KIDNEY TRANSPLANT

This study tests if the drug ravulizumab can help transplanted kidneys start working sooner, reducing the need for dialysis after surgery. It involves 450 adults at high risk for delayed graft function who are receiving a kidney from a deceased donor. Participants will receive ei…

This study tests the safety of giving stem cells to people with chronic kidney disease, including those who have had a kidney transplant. The stem cells come from donated bone marrow and are given through a vein or directly to the kidneys. Researchers will watch for side effects …

This study is testing whether the diabetes drug empagliflozin is safe for people who have received a kidney transplant. The goal is to see if it can help protect the heart and the transplanted kidney from long-term damage. The study will enroll 264 veterans who are at least 3 mon…

This study tests a drug called sparsentan for people who have protein in their urine after a kidney transplant due to IgA nephropathy or FSGS. About 20 adults will take the drug once daily for 36 weeks to see if it safely reduces protein levels and protects kidney function. The g…

This study is for people with kidney failure who have been on the transplant waiting list for at least a year and have very high antibody levels (cPRA 99.5% or higher), meaning their immune system would reject almost all donor kidneys. Researchers are testing whether a new treatm…

This study tests whether adding sodium thiosulfate to the fluid that keeps donated kidneys cold and healthy before transplant can reduce the chance of delayed function. About 120 adults receiving a deceased-donor kidney will be randomly assigned to get the additive or standard ca…

This study looks at whether using terlipressin, a drug that helps maintain blood pressure during kidney transplant surgery, can improve outcomes compared to the usual treatment. About 150 adults with end-stage kidney disease will take part. The main goal is to see if terlipressin…

This study compares two drug combinations for teenagers who receive a kidney transplant. The goal is to see if a newer drug combo (belatacept and sirolimus) works better than the standard one (tacrolimus and MMF) at preventing organ rejection and keeping the kidney healthy. 200 t…

This early-stage study tests whether a single infusion of cells from donated fat tissue, delivered directly into the kidney's blood supply, is safe for adults whose transplanted kidney is showing signs of rejection. The 12 participants will be closely monitored for side effects a…

This study tests whether injecting Berinert (C1 esterase inhibitor) into a deceased donor kidney just before transplant can improve kidney function one year later. About 180 adults on dialysis awaiting a kidney transplant will receive either Berinert or a placebo. The goal is to …

This study tests whether a doctor-led counseling program plus two smartphone apps can help older adults (60+) who have had a liver or kidney transplant eat better and move more. Sixty participants will first get lifestyle advice, then use the apps for 12 weeks. The goal is to see…

This study tests a treatment called VX-880 in 10 people who have type 1 diabetes and have already received a kidney transplant. The goal is to see if it can help them stop using insulin while keeping their blood sugar under control. Participants will need to stay on lifelong anti…

This study is for people who have received a kidney from a sibling. It tests a treatment that combines radiation and a drug to help the body accept the new kidney. The goal is to see if patients can safely stop taking immunosuppressive medications. About 15 participants will be f…

This study looks at 800 first-time kidney transplant recipients to see if a blood test can predict who is at risk for rejection. Six months after transplant, 300 eligible participants will be randomly assigned to switch from a standard drug (tacrolimus) to a newer one (abatacept)…

This study tests the safety of a special jacket that keeps donated kidneys warm during transplant surgery. About 20 adult kidney recipients will take part. The main goal is to see if the jacket causes any serious side effects within 30 days after the transplant.

This study tests a new drug, leymovir, against the standard valganciclovir for preventing CMV infection in 290 Chinese kidney transplant recipients. Leymovir targets a different part of the virus, reducing side effects like low white blood cells and kidney damage. The goal is to …

This study explores whether artificial intelligence can create personalized stories to help children aged 5 to 12 who have received a kidney transplant. The goal is to ease the emotional and social challenges they face. Researchers will ask families for feedback on the stories to…

This study is testing a new, non-invasive MRI technique to monitor the health of transplanted kidneys. Instead of relying on blood tests or painful biopsies, the MRI measures blood flow and oxygen levels in the kidney. Researchers will scan 1000 kidney transplant recipients and s…

This study watches 30 adults who just got a kidney transplant to see how their health changes over one year. Researchers will track heart disease and stroke risks, plus other health conditions. There is no treatment or medicine given—just checkups and tests like blood pressure an…

This study is testing whether a special type of MRI scan, called manganese-enhanced MRI (MEMRI), can detect early signs of heart and kidney problems in people with various kidney conditions, including acute kidney injury, chronic kidney disease, kidney transplant, and vasculitis.…

This study will follow 80 people with chronic kidney disease who are waiting for a kidney transplant. Researchers want to see if getting a new kidney improves blood flow to the heart and reduces inflammation. Participants will have heart scans and blood tests before and after the…

This study looks at why some kidney transplant patients develop blood sugar problems like diabetes or prediabetes. It focuses on how the body processes the drug tacrolimus, which is used to protect the new kidney. Researchers will track 120 adults in Poland who receive a kidney t…

This study collects blood samples from 400 kidney transplant patients to help develop a simple blood test that can check the health of the transplanted kidney without needing a biopsy. Participants must be 18 or older, have had a kidney transplant, and be scheduled for a biopsy. …

This study looks at whether certain biological markers can help doctors better predict and manage kidney transplant outcomes. Researchers will follow 200 kidney transplant patients in Scotland during their routine check-ups. The goal is to see if these markers can signal early si…

This study surveys 1,000 kidney transplant recipients in France and the U.S. to learn their thoughts on using artificial intelligence to predict whether a transplanted kidney might fail. Participants fill out an online questionnaire about their hopes, worries, and how AI predicti…

This study follows children (aged 16 and older) whose mothers had a solid organ transplant before pregnancy. Researchers want to see if these children have higher risks for heart or kidney problems, possibly due to the mother's anti-rejection medications. About 200 participants w…

This study tests two new imaging methods—ultrasound and light-based scanning—to see if they can safely check the health of a kidney transplant without needing a needle biopsy. Ten adult kidney transplant patients who already need a biopsy will also get these scans. If the scans w…