KIDNEY FAILURE

This study looks at how well the shingles vaccine (Shingrix) works in adults with kidney failure who are waiting for a kidney transplant. Researchers want to see if giving an extra dose after the transplant boosts the immune response. About 132 participants will be followed for u…

This early-phase study tests a treatment called Sip-Tego in 12 adults with kidney failure who need a living-donor kidney transplant. The goal is to see if it can train the body to accept the new kidney without needing lifelong anti-rejection drugs. Participants will be monitored …

This study is testing a new device called the InnAVasc graft, which helps connect kidney failure patients to dialysis machines. About 133 adults with end-stage kidney disease will receive the graft and be followed for 2 years. The main goal is to see if the graft stays open and w…

This study tests a new preservation solution, Custodiol-N, against the standard one for keeping donated kidneys, livers, and pancreases healthy during transplant. About 362 adults receiving these organs will take part. The goal is to see if the new solution reduces early organ da…

This study tests whether the diabetes drug empagliflozin (Jardiance) can safely raise low sodium levels in people with certain conditions like SIADH, liver failure, or kidney failure. About 172 adults with chronic low sodium will receive either the drug or a placebo for up to 30 …

This study is for people with kidney failure who have been on the transplant waiting list for at least a year and have very high antibody levels (cPRA 99.5% or higher), meaning their immune system would reject almost all donor kidneys. Researchers are testing whether a new treatm…

This study tests whether starting haemodialysis gradually (incremental dialysis) can help preserve quality of life and remaining kidney function in adults with kidney failure. About 372 people who are just beginning dialysis will take part. The goal is to see if this approach is …

This study looks at whether a special solution called DefenCath can help prevent serious bloodstream infections in children (from birth to under 18) with kidney failure who need dialysis through a tube in a vein. About 36 kids will get either DefenCath or the usual care. The goal…

This study looks at whether a 12-week home-based exercise program is safe and helpful for adults aged 60 and older who are waiting for a kidney transplant. Participants will either receive usual care plus a fitness tracker, or usual care plus online exercise classes. The goal is …

This study tests whether starting peritoneal dialysis (a home-based treatment for kidney failure) at a lower dose and gradually increasing it is better than the standard full-dose approach. The goal is to see if this gentler start improves patients' quality of life and reduces si…

This study looks at whether a special egg white pudding can help improve nutrition and frailty in people with kidney failure who are on dialysis. About 54 adults will get either the egg white pudding or a standard supplement after their dialysis sessions, three times a week for 1…

This study reviews existing medical records to see how safe the drug maribavir is for adults who have had an organ transplant and later develop a serious viral infection (CMV) along with severe kidney disease or kidney failure. Researchers will look at side effects and other safe…

This study looks at blood flow changes in the kidneys and liver of adults admitted to the ICU after major trauma. Using a simple bedside ultrasound, researchers will check for abnormal patterns during the first 72 hours. The goal is to see if these patterns are linked to kidney i…