Boston University

This study aims to help people with HIV stay in care, especially during the first six months of treatment when the risk of dropping out is highest. Researchers will create and test a toolkit that includes risk assessments, a treatment roadmap, and a WhatsApp support coach. The st…

This study tests a virtual, 5-session program called MATTER for people living with HIV and substance use disorders. The program aims to help them overcome internalized stigma and shame, which can be barriers to staying on HIV treatment and achieving viral suppression. Researchers…

This study tests whether a combination of two creams (5-fluorouracil and calcipotriene) can treat low-risk skin cancers like superficial basal cell carcinoma and squamous cell carcinoma in situ in just 7 to 14 days, instead of the usual 4 weeks. About 200 adults with these skin c…

This study is testing whether a quick, painless light-based imaging method called SFDI can more accurately measure skin thickness in people with scleroderma than the current standard 'pinch test.' Researchers will compare SFDI results with the pinch test and ultrasound in 65 part…

This study tests two short counseling programs for veterans who have experienced intimate partner violence in the past year. One program offers up to 8 sessions focusing on strengths and empowerment, while the other is a single session providing support and safety resources. Rese…

This study looks at whether vitamin K supplements can improve knee osteoarthritis in people aged 60 and older. Researchers will test different types and doses of vitamin K to see how they affect blood markers related to joint health. The goal is to find the best way to use vitami…

This study tests whether adding special memory-support techniques to a standard PTSD therapy (Cognitive Processing Therapy) helps veterans learn and remember the therapy content better. About 100 adults with PTSD will take part. The goal is to see if better memory of therapy lead…

This study looks at whether adding a peer support program to a self-help version of Cognitive Processing Therapy (a proven talk therapy) can help women veterans with PTSD feel better and improve their mental well-being. About 100 women who have served in the U.S. military and hav…

This study tests a stress management program called Self-Help Plus for women with breast or gynecologic cancer in Vietnam. About 285 participants will either join the program or receive usual care. The goal is to see if the program helps reduce anxiety and depression and improves…

This study tests a remote counseling program for people with HIV who have chronic pain and drink too much. About 250 participants will receive either the special program or basic advice through video calls. The goal is to see if the program can reduce pain and drinking over six m…

This study tests a new 3D-printed device that helps dentists give numbing injections more accurately for lower teeth. Traditional injections often miss the target, causing pain and failure. The device uses a 3D scan to guide the needle to the right spot. Ten adults needing root c…

This study tests a brief writing therapy (WET-SP) for active-duty military members hospitalized for suicidal thoughts or attempts. Participants write about stressful experiences to reduce distress and future suicide risk. The trial compares those receiving the therapy plus usual …

This study tests whether adding a brief writing exercise called AWARE to standard PTSD treatments (CPT or PE) can improve how patients and therapists communicate, leading to better results. About 54 adults with PTSD will participate, first in a small pilot phase and then in a lar…

This study tests whether wearing virtual reality (VR) glasses during oral surgery can lower anxiety and reduce the amount of sedation medicine needed. 80 adults having non-emergency oral surgery under IV sedation will be randomly assigned to either VR with relaxing video and audi…

This study looks at the best way to manage pain in young children after dental surgery under anesthesia. It compares giving ibuprofen alone, alternating ibuprofen and acetaminophen, or giving both together. The goal is to find which method reduces discomfort most effectively usin…

This study tests whether a short, evidence-based writing therapy can reduce PTSD symptoms in pregnant women. It compares therapy delivered by community health workers versus mental health clinicians. About 240 pregnant women with PTSD will participate, and their symptoms will be …

This study looks at whether a telehealth interview before a dental visit helps youth with intellectual or developmental disabilities (IDD) and their caregivers. About 50 participants will be randomly assigned to have a video call with the dentist beforehand or not. Researchers wi…

This study follows 10,000 pregnant women in Nagpur, India, from early pregnancy through 42 days after birth. Researchers want to see if catching flu or COVID-19 raises the risk of problems like preterm labor or severe pre-eclampsia. The goal is to gather evidence that could chang…

This study looks at medical records from about 7 million people with HIV in South Africa. Researchers want to see how different ways of delivering HIV treatment are working. They will not interact with patients directly. The goal is to find out which methods help people stay heal…

This study is observing about 11,800 adults in Zambia who start HIV treatment with advanced disease. Researchers want to learn who these patients are, what challenges they face, and how they do in the first six months. The goal is to help health officials improve care and keep mo…

This study looks at how changes in the way your teeth come together (your bite) can affect your balance and walking. Researchers will use dental splints or dentures to temporarily change the bite height in healthy adults aged 30-45 and denture wearers aged 50-65. They will measur…

This study looks at existing medical records from over a million people in Zambia to understand how HIV treatment is being delivered. Researchers want to see which care models work best, how many patients are using them, and what the costs are. The goal is to help make HIV care m…

This study aims to understand why COVID-19 is much less severe in Malawi than in Europe and the Americas. Researchers will follow 1500 people, including those infected and their household contacts, to see how immune responses, past infections like malaria, and nutrition affect CO…

This study aims to see how well wrist-worn devices like smartwatches can measure the intensity of movement and exercise. Researchers will have 54 participants wear these devices while doing different activities and compare the results to a gold-standard measurement. The goal is t…

This study looks at medical records from up to 1 million people with HIV in Malawi to understand how different ways of delivering treatment are working. The goal is to see which models help more patients stay healthy and use resources wisely. No new treatments or patient visits a…

This study looks at how changes in federal rules for opioid addiction medications (buprenorphine and methadone) affected treatment use and patient outcomes. Researchers will compare data from before and after these policy changes among veterans with opioid or alcohol use disorder…

This study looks at how people with advanced HIV move from hospital care to regular clinic care after being discharged. Researchers will interview 150 patients in South Africa and review their medical records to find where the system fails. The goal is to learn what barriers prev…