STROKE

This study tests whether the drug tenecteplase can help people who have had a stroke caused by a blocked artery in the brain, even when treatment starts 24 to 72 hours after symptoms began. About 330 adults will receive either tenecteplase or standard care. The goal is to see if …

This study looks at how adjusting deep brain stimulation (DBS) settings can improve movement, speech, and swallowing in people with conditions like traumatic brain injury, stroke, or essential tremor. About 60 adults who already have DBS implants will perform tasks like grasping …

This study tests whether lowering blood pressure more aggressively than usual after a stroke procedure (thrombectomy) can improve recovery and reduce complications. About 910 adults who had a stroke from a blocked artery in the front part of the brain will be randomly assigned to…

This study tests a healthy lifestyle program that has been specially adapted for Hispanic/Latino people who have had a stroke. The goal is to help participants lose weight and improve health measures like blood sugar and cholesterol. About 24 adults who are at least one year past…

This study tests a new decision-making tool for emergency responders to help get stroke patients to the best hospital faster, especially in rural areas. About 360 adults with suspected stroke will be enrolled, and researchers will compare the new approach to the current standard.…

This study compares two treatments for arm muscle stiffness (spasticity) caused by stroke, spinal cord injury, or brain injury. Thirty adults will receive both surgery and Botox injections at different times, so each person acts as their own comparison. The goal is to see which a…

This study tests an experimental drug called DM199 in people who have had a moderate stroke and cannot get standard treatments like clot removal. The goal is to see if DM199 helps improve recovery and reduce disability 90 days after the stroke. About 728 participants will receive…

This study looks at whether a cardiac rehabilitation program can improve recovery for people who have had a stroke. Researchers will compare standard stroke care plus cardiac rehab to standard care alone in 150 adults. They will measure walking ability, daily function, and whethe…

This study tests whether an artificial intelligence (AI) system can improve arm movement in people who had a stroke at least six months ago. About 192 participants will use a special video game for rehab, either with or without AI guidance, or receive standard care. The goal is t…

This study tests if a gentle, keyhole surgery to remove a brain clot within 8 hours of a stroke helps people recover better than standard medical care. About 240 adults with a large brain bleed will be randomly assigned to either the new surgery or usual treatment. The goal is to…

This study tests whether a program that helps stroke survivors with social challenges—like finding stable housing, getting enough food, or accessing transportation—can improve their recovery. Researchers will enroll 275 Black and Hispanic adults aged 18-75 who have had a stroke a…

This study tests whether Diroximel Fumarate, a drug already used for multiple sclerosis, can reduce harmful brain swelling that often occurs after a hemorrhagic stroke. The swelling can worsen recovery, and there is currently no specific treatment for it. The trial will involve 1…

This study looks at two ways to help people who have had a stroke lower their blood pressure: checking it at home, and also attending group medical visits to learn about blood pressure together. The goal is to see if combining both methods works better than home monitoring alone.…

This study tests whether a robot-assisted foot and ankle training program, combined with virtual reality, can improve walking speed and balance in people who have had a stroke. Thirty participants with chronic stroke will either receive this robotic training or the same exercises…

This study tests a new device called CLAAS that closes a small pouch in the heart to prevent strokes in people with atrial fibrillation (an irregular heartbeat). About 1,600 participants will be randomly assigned to get either the new device or an already-approved device. The goa…

This study looks at whether the blood thinner warfarin is safe and effective for preventing strokes in people with kidney failure who are on dialysis and have atrial fibrillation (an irregular heartbeat). About 718 adults will be randomly assigned to take warfarin or not, and res…

This study tests whether combining Tai Chi movements with a robotic arm device helps people who have had a stroke regain better use of their affected arm. About 120 participants will be randomly assigned to either robot-assisted Tai Chi training or standard exercises for 60 minut…

This study looks at whether stroke patients who take a type of blood thinner called FXa inhibitors can safely receive a standard clot-busting drug (IVT). Current guidelines say no, due to bleeding risk, but new evidence suggests it may be safe. The trial will compare recovery and…

This study looks at whether adding a blood thinner to standard aspirin therapy helps prevent strokes and blood clots in people who develop a new irregular heartbeat after coronary bypass surgery. About 3,200 adults who had bypass surgery and then experienced atrial fibrillation w…

This study tests a weight-loss program delivered by video or phone for people who have had a stroke. About 94 participants with a BMI of 25 or higher will be randomly assigned to start the program right away or wait 6 months. The goal is to see if the program helps them lose weig…

This study compares two common procedures—radiofrequency and cryoablation—to treat persistent atrial fibrillation (AFib), a heart rhythm problem that raises stroke risk. Researchers will track 158 adults over 24 months to see which method better prevents strokes, mini-strokes, an…

This study tests whether using remote-controlled CT scans with live video guidance from stroke experts can help smaller hospitals treat stroke patients faster. About 52 adults with suspected stroke will be enrolled. The goal is to see if this approach reduces the time from emerge…

This study tests a non-invasive treatment called remote ischemic conditioning (RIC) in 40 people who had surgery for a bleeding brain aneurysm. RIC uses a blood pressure cuff on the arm to create brief, harmless cycles of reduced and restored blood flow, which may help protect th…

This study tests whether combining two types of nerve stimulation can improve arm and hand function in people who had a stroke at least 6 months ago. 120 participants aged 55-75 will receive either the combined stimulation or a placebo, and researchers will measure changes in mov…

This study tests whether taking spirulina (microalgae) or seaweed (macroalgae) supplements for 20 weeks can improve heart health and gut bacteria in 150 adults aged 50 and older who have heart disease, diabetes, or kidney disease. Participants will be randomly assigned to receive…

This early study tests a brain-computer implant called Connexus in 2 people with severe paralysis from conditions like ALS or spinal cord injury. The device aims to decode imagined speech and allow users to control computers, helping them communicate. The main goal is to check sa…

This study tests whether a structured package of treatments—including early blood pressure lowering, fever control, and glucose management—can improve recovery in people with a bleeding stroke (intracerebral hemorrhage). About 3,500 adults in Sweden and Australia will receive eit…

This study tests a tool called Savvy, which includes phone exercises, a weekly pill organizer, and text reminders, to help stroke survivors take their medication as prescribed. Researchers want to see if it improves medication adherence and blood pressure control compared to usua…

This study looks at whether follow-up care for stroke survivors can be done through video or phone calls with a nurse instead of in-person clinic visits. About 196 adults who recently had a stroke and own a smartphone will take part. The goal is to see if telecare can reduce disa…

This study tests a smartphone app that uses virtual and augmented reality to help people who have had a stroke improve their arm and thinking skills at home. Seventy adults who are at least three months past their stroke will either use the app or receive standard therapy for six…

This study tests whether a drug called Dimephosphon can help people recover from a recent ischemic stroke (a stroke caused by a blood clot). About 184 adults aged 35-80 who had a stroke within the last 24-72 hours will receive either Dimephosphon or a placebo (a dummy treatment) …

This study tests whether adjusting blood pressure differently during standard clot-busting treatment for stroke can lower the risk of dangerous brain bleeding. About 340 adults with acute ischemic stroke and high blood pressure will be randomly assigned to either the new or usual…

This study is for people who had a stroke with no clear cause and have a small hole in the heart called a PFO. Researchers want to see if closing the hole with a special device, plus taking blood thinners, can lower the chance of having another stroke. About 636 participants will…

This study tests whether using a balloon guide catheter that temporarily stops blood flow helps remove clots more effectively in people having a stroke due to a blocked internal carotid artery. About 364 adults will be randomly assigned to receive either the balloon catheter or s…

This study tests whether combining a special arm-training device (MyoCI) with memory reactivation during sleep can improve arm movement in people who had a stroke at least 6 months ago. Researchers will enroll 70 adults with moderate to severe arm weakness. The goal is to see if …

This study tests whether adding the antibiotic minocycline to standard stroke care can improve survival and reduce disability in adults who have had a moderate stroke. About 1,164 participants will be randomly assigned to receive either minocycline pills for five days plus usual …

This study looks at whether taking blood thinners can prevent strokes in people who have brief episodes of atrial fibrillation (a fast, irregular heartbeat) triggered by stress, such as after surgery or a serious illness. About 2,270 participants with additional stroke risk facto…

This study tests a program to help people aged 55 and older return home safely after a stroke. Half of the 520 participants will get a stroke education program, while the other half will receive help modifying their home environment. The goal is to reduce disability and avoid adm…

This study tests a program to help low-income people with chronic conditions like diabetes and heart disease take their medications after leaving the hospital. The program provides free medications, delivers them to the bedside and home, and offers coaching to overcome barriers l…

This study tests whether starting a special exercise program soon after a stroke can protect the brain from memory loss and dementia. Researchers will work with 120 people who had a stroke in the last 6 months. They will measure thinking skills and brain blood flow to see if exer…

This study tests whether injecting a clot-dissolving drug directly into the blocked brain artery can improve recovery for people with medium vessel stroke. About 282 adults with a stroke caused by a medium-sized artery blockage will be randomly assigned to get the drug injection …

This study compares two treatments for small ischemic strokes (lacunar strokes): a combination of antiplatelet drugs (pills) versus the standard clot-busting drug tPA given through an IV. The goal is to see if the pill combo works just as well but causes fewer bleeding problems. …

This study tests whether combining non-invasive brain stimulation (rTMS) with a special electrical therapy (CCFES) can improve arm and hand function in people who had a severe stroke at least 6 months ago. The therapy aims to excite the undamaged side of the brain while the patie…

This study tests whether the IV drug clevidipine can lower blood pressure quickly and steadily in people having a bleeding stroke (intracerebral hemorrhage). About 1,000 adults with high blood pressure and stroke symptoms will receive either clevidipine or another IV blood pressu…

This study tests whether a robotic exoskeleton (Gloreha Sinfonia®) can help people who recently had a stroke regain better arm and hand control. About 130 adults with arm weakness after a stroke will either get robotic therapy plus standard rehab, or standard rehab alone. The goa…

This study tests whether combining a gentle brain stimulation technique (tDCS) with training that does two things at once (like walking while counting) can improve movement and thinking in stroke survivors. Researchers will measure walking speed, mental performance, and brain act…

This study tests whether adding a drug called GM1 to the standard clot-removal procedure helps people recover better after a major stroke. About 868 adults with a blocked artery in the front part of the brain will receive either GM1 or a placebo. The goal is to see if more people…

This study tests whether placing small filter devices in the neck arteries can catch blood clots before they reach the brain, reducing stroke risk in people with atrial fibrillation who have already had a stroke. About 2,000 participants will either receive the implants plus stan…

This study is testing whether two drugs—colchicine (an anti-inflammatory) and ticagrelor (a blood thinner)—can reduce the risk of another stroke, heart attack, or related events in people who have already had a stroke. About 2,800 participants will take these medications long-ter…

This study tests if placing a small tube (stent) in a hardened brain artery during a stroke helps patients recover better than standard clot removal methods. About 500 adults with severe stroke from a blocked large artery will be randomly assigned to one of the two treatments. Th…

This study tests a treatment called deep brain stimulation (DBS) combined with rehabilitation for people who have arm weakness after a stroke. About 202 participants who had a stroke 1 to 6 years ago will receive either the DBS plus rehab or rehab alone. The goal is to see if the…

This study tests whether giving a strong cholesterol-lowering drug (PCSK9 inhibitor) before a procedure to remove a blood clot in the brain can improve recovery in people having a stroke. About 652 adults with a severe type of stroke will be randomly assigned to receive either th…

This study looks at whether a procedure called endovascular thrombectomy (EVT) can help people who have a stroke but already had a moderate-to-severe disability before the stroke. About 1,060 adults with a large blood vessel blockage in the brain will be randomly assigned to get …

This early study tests a wireless brain implant from Neuralink that aims to let people with severe paralysis or ALS communicate just by thinking. The device is placed in the brain by a robot. The study will check if it is safe and works for 6 adults who cannot speak or use their …

This study compares two ways of performing a Valsalva maneuver (bearing down) during a heart ultrasound to detect a small hole called PFO, which can cause strokes in young people. About 488 adults referred for a routine bubble study will try both a standard self-directed method a…

This study tests a wearable device called Neuralert that monitors patients for signs of stroke. About 50 adults at high risk for stroke after heart or blood vessel surgery will wear the device on both arms for up to five days. The goal is to see if the device can detect strokes f…

This study aims to develop a quick blood test that can tell if a stroke is caused by bleeding or a clot, helping doctors give the right treatment faster. About 527 adults with suspected stroke will be enrolled within 3 hours of symptoms. The test looks for a protein called GFAP, …

This study tests whether using multiple types of CT scans (multimodal CT) can more accurately identify the blocked artery in people having a stroke caused by a medium-sized vessel blockage. Researchers will compare the accuracy of multimodal CT against standard CT scans. The goal…

This study tests a portable EEG device called StrokePointer that ambulance crews can use on people with suspected stroke. The goal is to see if it can accurately identify patients with a severe type of stroke who need to go directly to a hospital that offers a specialized clot-re…

This study looks at whether a simple, safe ultrasound of the optic nerve can quickly detect brain swelling and inflammation in ICU patients with conditions like meningitis, stroke, or brain tumors. Researchers will measure the optic nerve sheath diameter and compare it with stand…

This study tests whether a special tracer called Florbetaben, used with a PET scan, can detect inflamed plaque in the arteries of people who recently had a heart attack, stroke, or mini-stroke. About 30 participants will receive the tracer and undergo imaging to see if it highlig…

This study tests a special sensor that listens to chest sounds to help doctors detect pneumonia early. It includes 50 adults who have had a stroke or are on dialysis for kidney failure. The sensor picks up abnormal sounds that might mean pneumonia or fluid in the lungs, which is …

This study tests whether a nurse-led health education program for first-time stroke patients and their family caregivers can lower the chance of having another stroke. The program focuses on managing risk factors like blood pressure and lifestyle changes. Researchers will compare…

This study tests a music-inspired program called Music4Health to help prevent high blood pressure and stroke in Nigeria. It involves about 1,400 youth (ages 14-24) and their caregivers (ages 40+). The program uses community-designed music and campaigns to improve blood pressure, …

This study tests whether extra balance therapy and fall-risk education given to stroke patients while still in the hospital can reduce falls after they go home. About 134 participants will be split into two groups: one gets the extra treatment, the other gets usual care. Research…

This study tests whether a medicine called hydroxyurea can prevent strokes in children with sickle cell anemia who are at high risk. About 220 children in Nigeria will take low or moderate doses of the drug and be monitored for strokes and hospitalizations. The goal is to find a …

This study tests a gentle brain stimulation technique called kTMP to help improve arm and hand movement in people who have had a stroke at least a year ago. Twelve adults aged 18-80 with moderate arm weakness will receive the stimulation while doing motor rehabilitation exercises…

This study tests whether a non-invasive brain stimulation technique called TMS, combined with speech therapy, can improve language in people who had a stroke 2-6 weeks earlier. 63 participants will receive either real or fake TMS along with therapy. The goal is to see if this com…

This study looks at whether escitalopram, a type of antidepressant, can make language therapy work better for people who have trouble speaking after a stroke. The trial includes 88 adults who had a stroke within the past three months. Participants will receive either escitalopram…

This study tests a new rehabilitation program called ACES that combines acceptance and commitment therapy with strategy training to help people who had a stroke rejoin social activities. About 54 chronic stroke survivors living in the community will take part. They will receive e…

This study tests whether using a soft robotic hand together with electrical stimulation can help stroke survivors regain hand function better than either therapy alone. About 64 adults who had a stroke 3 to 6 months ago will take part. They will receive the combined treatment for…

This study tests whether a music-based program done at home can improve thinking, speech, movement, and mood in people who have had a stroke. One hundred stroke survivors will either do music exercises five times a week for 10 weeks plus usual care, or just usual care. Researcher…

This study tests a new exercise called CUped, designed to help stroke survivors recover leg movement and improve walking. It uses a robotic device to prevent bad movement habits and encourage use of the weaker leg. The study will include 12 adults who have had a single stroke and…

This study tests whether combining mirror therapy with a soft robotic glove helps stroke survivors with arm weakness regain hand function. About 104 adults who had a stroke will be assigned to different therapy groups. The goal is to see if the combo approach improves movement an…

This study tests whether a 12-week home telerehabilitation program using the MindMotion GO device can help stroke survivors improve motor function. 51 participants who had a stroke more than 30 days ago will use the device for 300 minutes of weekly therapy, guided remotely by a t…

This study tests whether a program that combines exercise counseling with a personalized activity plan can help stroke survivors become more physically active. Researchers will compare a group receiving this program plus usual care to a group receiving only usual care. The study …

This study tests whether a spinal cord stimulator, combined with physical therapy, can help people who have had a stroke regain arm and hand movement. Twenty adults with long-term arm weakness will first do therapy alone, then get a spinal implant and repeat therapy with stimulat…

This study looks at whether special exercises to strengthen the pelvis can improve leg movement and walking in people who had a stroke within the past few months. 34 adults aged 40-60 who had their first stroke will be split into two groups. One group will get pelvic stability tr…

This study tests whether adding one hour of arm-hand exercises daily (5 days a week for 4 weeks) to usual care helps stroke patients regain arm and hand function better than a similar amount of leg exercises. 80 patients in Belgium will be followed for a year to measure movement,…

This study tests a new way to help stroke patients who have trouble swallowing. Instead of just watching videos, patients will observe real people eating in daily life and then try to copy those movements. The goal is to see if this method works better than standard therapy for i…

This study compares three rehabilitation approaches for people who have had a stroke: mirror therapy, cognitive orientation to daily occupational performance (CO-OP), and conventional occupational therapy. All participants also receive robotic balance training. The goal is to see…

This study tests whether a gentle nerve stimulation on the ear (taVNS) combined with robot-assisted arm training can improve arm movement, breathing strength, and quality of life in people who had a stroke at least six months ago. Thirty adults with moderate to severe arm weaknes…

This study compares two physical therapy approaches—rhythmic guided movements versus static muscle contractions—to see which better improves arm function, strength, and coordination in people who had a stroke 1 to 6 months ago. Forty participants aged 40 to 60 will receive one of…

This study tests whether forced aerobic exercise on a stationary bike can improve arm and leg recovery in people who had a stroke 3-9 months ago. Researchers will compare this cycling therapy to standard rehab and measure movement, brain activity, and cost. The goal is to find a …

This study looks at whether practicing driving in a simulator can improve driving skills for veteran stroke survivors. One hundred participants will each try both active training (focusing on skills like speed control and avoiding crashes) and a control session (just getting used…

This study tests if a gentle brain stimulation technique called tDCS, combined with computer-based cognitive training, can improve memory and thinking in people who had a mild stroke. About 60 participants will receive either real tDCS or a sham (fake) version, plus cognitive tra…

This study tests whether a non-invasive treatment called extracorporeal shock wave therapy (ESWT) can reduce muscle stiffness (spasticity) in the wrist of people who have had a stroke. About 32 adults aged 35 to 65, who had a stroke more than 6 months ago, will receive either ESW…

This study tests a 12-week home exercise program for older adults who had a stroke and now have trouble swallowing. Participants do chin-tuck exercises against resistance and use a special pressure-measuring ball. The goal is to see if this improves swallowing function and qualit…

This study compares two walking training methods for people who have had a stroke: body weight-supported forward and backward walking versus virtual reality-assisted walking. The goal is to see which approach better improves walking ability, balance, and thinking skills. The stud…

This study tests a therapy called Constraint-Induced Movement Therapy for people who had a stroke at least 6 months ago and have mild arm weakness. The treatment involves daily practice sessions over consecutive weekdays, using shaping techniques and a transfer package to encoura…

This study is testing a wearable device called a myoelectric-computer interface (MCI) to help people who have had a stroke improve arm movement. The device gives feedback on muscle activity to reduce abnormal coordination between muscles. The study will enroll 96 participants, in…

This study compares two types of balance exercises—trunk training and lateral tilt training—to see which better improves trunk control, balance, and daily activities in stroke patients. It involves 44 adults aged 40-75 who had a stroke 6 months to 1.5 years ago and can walk 10 me…

This study tests a home-based occupational therapy program that uses activity monitoring, coaching, and video calls to help stroke survivors transition from hospital to home. Researchers will compare this approach to usual care in 171 adults aged 60 and older. The goal is to see …

This study tests a web-based program that helps stroke survivors practice arm exercises at home with support from a family care partner. The goal is to improve arm function, social participation, and quality of life for survivors while also reducing strain on caregivers. About 22…

This study tests whether a mild electrical current applied to the back of the brain (cerebellar tDCS) can boost language therapy for people who have trouble speaking after a stroke. About 60 adults with chronic aphasia will receive either real or fake stimulation during naming pr…

This study tests a special hand device that helps people who had a stroke and cannot open their hand to grab things. The device is designed to let users control it themselves to pick up, move, and release objects like a glass or spoon. Researchers will compare how well 30 partici…

This study compares two robotic devices—the Lokomat exoskeleton and the C-Mill treadmill—to see which helps stroke survivors walk better and feel better. Forty adults who have had a stroke will use one of the devices for gait training. Researchers will measure walking ability, ba…

This study compares three types of non-invasive brain stimulation combined with hand therapy to see which best helps stroke survivors regain the ability to open their affected hand. Researchers will enroll 63 adults who had a stroke 6 to 24 months ago. Participants will receive t…

This study tests a mobile app called MAYA that provides cognitive behavioral therapy (CBT) for anxiety and depression in adults who have had a stroke. Ten participants aged 40-79 will use the app and provide feedback on its ease of use and helpfulness. The goal is to see if the a…

This study looks at whether special balance exercises (vestibular exercises) can help reduce fatigue in people who have had a stroke. The researchers will compare these exercises to standard rehabilitation. Thirty adults who had a stroke at least 6 months ago will participate in …

This study tests whether adding EEG neurofeedback (a brain-training technique) to standard rehabilitation can improve arm movement in people who recently had a stroke. About 40 adults with a stroke within the past 3 weeks will be randomly assigned to receive either real or fake (…

This study tests whether adjusting the timing of word-practice sessions can help people with aphasia (trouble finding words after a stroke) remember words better and use them in everyday conversations. About 32 adults who had a stroke at least 6 months ago will practice naming pi…

This study looks at whether an over-the-counter supplement called MitoQ and a technique called ischemic conditioning can improve blood vessel health in people who have had a stroke. The goal is to see if these simple approaches can lower the risk of another stroke and improve exe…

This study looks at whether a regular exercise program can improve sleep quality in people who had a stroke at least a year ago and currently sleep poorly. About 62 adults aged 55 and older will take part in a 6-month program with twice-weekly exercise sessions. The goal is to se…

This study tests whether numbing a nerve in the arm or leg can reduce the severe, hard-to-treat pain some people feel after a stroke. Researchers will give 36 adults either one of two numbing medicines or a saltwater injection, then measure pain changes. The goal is to see if blo…

This study tests whether a robotic device called Pablo Tyromotion can help improve arm and hand function in people who had a stroke months or years ago. About 120 adults aged 45-80 with mild to moderate arm weakness will use the device in rehab sessions. The goal is to see if it …

This study compares robot-assisted training to standard therapy for people who have had a stroke and still have moderate to severe movement problems. About 40 participants, 6 to 24 months after their stroke, will receive either robot-assisted or standard training. The goal is to …

This study tests a physical therapy technique called Mobilization and Tactile Stimulation (MTS) for stroke survivors who have neglect—a condition where they are unaware of one side of their body. Six adults who had a stroke at least 20 weeks ago will receive MTS at home for 45-60…

This study tests a new approach to help people with aphasia (trouble finding words after a stroke) improve their ability to name objects. About 30 adults who had a stroke at least 6 months ago will practice naming pictures under timed conditions designed to balance effort and acc…

This study tests a home grip assistance glove (SaeboGlove) to help stroke survivors use their weaker arm in everyday tasks. About 100 adults who had a stroke more than three months ago and have trouble opening their hand will try the glove at home. Researchers will compare how we…

This study tests whether a home-based arm exercise program, called GRASP, helps stroke survivors improve arm movement and prevent the affected arm from being ignored. About 52 adults who had a stroke and have some arm movement will participate. They will do the exercises at home …

This study tests a 10-week power exercise program for people who had a stroke at least 6 months ago. Researchers want to see if it improves walking, strength, and balance better than standard strength training. Sixty participants will be randomly assigned to either the power prog…

This study tests whether adding sensory training to a proven arm therapy (Constraint-Induced Movement therapy) helps stroke survivors use their weaker arm more in daily life. About 15 adults who had a stroke at least 6 months ago will receive intensive training over consecutive d…

This study tests a new, low-cost shoe called the Variable Friction shoe for people who have foot drop after a stroke. Foot drop makes it hard to lift the front part of the foot, causing trips and falls. The study will enroll 50 adults who are at least 3 months past their stroke a…

This study tests whether adding a home-based telerehabilitation program to usual care improves arm function and reduces disability in people who had a stroke 90-150 days ago. 202 participants with arm weakness will be randomly assigned to either receive telerehabilitation plus us…

This study tests a new wearable device that gives feedback on throat muscle activity during swallowing therapy. It aims to improve swallowing in people who have had a stroke or have Parkinson's disease. The study will also see if doing therapy at home via video is as effective as…

This study tests whether playing music during routine hygiene care (like bed baths) can make stroke patients in the intensive care unit feel more comfortable. About 102 adults who recently had a stroke and need a full bed bath will take part. After care, patients will rate their …

This study compares robotic gait training to standard physical therapy for people recovering from a stroke. Researchers want to see if using a robotic exoskeleton early in rehabilitation improves walking speed and ability. The study involves 54 adults aged 18-85 who are in the su…

This study tests whether using a mobile breathing trainer (AiroFit PRO™) for 6 weeks can improve lung function, muscle strength, and quality of life in people with hemiplegia (weakness on one side) after a stroke. About 54 adults who are at least 3 months post-stroke will be rand…

This study tests whether a wearable robotic exoskeleton can improve walking and daily function in people recovering from a stroke. About 50 participants in inpatient rehab will use the device during therapy. Researchers will measure walking distance, independence, and muscle stif…

This study compares two language therapies for people with aphasia, a communication disorder caused by stroke. One therapy aims to stimulate the right side of the brain to improve storytelling and conversation, while the other focuses on word-finding. The goal is to see which app…

This study tests whether a gentle, non-invasive ultrasound technique can help stroke patients regain arm movement. Researchers will treat 50 adults who had a stroke within the past three months and have mild to moderate arm weakness. The goal is to see if focused ultrasound can s…

This study is testing a device called MyHand that helps people who have had a stroke use their affected hand better. The device is worn like a glove and assists with hand movements. Researchers want to make it easier and more useful for daily activities. The study involves 60 adu…

This study tests a 6-week online program that combines personal skill-building with inclusive volunteering to help young adults (18-64) who have had a stroke improve their ability to work. About 160 participants will be randomly assigned to either the program plus usual care or u…

This study tests a new type of rehabilitation called NICE that helps stroke patients improve arm movement by using a computer to guide them in activating specific muscle groups. Researchers will enroll 48 adults who have had a stroke to see if this approach leads to better motor …

This study looks at whether task-based mirror therapy can reduce pain, swelling, and improve arm movement in stroke survivors who develop shoulder-hand syndrome. About 34 people aged 45-75 will be split into two groups: one gets mirror therapy plus standard care, the other gets s…

This study tests whether using a device that projects a video of the good arm to look like the weak arm can improve hand and arm function in people who had a stroke 4 to 10 weeks earlier. About 66 participants will either get standard therapy or standard therapy plus extra sessio…

This study tests a home-based telerehabilitation program for stroke survivors who did not receive outpatient therapy. Two hundred participants across Alberta will use the Tenzr system, which includes fun, game-like exercises with wearable sensors guided by remote therapists. The …

This study tests a device called SynPhNe that stroke survivors can use at home to retrain their hand and arm movement. Researchers want to see if it works better than standard care alone. About 40 people who had a stroke at least 6 months ago and have moderate hand weakness will …

This study tests whether mild electrical stimulation of the spinal cord can help people who had a stroke move their arm and hand better and reduce pain. About 20 adults aged 20 to 70 with weakness on one side will receive a surgically placed stimulator. Researchers will measure c…

This study tests whether a non-invasive brain stimulation technique called iTBS can improve balance and leg movement in people who had a stroke more than six months ago. Researchers will compare the effects of adding iTBS to standard physical therapy in 56 adults with lasting wea…

This study tests whether a gentle, non-invasive electrical stimulation on the ear (called trans-auricular vagus nerve stimulation) can help people recover arm movement after a stroke. About 48 adults who had a stroke within the last 6 months will receive either real or fake stimu…

This study compares two types of exercise—high intensity interval training and intermittent functional training—to see which better improves heart fitness, physical function, and thinking skills in people who have had a stroke. About 52 adults aged 50-75 who had a stroke at least…

This study tests whether a non-invasive device called NESA, which delivers tiny electrical currents through the skin, can help people who had a stroke 6 months to 6 years ago. Researchers will measure changes in pain, muscle tightness, balance, sleep, and daily activities in 30 p…

This study tests a program that uses storytelling and skill-building to help young stroke survivors (ages 18-64) reintegrate into their communities. 208 participants will be randomly assigned to the program or usual care. The goal is to improve daily activities, social connection…

This study tests a new robot that helps people who had a stroke 6 months to 3 years ago improve their walking. The robot can adjust how much help it gives, encouraging patients to move on their own. Sixty participants will be split into two groups: one gets the adjustable assista…

This study tests whether special knee-strengthening exercises can improve balance and body awareness (proprioception) in people who had a stroke. About 34 adults who had a stroke 3 to 12 months ago will take part. They will do isokinetic exercises, which involve moving the knee a…

This study tests whether using a virtual reality (VR) treadmill is a practical and helpful way to improve walking, balance, and thinking in people who had a stroke at least 6 months ago. Thirty participants will either use the VR treadmill or do traditional exercises for 45 minut…

This study tests a new type of stroke rehabilitation that uses mirror priming to help people with chronic stroke improve arm and hand function. About 81 adults who had a stroke at least 3 months ago will try this enhanced mirror therapy. The goal is to see if it can improve movem…

This study tests a non-invasive treatment that sends mild electrical pulses to the spinal cord to improve walking and balance in people who have weakness on one side of the body due to a stroke. About 115 adults who are at least 6 months past their stroke will receive the stimula…

This study tests whether combining hand exercises with gentle vibration improves hand function, sensation, and muscle stiffness in people who have had a stroke. 38 adults who had a stroke at least 3 months ago will be randomly assigned to either standard hand exercises or the sam…

This study tests whether a 4-week home-based cognitive strategy program can help adults with chronic stroke become more independent in daily activities like dressing and cooking. Researchers will enroll 18 participants to see if the program is practical and effective. The goal is…

This study compares two methods of giving attention cues during arm exercises for people who had a stroke within the last 6 months. One method combines internal and external focus cues in the same session, while the other uses them in a set order. The goal is to see which approac…

This study tests whether a special virtual reality (VR) training program can help people who had a stroke more than 6 months ago improve their balance and walking. 38 participants will be split into two groups: one gets VR with specific visual and balance cues, the other gets the…

This study tests if combining mindfulness exercises with dual-task training (doing two things at once) can improve thinking and physical abilities in people with mild memory or attention problems after a stroke. About 60 participants who had a stroke at least 3 months ago will ta…

This study tests whether adding rhythmic music cues to treadmill walking with thinking tasks helps people who had a stroke more than six months ago walk better in their community. About 90 adults will be randomly assigned to one of three training groups. The goal is to see if thi…

This early-stage study is testing whether a device that sends mild electrical pulses to the spinal cord and limbs can help people with paralysis or weakness move their arms, hands, or legs. About 64 adults with spinal cord injury, stroke, or other nerve damage will attend up to f…

This study looks at how much walking practice on a special treadmill (split-belt) with virtual reality stroke survivors can handle in early recovery. About 72 people who had their first stroke within the past three months will try different amounts of training to find the safest …

This study explores whether listening to music for one hour each day can improve emotional well-being, thinking, and memory in people who have had a stroke. About 60 adults aged 50 to 90 who had a stroke at least six months ago will be randomly assigned to listen to music or an a…

This study compares two ways to help stroke patients with a tracheostomy (a tube in the throat) safely remove it. One method uses a speaking valve, the other a cap on the tube. The goal is to see which approach leads to more successful tube removal without needing it reinserted. …

This study tests whether a non-invasive treatment called high-frequency repetitive transcranial magnetic stimulation (rTMS) can help improve memory and thinking in people who have had a stroke. Researchers will use brain scans to see how the treatment affects brain activity. The …

This study tests if two non-invasive brain stimulation techniques can improve arm movement in people who have had a stroke. The techniques involve stimulating the arm muscles and the tongue. The goal is to see if these methods can help stroke survivors recover more arm function.

This study is testing a new robotic ankle exoskeleton designed to help people who have had a stroke walk more easily. About 15 stroke survivors will wear the device while walking on a treadmill, over ground, and on stairs and ramps. Researchers will compare walking with the power…

This study tests whether combining intensive arm movement training with a gentle brain stimulation technique can improve arm function and quality of life in women who have had a stroke. Twenty-four women from the Araucanía region will receive either the real stimulation or a plac…

This study tests a special exercise program called Task-Oriented Circuit Training (TOCT) to see if it helps stroke survivors improve arm and hand movement. The program involves 15 exercise stations that focus on everyday tasks. Researchers will measure hand dexterity, finger func…

This study tests whether a digital program on an iPad, combined with learning thinking strategies, can improve mood and mental skills in people who have had a stroke. About 70 adults who had a stroke at least 6 months ago and now have depression and trouble with focus or memory w…

This study tests if a non-invasive nerve stimulation device, used alongside occupational therapy, can help people who had a stroke more than 6 months ago regain arm movement. 60 participants will receive the stimulation or a placebo while doing therapy. The goal is to see if this…

This study tests whether adding mindfulness exercises to standard neuromuscular stimulation can improve lung function, physical abilities, and stress levels in stroke survivors. Sixty adults aged 50-65 who have had a stroke will be split into two groups: one gets both treatments,…

This study tests whether adding a vibrating device (Vibramoov®) to robotic walking training helps stroke survivors walk better than robotic training alone. Forty adults who had a stroke at least 3 months ago will take part in a 4-week rehab program. The goal is to see if the comb…

This study tests a home-based robotic device combined with mild electrical stimulation to help stroke survivors improve leg movement and walking. About 60 people who are at least 6 months post-stroke will use the robot alone or with stimulation for several weeks. The goal is to s…

This study tests a device implanted in the body that sends electrical signals to help stroke survivors walk more easily. About 6 people who had a stroke at least 6 months ago and have trouble walking will try it. The goal is to see if the device improves walking speed and feels e…

This study tests whether adding aerobic exercise (like walking or cycling) to standard physical therapy can improve arm movement, thinking, and mood in people who have had a stroke. The study will include 40 Veterans aged 50-90 who had a stroke at least 6 months ago. Researchers …

This early study tests whether electrical stimulation of the spinal cord can improve arm and leg movement in people who had a stroke at least 6 months ago. Six participants will receive the treatment to see if it is safe and helps them move more easily. The goal is to improve dai…

This study tests whether a gentle electrical current applied to the brain can make speech therapy more effective for people with chronic aphasia (trouble speaking) after a stroke. About 50 adults who had a stroke at least 6 months ago will receive either real or fake stimulation …

This study tests whether arm therapy done at home via video calls works as well as in-clinic therapy for people who had a stroke within the last 6 months. 28 participants will be split into two groups, one doing therapy in a clinic and the other doing the same therapy online from…

This study looks at whether a gentle nerve stimulation device (tVNS) combined with a hand therapy program (mCIMT) can help people who had a stroke more than 6 months ago improve arm movement, thinking, and quality of life. About 50 participants will be split into two groups: one …

This study tests a digital speech therapy app called Zenicom for people who have trouble speaking after a stroke. Twenty adults with aphasia will either do standard speech therapy alone or add the app for two weeks. The goal is to see if the app safely improves language skills.

This study tests whether a special brain-training system can help people who had a stroke regain hand control. 30 participants in the early recovery phase will either do standard hand therapy or add neurofeedback sessions where they control a virtual hand with their focus. The go…

This study tests whether adding mental imagery training to robotic hand exercises can improve arm and hand function in people who had a stroke at least six months ago. Forty adults aged 18–70 will use a special robotic glove while imagining the movements. The goal is to see if th…

This study tests a wrist-worn sensor system called StrokeWear to help people who have had a stroke use their weaker arm more in daily life. About 88 participants who had a stroke 1 to 6 months ago will either use the sensor with a home exercise program or follow standard care. Th…

This study tests whether a technique called biofeedback can improve arm and hand function in people who have had a stroke. Researchers will measure changes in movement and grip strength in 120 adults aged 45 to 80. The goal is to see if this type of training helps with recovery.

This study compares two technology-based therapies—robot-assisted walking training and visual feedback balance training—to see which better improves balance and walking in stroke survivors. About 60 adults who have had a stroke will participate in 4 weeks of therapy. The goal is …

This study tests whether a precise type of brain stimulation (called high-definition tDCS) can reduce arm stiffness and improve movement in 30 people who have had a stroke. The treatment targets specific brain areas to help rebalance the signals that control arm muscles. The goal…

This study tests a new virtual reality system that combines mirror therapy with fun, digital games to help stroke patients improve arm movement. Researchers will check if the system is easy to use and comfortable, and will measure any side effects like dizziness. The study includ…

This study tests a gentle ultrasound technique called LIFUS to see if it can improve arm weakness in people who had a stroke. Researchers will try different power levels and timing to find the best settings. 24 adults with arm weakness from a first stroke will participate. The go…

This study tests a new device called SSMD to see if it can help improve arm and hand movement in people who have had a stroke or traumatic brain injury. About 150 adults will be randomly assigned to receive either SSMD therapy or standard electrical stimulation, along with usual …

This study looks at whether fun activities like dance and virtual reality gaming can help people who have had a stroke improve their balance, movement, and daily function. Researchers will compare these alternative therapies to standard rehabilitation in 120 adults aged 18-90. Th…

This study tests whether a gentle brain stimulation technique, called cortical priming, can boost the effects of walking therapy for people who have had a stroke. Researchers will enroll 100 adults who are at least 3 months past their first stroke and still have trouble walking. …

This study tests a non-invasive treatment called shockwave therapy to improve arm and hand function in people who had a stroke at least 6 months ago. The therapy uses sound waves to reduce muscle stiffness and improve movement. Researchers will enroll 50 adults aged 25 to 65 to s…

This study compares two types of exercise training—sensorimotor training and dual-task training—to see which better improves balance, movement, and fall risk in people who have had a stroke. It involves 54 participants who are at least 6 months post-stroke and can walk independen…

This study looks at whether Vojta therapy, a type of physical therapy that uses gentle pressure on specific body areas to trigger natural movement patterns, can improve posture and trunk control in people recovering from a stroke. Researchers will include 62 adults aged 45-65 who…

This study tests whether sensor-based robotic rehabilitation can improve both cognitive functions (like memory and attention) and motor skills in adults with Parkinson's disease, multiple sclerosis, or stroke. Participants will receive 25 sessions of either robotic therapy with v…

This study tests whether adding electroacupuncture to standard repetitive transcranial magnetic stimulation (rTMS) improves arm and leg movement after a stroke. About 180 adults aged 40-75 who had a first stroke within the last 2 weeks to 6 months will receive either real or sham…

This study looks at whether adding electrical stimulation to arm cycling exercises can help people who had a stroke improve their fitness and arm movement. About 24 people who had a stroke within the last 6 months will take part. They will do either regular arm cycling or arm cyc…

This study looks at whether a 15-week lifestyle program combining weight loss and exercise can improve walking and daily life for obese veterans who had a stroke at least 6 months ago. About 99 veterans will take part. The goal is to see if this approach helps with physical movem…

This study tests whether a fast form of brain stimulation (accelerated rTMS) can safely improve apathy—loss of motivation and withdrawal—in people who had a stroke at least 6 months ago. Forty adults aged 40+ will receive either real or sham stimulation to a front part of the bra…

This study tests if a minimally invasive freezing procedure (cryoneurotomy) works as well as traditional surgery to relax a stiff, twisted foot caused by stroke. About 114 adults who have had a stroke and suffer from this foot problem will be randomly assigned to one of the two t…

This study looks at whether adding repetitive transcranial magnetic stimulation (rTMS) to standard rehab can improve heart rate variability, quality of life, and muscle strength in people who have had a stroke. About 44 adults aged 35-80 with a stroke at least 3 months ago will r…

This study tests whether adding mirror therapy, brain stimulation, or robotic hand training to standard rehab helps stroke survivors move their arms better, feel less pain, and improve quality of life. About 120 adults aged 40-80 who had a stroke at least 3 months ago will take p…

This study tests if a non-invasive magnetic brain stimulation technique called rTMS can reduce fatigue in people who had a stroke more than six months ago. About 60 participants will receive rTMS, and researchers will measure changes in fatigue, mood, and thinking. The goal is to…

This study tests a new approach to help people who have lost part of their vision after a stroke. Participants will do eye exercises with sounds and lights while receiving mild brain stimulation or a placebo. The goal is to see if this combination can improve vision and daily act…

This study tests whether combining special movement training with mild electrical stimulation can improve arm function in people who had a stroke. About 40 adults aged 50 to 65 with moderate arm weakness will participate. The goal is to see if this approach helps them regain more…

This study looks at two ways to help people who had a stroke more than 6 months ago get more physical activity. One group will follow a personalized exercise program at a special facility, while the other group will do their own program at home. The goal is to see which approach …

This study tests a 6-month nurse-led rehabilitation program for stroke patients in Bangladesh after they leave the hospital. The program includes a team of nurses, physical therapists, and occupational therapists to help with self-care and using assistive devices. The goal is to …

This study tests a wrist-worn sensor system called StrokeWear that reminds and encourages stroke survivors to use their weaker arm during daily activities at home. About 32 adults who had a stroke 6 months to 5 years ago will either use the sensor with a home exercise program or …

This study tests whether adding virtual reality therapy to standard rehabilitation and action observation therapy can improve arm and hand function in people who had a stroke 6 weeks to 6 months ago. About 38 adults with first-time stroke and some remaining arm movement will be r…

This study is testing a wearable suit called Neuro20 that uses mild electrical pulses to help muscles work. Researchers want to see if it can improve walking, muscle strength, and heart rate in 30 people who have had a spinal cord injury, stroke, or amputation. Participants must …

This study tests a non-invasive brain stimulation technique called iTBS to see if it can improve arm and hand function in people who had a stroke more than six months ago. Researchers will enroll 48 adults with lasting weakness on one side. The goal is to understand if this stimu…

This study tests whether adding virtual reality to brain-computer interface training helps stroke survivors regain arm and hand function. Twelve adults who had a stroke 6 to 24 months ago will try both standard brain-training and VR-enhanced sessions. Researchers will measure mov…

This study tests whether a smartphone app, combined with rehabilitation and a personalized nutrition plan, can improve swallowing recovery in people who have had a stroke. About 74 adults with swallowing difficulties after a stroke will either receive usual care or usual care plu…

This study tests whether adding pelvic coordination exercises to standard core training helps people who had a stroke within the last 6 months improve their trunk control and balance. 38 adults aged 45-60 who can walk a few minutes with or without help will be assigned to one of …

This study tests a wearable device that delivers gentle, low-frequency electromagnetic fields to the brain. The goal is to help people who had a stroke more than 6 months ago improve arm movement and daily independence. About 25 adults with chronic stroke will use the device duri…

This study tests a mental strategy training for people who have had a stroke and struggle with spatial neglect—a condition where they ignore one side of their body or environment. The training aims to improve their attention and awareness, making daily tasks easier. Researchers a…

This study compares two treatments—Botox injections and dry needling—for reducing leg muscle stiffness (spasticity) after a stroke. About 90 adults who had a first stroke within the past year will receive either one Botox session or 12 weekly dry needling sessions. Researchers wi…

This study tests a small-group, video-based self-management program for people who had a mild or moderate stroke within the last 6 months. The program is designed to help participants improve their ability to perform daily activities, feel more confident, and enhance their qualit…

This study tests a 12-week dance program designed for stroke survivors who have weakness on one side of the body. The program combines movement improvisation and adaptive dance to help improve balance, mobility, confidence, and participation in daily and social activities. Resear…

This study tests whether combining Transcranial Magnetic Stimulation (TMS) with speech therapy helps people with mild aphasia after a stroke speak and understand better. About 24 adults who had a left-brain stroke at least 6 months ago will receive either real or fake TMS along w…

This study tests whether a personalized exercise program, designed using data from wearable body sensors, can improve walking patterns in people who had a stroke at least six months ago. Fifty-two participants will do supervised exercises twice a week for six weeks. The goal is t…

This small pilot study tests whether combining non-invasive brain stimulation with electrical muscle stimulation can improve hand movement in people who had a stroke at least 6 months ago. The study involves 15 participants and focuses on changes in brain activity and reaction ti…

This study tests if a hands-on ankle adjustment (called talocrural joint manipulation) can improve a stroke survivor's ability to sense where their foot is in space. Researchers will measure ankle awareness in 26 adults who had a stroke at least two months ago. The goal is to see…

This study tests whether psilocybin, a psychedelic substance, is safe for people who had a stroke at least a year ago. Researchers will monitor blood pressure and other vital signs in 20 participants. The goal is to see if psilocybin can be used safely as part of therapy to help …

This study looks at whether injecting Xeomin® into the upper arm can improve walking and mobility in adults who have had a stroke. About 20 people with arm and leg stiffness will be tested before and 4-6 weeks after the injection using simple walking tests. The goal is to see if …

This study looks at whether doing high-intensity walking training more often helps people who had a stroke walk farther and faster. Researchers will compare two training schedules in 40 adults who are at least 6 months past their stroke. The goal is to find the best way to improv…

This study tests whether a non-invasive brain stimulation technique called tDCS can improve arm recovery in people who recently had a stroke and have severe arm weakness. Fifty participants will receive either real or sham stimulation during rehab. The goal is to see if adding tD…

This study tests a new system that combines virtual reality with a walking robot to help people who have had a stroke walk more evenly. 30 people (15 stroke survivors and 15 healthy adults) will try the system in one session. The goal is to see if real-time visual feedback can im…

This study explores whether hypnosis can help people with stroke, traumatic brain injury, or multiple sclerosis improve their attention and feel less tired. Researchers will use EEG to watch brain activity during hypnosis sessions. The goal is to see if adding hypnosis to standar…

This study tests whether a digital program called Sleepio, which uses cognitive behavioral therapy for insomnia, can improve sleep in stroke survivors. Researchers will also see if better sleep helps with learning motor skills. The study involves 100 adults who have had a stroke …

This study is testing whether a precise vibration exercise system can help older adults and stroke survivors improve muscle strength, movement, balance, and reduce pain. The researchers will recruit 80 participants to try the vibration therapy and measure changes in strength, wal…

This study tests a new speech therapy technique for people with aphasia after a stroke. Participants use a mobile app to practice speaking along with an AI-cloned version of their own voice, instead of a therapist's voice. The goal is to see if hearing their own voice helps them …

This study tests whether adding neuromuscular electrical stimulation (NMES) to standard facial exercises helps people who have facial weakness after a first-time stroke. About 130 adults with central facial palsy will be randomly assigned to receive either usual training alone or…

This study tests whether a gentle brain stimulation technique (rTMS) can make walking and thinking training work better for people who had a stroke at least 6 months ago. About 184 adults aged 50+ will get either real or fake stimulation before 12 sessions of walking while doing …

This study tests whether a robotic exoskeleton that limits certain arm and trunk movements can help people recovering from a stroke regain better control of their arm. The trial will enroll 44 adults who had a stroke within the past 12 weeks and have limited arm movement. Partici…

This study tests a new way to help people with chronic stroke improve their balance. The method uses gentle, non-invasive vibrations on the skin to give the brain extra sensory cues about body position. Researchers will enroll 36 adults who had a stroke at least 6 months ago and …

This small pilot study tests whether a gentle electrical stimulation to the spinal cord, combined with balance training, can help people who had a stroke over a year ago improve their balance and reduce fall risk. Sixteen participants will be randomly assigned to receive either r…

This study tests a robotic glove that reads brain signals to help people who had a stroke move their hand and arm better. The glove is designed for those with lasting weakness, at least 16 weeks after their stroke. The goal is to improve hand function and grip strength through br…

This study tests whether exercising one arm alone or both arms together works better for improving arm and hand function after a stroke. Thirty-two adults who had a stroke 6 to 24 months ago will do structured training for four weeks. Researchers will measure motor recovery and h…

This study looks at how different types of walking therapy affect recovery in people who had a stroke 1 to 6 months ago. Researchers will test whether focusing on walking practice or exercise intensity helps improve walking ability, community mobility, and quality of life. About …

This study tests whether a gentle magnetic brain stimulation (TMS) combined with language therapy can improve word-finding in people who have trouble speaking after a stroke. About 50 adults with left-hemisphere stroke will receive either precise or standard TMS during therapy se…

This study tests a new rehabilitation method for people who lost part of their vision due to a stroke. The approach combines gentle electrical brain stimulation with moving visual targets, sometimes using a virtual reality headset, to try to retrain the brain to see in the blind …

This study compares digital mirror therapy (using augmented reality) to standard mirror therapy for improving arm function in people who had a stroke at least 6 months ago. 44 participants will receive 10 therapy sessions over 3 weeks. The goal is to see if the digital version wo…

This study looks at whether adding music training and group leisure activities to standard hospital rehab helps people recover better after a stroke. About 90 adults who recently had a stroke will be split into three groups: usual rehab, usual rehab plus individual music training…

This study looks at whether adding visual-motor training (exercises that coordinate what you see with how you move) to standard physiotherapy can improve arm and hand function in people who have had a stroke. About 38 adults who had a stroke at least 6 months ago will participate…

This study tests whether virtual reality (VR) and mixed reality (MR) versions of mirror therapy can help stroke survivors improve arm and hand function. Researchers will compare these high-tech approaches to traditional mirror therapy in 45 adults who had a stroke. The goal is to…

This study tests if a gentle electrical stimulation on the ear (called taVNS) can improve arm and hand function in people who have had a stroke. Thirty adults with arm weakness from a stroke will receive either real taVNS or a fake version (sham) combined with physical therapy fo…

This study tests whether adding action observation (watching movements) and motor imagery (imagining movements) to standard physical therapy can improve balance, daily function, and quality of life in people who had a stroke within the last year. About 56 participants will be ran…

This study tests whether a smartphone app powered by artificial intelligence can improve memory, attention, and other thinking skills in people who have had a stroke. Researchers will enroll 40 adults aged 45-60 who have had a stroke at least 3 months ago and still have mild cogn…

This study looks at whether high-intensity interval training (HIIT) can help reduce tiredness in people who have had a stroke. About 60 adults aged 40-80 who had a stroke 6 months to 5 years ago and still feel fatigued will be randomly placed into one of three exercise groups. Al…

This study compares two ways of delivering speech therapy to people with aphasia (trouble speaking or understanding language) after a stroke. One group gets therapy at home through a computer or tablet, and the other group gets therapy in a clinic. The goal is to see if remote th…

This study tests whether adding musical auditory cues (sonification) to standard physical therapy can improve walking in people with Parkinson's disease, stroke, or multiple sclerosis. 120 participants will receive either standard rehab or rehab with sonification for 20 sessions.…

This study tests whether a program of repetitive, strength-based hand exercises can improve arm and hand function in children aged 7 to 12 who have had a stroke. The therapy focuses on high-repetition, goal-oriented movements to boost coordination and use of the affected upper li…

This study is testing whether adding robotic exoskeletons and virtual or augmented reality to treadmill training can help people who have had a stroke improve their walking and daily independence. Researchers will compare different training methods in 80 participants to see which…

This study tests whether injecting hyaluronic acid into shoulder muscles can reduce pain and improve movement in people who have had a stroke. About 68 adults with shoulder pain starting 3 to 180 months after a stroke will receive either the injection or a placebo. The goal is to…

This study tests whether combining virtual reality training with a gentle brain stimulation technique can improve arm and hand movement in people who had a stroke at least three months ago. Researchers will enroll 100 adults to compare the effects of this combined approach on mot…

This study tests a new way to help people who have trouble swallowing after a stroke. It combines special swallowing exercises with visual feedback and mild electrical stimulation to strengthen throat muscles. 34 adults who had a stroke within the last 6 months will take part in …

This study tests whether using augmented reality (AR) or virtual reality (VR) during treadmill training can improve balance and walking in people who have had a stroke. 66 participants will be split into three groups: one using VR, one using AR, and one doing home exercises. All …

This study tests whether a gentle, non-invasive nerve stimulation (applied to the ear or neck) can improve arm function, thinking skills, and quality of life when paired with standard therapy in people who had a stroke 3–6 months ago. Fifty-four participants will receive either e…

This study is testing a new soft robotic glove designed to help people who have had a stroke regain movement in their wrist and hand. Sixty stroke survivors will be split into three groups to compare the glove with standard rehab. Participants will attend 20 training sessions usi…

This pilot study tests a task-specific self-rehabilitation program (TASSRET) for stroke survivors living in communities with no access to physiotherapy. About 50 Hausa-speaking adults who had a stroke will use either a video or a manual guide to practice movements at home. The go…

This study tests whether a special virtual reality program that stimulates multiple senses can help people who have had a stroke improve their movement and thinking skills. About 40 stroke survivors will be randomly assigned to either the VR therapy or standard care. The goal is …

This study tests whether personalized brain stimulation (rTMS) can improve arm movement in people who had a stroke within the past 3 months. About 120 participants will receive either a tailored treatment based on their brain's recovery potential or a standard approach. The goal …

This study tests whether combining simple passive robots with mild muscle stimulation can help people who had a stroke regain arm movement. Researchers will ask 4 participants to try the device and give feedback on how easy and useful it is. The goal is to see if this approach is…

This study tests whether applying kinesio tape (a stretchy, therapeutic tape) to the neck muscles can improve swallowing safety in people who have trouble swallowing after a stroke. Researchers will measure changes using video X-rays before and right after taping. The study enrol…

This study tests a new, non-invasive brain stimulation method called mirror-PAS in 36 adults with stroke-related arm weakness or phantom limb pain. Participants will try both standard and mirror-based stimulation to see which better promotes brain plasticity and improves movement…

This study tests whether using a screen that shows real-time muscle activity (biofeedback) helps stroke survivors with swallowing problems recover better than standard therapy. One hundred adults who had a first stroke and still have trouble swallowing will be split into two grou…

This study tests whether a virtual reality therapy that uses mirror images of the good arm can help stroke survivors improve movement in their affected arm. About 44 people who had a stroke at least 6 months ago will try either standard VR mirror therapy or a new cooperative vers…

This study tests a new walking training method for people who have had a stroke. It uses a split-belt treadmill (where each leg moves at a different speed) and adds gentle resistance and real-time feedback (like sounds or visuals) to help the weaker leg push off more strongly. Th…

This study looks at whether losing weight and exercising can improve walking and emotional well-being in veterans who have had a stroke and are overweight. About 130 people will take part. Researchers will compare a diet-only program, a diet-plus-exercise program, and a waitlist …

This study tests whether having a trained peer coach (another stroke survivor) can improve well-being and quality of life for people who recently had a stroke. Twenty participants will receive five coaching sessions and complete surveys over several weeks. The goal is to see if t…

This study tests a new way to help people who have had a stroke move their arm better. It uses a virtual reality system that senses muscle signals and helps guide hand movements, combined with gentle brain stimulation. The goal is to improve arm function and dexterity. The study …

This study is testing whether a high-dose, high-intensity neurorehabilitation program is practical and helpful for adults recovering from a stroke. Participants will get about 300 minutes of active, technology-supported training each week, in addition to standard care, across hos…

This study tests a camera-based system that uses artificial intelligence to track how well stroke survivors perform arm exercises during robot-assisted therapy. The goal is to see if this feedback helps people recover better, especially when therapy is done in small groups instea…

This study tests whether stimulating the tongue with a gentle device can improve arm function and brain plasticity in people who had a stroke at least 6 months ago. 74 participants will receive either real or sham tongue stimulation combined with a personalized 4-week arm trainin…

This study tests whether a personalized form of brain stimulation (tDCS) can help people who had a stroke more than 3 months ago regain arm movement. Researchers will use brain scans to tailor the stimulation to each person and measure changes in brain connectivity and motor func…

This study compares two ways of making ankle-foot braces (AFOs) for people with leg weakness due to conditions like cerebral palsy, stroke, or spinal cord injury. The traditional method uses a plaster cast, while the newer method uses 3D scanning and printing. Researchers want to…

This study looks at whether high-intensity interval training (HIIT) on a stepper machine can improve muscle power in people who had a stroke 1-5 years ago. 66 adults aged 50-80 will be split into three groups: HIIT, moderate exercise, or stretching. They will train three times a …

This study tests if a hands-on therapy called thoracic spinal manipulation can improve balance, reduce fall risk, and increase upper back movement in people who have had a chronic stroke. Researchers will measure balance and fall risk using a special platform. The study involves …

This study tests a new program that combines virtual reality (VR) training with real-world practice to help stroke survivors walk better in their communities. Forty adults who had a stroke 9 to 24 months ago will use VR goggles and game controllers to navigate a virtual mall and …

This study tests whether combining prism adaptation training (PAT) with a mild electrical stimulation (TENS) helps stroke survivors who ignore one side of their body. 20 participants will be assigned to PAT alone or PAT plus TENS. The goal is to see if the combo improves attentio…

This study compares doing rehabilitation at home via video calls to going to a clinic for in-person therapy, to see which helps stroke survivors improve their thinking and memory. About 32 adults aged 50-80 who have had a stroke and have mild to moderate thinking problems will ta…

This study compares two modern therapies—mirror therapy and virtual reality (VR)—to see which one better improves arm movement in people who had a stroke 6 to 12 months ago. 42 participants aged 18 to 75 will be randomly assigned to one session of either therapy. Researchers will…

This study tests a new type of therapy that uses virtual reality and motion-tracking to help people who have had a stroke move their arm and hand better. 56 participants will either get this new VR therapy or standard mirror therapy. The goal is to see if the VR approach leads to…

This study is testing a special suit called Mollii that uses mild electrical pulses to help people with stroke or multiple sclerosis move more easily and improve their daily life. About 40 participants will wear either the active suit or a placebo version to see if it really work…

This study looks at whether moderate or high-intensity walking exercise is better for improving walking in people who had a stroke at least 6 months ago. Participants will do 45-minute walking sessions with a physical therapist three times a week for 12 weeks. The goal is to see …

This study tests whether a tongue endurance exercise program can improve swallowing in adults who have trouble swallowing after a stroke. About 70 people will be randomly assigned to do either the tongue exercises or a sham therapy at home for 8 weeks. Researchers will measure ch…

This study tests whether virtual reality (VR) training that looks like a real home can help stroke survivors improve arm and hand function. About 86 people who had a stroke 1 to 6 months ago will be split into three groups: VR-based task training, standard task training, or usual…

This study tests whether adding intensive virtual reality-based balance and gait training to standard physical therapy helps people who had a stroke within the last six months. About 48 adults will be randomly assigned to either standard rehab alone or standard rehab plus VR trai…

This study tests whether watching videos of functional actions (like walking) combined with rhythmic sounds can improve balance and walking in people who have had a stroke. Forty participants will either receive standard therapy or watch these videos with music for 30 minutes a d…

This study compares two ways of using a robot to help people who had a stroke more than 3 months ago regain arm and hand function. About 72 adults aged 20-75 will receive 18 therapy sessions over 6 weeks. The goal is to see which robotic training sequence works better for improvi…

This study tests whether a 12-week sitting Tai Chi program can improve thinking, movement, mood, and daily function in chronic stroke survivors who have memory or thinking problems. About 176 participants (88 stroke survivors and 88 caregivers) will be randomly assigned to either…

This study is testing whether virtual reality exercises can help people who have trouble paying attention after a brain injury, such as from a stroke, accident, or tumor. The researchers will enroll 135 adults and use fun, game-like VR tasks to train attention and thinking skills…

This study tests a procedure called cryoneurolysis, which uses cold to freeze specific nerves in the shoulder, to see if it relieves pain and improves movement in people with spasticity (muscle tightness) after stroke, brain injury, or multiple sclerosis. It compares the freezing…

This study looks at whether adding electrical muscle stimulation or special sound beats to mirror therapy can improve leg function in people who had a stroke at least 6 months ago. About 72 adults aged 20-80 will be enrolled. The goal is to see which combination works best for mo…

This study tests whether showing stroke survivors real-time data from wearable ring sensors on their smartphone can encourage them to use their stroke-affected arm more during daily activities. About 50 chronic stroke survivors (more than 12 months since their stroke) aged 18 to …

This study tests whether a gentle nerve stimulation device placed on the ear (taVNS) combined with robot-assisted arm training can help people who had a stroke more than 6 months ago regain arm movement. Thirty adults with moderate to severe arm weakness will receive either real …

This study tests a special mouth exercise program using a device to help people who still have trouble swallowing 12 weeks after a stroke. About 60 participants will be randomly assigned to the program or standard care. The goal is to see if the exercises improve swallowing funct…

This study tests whether adding a vibrating sensation to the arm can help stroke survivors who have lost some sense of where their arm is. Thirty people who had a stroke at least six months ago will try reaching for objects and drinking from a glass while wearing a device that bu…

This study explores whether a brain-computer interface (BCI) can help people with motor disorders (like spinal cord injury or stroke) control assistive devices using only their thoughts. Researchers will use electrical stimulation to improve brain signals. The goal is to make BCI…

This study looks at brain activity in 25 stroke patients while they do mirror movement exercises. Researchers use a special brain scanner to see which areas of the brain light up. The goal is to understand how the brain works during this therapy, not to test a new treatment. Part…

This study looks at whether thinking about your body movements (internal focus) or about a target outside your body (external focus) helps people who had a stroke more than six months ago stand up from a chair more evenly. Twenty participants will practice sit-to-stand moves unde…

This study tests an 8-week online or hybrid program to help working-age stroke survivors start their own business. Researchers will measure how many participants become self-employed, and whether their confidence and life satisfaction improve. The program is designed for people w…

This study aims to understand why some people recover language after a stroke while others do not. Researchers will use genetic tests and MRI brain scans to find markers of brain flexibility (neuroplasticity) in 90 adults aged 40-90 who have had a stroke. The goal is to better pr…

This study looks at how brain stimulation combined with stepping practice affects leg skill learning in healthy adults and people with chronic stroke. Researchers will measure changes in stepping speed and brain activity after five sessions. The goal is to understand if this appr…

This study tests whether a live video call between a neurologist and paramedics can improve the accuracy of stroke detection in the ambulance. About 512 adults with suspected stroke will take part. The goal is to see if video assistance helps diagnose stroke better than standard …

This study is following 5,000 adults in Hong Kong who either have a brain disease (like stroke or dementia) or are at high risk. Researchers will track their health over many years using medical records and questionnaires. The goal is to find what factors lead to brain diseases a…

This study tests whether a smartphone app called ICanWALK can teach people to use walking aids like crutches, canes, and walkers more safely. About 52 adults with leg injuries or conditions like stroke or multiple sclerosis will use the app or receive standard care. The goal is t…

This study aims to understand how a protein called BD-tau, released from the brain after injury, changes in the blood over time in people having a stroke. Researchers will take blood samples every hour for 48 hours from 100 adults with acute ischemic stroke. The goal is to learn …

This study looks at how shoulder pain on the paralyzed side affects arm function, balance, fear of falling, and independence in daily activities for people who have had a stroke. Researchers will measure these factors using standard tests and ultrasound imaging. The goal is to be…

This study looks at how muscles work together after a stroke and whether special exercises can improve arm movement. Researchers will test a non-invasive EMG-guided exercise in 74 people, including stroke survivors and healthy adults. The goal is to see if changing muscle coordin…

This study is testing whether a virtual reality walking program is practical and well-liked by stroke patients and their therapists. About 40 people who had a stroke will try personalized VR exercises for 4 weeks. The goal is to see if this approach can be easily added to regular…

This study looks at how things like education, race, and income might affect a person's memory and thinking after a stroke. Researchers will interview 450 adults who had a stroke and had a brain scan. The goal is to understand why some people recover better than others.

This study compares a pressure-sensitive smart insole (Ceriter Stride One) to a high-tech lab system (GRAIL) for measuring walking patterns. About 30 people with stroke, brain injury, or spinal cord injury will wear the insoles while walking on a treadmill. The goal is to see if …

This study aims to find ways to predict which stroke survivors will improve their walking speed with high-intensity interval training (HIIT). Researchers will measure blood lactate levels during exercise and use brain scans to look at key chemicals and blood flow. The goal is to …

This early study is testing whether a robot can help doctors perform procedures on brain blood vessels, such as angiography, embolization, and thrombectomy. Ten patients scheduled for these standard treatments will have their procedure done with the Vasco Robotic system instead. …

This study follows 150 people who recently had a stroke to understand how their walking ability recovers over time. Researchers will measure walking speed and distance, and see if specific therapies can improve recovery. The goal is to create better rules for predicting and enhan…

This study is testing a new questionnaire called the Pressure Relief Frequency Scale (PReFS) to see if it can help wheelchair users with neurologic disorders (like spinal cord injury, stroke, or traumatic brain injury) know how often they should shift their weight to prevent pres…

This study tests whether a modified cardiac rehabilitation program can improve physical and emotional recovery in people who have had a stroke. Researchers will enroll 76 adults aged 18-80 who had a stroke at least 6 months ago and still have some leg weakness. The goal is to see…

This study looks for brain signals (biomarkers) that can track and predict how well stroke patients recover walking ability. About 30 adults who have had a stroke and can walk with some help will use a robotic exoskeleton while their brain activity and movement are measured. The …

This study uses ultra-powerful MRI scanners to create detailed maps of how the brain reorganizes after a stroke. Researchers will scan 100 stroke patients and 10 healthy volunteers to understand how brain connections relate to arm and hand movement. The goal is to improve future …

This study looks at whether combining prism adaptation training with electrical stimulation can help people who have had a stroke improve their spatial awareness and walking. Researchers will measure changes in pointing behavior, brain activity, and walking ability. The study inc…

This study looks at whether simple, fast tests of movement speed can help doctors better diagnose and predict outcomes in people with stroke or memory-related brain diseases like Alzheimer's. Researchers will test 129 adults aged 40-85 using two new test batteries. The goal is to…

This study aims to create a large collection of blood samples from 1,000 people with atrial fibrillation (an irregular heartbeat) and/or stroke. Researchers will analyze the DNA and plasma to better understand the genetic causes of these conditions and why they are linked. The go…

This study looks at how taking several different medicines at once affects the health of older adults with chronic conditions like heart disease, diabetes, and high blood pressure. Researchers will survey 2,000 people aged 65 and older in Shaanxi Province, China, over two years. …

This study looks at better ways to measure and treat a condition called neglect that can happen after a stroke, where people ignore one side of their body or space. Researchers are testing a treatment that combines repetitive task practice with a gentle brain stimulation techniqu…

This study looks at how stroke changes the way people move their arms when walking. Researchers will measure brain activity and muscle patterns in 84 people (stroke survivors and healthy volunteers) to understand why arm swing is different after a stroke. The goal is to use these…

This study is watching how well the clot-dissolving drug tenecteplase works for stroke patients in regular Chinese hospitals. About 10,000 adults with a confirmed stroke will be followed for 90 days to see their recovery and any side effects. The goal is to learn how the drug per…

This study looks at whether people who have a blood clot in the lungs (pulmonary embolism) and also have a small hole in their heart (called a PFO) are more likely to have a stroke. About 1 in 4 people have this hole, which can let a clot travel to the brain. Researchers will use…

This study looks at how well stroke survivors can identify whether an image shows a left or right hand. About 30 adults who have had a stroke will complete a simple reaction time task and a hand laterality judgment task. The goal is to measure accuracy and decision-making speed, …

This study is testing whether a new digital test battery called Mindmore Distance can accurately assess thinking and memory skills in people with neurological conditions like traumatic brain injury, stroke, multiple sclerosis, Parkinson's disease, epilepsy, and brain tumors. Rese…

This study is a registry that gathers medical information from up to 40,000 people who have had surgery for stroke, brain aneurysm, or other blood vessel problems in the brain. Researchers will use this data to better understand what affects recovery and to compare different surg…

This study is testing a special glove with sensors to see how well it can measure touch and thinking problems in people who have had a stroke. About 126 adults who had a stroke within the last six months will wear the glove while doing rehab exercises. The goal is to make the glo…

This pilot study looks at how Botox injections affect the muscles, tendons, and nerves in the feet of people who had a stroke for the first time. Researchers will use a special 3D ultrasound and a device that measures muscle stiffness to track these changes. The goal is to gather…

This study looks at why walking is harder for people after a stroke. Researchers will test a new method to measure walking efficiency in 18 adults who have had a stroke. Participants will walk on a treadmill for three 5-minute sessions to compare this new measure with standard en…

This study tests whether delivering magnetic brain stimulation in sync with a person's own brain waves can make the treatment more effective for improving arm and hand movement. Researchers will compare healthy older adults and people who had a stroke at least six months ago. Par…

This study looks at how the brain changes after a stroke and how those changes affect arm and hand movement. Researchers will use brain scans and movement tests to find early signs that can predict recovery over six months. The goal is to better understand why some people develop…

This study will follow 1,000 adults with psoriasis to understand how the skin condition is linked to heart disease. Researchers will use heart tests and blood markers to find early signs of heart problems. The goal is to improve heart health monitoring for people with psoriasis.

This study looks at whether backward walking training can improve walking and balance in people who have had a stroke. About 48 Veterans who had a stroke 2-4 months ago will try either 18 or 27 training sessions. Researchers will also use brain scans to see how the brain changes …

This study uses a robotic arm and gentle brain stimulation to learn how different brain areas control reaching movements in people who have had a stroke. Researchers will compare results from stroke survivors and healthy volunteers aged 45-90. The goal is to better understand bra…

This study is collecting information from 200 people with cerebral palsy, multiple sclerosis, stroke, fibromyalgia, or similar nerve disorders to see how the EXOPULSE Suit affects their balance and risk of falling over time. Participants will be followed routinely, and researcher…

This study follows 140 working-age stroke survivors in France to find out what factors help or hurt their return to work. Researchers will look at medical details, personal feelings, and job-related issues. The goal is to create better rehab and workplace support for stroke survi…

This study is testing whether wearable body sensors can accurately monitor and measure recovery in people recovering from a stroke during inpatient rehabilitation. Researchers will use data from the sensors to estimate how well patients are doing when they leave the hospital. The…

This study looks at how the spinal cord processes sensory information in people who have had a stroke and in healthy individuals. Researchers will stimulate nerve roots in the neck during surgery and measure muscle and brain responses. The goal is to learn how stroke changes spin…

This study looks at how combining a gentle brain stimulation technique (tDCS) with watching hand movements (action observation therapy) affects hand muscle recovery in people who had a stroke. Sixty adults with chronic stroke will receive 10 sessions of either both treatments tog…

This study looks at whether low magnesium levels in the blood are linked to thinking problems after a stroke. Researchers will measure magnesium and cognitive skills in 80 stroke patients over several weeks. The goal is to understand if magnesium deficiency or the stroke itself c…

This study follows 130 patients with severe brain injuries (from stroke, trauma, or lack of oxygen) who are in a coma or minimally conscious state. Researchers will use brain scans, electrical tests, and regular check-ups to find clues that might predict if and when a patient wil…

This study is testing a new device that measures pressure around the brain from outside the head, avoiding the need for surgery. Currently, doctors must drill a hole in the skull to monitor this pressure, which can cause infections and pain. The research will collect data from 58…

This study aims to understand why some stroke survivors move slowly and how to improve that. Researchers will use brain stimulation (TMS) and brain imaging (EEG, fNIRS) in 80 healthy people and 20 stroke patients to map the brain circuits controlling movement speed. The goal is t…

This study looks at whether brain scans and electrical tests done soon after a stroke can predict how well a person will recover arm movement. Researchers will collect data from 657 adults who had a stroke and have arm weakness. The goal is to create a large dataset to help desig…

This study uses a special brain scan called MEG to learn why many people have trouble with attention, memory, and thinking after a minor stroke. Researchers will compare brain activity in stroke patients and healthy volunteers at 1, 6, and 12 months after the stroke. The goal is …

This study looks at whether combining ultrasound with artificial intelligence can help doctors quickly identify bleeding strokes. About 500 adults with stroke symptoms will get a non-invasive ultrasound scan within 48 hours. Researchers will compare the AI's reading of the ultras…

This study looks at how the brain talks to muscles in people who have had a stroke. Researchers will use gentle, non-invasive brain stimulation and measure brain and muscle activity while participants squeeze a device with their weak hand. The goal is to see if this stimulation c…

This study looks at how deep brain stimulation (DBS) changes brain activity and movement in people with conditions like Parkinson's disease and essential tremor. About 60 participants scheduled for DBS surgery will have temporary electrodes placed on the brain to measure muscle r…

This study looks at how stroke changes brain activity when people walk and think at the same time. Researchers will monitor 50 adults who had a stroke at least 6 months ago as they walk, navigate, and perform simple mental tasks. The goal is to better understand these difficultie…

This study looks at how damage to tiny blood vessels in the brain affects thinking and memory in older adults. Researchers will use EEG to measure brain activity and test if personalized brain training or gentle electrical stimulation can help. The goal is to find better ways to …

This study monitors how much and how well stroke survivors move their affected arm during everyday activities. Researchers will track hand movements, joint range, and wrist distance using wearable sensors. The goal is to link real-world movement data with standard recovery tests.…

This study looks at why people who have had a stroke often have trouble coordinating their legs when walking. Researchers will measure brain and nerve signals in 50 adults with chronic stroke to find out what causes these coordination problems. The goal is to gather knowledge tha…

This study looks at whether giving clot-busting medicine to stroke patients 4.5 to 24 hours after symptoms start can lead to better recovery. Researchers will review medical records from 2600 adults to see how many achieve good function (mRS 0-1) after treatment. The goal is to f…

This study aims to find which of two rehabilitation methods works best for improving finger movement in people who have had a stroke. Forty participants will complete 10 days of piano training and have MRI scans to see how their brains change. The goal is to learn who benefits fr…

This study looks at how the diaphragm (the main breathing muscle) changes shape and moves in people who have had a stroke and have weakness on one side of the body. Researchers will measure diaphragm thickness and movement using ultrasound and compare it to breathing muscle stren…

This study looks at whether a simple ECG test can tell which patients are likely to develop dangerous blood clots that lead to stroke. Researchers will study heart tissue and blood samples from 1000 adults undergoing open-heart surgery. The goal is to better understand how to pre…

This study is testing a wearable exoskeleton to help people who have had a stroke walk with better balance. About 21 stroke survivors who have trouble walking and have fallen before will try the device on a treadmill. Researchers will measure how well the exoskeleton helps them a…

This study will follow 5,000 people who are getting a brain aneurysm treated with new tube-like devices. Researchers want to see how often the aneurysm comes back and what factors, like smoking, might cause that. The goal is to learn which devices work best and for whom, but this…

This study enrolls 500 people with signs of cerebral small vessel disease (CSVD) to see how genetics and MRI brain changes affect future stroke and dementia risk. Participants provide a blood sample for genetic testing and undergo brain scans, then are followed for at least 2 yea…

This study is building a large registry of people who have had a stroke and still have symptoms. By joining, you help researchers find new ways to improve recovery. The goal is to enroll 60,000 participants nationwide.

This study is testing whether a short-term brain implant that sends electrical pulses can improve hand, arm, and speech abilities in people who had a stroke at least 6 months ago. Ten participants will have the device implanted for less than 30 days, then removed. The main goal i…

This study is testing a new smartphone app that creates a "digital twin" of the patient to help manage health after a stroke or related conditions like moyamoya disease or cerebral amyloid angiopathy. About 20 adults will use the app daily for six months alongside standard care, …

This study looks at whether a new test called the Ad-AHA Stroke accurately measures how stroke survivors use both hands together in everyday activities. Researchers will compare test scores with real-world data from wrist-worn sensors worn for three days at home. The goal is to s…

This study is testing a new imaging method to find blood clots in people who have had a stroke. Researchers will use a special PET scan tracer that sticks to activated platelets, the cells that form clots. The goal is to better understand where clots come from and how they cause …

This study follows 400 stroke patients in rehabilitation units to see how their walking and balance improve over six months. Researchers will measure walking ability and balance at several points to better understand recovery patterns. The goal is to improve future rehabilitation…

This study looks at whether a fast genetic test can help doctors choose the best antiplatelet medication for people who have had a minor stroke or a high-risk transient ischemic attack (TIA). About 200 adults admitted to the hospital will provide a cheek swab for CYP2C19 gene tes…

This study looks at a specific layer of tissue in the lower back (thoracolumbar fascia) in people who had a stroke at least 6 months ago. Researchers want to see if the thickness of this tissue is related to balance, trunk control, flexibility, and daily independence. About 70 pa…

This study looks at brain swelling that happens after a bleeding stroke (intracerebral hemorrhage). Researchers want to understand how this swelling affects recovery. They will follow 500 adults in France who had a stroke within the last 12 hours. No new treatment is given; the g…

This study looks at how imagining or watching movements affects muscle activity in the arms of stroke survivors. Researchers will measure tiny electrical signals in the muscles of 28 participants during these mental exercises. The goal is to understand which techniques might help…

This study aims to understand how a touch signal moves from the finger through the nerves to the brain. Researchers will measure when people first feel a light touch and use brain scans to see which areas light up. They will compare young adults, stroke survivors, and healthy peo…

This study explores whether combining non-invasive brain and spinal cord stimulation during a thinking-and-moving task can improve hand function and thinking skills in people who have had a stroke or spinal cord injury. About 45 adults will take part, including healthy volunteers…

This study looks at how a gentle electrical current applied to the brain (called tACS) affects movement in people who had a stroke more than 6 months ago. Researchers will test two different stimulation frequencies and a placebo to see how brain activity changes. The goal is to l…

This study tests a non-invasive wrist monitor that continuously checks for stroke by detecting arm weakness. It involves 1,200 hospital patients at high risk for stroke. The goal is to see if the device can spot strokes quickly with few false alarms.

This study is testing a detailed health assessment process called 'deep phenotyping' in up to 100 young adults aged 18-55 who have had a stroke. Researchers will collect a wide range of information and samples to better understand recovery. The goal is to see how practical and ac…

This study looks at how blood flow in the brain affects breathing stability during sleep, especially when oxygen levels are low. Researchers will test 12 healthy adults in a controlled setting to measure changes in breathing reflexes and blood markers. The goal is to better under…

This study aims to create a 'digital twin' for each stroke patient by collecting movement data, daily activity patterns, and genetic information. Researchers will use this to predict how well a patient may recover. The study involves 70 adults who have had a stroke within the pas…

This early-stage study looks at how changing what stroke survivors see in a virtual reality headset affects their hand movements. 15 chronic stroke survivors and 15 healthy adults will perform finger exercises while their joint motion and muscle activity are recorded. The goal is…

This study tests three different doses of a non-invasive brain stimulation technique called rTMS to see which best improves hand muscle function in people who had a stroke at least three months ago. Researchers will measure changes in brain activity and motor learning after each …

This study looks at how memory and thinking problems after a stroke affect a person's ability to learn new walking patterns. Researchers will use walking tests, thinking assessments, and brain scans in 65 older adults who had a stroke more than 6 months ago. The goal is to find b…

This study uses MRI scans to look at brain and spinal cord activity in people who have had a stroke and have weakness on one side. Researchers want to see which nerve pathways the brain uses to move the shoulder. The goal is to better understand how movement is controlled after a…

This study looks at how Tizanidine, a FDA-approved muscle relaxant, changes arm movement in people who have had a stroke and those who haven't. Researchers will measure movement, brain activity, and reflexes to understand what causes movement difficulties after stroke. The goal i…

This study aims to understand if COVID-19 vaccines have any impact on brain health. Researchers will use MRI scans to compare brain images from 500 healthy adults before and after vaccination. The goal is to provide clear, evidence-based information to address safety concerns and…

This study follows 252 adults with muscle, bone, or joint problems (like arthritis, back pain, or after surgery) to see how well they do their prescribed home exercises. Researchers will track who sticks with the program and why, looking at factors like pain, mood, and support. T…

This study looks at a small leg muscle called the plantaris and its role in treating tight ankles (equinus) in children. About 42 kids aged 4-17 with conditions like cerebral palsy or idiopathic toe walking will have surgery to loosen tight ankle muscles. The order of which muscl…

This study aims to learn how the brain and spinal cord change after a stroke. Researchers will use MRI scans to compare stroke patients with healthy volunteers. The goal is to find markers that can predict recovery and understand what affects a patient's symptoms.

This study looks at why stroke survivors' muscles tire faster during activities like walking. Researchers will measure blood flow to leg muscles during exercise and test a safe, non-invasive technique called ischemic conditioning to see if it can reduce fatigue. The study involve…

This study looks at how a single session of exercise can temporarily reduce pain sensitivity in both healthy adults and stroke survivors who don't currently have pain. Researchers will measure pain thresholds before and after exercise to understand how the nervous system responds…

This study tests a non-invasive device that stimulates the vagus nerve through the ear in people who had a stroke within the past month. Researchers will measure changes in brain activity (EEG) and look at certain genes to understand how this stimulation might help motor recovery…

This study is looking at whether certain gene changes (variants) in a protein called annexin A2 are linked to strokes that happen for no clear reason, especially in younger adults. Researchers will compare blood samples from 240 people who have had a stroke with no known cause. T…

This study tests a noninvasive technique that sends mild electrical currents to the spinal cord to help improve arm and hand function in people with stroke or spinal cord injury. Researchers will measure changes in nerve activity and movement in 30 adults aged 18-75. The goal is …

This study looks at how people who had a stroke more than 6 months ago learn a new way of walking using a screen that shows a distorted view of their steps. Researchers want to see if a short bout of exercise right after learning helps them remember the new walking pattern the ne…

This study tests whether vibrating certain muscles can help the brain form new connections after a stroke or traumatic brain injury. Researchers will measure brain and nerve activity in 56 people with leg weakness to see if this therapy improves walking. The goal is to understand…

This study explores whether a special MRI technique can help people who have had a stroke improve their reading. Participants will practice controlling their own brain activity using real-time feedback from the MRI scanner. The goal is to retrain the brain's language areas to wor…

This study looks at how the brain controls arm movement after a stroke and how rehabilitation therapy changes those brain pathways. Researchers will enroll 50 people who had a stroke 3 to 6 months ago and have moderate to severe arm weakness. Participants will either receive 30 h…

This study records occupational therapy sessions for adults recovering from stroke or spinal cord injury to understand what makes rehab effective. Researchers will analyze the videos to identify key treatment techniques and patient responses. The goal is to create a toolkit that …

This observational study follows 213 adults recovering from a first ischemic stroke to see if the intensity of inpatient rehabilitation affects their functional recovery. Researchers will compare people whose stroke was linked to atrial fibrillation (AFRS) with those who had othe…

This study looks at how using arm support (like a cane or walker) changes walking patterns in people who have had a stroke. About 34 adults with stroke will walk on a special treadmill with no support, one-arm support, and two-arm support. The goal is to help physical therapists …

This study tests whether a computer model can predict which reading therapy works best for people who developed dyslexia after a stroke. Twelve participants will receive two different types of intensive reading therapy, and the model's predictions will be compared to actual resul…

This study explores whether certain DNA markers can predict the risk of silent strokes in older adults undergoing a heart valve replacement procedure called TAVR. Researchers will measure DNA methylation levels in blood samples from 542 patients over 70 before and after the proce…

This study explores whether a personalized form of transcranial magnetic stimulation (TMS) can better activate the brain pathways that control hand movement in people who have had a stroke. Researchers will compare the new personalized TMS with standard TMS in 37 participants who…

This study tracks 150 adults getting a HeartMate 3 heart pump to see if the pump's data (like alarms and power changes) can predict problems such as bleeding, infection, or frailty. Researchers will also check if this data relates to quality of life. The goal is to find patterns …

This study tests a new ultrasound technology called NeoDoppler that can continuously monitor blood flow in the brains of sick and premature infants. Researchers will enroll 180 newborns, including healthy preemies and those with conditions like heart defects, infections, or strok…

This study is testing a new system that uses brain scans to time magnetic pulses to the brain, aiming to improve arm movement in stroke survivors. Researchers will first test the system in healthy adults, then in 100 people who had a stroke at least 6 months ago. The goal is to s…

This study is testing whether using a 7-day heart monitor in people with elevated NT-proBNP (a blood marker) can find undiagnosed atrial fibrillation and prevent strokes. 4,000 adults aged 40+ with no known AF or blood thinners will be randomly assigned to monitoring or usual car…

This study looks at how fear of movement (kinesiophobia), balance, and fear of falling are connected in people recovering from a stroke. Researchers will measure these factors in 138 stroke patients using surveys and balance tests. The goal is to better understand these relations…

This study looks at sleep problems like sleep apnea, insomnia, and daytime sleepiness in people who have had a stroke. Researchers want to understand how these sleep issues affect recovery, thinking, mood, and daily activity. 226 participants will use home sleep tests and wearabl…

This study uses special high-resolution and high-speed cameras to take detailed pictures of the eye. The goal is to see tiny structures, like cells and blood flow, that regular eye exams miss. Researchers will study 1200 people with various eye conditions and healthy volunteers t…

This study looks at how often fatigue occurs in people who have had their first stroke and what factors might make it worse. Researchers will measure fatigue using simple questionnaires and also check things like pain, mood, sleep, and physical ability. The goal is to better unde…

This study tests if a wearable device that uses light and sound waves can safely monitor blood flow in the brains of 140 people, including healthy older adults and those with stroke, dementia, depression, or delirium. Researchers want to see if the device works well and can be us…

This study looks at whether a training program that mixes mental tasks with physical exercises can improve thinking and movement in people who have had a stroke or have Moyamoya disease. Researchers will also use brain scans to see how the brain changes during these activities. T…

This study follows 180 adults with cerebral small vessel disease (CSVD) to see how the condition progresses after a stroke. Participants will have MRI scans and blood tests over time. The goal is to learn whether certain proteins in the blood can help track disease changes and pr…

This study tests a new way to decide which patients with a narrowed neck artery need surgery to prevent a stroke. The standard method looks mainly at how narrow the artery is, but the new method uses an MRI scan to find unstable plaques that are more likely to cause a stroke. Abo…

This study looks at how to make stroke rehabilitation research fairer by including more women and people with aphasia (trouble speaking or understanding language). Researchers will test a new recruitment method against the usual one at several hospitals. About 120 adults who rece…

This observational study looks at whether certain breathing machine settings (like pressure and power) are linked to the severity of brain injury in adults. It includes 19 patients with stroke, traumatic brain injury, or bleeding around the brain who need a breathing tube. The go…

This study checks if new guidelines for placing sticky electrodes on the calf muscles give more accurate readings in people who have had a stroke. Researchers will compare the new method with the standard one using ultrasound to see which places the electrodes better over the rig…

This study tests a new, non-invasive wearable patch with a microphone that listens to swallowing sounds in people who have trouble swallowing after a stroke. Researchers will collect these sounds during a standard swallowing X-ray test and use machine learning to find patterns of…

This study tracks 350 adults who had a stroke caused by a large blood clot in the brain. Researchers want to see how well a procedure called endovascular thrombectomy (which removes the clot) works in real hospitals, not just in controlled trials. The goal is to find ways to impr…

This study tests whether high-density brain recordings can decode Mandarin Chinese speech features, including tone, from imagined (silent) speech. About 50 adults with conditions like epilepsy, brain tumors, or stroke will have temporary or permanent brain electrodes placed durin…

This study looks at 100 people who had a stroke with no clear cause. They will get a heart MRI to measure scar tissue in the left atrium, which might lead to atrial fibrillation. The goal is to see if the MRI can predict who will develop atrial fibrillation, so doctors can better…

This study aims to understand why many people feel extremely tired after a stroke, a condition called post-stroke fatigue. Researchers will monitor 250 stroke patients' heart rate, blood pressure, and heart function to see if problems with the body's automatic nervous system are …

This study looks at how placebos (inactive treatments) affect the brains of people recovering from stroke. Researchers will give placebos openly or secretly to 56 adults with chronic stroke and measure brain activity with EEG. The goal is to understand how placebos work in the br…

This study follows 24 adults who had a stroke and were recently diagnosed with atrial fibrillation (AF), a heart rhythm problem. Researchers will track how AF changes over two years using heart monitors and blood tests. The goal is to better understand AF progression in stroke su…

This study reviews medical records from 100 adults who had a stroke and were treated at hospitals in Villavicencio, Colombia. Researchers want to see how quickly and effectively stroke care is given, and whether it follows best-practice guidelines. The goal is to find ways to imp…

This early study tests whether a brain implant can help people with severe paralysis from conditions like ALS, spinal cord injury, or stroke control devices using their thoughts. The implant records brain signals to decode intended movements or speech, aiming to restore communica…

This study looks at 500 people who have had a stroke and also have atrial fibrillation (an irregular heartbeat). The goal is to understand why some people still have strokes even when taking blood thinners. Researchers will collect blood samples and heart ultrasound images to fin…