EWING SARCOMA

This study tests a personalized peptide vaccine for children and young adults (up to age 30) with metastatic fusion-driven sarcomas (Ewing sarcoma, rhabdomyosarcoma, synovial sarcoma) who have completed standard treatment. The vaccine is custom-made for each patient based on thei…

This early-phase study tests a four-drug combination (vorinostat plus three chemotherapy drugs) in children, teens, and young adults up to age 30 whose solid tumors or brain cancers have returned or not responded to standard treatment. The main goal is to find a safe dose and und…

This early-stage study tests a new type of stem cell transplant for children whose blood cancers or solid tumors have returned or are hard to treat. Doctors use a special method to remove certain immune cells from the donor's stem cells and give a drug called zoledronate after tr…

This early-phase study tests a new drug called INBRX-109 in people with advanced solid tumors, including Ewing sarcoma and colorectal cancer. The drug is designed to attach to a protein on cancer cells and trigger their death. The main goals are to check safety and see if the dru…

This early-stage study tests a new treatment for children and young adults (up to age 21) with solid tumors that have come back or not responded to standard therapy. The treatment uses the patient's own immune cells, which are modified in a lab to recognize and attack a protein c…

This early-phase study tests whether giving specially engineered immune cells (HER2 CAR T cells) along with drugs that boost the immune system (pembrolizumab or nivolumab) is safe and helpful for people with advanced sarcoma. About 25 participants will receive chemotherapy before…

This study tests whether the drug regorafenib can help prevent bone sarcomas from coming back after initial treatment. About 168 people with bone sarcomas like osteosarcoma or Ewing sarcoma will either take regorafenib for up to 12 months or receive standard monitoring. The goal …

This early-phase study tests a new oral drug, ST-01156, in about 171 adults with advanced solid tumors that have spread or cannot be removed. The main goals are to check safety, find the best dose, and see how the body processes the drug. Participants take the pill for 5 days in …

This study tests an experimental pill called silmitasertib combined with standard chemotherapy in children and young adults (under 30) whose solid tumors have come back or not responded to treatment. The goal is to find a safe dose and see if the combination helps shrink tumors o…

This early-phase study tests a new drug, DXC008, in people with advanced prostate cancer or other solid tumors like Ewing sarcoma who have not responded to standard treatments. The main goals are to check the drug's safety, find the right dose, and see if it can shrink tumors. Ab…

This early-phase study tests a new treatment using a patient's own immune cells, modified to better recognize and attack certain childhood cancers (rhabdomyosarcoma, Ewing sarcoma, neuroblastoma, and Wilms tumor). The treatment combines two types of engineered cells and is given …

This study tests an experimental drug called zilovertamab vedotin in children and young adults (ages 1 to <18) whose blood cancers (like B-cell acute lymphoblastic leukemia, diffuse large B-cell lymphoma, or Burkitt lymphoma) or solid tumors (neuroblastoma or Ewing sarcoma) have …

This study tests two drugs, pembrolizumab and cabozantinib, in people with advanced sarcomas (soft tissue or bone cancers) that have spread or cannot be removed. The goal is to see if the combination can stop the cancer from growing for at least 6 months. About 119 adults who hav…

This study tests a stem cell transplant that removes certain immune cells (alpha/beta T cells and CD19+ B cells) and adds a drug called zoledronic acid. The goal is to help the donor immune cells fight solid tumors that have come back or not responded to other treatments. The tri…

This study tests an experimental oral drug called AMXT 1501 combined with another drug, eflornithine (DFMO), in children and young adults up to age 21 with neuroblastoma, brain tumors, or sarcomas. The goal is to find a safe dose and see if the combination can delay cancer growth…

This early-phase trial is testing whether combining the targeted drug cabozantinib with high-dose ifosfamide is safe and effective for people with sarcomas (bone or soft-tissue cancers) that have returned or stopped responding to standard therapy. About 30 children and adults wil…

This study tests whether adding the drug eflornithine (DFMO) to standard chemotherapy can help people with Ewing sarcoma or osteosarcoma live longer without their cancer returning. It includes about 400 participants across five different groups, such as those with newly diagnosed…

This study tests a new way of giving radiation therapy for Ewing sarcoma, a rare bone and soft tissue cancer. The radiation dose is tailored to each patient's tumor size and features, with higher doses for larger tumors that are harder to treat. The goal is to lower the chance of…

This study is testing a drug called lurbinectedin in people aged 10 and older whose solid tumors (like Ewing sarcoma) have come back or not responded to standard treatment. The goal is to see if the drug is safe and can shrink tumors or delay their growth. The study has two phase…

This early-stage study tests whether giving special immune cells (B7-H3-CAR T cells) along with targeted radiation is safe for children and young adults up to age 21 whose sarcomas have returned or not responded to standard treatments. The approach aims to help the immune system …

This study tests a drug called lurbinectedin in children and young adults (ages 2 to 30) with Ewing sarcoma, a type of bone cancer, that has returned or not responded to prior treatments. The first part finds the safest dose and checks for side effects; the second part measures h…

This early-stage trial tests a new drug called xaluritamig in about 50 people (adults, teens, and children) whose Ewing sarcoma has returned or stopped responding to standard treatments. The main goals are to find a safe dose and check for side effects. Researchers will also meas…

This study is for children, teens, and young adults (up to age 39) with sarcoma that has spread to a few other places in the body. The goal is to see if giving radiation to those spread spots, along with standard treatment, can help them live longer without the cancer getting wor…

This study tests whether people with advanced solid tumors can stick to a diet low in methionine, a protein building block. Researchers want to see if this diet is safe and changes methionine levels in the blood. About 25 adults will follow the diet while receiving their usual ca…

This study looks at how closely bone cancer patients follow a personalized home exercise program in the first six months after lower leg surgery. Researchers will track daily exercise logs and explore what factors help or hinder adherence. The goal is to improve rehabilitation su…

This study looks at how to safely preserve fertility in children with neuroblastoma or Ewing sarcoma. When ovarian or testicular tissue is frozen before cancer treatment, there is a risk that cancer cells might be hidden in that tissue. Researchers are comparing two very sensitiv…