HIV

This study tests whether adding the drug efavirenz to standard HIV treatment can kill the last infected cells that keep the virus alive. About 26 adults with HIV who have very low but detectable virus levels will take efavirenz for 8 weeks. The goal is to see if this approach can…

This early-stage trial is testing a new HIV vaccine called GRAdHIVNE1 in 120 healthy adults, both with and without HIV, in Southern Africa. The vaccine uses a harmless gorilla virus to deliver HIV protein pieces to train the immune system. The main goal is to check safety and see…

This early-stage study tests whether a two-part HIV vaccine is safe and can trigger the immune system to produce special antibodies that may fight HIV. About 42 healthy adults without HIV will receive the vaccine, which uses two different virus-like particles to train the body. T…

This early-stage trial tests two experimental mRNA vaccines designed to train the immune system to make powerful antibodies against HIV. The study involves 40 healthy adults without HIV to check safety and immune responses. If successful, this approach could lead to a vaccine tha…

This study compares a proactive, opt-out smoking cessation program for people living with HIV against standard care. Researchers will enroll 231 adults with HIV who currently smoke cigarettes. The goal is to see which approach helps more people quit and to understand what makes t…

This study tests if a simpler, two-drug HIV regimen (dolutegravir/lamivudine) works as well as the standard three-drug regimen for people who are newly starting HIV treatment and also being treated for tuberculosis. About 150 adults will take part. The goal is to see if the simpl…

This study tests whether taking 75 mg of zinc daily can improve immune function in people with HIV who still have low CD4 counts despite effective antiretroviral therapy. Researchers will measure changes in CD4 cells, inflammation, and quality of life over time. The goal is to fi…

This study tests whether giving monthly cash payments to pregnant women with HIV in Botswana helps them better manage their health. Researchers want to see if the money improves their ability to stick to HIV medication and stay in care after giving birth. About 100 women will tak…

This study tests whether using medical drones to deliver HIV medication to people living in remote fishing communities on Ugandan islands can help more patients achieve undetectable viral loads compared to standard delivery by boat or road. About 1,086 adults and teens on antiret…

This study looks at the right dose of the HIV drug doravirine for pregnant women. About 76 pregnant women with HIV will take doravirine plus two other HIV drugs starting in the second trimester. Researchers will measure drug levels in the blood and check safety for both mothers a…

This study tests a set of tools to help people living with HIV in Malawi keep up with their antiretroviral therapy (ART) even when they travel. The tools include special counseling for healthcare workers, a toll-free hotline, and training on giving out several months of medicatio…

This study looks at whether switching to a simpler two-drug HIV treatment (dolutegravir plus lamivudine) works as well as the standard three-drug regimen in transgender women. About 50 participants who already have their HIV under control will take the two-drug combo for 48 weeks…

This study is testing a program that combines counseling and technology to help young sexual and gender minority people (ages 18-24) in Rio de Janeiro, Brazil, take their HIV medication consistently. The goal is to improve social support and problem-solving skills to overcome bar…

This study tests a program called PrTNER that helps young people aged 15-29 who are at risk for HIV or already living with it, and who also have substance use issues. The program provides prevention, treatment, and support to help them start HIV prevention medication (PrEP) or lo…

This study tests a 5-session program for Black women living with HIV who have experienced intimate partner violence in the past two years. The program teaches skills to find inner strength, build a safety net, improve communication, and overcome barriers to HIV care. Researchers …

This study tests whether a new combination of drugs (cyclophosphamide, bortezomib, and maraviroc) can safely prevent graft-versus-host disease (GVHD) after a half-matched bone marrow transplant in people living with HIV who also have blood cancer. About 265 participants will be e…

This study tests whether automated, personalized text messages can help people living with HIV who smoke to quit. Researchers will enroll 800 smokers in Cambodia and provide a text-based program to support quitting. The goal is to see if this simple, low-cost approach helps more …

This study looks at whether having a peer supporter and switching to a long-acting injectable HIV medication can help teenagers in South Africa keep the virus under control and stay in care. About 720 adolescents aged 12 to 19 who already know their HIV status and are on daily pi…

This study aims to help people with HIV stay in care, especially during the first six months of treatment when the risk of dropping out is highest. Researchers will create and test a toolkit that includes risk assessments, a treatment roadmap, and a WhatsApp support coach. The st…

This study tests a virtual, 5-session program called MATTER for people living with HIV and substance use disorders. The program aims to help them overcome internalized stigma and shame, which can be barriers to staying on HIV treatment and achieving viral suppression. Researchers…

This study tests a 6-month holistic program that offers counseling, peer support, and education to people living with HIV or seeking HIV prevention. Researchers want to see if the program improves depression, anxiety, substance use, and social support. About 200 adults in Mecklen…

This study tests a program to help women in Botswana who have both HIV and a serious mental illness. The program aims to reduce stigma related to both conditions, especially after they leave a psychiatric hospital. Researchers will compare this program to a control group to see i…

This study tests a counseling program for Black women living with HIV who have a history of trauma. The goal is to help them take their HIV medication regularly and achieve viral suppression. About 250 participants will be enrolled to see if the program improves medication adhere…

This study tests a new way to provide HIV care for people who have trouble keeping regular doctor appointments. It offers drop-in visits and mobile care at convenient locations like a needle exchange site. The goal is to help 400 participants stay in care and get their HIV virus …

This study tests whether offering a choice of nicotine replacement products (e-cigarettes, nicotine pouches, or patches) helps people with HIV quit smoking. About 972 smokers from the Swiss HIV Cohort Study will be randomly assigned to receive either the usual care or a menu of t…

This study looks at a Philadelphia program that provides housing to people with HIV who are homeless or at risk. The goal is to see if stable housing helps them stay on HIV medication and keep the virus under control. Two hundred participants will be randomly assigned to get hous…

This study tests a three-session program called We-INtervention for 160 Chinese male couples where one partner has HIV and the other does not. The program focuses on improving relationship dynamics to reduce stigma and enhance quality of life, mental health, and HIV management. P…

This study is testing a counseling program called Friendship Bench + Safety Planning for teenagers (ages 13-19) living with HIV who have had suicidal thoughts. The goal is to see if the program is practical, acceptable, and helps reduce suicidal thoughts and improve engagement in…

This study tests an 8-week exercise program for people with HIV who are at risk for heart failure. The program combines weekly supervised workouts at a center with two home-based sessions, plus education and coaching. Researchers want to see if this approach helps participants be…

This study tests whether providing $500 per month for 6 months to low-income Black men living with HIV in Arkansas helps them get more HIV care and stick with their medication. Researchers want to see if this extra money improves health outcomes like viral suppression. The study …

This study tests whether an online depression treatment (cognitive behavioral therapy) can improve how the body uses insulin to control blood sugar in people with HIV who are on HIV medications. Researchers will compare the online therapy to depression education in 150 adults. Th…

This study tests two remote programs—peer support groups and strengths-based case management—to help rural older adults (50+) with HIV in the Southern U.S. stay engaged in care and take their medications consistently. The goal is to improve viral suppression, quality of life, and…

This study tests if gabapentin, a medication for nerve pain, can help people with HIV who drink heavily achieve undetectable viral levels. About 220 participants will receive either gabapentin or a placebo for 3 months, plus counseling. The goal is to see if the drug improves HIV…

This study aims to reduce sexually transmitted infections like chlamydia and gonorrhea among Black youth aged 15-26 in New Orleans. Participants receive free testing for four STIs and, if positive, get counseling and treatment options for themselves and their partners. The goal i…

This study compares two sets of strategies to help HIV patients with depression start evidence-based treatment. Researchers will track how many patients begin treatment and whether their depression and HIV viral levels improve within a year. Ten clinics in Cape Town, South Africa…

This study tests an experimental injectable drug called LP-98 in 30 adults with HIV who have not taken any antiviral medications. The goal is to see if the shot can lower the amount of virus in the blood and improve immune cell counts. Participants will receive the injection and …

This study tests whether semaglutide, a drug used for diabetes, can help adults with HIV reduce their alcohol intake and smoking. Researchers will also check if it lowers heart disease risk. About 200 participants will take the drug or a placebo for 3 months and provide blood, st…

This study looks at how not having enough food (food insecurity) affects the heart health of people with HIV. Researchers will test a program where trained peers and a mobile app help participants get better access to food and support. The goal is to see if this can lower the ris…

This study is testing a program that combines peer support and text messages to help young men and transgender women (ages 15-29) with HIV in Nigeria stick to their treatment and lower their virus levels. The goal is to see if this approach improves medication adherence and viral…

This study tests if tirzepatide, a weekly injection, can help overweight or obese people with well-controlled HIV lose weight and reduce chronic inflammation. Twelve adults will receive increasing doses over 12 weeks. Researchers will measure changes in body weight, body composit…

This study tests whether a combination of an HIV vaccine and a long-acting antibody (bNAb) can help people with HIV control the virus after stopping daily antiretroviral therapy (ART). The antibody may last up to six months per dose. The goal is to see if this approach can train …

This study tests whether giving three powerful antibodies to children with HIV can keep the virus under control, possibly allowing them to stop their daily antiretroviral therapy (ART) for a while. About 41 children in Botswana who started HIV treatment early will receive the ant…

This early-phase study tests whether a patient's own modified immune cells (CAR-T cells) can control HIV without lifelong medication. Three adults with well-controlled HIV will receive the therapy and be monitored for safety and viral levels. The goal is a 'functional cure,' mean…

This study tests two types of support for people recently involved with the criminal legal system. Participants are randomly assigned to either basic health navigation or an enhanced program that also includes employment help and financial incentives. The goal is to see which app…

This study tests whether metformin, a common diabetes drug, can reduce harmful inflammation and improve immune function in 100 adults aged 18-64 who have a history of injection drug use, some of whom also have HIV. Participants will take either metformin or a placebo for 16 weeks…

This study tests a new approach for people with HIV who have stopped taking their medication. Instead of a standard program, participants can choose from different services to fit their needs. The goal is to see if this flexibility helps more people get the virus under control an…

This study tests whether a mobile app with a virtual group chat can help young African American women (ages 18-30) who misuse alcohol reduce their drinking and risky sexual behavior, and increase their use of PrEP (a daily pill that prevents HIV). About 500 HIV-negative women in …

This study adapts a peer-led program for pregnant and breastfeeding women who drink alcohol. Researchers will test whether trained "mentor mothers" can help 100 women reduce alcohol use and improve adherence to HIV prevention (PrEP) or treatment (ART). The goal is to support heal…

This study tests a new program called 'One Mind One Heart' that combines mindfulness and behavior change to help older adults with HIV reduce stress and improve heart health. Researchers will work with 50 participants aged 50 and older who have HIV and high stress levels. The pro…

This study tests whether a medication already approved for other uses can help people with HIV who also have alcohol use disorder drink less. Researchers will enroll 30 adults from the Atlanta VA Healthcare System. Participants will receive the medication along with counseling fr…

This study tests a harm reduction approach for 400 people with HIV who smoke cigarettes. Instead of pushing for complete quitting, it helps participants cut down, get screened for lung cancer, and manage blood pressure and cholesterol. The goal is to improve overall health and re…

This study aims to see if starting HIV treatment right after diagnosis, instead of waiting, can reduce stigma and improve health in people who inject drugs. About 135 participants will be randomly assigned to either rapid-start or standard care. The goal is to lower HIV-related s…

This early-stage study tests whether lab-made antibodies that target HIV are safe and how the body processes them. About 83 healthy adults without HIV will receive the antibodies through an IV or under-the-skin shots, alone or combined. The goal is to find the right dose and chec…

This study tests a short, computer-based program to help people with HIV and alcohol use disorder avoid relapse. About 150 participants will receive two sessions designed to prevent a return to drinking. The goal is to see if this approach is practical and effective in reducing a…

This study tests a behavioral program for sexually active teens and young adults (ages 16-24) who use stimulants like meth, cocaine, or MDMA. The goal is to help them reduce stimulant use and have safer sex to lower HIV risk. About 360 participants will join, and the program is d…

This study works to make needle exchange programs more available and easier to use in nine Canadian federal prisons, including five women's prisons. The goal is to reduce the spread of HIV and hepatitis C among people who inject drugs while incarcerated. Researchers will identify…

This study tests a new program to help people living with HIV who also use substances stick to their HIV medications and stay in care. The program focuses on coping skills, managing substance use, and staying engaged with healthcare. Researchers want to see if the program is prac…

This study tests a mobile game called Change My Story for young people (ages 16-24) living with HIV who also have depression. The game is designed to help them manage stress and stick to their HIV medication. Researchers will compare the game plus standard counseling to counselin…

This study tests a program called the Enhanced Friendship Bench, which combines problem-solving therapy with HIV support, for pregnant women with HIV and depression in Malawi. Researchers will enroll 400 women to see if the program reduces depression and improves HIV care engagem…

This study tests new drug combinations for cryptococcal meningitis, a brain infection that is always fatal without treatment and still kills many people with HIV. The trial aims to find safer and more effective therapies by comparing several new antifungal regimens. About 2,000 a…

This study is testing a new device called MagIA H3S that can screen for HIV, hepatitis B, hepatitis C, and syphilis from a single blood sample. Researchers will enroll about 2,950 people in Ivory Coast and Kenya to see how accurate the device is compared to standard lab tests. Th…

This study tests whether a long-acting injectable HIV prevention medication (cabotegravir) is practical and effective for adults who inject non-prescription drugs. 100 participants will receive the shot along with support services. The goal is to see how many stick with the treat…

This study tests whether a peer-led community program can help Black men in Prince George's County, Maryland, start taking PrEP, a daily pill that prevents HIV. Participants attend events focused on reducing HIV stigma and building social support. Researchers will compare how man…

This study tests whether a farming program called Shamba Maisha can reduce sexually transmitted infections (STIs) and HIV risk in 900 teen girls (ages 15-19) in Kenya. The program provides water pumps, farming tools, and training to improve food security and mental health. Resear…

This study tests two approaches to help men who have sex with men and use methamphetamine start or restart HIV prevention (PrEP) or treatment (ART). Four hundred participants will receive either contingency management (rewards for filling prescriptions) alone or combined with mot…

This study tests a program called CUPID that helps couples make decisions together about HIV prevention. About 1,400 women in Uganda will join with their male partners to choose and stick with prevention options like PrEP pills, rings, or shots. The goal is to see if involving pa…

This study tests whether a combination of three lab-made antibodies can safely prevent HIV in healthy adults. About 200 participants will receive the antibodies through an IV and be monitored for 18 months. The goal is to see if these antibodies are safe and how long they stay in…

This study looks at whether patients and doctors in a family planning clinic find it acceptable to discuss and start PrEP, a daily pill that prevents HIV. About 83 English- or Spanish-speaking patients aged 16 and older, along with their doctors, will take part. Patients will rec…

This study aims to find low-cost ways to encourage people at higher risk of HIV to get retested. Researchers will test several simple behavioral interventions, like phone messages, in 40,000 adults in Kenya and Uganda. The goal is to see which methods work best to increase repeat…

This study follows 5,000 HIV-negative adults in Italy who are taking or starting PrEP, a daily pill that prevents HIV. Researchers will track how well PrEP works in real life, how often people take it, and any side effects. The goal is to gather data to help eliminate new HIV inf…

This study tests a new program called STEP-UP that helps people get HIV prevention medication (PrEP) through trusted community organizations instead of going to a clinic alone. About 92 adults in Philadelphia will either get PrEP through a community partner or directly online. Re…

This study tests a digital health program designed to help women involved in the criminal justice system (like probation or parole) start and stick with HIV prevention medication (PrEP) and treatment for opioid use disorder. Researchers will compare the full program to a simpler …

This study looks at people with HIV between 65 and 74 years old to find those at risk for frailty—a condition that can lead to falls, disability, and hospital stays. Participants will be screened using a simple test called the Fried scale, and those at risk will get a special che…

This study tests a new data dashboard to help clinics in Alabama better track and improve HIV prevention services (PrEP). Researchers will work with 7 clinics to see if the dashboard helps more Black patients get PrEP, reducing racial gaps. The study involves clinic staff, not pa…

This study tests a program called JUNTOS that helps HIV test counselors refer Latino men who have sex with men to prevention and treatment services. The goal is to see if this referral network increases the number of men who use HIV prevention or get treatment. About 245 particip…

This study tests whether a relationship education program can lower HIV and STI rates in gay, bisexual, queer, and transgender/non-binary people who partner with cisgender men. About 5,000 participants will be randomly assigned to either the program or no program, and followed fo…

This study tests whether adding testing for common sexually transmitted infections (like chlamydia and gonorrhea) to standard risk screening helps more women in Uganda start and continue taking PrEP, a daily pill that prevents HIV. About 4,500 HIV-negative women aged 15-39 will b…

This study looks at whether long-acting antiretroviral drugs could be a better way to prevent HIV in Thai men who have sex with men and transgender women. Researchers will survey over 10,000 people about their preferences and use computer models to compare costs and health effect…

This study looks at a new way to help people in the Dallas County Jail get access to PrEP, a daily pill that prevents HIV. A patient navigator will meet with interested inmates to discuss HIV risk, offer testing, and connect them with PrEP providers after they are released. The g…

This study tests a new way to help Latinx men at risk for HIV start and stick with PrEP, a daily pill that prevents HIV. It combines a one-stop-shop clinic, a social network support program, and a national pharmacy chain to make getting PrEP easier. Researchers will enroll 624 ci…

This study tests a group counseling program with peer support to help people reduce the internal shame and worry caused by health conditions like obesity, skin disease, cancer, HIV, diabetes, or chronic pain. About 195 adults will join and be followed for 26 weeks. The goal is to…

This study looks at whether a program that combines physical activity with support from a peer is acceptable and practical for women living with both HIV and high blood pressure. About 50 women aged 40 and older will take part. The goal is to see if women stick with the program a…

This study tests a remote counseling program for people with HIV who have chronic pain and drink too much. About 250 participants will receive either the special program or basic advice through video calls. The goal is to see if the program can reduce pain and drinking over six m…

This study tests whether a type of brain stimulation called accelerated theta burst stimulation (a form of TMS) can lower methamphetamine cravings and change brain activity. Researchers will enroll 30 adults with HIV who have or had methamphetamine use disorder. Participants rece…

This study is testing whether an AI-powered conversational agent can deliver a proven therapy (Dialectical Behavior Therapy) to help older adults (50+) living with HIV manage suicidal thoughts and negative emotions. The goal is to see if this approach is practical, usable, and he…

This study compares two phone-delivered programs—Brief Behavioral Treatment for Insomnia and Brief Mindfulness Training—to see which better improves sleep, reduces chronic pain, and slows biological aging in 200 adults with HIV and ongoing pain. Participants must be 25–65 years o…

This study compares two drugs, pramipexole and escitalopram, to see which better treats major depression in people with HIV. About 186 participants will be randomly assigned to one of the two medications. The goal is to improve mood and thinking, while monitoring side effects.

This study tests whether a supplement called pregnenolone can help reduce depression in people living with HIV. About 120 adults with HIV and depression will take either pregnenolone or a placebo pill for a period, while continuing their usual depression medications. Researchers …

This study tests whether doing tai chi and qigong online for 12 weeks can reduce depressive symptoms in people aged 50-75 living with HIV. Participants will be randomly assigned to either a tai chi class or a health education class, both held twice a week over Zoom. Researchers w…

This study looks at where HIV hides in the body by comparing virus levels in blood, lymph nodes, and bone marrow. Researchers want to understand how HIV damages the immune system and why it's so hard to eliminate. Up to 400 adults with HIV will provide blood and tissue samples, a…

This study collects information from 2,500 adults with HIV who are having their first upper digestive tract exam (endoscopy). Researchers will track their health details and any findings from the procedure to better understand long-term digestive issues in this group. The goal is…

This study looks at how alcohol, cannabis use, and certain medications may increase the risk of falls and memory or thinking problems in people with HIV. Researchers will enroll 100 participants who take five or more non-HIV medications and currently drink alcohol. A clinical pha…

This study follows 150 adults with Kaposi sarcoma (KS) for up to 10 years to learn how the disease develops, improves, or comes back. Participants will have regular check-ups, scans, and tests, but no new treatments are given. The goal is to better understand KS, especially in pe…

This study looks at whether getting legal help can improve HIV care for people who have been in jail. Researchers will work with 100 adults living with HIV who have a detectable viral load and a history of incarceration. They want to see if legal aid helps people stay in care and…

This study is creating a large database of HIV patients in Washington, DC, to track their health over time and improve care. Researchers will follow about 19,000 people receiving HIV treatment or prevention services at local clinics. The goal is to understand what works best for …

This study looks at whether being more forgiving can improve the well-being of people living with HIV. Researchers will measure resentment, forgiveness, and quality of life in 206 participants over one year. The goal is to understand how forgiveness might help reduce stress and s…

This study looks at why people with HIV have about double the risk of heart attacks compared to the general population. Researchers will use MRI scans to measure fat stored around the heart and liver in 100 adults over 40 with HIV. The goal is to understand how this hidden fat af…

This study in Uganda tests whether trained peer counselors can help people with tuberculosis (TB) and HIV stay on track with their medications. About 1,920 adults will take part, and researchers will compare treatment success rates between clinics using peer-led education and tho…

This study looks at medical records from about 7 million people with HIV in South Africa. Researchers want to see how different ways of delivering HIV treatment are working. They will not interact with patients directly. The goal is to find out which methods help people stay heal…

This study looks at whether inflammation in the brain contributes to depression symptoms like loss of interest and slowed thinking in people with HIV. Sixty adults with HIV and depression who are on effective HIV treatment will receive either the anti-inflammatory drug baricitini…

This study aims to understand why a small group of people with HIV, called long-term non-progressors, can control the virus for years without antiretroviral therapy. Researchers will collect white blood cells and plasma from up to 400 participants through apheresis or blood draws…

This study aims to learn more about how HIV infects cells and affects the immune system by collecting blood samples from up to 2,419 adults, both with and without HIV. Researchers will analyze these samples to compare genetic and protein differences. The goal is to better underst…

This study looks at how two cannabis compounds, CBD and THC, affect inflammation and brain health in people with HIV. Researchers will measure changes in blood markers and brain function over about 6 weeks. The goal is to better understand how cannabis use interacts with HIV to p…

This study looks at 20 adults in Ethiopia who have both HIV and visceral leishmaniasis (a serious parasitic disease). Researchers want to find out why the parasite keeps coming back in some patients and how to better monitor treatment. Participants provide samples and attend foll…

This study aims to reduce stigma in HIV clinics so that people living with HIV feel more comfortable getting and staying in care. Researchers will work with five clinics in the southern and eastern US to train staff and change policies. About 1,000 clinic staff and patients will …

This study looks at whether text messages can encourage teenagers (ages 13-19) to get tested for HIV. About 360 teens who have had sex and are HIV-negative or don't know their status will receive either helpful texts or general health information. The main goal is to see if more …

This study is testing new decision-making tools to help doctors in Mozambique and Zambia diagnose and treat tuberculosis (TB) in children more effectively. Over 30,000 children under 15 years old will take part at district hospitals and health centers. The goal is to see if these…

This study follows 100 adults with HIV who were treated early and then paused their medication in a previous research study. The goal is to monitor their health and see if the virus stays under control without drugs. Participants will have regular check-ups for up to 144 weeks to…

This study looks at better ways to provide cervical cancer screening and treatment to women living with HIV in Nigeria. About 2,400 women will take part to see if adding extra support helps more women get screened and treated. The goal is to save lives by combining HIV care with …

This study looks at two ways to screen for cervical cancer in women living with HIV: going to a central clinic or having a mobile team come to them. About 1,180 women aged 25-49 in Cameroon will take part. The goal is to see which method helps more women complete all screening st…

This study collects blood samples from 2000 people, both with and without HIV, to provide researchers with specimens for collaborative studies. Participants must have good vein access and be able to give consent. No treatment is given; the goal is to support basic science researc…

This study tests a program that gives people who inject drugs special syringes with less leftover space for blood, which can reduce the spread of HIV and hepatitis. Researchers will work with 2,400 participants across nine countries to see if the program is accepted and used. The…

This study looks at existing medical records from over a million people in Zambia to understand how HIV treatment is being delivered. Researchers want to see which care models work best, how many patients are using them, and what the costs are. The goal is to help make HIV care m…

This study aims to make cervical cancer screening easier for women living with HIV in Cameroon. Currently, many women drop out because screening requires multiple visits. The researchers will test a single-visit approach where women get tested for HPV and, if needed, treated righ…

This study looks at whether menopause and HIV together increase the risk of heart disease in women. Researchers will examine inflammation and body changes using MRI scans and blood tests. The goal is to understand why heart risks may rise in menopausal women with HIV. About 90 wo…

This 20-year study will collect information from up to 300,000 people who visit HIV and sexual health clinics in Thailand. Researchers aim to understand behaviors, social factors, and health needs to improve services. No new treatments are tested; the focus is on gathering data t…

This study collects large numbers of white blood cells from people with HIV using a process called leukapheresis. The goal is to learn more about how the virus hides in the body and causes ongoing inflammation, even during treatment. Up to 100 participants will provide blood samp…

This study follows 390 adults in Zambia with hepatitis B, some also with HIV, to see how their liver and immune system change over years. Participants join when diagnosed or starting standard antiviral treatments. Researchers collect data through blood tests and liver biopsies to…

This study looks at how a damaged vagus nerve may cause gut bacteria overgrowth and inflammation in people with HIV. Researchers will test if a drug called pyridostigmine or vagus nerve stimulation can help. About 207 adults with well-controlled HIV will participate over 5 years.

This study looks at how medical care affects the quality of life of 100 pregnant women living with HIV. Researchers will ask women to fill out questionnaires about their feelings and experiences during pregnancy and one year after giving birth. The goal is to improve care and sup…

This study looks at three approaches to help older adults with HIV increase their physical activity: one-on-one coaching, cognitive behavioral therapy to address barriers like low motivation or pain, and a Fitbit-based social support program. About 196 participants will wear a Fi…

This study tests whether a specially designed play can help reduce stigma around Pre-exposure Prophylaxis (PrEP) for young women in Kenya. Researchers will measure how well the play reaches audiences and whether it changes people's views. About 160 participants, including young w…

This study looks at how to help people in Zimbabwe who have both HIV and cancer stay engaged in their HIV care while they are being treated for cancer. Researchers will first observe 150 patients to understand the barriers, then develop and test strategies to overcome them with a…

This study looks at medical records from up to 1 million people with HIV in Malawi to understand how different ways of delivering treatment are working. The goal is to see which models help more patients stay healthy and use resources wisely. No new treatments or patient visits a…

This study follows 30,000 HIV patients in 15 French clinics to track how well treatments work over time. Researchers will collect data on viral load, medications, and related infections like hepatitis C. The goal is to improve care and understand long-term trends, not to test a n…

This study looks at how chronic marijuana use changes brain inflammation and thinking abilities in people with HIV. Researchers will use brain scans and blood tests to measure brain health in 220 adults. The goal is to understand the effects, not to test a new treatment.

This study looks at whether people who use drugs can help their friends get tested for HIV by giving them self-testing kits and information about local services. The researchers will work with a syringe service program in California to see if this approach increases HIV testing a…

This study collects blood plasma and white blood cells from healthy volunteers, patients, and their relatives using a procedure called apheresis. The samples are used for laboratory research on HIV and immune function. Participants must be 18 or older and enrolled in an NIH proto…

This study looks at lymph node tissue from people with HIV to find out how the virus hides even when medicines are working. Researchers will remove small lymph nodes from the groin to measure HIV levels and tissue damage. The goal is to learn more about why HIV stays in the body …

This study looks at whether setting up special HIV teams in hospitals can help find undiagnosed HIV in patients who have conditions linked to HIV. About 5,200 patients across ten European countries will be included. The teams will review medical records, remind doctors to test fo…

This study looks at how well leg muscles produce energy in people aged 60 and older, both with and without HIV. Researchers want to see if muscle energy problems are linked to tiredness and less ability to exercise. Participants will have muscle tests and walking assessments, but…

This study looks at how stress changes hormones, pain, and mood in people living with HIV who also have cannabis use disorder and depression. Researchers will measure stress responses in 120 volunteers using pain tasks and blood tests. The goal is to better understand these conne…

This study looks at 320 people with HIV to create tools that predict who will develop fatty liver disease and liver scarring. Researchers will track changes in liver health over time using ultrasound and a special scan called FibroScan. The goal is to catch liver problems early a…

This study collects blood, bone marrow, tumor, and other tissue samples from adults with HIV, KSHV, or certain cancers. The goal is to gather samples for future research, not to provide treatment. Up to 999 participants will donate samples over time to help scientists learn more …

This study follows 380 children in Uganda for two years to understand how malaria and HIV treatments interact. Half the children have HIV and half do not. Researchers will measure changes in body weight, blood sugar, and drug levels to find the best ways to treat both infections …

This study looks at whether people with tuberculosis (TB) who have no symptoms can pass the infection to others. Researchers will track about 6,770 participants and their close contacts using advanced genetic testing. The goal is to better understand how TB spreads and improve co…

This study is testing a program to help more people in coastal Alabama get tested for HIV, quickly connect to care, and start treatment right away. The program uses data to find areas with high need, helps people link to care when diagnosed, and offers rapid antiretroviral therap…

This study tests whether pasteurized donor human milk (PDHM) is a practical feeding option for infants exposed to HIV. Ten caregivers in Saskatchewan will try PDHM as a supplement to breastfeeding or formula for 4 weeks. Researchers will track how often PDHM is used and ask careg…

This study looks at whether a two-day employment program helps young Black sexual minority men stay engaged in HIV care. About 132 participants will attend the program and complete surveys over 13 months. Researchers want to see if the program is acceptable and feasible, and if i…

This study looks at how the immune system works in people with HIV who start treatment early. Researchers will collect white blood cells through a process called leukapheresis before and during therapy. The goal is to learn more about immune function, not to provide a new treatme…

This study follows 600 adults with known or suspected HIV in the Washington, D.C., area to better understand the infection and related conditions. Participants visit the clinic every 3-4 months for check-ups and blood tests. The study does not offer experimental treatments but he…

This study tests a method called SAIA to help family planning clinics in Kenya better offer HIV testing, treatment, and prevention services, especially for adolescent girls and young women. About 40 clinics will either use SAIA or continue their usual procedures. Researchers want…

This study tests whether having traditional healers offer HIV counseling and testing can help more people in rural South Africa learn their HIV status. Over 230,000 adults will be invited to test during healer visits. The goal is to see if this approach increases testing and conn…

This study aims to understand what happens to HIV when people stop their daily medication for a short time. Researchers will use scans and tissue samples to measure virus levels in the blood and lymph nodes. About 50 adults with HIV who are on stable treatment will take part. The…

This study aims to identify frailty in people aged 50 and older living with HIV. Researchers will measure physical performance and quality of life to better understand the challenges of healthy aging. The study involves 100 participants from a specialty clinic and does not test a…

This study tests whether a telemedicine program is practical and well-received for treating substance use disorders in people living with HIV in Alabama. About 30 participants who misuse opioids or stimulants will receive care via video or phone. The main goal is to see if they a…