which approac…

This study tests two different drug combinations given before surgery for people with stage II to IIIa squamous non-small cell lung cancer. One group gets serplulimab plus chemotherapy, the other gets nivolumab plus chemotherapy. The goal is to see which combo works better at eli…

This study looks at people with thymic cancer who have had surgery to remove all visible tumor. It compares standard radiotherapy to radiotherapy plus chemotherapy (three drugs: paclitaxel, cisplatin, 5-FU) to see which better prevents the cancer from returning. About 172 adults …

This study tests whether adding the immunotherapy drug sintilimab to standard chemotherapy (SOX) after surgery can help prevent stomach cancer from returning in patients with high-risk or specific genetic types. About 276 adults with stage pIIIC or certain stage III stomach cance…

This study tests whether adding omega-3 fatty acids (EPA and DHA) to standard immunotherapy (PD-1 inhibitors) helps adults with advanced esophageal cancer. About 142 participants will receive either omega-3 or a placebo for 6 months. The main goal is to see if omega-3 prevents mu…

This study tests whether adding IL-11 to the standard drug G-CSF can help blood cells recover faster after a stem cell transplant. About 224 adults with multiple myeloma or lymphoma will take part. The goal is to see if the combo reduces the time to restore healthy blood counts a…

This study tests whether adding immunotherapy (a drug that helps the immune system fight cancer) after standard chemotherapy and radiation can better control advanced esophageal cancer. About 452 adults with a specific type of esophageal cancer will be randomly assigned to receiv…

This study tests whether adding a liver-directed chemotherapy (HAIC) to a combination of two drugs (sintilimab and bevacizumab) can help people with advanced liver cancer live longer without their disease getting worse. About 164 adults with liver cancer that cannot be treated wi…

This study tests a two-part treatment for people with advanced colorectal, breast, or melanoma cancer that has spread to the liver. First, doctors use heat or cold to destroy some liver tumors, which may release signals that wake up the immune system. Then, patients receive an im…

This study compares three types of surgery for ultra-low rectal cancer to find which best removes the tumor while preserving bowel control. About 100 adults with small tumors near the anal canal will be randomly assigned to one of the three procedures. Researchers will track reco…

This study tests whether a blood test that detects tumor DNA can help doctors decide how long chemotherapy should last for people with certain types of colorectal cancer. About 340 adults with T4N0 or low-risk stage III colorectal cancer will be randomly assigned to standard 3-mo…

This study tests whether adding a special type of radiotherapy guided by a PET scan and an immunotherapy drug (cadonilimab) to standard second-line treatment can shrink tumors better than standard treatment alone in people with colorectal cancer that has spread to the abdomen. Ab…

This study tests whether a combination of several drugs can help treat triple-negative breast cancer that has stopped responding to standard immunotherapy. About 80 adults with advanced breast cancer will receive one of seven treatment plans. The goal is to see if the tumors shri…

This study tests whether adding the drug VEGFR BP102 to standard chemotherapy can help people with a specific subtype (BLIS) of advanced triple-negative breast cancer live longer without their cancer growing. About 134 participants who have not had prior treatment for metastatic …

This study tests whether a combination of two hormone drugs (GnRHa and letrozole) works better than standard hormone therapy alone to shrink early-stage endometrial cancer while preserving fertility. About 104 women with stage I, low-grade endometrial cancer who wish to keep thei…

This study tests whether adding a drug called narlumosbart and precise radiation (SBRT) to standard chemotherapy and immunotherapy can help people with advanced non-small cell lung cancer that has spread to the bones. The trial will enroll 27 adults who have not had prior treatme…

This study tests whether a smaller, more targeted neck surgery (selective neck dissection) works as well as the standard larger surgery (modified neck dissection) for people with papillary thyroid cancer that has spread to only 1 or 2 small lymph nodes in the side of the neck. Ab…

This phase 3 study compares an all-oral, chemotherapy-free drug combination (pyrotinib, trastuzumab, and dalpiciclib) to a standard IV chemo regimen for people with advanced HER2-positive breast cancer. About 502 participants who have had up to one prior treatment will be enrolle…

This study tests several new drug combinations for people with advanced liver cancer (hepatocellular carcinoma) whose first treatment stopped working. About 350 adults will receive one of the experimental therapies, and researchers will use scans, blood tests, and tumor samples t…

This study tests whether combining two drugs—sintilimab and chidamide—can help people with a type of blood cancer called peripheral T-cell lymphoma that has come back or not responded to prior treatment. About 51 adults aged 18 to 75 will receive the combination therapy. The goal…

This study tests a drug called tunlametinib in people with advanced melanoma that has a specific NRAS gene change and has stopped responding to immunotherapy. About 110 adults will take the drug by mouth to see if it can shrink tumors. The goal is to control the disease and impro…

This study tests whether adding probiotics (good bacteria) to standard chemoradiation and an immunotherapy drug (adebrelimab) can help people with limited-stage small cell lung cancer live longer without the cancer growing. About 60 adults aged 18-80 will be enrolled. The goal is…

This study tests whether adding precise radiation to a four-drug combination can help people with advanced EGFR-mutant lung cancer whose first treatment stopped working. About 53 adults will receive the drugs (sintilimab, bevacizumab, platinum, pemetrexed) plus personalized radia…

This study tests whether adding the drug AK104 (cadonilimab) and radiation to standard chemotherapy can help people with colorectal cancer that has spread to the liver. About 73 adults who have not had treatment before will be randomly assigned to get either the new combo or stan…

This study tests a new drug called Becotatug vedotin in people with advanced liver cancer that has gotten worse after at least one prior treatment. The goal is to see if the drug can shrink tumors and help control the disease. About 40 adults will take part, and the study is curr…

This study is for people with high-risk stage III colorectal cancer. It uses a blood test (ctDNA) to see if adding a targeted drug (bevacizumab) to standard chemotherapy works better than chemo alone. About 100 participants will be randomly assigned to one of two treatment groups…

This study tests a new combination of three drugs—chemotherapy (GEMOX), a targeted therapy (donafenib), and an immunotherapy (tislelizumab)—in people with advanced biliary tract cancer that has spread. The goal is to see if this mix shrinks tumors and delays cancer growth. About …

This study is for people with early-stage natural killer/T-cell lymphoma, a rare and aggressive cancer often linked to EBV infection. Researchers are comparing three different sequences of chemotherapy, immunotherapy, and radiation to see which one works best to keep the cancer f…

This study tests a new drug (QL1706) combined with standard chemotherapy, with or without another drug (bevacizumab), as a first treatment for people with advanced pancreatic cancer that cannot be removed by surgery. The goal is to see if the combination shrinks tumors or control…

This study tests a new treatment for young women (ages 18-45) with a specific type of early-stage endometrial cancer (MMRd). The treatment combines an immune checkpoint inhibitor (TQB2450) with a high-dose progestin hormone therapy, aiming to eliminate the cancer while preserving…

This study tests a combination of chemotherapy, radiation, and an immunotherapy drug (tislelizumab) given before surgery for low rectal cancer. About 50 adults with a specific type of rectal cancer will receive this treatment. The goal is to see if the cancer disappears completel…

This study tests whether a transplant of donated umbilical cord blood can help people aged 14 to 80 with serious diseases caused by the Epstein-Barr virus, such as certain lymphomas or chronic active infection. The goal is to control the disease and improve survival, but lifelong…

This study is for women up to age 45 with endometrial cancer who want to preserve their fertility. Researchers will use the tumor's genetic profile to choose the best treatment, such as hormone therapy or immunotherapy, aiming to make the cancer disappear while keeping the uterus…

This study tests whether adding tislelizumab (an immunotherapy) to standard chemotherapy can help shrink or control advanced soft tissue sarcomas that cannot be removed by surgery. About 45 adults with specific sarcoma types will receive the combination as their first treatment. …

This phase 3 trial tests whether adding an antivascular drug to standard chemotherapy helps prevent cancer from returning in people with a specific, high-risk subtype of triple-negative breast cancer. About 764 women with stage II to III breast cancer will be enrolled. The study …

This study tests whether adding chemotherapy directly into the fluid around the brain (via a small device called an Ommaya reservoir) to standard body-wide chemo can help people with HER2-negative breast cancer that has spread to the brain lining. About 37 adults will be randomly…

This study tests whether adding an immunotherapy drug (anti-PD-1) to standard chemoradiation can better control anal squamous cell cancer and reduce the chance of it coming back. It includes 241 adults aged 18-75 with different stages of the disease, from early to advanced or rec…

This study looks at whether a blood test that detects tumor DNA (ctDNA) can help doctors decide if chemotherapy is needed after surgery for early-stage colorectal cancer. About 80 patients with stage I or low-risk stage II cancer who have ctDNA in their blood one month after surg…

This study tests two experimental drugs, SHR-0302 and SHR-2554, given together to people with a rare type of blood cancer called peripheral T-cell lymphoma that has returned or not improved after standard treatment. The goal is to see if the combination is safe and can shrink tum…

This study tests whether a combination of two drugs (Sac-TMT and bevacizumab) can shrink or control brain tumors in people with triple-negative breast cancer that has spread to the brain. About 24 adults with this condition will receive the treatment. The goal is to see how well …

This study tests a combination of two drugs, SKB264 and inetetamab, in people with advanced HER2-positive breast cancer whose disease got worse after treatment with T-DXd. The goal is to see if this new combination can shrink tumors. About 48 adults will take part in this single-…

This study tests whether adding a new drug (SHR-1701) to targeted radiation (SBRT) can slow the growth of advanced prostate cancer that no longer responds to hormone therapy. About 66 men with metastatic castration-resistant prostate cancer will be enrolled. The main goal is to s…

This early study tests two types of specially engineered immune cells (CAR-T and TCR-T) that target the Epstein-Barr virus (EBV) in patients with nasopharyngeal carcinoma that has come back or not responded to standard treatments. About 24 adults will receive one of the cell ther…

This study looks at different second-line treatments for people with advanced stomach or gastroesophageal junction cancer that has worsened after initial chemotherapy and immunotherapy. The goal is to see how well these treatments work and how safe they are. About 250 adults aged…

This study tests whether adding an immunotherapy drug (serplulimab) to standard second-line chemotherapy and targeted therapy can help people whose colorectal cancer returns within a year after initial treatment. About 40 adults with a specific type of tumor (pMMR/MSS) will be ra…

This study tests whether adding two amino acid-based drugs (L-Ornithine L-Aspartate and N-Acetylcysteine) to standard CDK4/6 inhibitors and Fulvestrant can shrink tumors or slow cancer growth in people with HR-positive/HER2-negative advanced breast cancer. The trial enrolls 40 ad…

This study tests a combination of two drugs, fruquintinib and serplulimab, in people with advanced colorectal cancer that has not spread to the liver and has stopped responding to standard treatments. The goal is to see if the combination can shrink tumors or slow the disease. Re…

This study tests a mix of three chemotherapy drugs plus an immunotherapy drug for people with advanced gallbladder cancer that cannot be removed by surgery. The goal is to see if this combination can shrink tumors and help people live longer. About 33 adults who have not had prio…

This study tests a daily pill called sunvozertinib in 34 people with advanced non-small cell lung cancer that has rare EGFR gene mutations. Participants have not had prior cancer treatment. The goal is to see if the drug shrinks tumors and delays cancer growth. This is a phase 2 …

This study tests whether adding radiation therapy to the usual radioactive iodine treatment can better prevent thyroid cancer from coming back in the neck area. It includes 124 people with high-risk differentiated thyroid cancer who had surgery but still had some cancer left behi…

This study tests whether giving a combination of radiation, chemotherapy, and immunotherapy before surgery can shrink high-risk soft tissue sarcomas. About 52 adults with large or hard-to-operate tumors on their arms, legs, or trunk will receive the treatment. The goal is to see …

This study tests whether adding a CDK4/6 inhibitor to standard hormone therapy can help prevent breast cancer from coming back in women with a high-risk type of early breast cancer (HR+/HER2+). About 1,900 women who have already completed anti-HER2 treatment will be randomly assi…

This study tests a new drug called vebrekotuzumab, which delivers a powerful cancer-killing agent directly to tumor cells, for people with advanced esophageal cancer that no longer responds to initial treatment. About 104 participants will receive the drug either alone or with an…

This study tests whether the drug golidocitinib can help keep peripheral T-cell lymphoma (a rare blood cancer) from returning in patients who already responded to initial chemotherapy but cannot or choose not to have a stem cell transplant. About 136 adults will take either golid…

This study looks at whether giving radiation therapy after surgery helps prevent thyroid cancer from coming back in people at high risk. About 80 adults with certain types of thyroid cancer will receive standard care plus radiation. Researchers will track how long patients stay c…

This study tests whether adding radiotherapy to a combination of chemotherapy (CAPOX) and an immunotherapy drug (Toripalimab) can improve outcomes for people with a specific type of locally advanced rectal cancer (MSS/pMMR). About 192 participants will receive either the drug com…

This study tests a chemotherapy regimen (R-CDOP) plus a drug injected into the spinal fluid (intrathecal methotrexate) to prevent central nervous system relapse in people with a high-risk type of aggressive lymphoma. About 83 adults aged 18-75 who have not yet been treated will t…

This study tests whether giving radiation only to the parts of the neck where cancer has spread (instead of the whole neck) can prevent cancer from coming back while causing fewer side effects. About 462 adults with nasopharyngeal cancer will be randomly assigned to standard or p…

This study tests whether adding retinoic acid (a vitamin A derivative) to an immune checkpoint inhibitor can help shrink or control tumors in people with HER2-negative breast cancer whose disease got worse on prior immunotherapy. About 10 participants will receive the combination…

This study tests a mix of radiation, chemotherapy, immunotherapy, and targeted therapy for people whose rectal cancer has returned after prior treatment. The goal is to shrink tumors and possibly allow for surgery. About 44 adults with limited spread will receive the combination,…

This study tests whether AI-assisted breast ultrasound and mammography can find breast cancer earlier than standard screening. About 16,000 women aged 35-69 will be split into two groups: one gets AI-assisted imaging, the other gets routine screening. The goal is to see if AI hel…

This study is testing a new way to screen for stomach cancer using a stool (fecal) sample and a risk questionnaire. Researchers want to see if looking for DNA markers and bacteria in stool can find cancer earlier than current methods. About 15,000 people aged 40 and older will ta…

This study is testing a new blood test that looks at tiny pieces of DNA floating in the blood to find pancreatic neuroendocrine tumors early and tell them apart from other types of pancreatic tumors. Researchers will enroll 1,000 adults who have been diagnosed with certain pancre…

This study checks if a small tissue sample taken during an endoscopy (a tube down the throat) can provide the same detailed information about stomach cancer as a larger sample removed during surgery. The goal is to see if the less invasive biopsy is just as good at identifying ca…

This study aims to see if a new blood test can accurately identify different types of breast cancer. Researchers will compare the test results with standard tissue biopsies. About 1500 participants with advanced breast cancer will provide blood and tissue samples. If successful, …

This study compares a new stool test that looks for high-risk gene changes in H. pylori bacteria with a standard risk questionnaire to see which method finds stomach cancer earlier. Researchers will enroll 15,000 adults aged 40 and older. Participants will provide a stool sample …

This study tests whether limiting eating to a 10-hour window each day can lower the chance of developing gestational diabetes in pregnant women at high risk. Researchers will compare this approach to usual eating habits over 3 months in 240 women. The goal is to see if this simpl…

This study tests a skin cream called Pinoxin to see if it can prevent serious skin damage in cancer patients getting radiation therapy. About 202 adults with cancer who have never had radiation before will be randomly assigned to use either Pinoxin or a placebo cream during their…

This study aims to prevent catheter-related bloodstream infections in intensive care units (ICUs) by implementing a quality improvement program called "ICU-NO CRBSI." Over 8,000 ICU patients with central venous catheters will take part across multiple hospitals in China. Research…

This study tests a digital mind-body therapy that uses music and biofeedback to help women with locally advanced breast cancer sleep better and feel less anxious or depressed during their neoadjuvant treatment. About 66 participants will be randomly assigned to receive the digita…

This study looks at how Chinese patients with metastatic triple-negative breast cancer feel during treatment with sacituzumab govitecan or standard chemotherapy. It involves 300 adults aged 18 to 75 whose cancer has worsened after first treatment. The main goal is to track change…

This study tests whether metformin, a common diabetes drug, can improve memory and thinking in overweight or obese older adults with mild cognitive impairment (MCI). Researchers will give 54 participants either metformin plus lifestyle advice or lifestyle advice alone for 26 week…

This study tests whether a personalized palliative care plan can help people with advanced esophageal cancer live longer and feel better. About 624 adults will receive either precision or standard palliative care. Researchers will track survival, quality of life, and emotional we…

This study tests whether corticosteroids can reduce hand-foot syndrome, a painful skin reaction caused by a common breast cancer chemotherapy drug. About 182 adults with breast cancer will receive either high-dose, standard-dose, or no steroids alongside their treatment. The goal…

This study follows 1,000 adults who visit fever clinics with respiratory infections. Researchers collect data on symptoms, lab tests, and chest scans at the start, then track recovery and complications over time. The goal is to better understand how these infections progress and …

This study looks at whether the bacteria in your gut can help predict how well a combination of immunotherapy and chemotherapy works for advanced stomach cancer. About 300 adults with metastatic or locally advanced stomach cancer who haven't had chemo or immunotherapy before will…

This study is testing whether a new blood test that looks for tumor DNA can detect the return of colorectal cancer earlier than standard methods. About 584 people who had surgery for early-stage colorectal cancer will be randomly assigned to either the new blood test monitoring o…

This study examines blood components in 120 women with HR+HER2- breast cancer to see if age-related differences affect how well treatment works. Participants receive standard care, and researchers collect blood and tumor samples before and during therapy. The goal is to identify …

This study is creating a large, shared database of information from people with a rare pancreatic tumor called solid pseudopapillary neoplasm (SPN). Researchers will collect data from up to 2,000 participants to track long-term survival and cancer return. The goal is to provide h…

This study is creating a large database of 1,000 people with a specific type of pancreatic cancer (KRAS-mutant). Researchers will track how long patients live and how long their cancer stays under control after targeted therapy. The goal is to better understand which treatments w…

This study aims to find out what factors help predict whether CAR-T therapy will work for people with relapsed or refractory large B-cell lymphoma. Researchers will analyze patient and tumor characteristics, as well as how CAR-T cells behave in the body. The goal is to improve tr…

This study looks at whether a person's mental state—like anxiety or depression—can influence how well immunotherapy works for triple-negative breast cancer. About 120 women will receive standard treatment, complete psychological surveys, and give blood and saliva samples. Researc…

This study looks at whether a blood test that detects tumor DNA (ctDNA) can help doctors monitor how well treatment is working in people with stomach cancer. About 600 participants will provide blood samples before and during treatment to see if changes in ctDNA levels predict re…

This study follows 3000 adults aged 40 and older to see if certain genetic types of H. pylori bacteria raise the risk of stomach cancer. Participants will have initial and follow-up exams over 3 to 10 years. The goal is to identify high-risk bacterial strains to improve cancer pr…

This study aims to find out which types of HPV are most common in anal cancer patients in China and how the disease affects people. Researchers will collect samples and health data from 300 patients across multiple hospitals. The goal is to better understand the virus's role and …

This study follows 1100 people with esophageal cancer to see how often the cancer spreads to lymph nodes under the windpipe. Researchers will also look for factors that raise the risk of this spread. The goal is to help doctors decide on the best surgery approach.

This study looks at why some ROS1-positive lung cancers stop responding to the drug entrectinib. Researchers will analyze tumor or blood samples from 38 patients who have already taken entrectinib as part of their regular care. The goal is to find genetic changes that cause resis…

This study looks at how the pain medicine remifentanil behaves in low-weight intensive care patients who need a breathing machine. Researchers will measure drug levels in the blood and check blood pressure changes. The goal is to find the right dose for this vulnerable group to i…

This study looks at how different types of anesthesia affect cancer cells and recovery in 90 adults having colorectal cancer surgery. Researchers compare opioid-free, opioid-sparing, and standard opioid-based anesthesia. They measure blood markers and cancer cell activity before …

This study is testing whether a special PET scan (HER2-PET) can predict how well the drug T-DXd works in people with advanced breast cancer. About 100 participants will get the scan before starting T-DXd treatment, and researchers will track their response. The goal is to see if …

This study tracks how often esophageal cancer spreads to a specific lymph node near the windpipe. Researchers will follow about 1,850 patients to identify risk factors for this spread. The goal is to better understand the disease, not to test a new treatment.

This study is watching how 3000 people with peripheral T-cell lymphoma are treated in regular clinics and how they do over time. It aims to learn which treatments work best, find patterns in the disease, and discover why some patients relapse. No new drugs are tested—just careful…

This study follows 2,500 people newly diagnosed with marginal zone B-cell lymphoma to better understand the disease and how different treatments work. Researchers will track how long patients live without the cancer getting worse and how well treatments control the disease. The g…

This study is testing whether special PET scans can predict how well a targeted drug works in people with advanced HER2-negative breast cancer. About 45 participants will get two types of PET scans before starting treatment. The goal is to see if scan results can forecast treatme…

This study looks at whether a blood test that detects tumor DNA (ctDNA) can better assess how well treatment is working and predict if cancer will return in people with advanced colorectal cancer. About 497 participants will receive standard radiotherapy and chemotherapy, with or…

This study is watching 150 adults with advanced liver cancer who are starting immunotherapy for the first time. Researchers want to see how well different treatments shrink tumors and how the immune system changes. The goal is to learn which approach works best, not to test a new…