LIVER CIRRHOSIS

This study compares early placement of a small tube (TIPS) that reroutes blood flow in the liver against standard treatments like water pills and fluid drainage. The goal is to see if the shunt helps people with liver cirrhosis and severe fluid buildup live longer without needing…

This study tests whether phycocyanin, a natural protein from spirulina, can help control liver fibrosis or cirrhosis in adults. Ten participants will take either phycocyanin or a placebo daily for at least 4 weeks. Researchers will measure changes in liver stiffness and blood mar…

This study tests a technique called 'underdilated stent' during a liver shunt procedure (TIPS) for people with cirrhosis. The goal is to see if using a smaller balloon to place the stent can lower the risk of hepatic encephalopathy (brain confusion) after the procedure, while sti…

This study tests whether taking capsules of healthy donor stool (fecal transplant) can lower the risk of serious infections in people with liver cirrhosis. About 300 adults with alcohol-related or fatty liver cirrhosis will receive either the transplant or a placebo and be follow…

This study looks at how well liver transplantation works for people with severe acute-on-chronic liver failure (ACLF). Researchers will track 3,000 adults with liver cirrhosis who are listed for a transplant. The goal is to understand which patients benefit most and improve survi…

This study tests whether a liver transplant can stop or slow the buildup of calcium in arteries, a condition that raises heart attack risk. Researchers will follow 95 people with liver cirrhosis who need a transplant, measuring artery changes and blood markers before and after su…

This study tests whether eating protein evenly throughout the day combined with exercise can improve nutrition, muscle mass, and physical function in 90 adults awaiting a liver transplant. Participants are split into three groups: even protein plus exercise, uneven protein plus e…

This study tests a new way to manage bleeding risk in people with liver cirrhosis who need a TIPS procedure (a shunt placed in the liver). The new method uses a special blood test (thrombelastography) to guide when and how much blood product to give. The goal is to see if this ap…

This study tests a new medicine, BI 3802876, in 30 adults with compensated cirrhosis caused by MASH (a type of fatty liver disease). The goal is to see if the drug is safe and how the body processes it. Participants receive two infusions over about six months and are monitored fo…

This study compares two ways of placing a stent (a small tube) in the liver to prevent dangerous bleeding from enlarged veins in the throat and stomach in people with liver scarring (cirrhosis). The standard method uses a fully opened stent, while the experimental method uses a s…

This study tests a new blood test called Elecsys GAAD in 600 people with liver cirrhosis, who are at high risk for liver cancer. The goal is to see if the test finds cancer earlier than current methods, reduces false alarms, and helps more people stick with regular check-ups. If …

This study aims to improve how doctors see liver damage (cirrhosis), liver cancer, and high blood pressure in the liver using a special PET/MRI scan. About 45 adults with cirrhosis will get this scan to see if it gives clearer pictures than current methods. The goal is to make di…

This study looks at whether combining a special ultrasound technique (SHAPE), liver stiffness measurements, and a routine blood test (platelet count) can accurately identify high-risk varices in the stomach and esophagus of people with liver cirrhosis. If successful, this non-inv…

This study looks at whether a high-flow nasal cannula (a device that delivers warm, moist oxygen at high rates) can reduce the chance of dangerously low oxygen levels during sedated gastrointestinal endoscopy in critically ill patients. About 450 adults with serious health condit…

This study aims to create and test a new questionnaire called LiCCoS that helps identify thinking and memory problems in adults with liver cirrhosis. These issues are common but often missed in regular checkups. Participants will fill out the questionnaire and take standard think…

This study looks at whether handgrip strength—a measure of muscle function—is linked to blood flow in the liver's main vein (portal vein) in people with liver cirrhosis. Researchers will measure pressure, speed, and direction of blood flow using different methods like ultrasound …

This study follows 2000 people who are getting a TIPS procedure—a small tube placed in the liver to relieve dangerously high blood pressure. Researchers will track survival, liver function, and complications for one year after the procedure. The goal is to learn more about outcom…

This study will look at medical records from 600 adults with liver cirrhosis to understand how often they visit doctors, get scans, or have procedures. The goal is to find patterns in healthcare use and see what factors, like mental health, play a role. No new treatments are bein…

This study follows 10,000 people with advanced chronic liver disease to track their health over time. Researchers will collect medical data and samples like blood, urine, and tissue to better understand how cirrhosis progresses. The goal is to learn more about the disease, not to…

This study looks at why some people with liver cirrhosis develop blood clots in the portal vein (a major liver blood vessel). Researchers will compare blood samples taken from a neck vein and the portal vein during a routine procedure (TIPS) in 45 adults. The goal is to understan…

This study looks at whether easy-to-measure vital signs like heart rate and blood pressure can help predict how well liver cirrhosis patients will recover from a gastrointestinal bleed. Researchers will track 150 patients and use special scores based on these vital signs. The goa…

This study involves 30 adults with end-stage liver cirrhosis who are receiving a liver transplant from a living donor. Researchers want to find out what factors increase the risk of dangerous bleeding or blood clots after surgery. The goal is to create a better prevention plan to…

This study looks at how well people with alcohol-related liver cirrhosis understand health information and feel confident managing their condition. Researchers will measure these skills in 200 adults using questionnaires. The goal is to see if health literacy and self-efficacy re…

This study is a registry that will follow 500 adults with primary biliary cholangitis (PBC) in Austria to learn how the disease changes over time. Researchers will collect medical data and optional blood or liver samples to study biomarkers and complications. The goal is to bette…

This study looks at how well beta-lactam antibiotics work in people with liver cirrhosis and bacterial infections. Researchers will review past cases and follow new patients to build a model that predicts the best dose for each person. The goal is to lower death rates by tailorin…

This study compares two liver cancer screening methods in 5,500 people with cirrhosis or chronic hepatitis B. Half will get standard ultrasound and blood tests every six months, while the other half will get a new blood test (GALAD) alone. The goal is to see which approach catche…

This study is collecting information from 10,000 liver transplant patients across Europe to create a new, up-to-date reference for what good outcomes look like when using machine perfusion (a technique that keeps donated livers healthier before transplant). The goal is to help do…

This study looks at how two common blood thinners, rivaroxaban and apixaban, behave in people with mild to moderate liver cirrhosis. 24 adults will take a single low dose of one of the drugs, and researchers will track the drug levels and effects through blood samples over 12 hou…