OBESITY & OVERWEIGHT

This study tests whether wearing a continuous glucose monitor (CGM) for 3 months helps people with prediabetes control their blood sugar better than traditional finger-prick testing. About 80 adults with prediabetes will be randomly assigned to use either a CGM or standard self-m…

This study tests whether a supplement called Xanthigen helps overweight adults lose weight and improve health measures like BMI and waist size. About 180 participants will take either a low or high dose of Xanthigen or a placebo for 16 weeks. The goal is to see if the supplement …

This study tests whether a supplement containing a beneficial gut bacterium (Akkermansia muciniphila) and a plant compound (berberine) can improve how night-shift workers process sugar. Two hundred healthcare and industrial shift workers in Austria and Denmark will take either th…

This study tests whether tirzepatide, a drug already used for diabetes and weight loss, can help restore regular menstrual cycles in women with PCOS who are overweight or have obesity. About 198 women will receive either tirzepatide or a placebo for 72 weeks. The goal is to see i…

This study will track 10,000 adults with obesity to see how well combining traditional Chinese medicine with standard Western medicine works for weight loss. Participants will receive integrated treatments and be followed for 24 weeks. The goal is to find better, more personalize…

This study looks at whether wearing a continuous glucose monitor (CGM) that shows real-time blood sugar levels helps people with prediabetes and obesity make healthier choices, compared to a hidden CGM. About 30 adults will try both methods to see if seeing their numbers leads to…

This study tests whether empagliflozin, a diabetes drug, can help people with HIV who are overweight or obese and on certain HIV medications. About 66 participants will take either the drug or a placebo for 6 months. The goal is to see if it reduces weight and improves cholestero…

This study tests whether a gentle electrical stimulation of a nerve in the ear (called taVNS) can help people with obesity or overweight lose more weight when added to a standard weight-loss medication (tirzepatide). 24 adults who have not lost enough weight with medication alone…

This study is testing a weight-loss drug called Spartina® (Tirzepatide) in 175 adults who are obese or overweight. Participants will take the drug and be monitored for weight loss and side effects. The goal is to see if the drug works and is safe in everyday use.

This study looks at whether adding a structured exercise program to the weight-loss drug tirzepatide can help overweight or obese women ages 25-50 preserve muscle mass and physical function. Sixty women will receive tirzepatide for 20 weeks; half will also follow a supervised res…

This study looks at whether adding exercise to a structured weight loss program helps teens (ages 10-20) with obesity improve their blood fat levels and blood vessel function. About 110 participants will be followed for 6 months. The goal is to see if more physical activity leads…

This study tests whether giving adults with obesity and food insecurity free, healthy groceries or grocery vouchers, along with weight loss coaching, helps them lose more weight than coaching alone. About 300 adults will be assigned to one of three groups for 24 weeks. The goal i…

This study tests a 24-week church program for Black men at risk of heart disease, diabetes, and obesity. Participants attend weekly sessions with exercise and health education, get one-on-one support, and use smart devices to track progress. The goal is to see if this approach im…

This study compares a new magnetic surgery procedure to the medication semaglutide for controlling obesity and type 2 diabetes. About 20 adults with a BMI between 30-40 and type 2 diabetes will be randomly assigned to either the magnetic procedure or semaglutide. The goal is to s…

This study tests two experimental drugs, AZD6234 and AZD9550, alone or together, in Chinese adults aged 18-55 who are overweight or obese. The goal is to see if they are safe and help with weight loss. Participants will receive injections and be monitored for side effects and wei…

This study tests whether adding enobosarm to the weight-loss drug semaglutide helps people aged 65 and older lose more weight while preserving muscle and physical function. About 200 participants with obesity will receive either the combination or semaglutide alone. The goal is t…

This study aims to see if giving overweight adults a specific daily step goal, based on their body fat, can help them lose weight and improve heart health markers like cholesterol and blood pressure. Researchers will track 200 adults aged 20 and older over 8 months as they walk w…

This study tests a special medical food designed to help adults preserve muscle mass while losing weight with popular GLP-1 drugs like Wegovy or Mounjaro. About 144 overweight or obese adults will take either the food or a placebo for 24 weeks alongside their regular medication. …

This study tests whether a 12-month personalized exercise and diet program can reduce the amount of time spent in atrial fibrillation (an irregular heartbeat) and decrease fat around the heart in overweight or obese adults. About 158 participants with atrial fibrillation will eit…

This study tests whether adding semaglutide (a diabetes and weight-loss drug) to a standard topical cream can better control psoriasis and reduce body-wide inflammation. About 62 adults with plaque psoriasis who are overweight or have type 2 diabetes will take either semaglutide …

This small pilot study tests whether eating bottarga (cured fish roe) daily for 8 weeks can improve blood sugar, cholesterol, and inflammation in adults with prediabetes, diabetes, or obesity. About 20 participants will compare bottarga to a dairy product with similar calories. T…

This study tests whether giving free summer day camp vouchers to low-income children with overweight or obesity can help them manage their weight. Eighty children aged 5-11 who have Medicaid will either receive an 8-week camp voucher or standard care. Researchers will measure wei…

This study tests whether powerful weight loss drugs can lower blood pressure enough for young adults (ages 18-40) with obesity and early-stage hypertension to stop taking lifelong blood pressure medication. Sixty participants will either receive standard care (medication and life…

This study tests a new medicine called HDM1005, given as a weekly injection, to help people with obesity or overweight lose weight. About 825 Chinese adults who do not have diabetes will receive either the drug or a placebo for 52 weeks, along with diet and exercise advice. The m…

This study tests a new surgical clip for a stomach bypass procedure in people with type 2 diabetes and a BMI between 25 and 35. The goal is to improve diabetes control and reduce surgical complications. About 90 adults will be randomly assigned to different surgical methods and f…

This study is testing whether a breath test can identify metabolic syndrome and a condition called metabolically healthy obesity. Researchers will analyze the breath of 300 adults using a special machine and computer programs to see if they can tell the difference between healthy…

This study tests a 6-month lifestyle program for transgender and gender-diverse adolescents aged 10-14. The program includes group sessions for teens and their caregivers, plus weekly supportive messages, to prevent obesity and eating disorders. Researchers will measure quality o…

This study tests a program to help families with babies and young children (6 months to 3 years) adopt healthy habits to prevent obesity. About 526 families where at least one parent has overweight or obesity will take part. The program includes group sessions on feeding, physica…

This study tests whether a daily supplement made from artichoke by-products, combined with a calorie-controlled Mediterranean diet, can help prevent type 2 diabetes in 150 overweight or obese adults. Participants will take the supplement and follow the diet for several months. Re…

This study looks at whether adding peanuts to daily meals helps people taking GLP-1 medicines (like semaglutide or tirzepatide) feel fuller, have more energy, and improve their diet quality. About 64 adults who have been on these drugs for at least 6 months will eat peanuts every…

This study tests if a safe, non-invasive brain stimulation technique called tDCS can improve memory, attention, and thinking speed in breast cancer survivors who have cognitive problems after treatment. Forty women who finished cancer therapy at least three months ago will either…

This study tests a special bed scale called FIT that automatically tracks weight when you get in and out of bed. It is designed for wheelchair users who have trouble using regular scales. About 92 adults who use wheelchairs and are overweight or obese will try the scale along wit…

This study looks at whether adding pistachios to your daily diet can help people taking GLP-1 medications (like semaglutide or tirzepatide) feel fuller, have more energy, and improve their overall diet quality. Researchers will track 108 adults for 12 weeks to see if pistachios m…

This study looks at whether special breathing exercises (inspiratory muscle training) can improve lung function and reduce inflammation in people with obesity. Researchers will measure breathing, muscle strength, and blood markers in 40 adults aged 30-60 with a BMI of 30 or highe…

This early study tests whether a cold water extract from saffron flower tepals, taken just before a meal, can improve blood sugar and metabolism in 20 adults with obesity or prediabetes. Participants will drink either the extract or plain water before eating white bread, and rese…

This study looks at whether a 5-week exercise program (a mix of aerobic and strength training) can improve muscle health, body composition, and quality of life for people who have had bariatric surgery. About 84 adults aged 18 to 60 who had sleeve gastrectomy or gastric bypass wi…

This study looks at how weight loss (using tirzepatide) and a biologic drug (ixekizumab) change skin, joint, and fat tissues in people with psoriatic arthritis who are overweight or obese. 45 participants will receive one or both treatments. Tissue and blood samples are taken at …

This study explores how semaglutide, a drug used for diabetes and weight loss, affects fat around the kidneys, heart, and liver in people with type 2 diabetes and chronic kidney disease. Researchers want to understand if changes in fat tissue can help slow kidney damage. About 52…

This study looks at whether a single 40-minute sauna session before a meal can lower blood sugar spikes in overweight adults aged 30-55. Participants will wear a continuous glucose monitor and visit the lab twice—once for sauna and once for rest. The goal is to see if heat exposu…

This study looks at whether people who became obese as children have different fat, muscle, and metabolism than those who became obese as adults. About 150 adults aged 25-40 with obesity will provide tissue samples, blood, and urine, and undergo scans and exercise tests. They wil…

This study looks at whether taking sirtuin activators (a type of supplement) for six months can improve how the body handles fats and sugars, and whether it affects cell aging and stress. Researchers will compare the supplement to a placebo in 120 women aged 40-65 who are overwei…

This study looks at how two natural hormones made by the pancreas—amylin and pancreatic polypeptide—affect hunger and food intake in healthy men. Over four separate days, 18 participants will receive different combinations of these hormones or a placebo to see how they influence …

This study tests five different ways to track eating and weight during a 24-week online weight loss program. The goal is to find out which tracking method works best for different people and at different times. Participants will be randomly assigned to switch between methods ever…

This study looks at how exercise affects blood components and physical fitness in 20 overweight or obese adults aged 25-45. Participants will undergo fitness tests and blood analysis to measure changes. The goal is to gather knowledge that could help develop better treatments or …

This study looks at how taking CX11 tablets with or without food changes the way the drug enters the bloodstream. It involves 32 healthy adults who will take the drug twice under different meal conditions. The goal is to gather information, not to treat any disease.

This study aims to find out how many adults in rural Bangladesh have a type of fatty liver disease called MAFLD, and how it relates to their diet, weight, and other health factors. Researchers will check 1,000 volunteers using body measurements, blood tests, and an ultrasound of …

This study is creating new questionnaires to better understand how overweight and obesity affect people's daily lives, health, and finances. Researchers will ask 500 adults with a BMI over 25, as well as healthcare professionals, to share their experiences. The goal is to develop…

This study is testing different ways to give weekly feedback to people trying to lose weight. Researchers want to see which type of message helps people lose the most weight. About 300 adults who are overweight or obese will take part. The study does not test a new drug or treatm…

This study looks at how the tongue changes in children and teens with obesity after a 30-week weight loss program. Researchers use ultrasound to measure tongue fat, stiffness, and shape, and see how these relate to sleep apnea. About 100 participants aged 6 to 18 will be scanned …

This study looks at whether a special type of high-intensity interval training can help adults with overweight or obesity improve their vitamin D levels during winter. Vitamin D deficiency is common in people with higher body weight, possibly because it gets trapped in fat tissue…

This study looks at how body weight and weight-loss surgery change the natural chemicals in scalp hair. Researchers will track 60 adults—some with severe obesity scheduled for bariatric surgery, and some healthy-weight controls—to see if hair chemistry can signal poor metabolic h…

This study watches 52 teens (ages 12-17) getting braces to see if being overweight leads to more gum swelling, white spots on teeth, or higher levels of mouth bacteria and inflammation. Researchers compare teens with higher body mass index (BMI) to those with normal BMI by checki…

This study tests whether offering personalized financial incentives can help people with obesity stick to diet tracking and weight loss goals. Researchers will enroll 80 adults with a BMI of 30 or higher in a 25-week program that includes group classes and personalized rewards. T…

This study looks at how ketone bodies—chemicals the body makes during fasting—affect energy use and insulin sensitivity. Ten overweight adults aged 55–70 will receive either a ketone drink or a placebo, plus other substances, on four separate days. Researchers will use PET scans …

This study tests five different group programs, all delivered remotely, to help adults with higher body weight eat healthy and be active. Some groups also include mindful eating, body image support, or finding enjoyable physical activities. The goal is to see which program people…

This study tests a new, radiation-free ultrasound technology called REMS to measure bone density in children aged 5 to 18 who have conditions that weaken bones, like osteogenesis imperfecta or osteoporosis. The goal is to see if REMS works well in children, since current methods …

This study looks at 52 adults having weight-loss surgery to see which method—a standard checklist or an ultrasound—better predicts when placing a breathing tube will be hard. Researchers will measure the neck and throat with ultrasound before surgery and compare it to the checkli…

This study looks at why some people choose to take prescription weight-loss medications while others do not. Researchers will follow 500 patients for up to 5 years to understand their medical history, habits, and how well the drugs work in everyday life. The goal is to learn more…

This pilot study will compare two diets—one high in ultra-processed foods and one typical American diet—in 6 adults with overweight or obesity. The goal is not to treat or cure, but to see if the study approach works and to gather data for planning larger future trials. Participa…

This study is collecting and analyzing genetic, metabolic, and microbiome data from over 6,000 people with and without metabolic syndrome. The goal is to find biological markers that predict disease progression and help create personalized prevention and treatment plans. Particip…

This study at Stanford University is working to create a simple index that measures how well the body uses insulin and overall heart and metabolic health in children and teens with obesity. Researchers will use data from wearable fitness trackers and glucose monitors, along with …

This study examines how GLP-1 receptor agonists (like semaglutide) affect taste perception, food preferences, and eating behaviors in adults with obesity. Researchers will review medical records and surveys from 150 participants treated at Italian clinics for at least 12 weeks. T…

This study looks at how two common anesthesia drugs—sevoflurane (inhaled) and propofol (given through a vein)—affect inflammation in obese patients having lower back surgery. Researchers will measure certain markers of inflammation in the blood before and after surgery. The goal …

This study aims to find what factors predict weight loss after obesity treatments like surgery or medication. Researchers will study 100 adults with obesity to see how eating behaviors, thinking patterns, and biological markers affect results. The goal is to personalize care and …

This study aims to understand how the stomach and intestines digest food after bariatric surgery. Researchers will collect digestive samples and use a swallowable capsule that measures things like acidity and movement in the gut. The study includes people who have had gastric byp…

This study looks at how the body processes a new weight-loss injection (GZR18) in people with different levels of kidney function. About 32 adults who are overweight or obese will receive a single dose and be monitored for up to 50 days. The goal is to find safe and effective dos…

This study looks at how different types of weekly feedback messages affect weight loss in adults who are overweight or have obesity. About 127 participants will use a smart scale and receive either positive or negative feedback on their progress. The goal is to learn which messag…

This study is testing a personalized program to help people who have lost weight keep it off. Researchers want to see if a flexible approach with health coaching and regular check-ins can prevent weight regain. About 30 adults who have intentionally lost at least 7% of their body…

This study looks at whether connecting youth (ages 12-25) to community programs rooted in Native Hawaiian values can improve their mental and physical health. About 100 participants from the Wai'anae area will take part in cultural activities and complete surveys over several mon…

This study looks at how different types of exercise—moderate, vigorous, or short bursts—change inflammation levels in the body. Researchers want to see if exercise can help reduce the low-grade inflammation linked to obesity and heart disease. The study is recruiting 33 overweigh…