DIABETES MELLITUS, TYPE 2

This study tests a procedure called duodenal mucosal resurfacing (DMR) for people with type 2 diabetes who take non-insulin medications. The treatment uses a thin tube to treat the lining of the upper gut, aiming to improve blood sugar control. The trial compares DMR to a sham (f…

This study looks at whether traditional kefir can improve blood vessel health and immune function in people at higher risk or living with type 2 diabetes. Over 12 weeks, 156 adults in Edmonton will drink kefir to see if it helps control blood sugar and reduce inflammation. The go…

This study tests whether adding semaglutide (a drug used for diabetes and weight loss) to a standard topical cream can improve psoriasis symptoms and reduce body-wide inflammation. About 62 adults with plaque psoriasis who are overweight or have type 2 diabetes will receive eithe…

This study looks at whether a minimally invasive stomach-shrinking procedure (endoscopic sleeve gastroplasty) plus lifestyle changes is better than lifestyle changes alone for treating obesity and a serious liver condition called MASH. About 132 adults with a BMI of 30 or higher …

This study tests a new way to help people with uncontrolled type 2 diabetes who also have unmet social needs like food or housing problems. About 900 adults will be assigned to either the new program or standard care. The program uses a special tool in the medical record to conne…

This early-stage study tests whether a new experimental medicine, NNC1679-0001, is safe and well-tolerated in healthy adults and people with type 2 diabetes. Participants receive a single injection of either the study drug or a placebo. The goal is to check for side effects and h…

This study tests whether a digital health program can help people with type 2 diabetes achieve remission through a strict meal replacement diet. Overweight adults recently diagnosed with type 2 diabetes will be randomly assigned to receive follow-up support either through an eHea…

This study tests whether a digital diet program, including extra vegetables and soy-based foods, can lower blood pressure in 300 adults with hypertension and obesity, half of whom also have type 2 diabetes. Participants will either follow the enhanced diet with high or low proces…

This study tests a new once-weekly injection called NNC0662-0419 for people with type 2 diabetes. About 270 adults will receive either the new drug, an approved drug (semaglutide), or a placebo to see how well it controls blood sugar and affects weight. The goal is to find the be…

This study tests whether mobile health apps like Weight Watchers and Healthi can help low-income Hispanic adults with type 2 diabetes lose weight and improve blood sugar control. Participants will weigh themselves daily and check blood glucose before and after meals for 6 months.…

This study is testing a new glucose monitoring system called Eversense Gemini, which includes a flash glucose measurement feature. The goal is to see how accurate and safe it is for adults with type 1 or type 2 diabetes. About 80 participants will wear the device and have their g…

This study looks at how well the drug tirzepatide works for weight loss and blood sugar control in everyday medical practice in Paraguay. It includes 160 adults: 80 with obesity but no diabetes, and 80 with type 2 diabetes (with or without obesity). Participants take tirzepatide …

This study tests if a new insulin that is injected just once a week works as well as daily insulin shots to control blood sugar in people with type 2 diabetes. About 586 adults who have never used insulin before will take either the weekly insulin or a standard daily insulin for …

This study tests whether a nutritional drink, designed using artificial intelligence, can help adults with type 2 diabetes lower their blood sugar levels. About 100 people will receive either the active drink or a placebo for 24 weeks, alongside their usual diabetes care. The mai…

This study looks at how fat cells work in normal-weight people with type 2 diabetes compared to those who are overweight or don't have diabetes. Researchers will test two drugs, pioglitazone and tirzepatide, to see if they improve insulin resistance and fat storage. About 104 adu…

This study aims to help people with diabetes who struggle to get enough healthy food. Participants will receive meal deliveries and nutrition education after leaving the hospital. The goal is to reduce food insecurity and improve diabetes management. About 160 adults with type 1 …

This study tests whether combining guided exercise with cognitive behavioral therapy (CBT) can help Black men with type 2 diabetes better control their blood sugar and improve their mood and quality of life. Eighty men from Michigan will take part in weekly online sessions over 7…

This study tests whether using a continuous glucose monitor (CGM) helps kidney transplant recipients with type 2 diabetes keep their blood sugar in a healthy range. About 80 adults who received a kidney transplant in the past year and use insulin will wear a CGM device for severa…

This study looks at whether combining two common diabetes drugs (GLP-1 agonists and SGLT2 inhibitors) can improve heart function and artery health in people with type 2 diabetes who are at high risk for heart problems. About 240 adults will be split into four groups, each receivi…

This study tests whether diabetes self-management education, delivered in churches by trained community health workers, can help Marshallese adults with type 2 diabetes better control their blood sugar. Up to 288 participants with diabetes and their family members will take part.…

This study tests whether an AI-powered app combined with wearable devices can help people with type 2 diabetes better manage their condition and avoid complications. Researchers will enroll 6,000 adults and track changes in blood sugar (HbA1c) over 3 months. The goal is to see if…

This early study is testing a new treatment for type 2 diabetes. Doctors will take a small amount of fat from each patient, use a special laser to prepare it, and then inject it into the lining of the small intestine. The goal is to see if this can safely improve blood sugar cont…

This study tests a remote 8-week program that combines positive psychology and motivational interviewing to help people with type 2 diabetes increase their physical activity. 280 adults with type 2 diabetes who are not very active will be randomly assigned to this program or a st…

This study tests an experimental drug called ARO-ALK7 in 138 adults with obesity, some of whom also have type 2 diabetes. The goal is to check the drug's safety and how well it works for weight loss, either alone or with another diabetes medication. Participants will receive sing…

This study tests whether a specially trained nurse case manager can help formerly incarcerated Black men with poorly controlled type 2 diabetes improve their blood sugar levels. One hundred men will be randomly assigned to either the nurse case management program or usual care. T…

This early-stage study tests a new medicine called MK-1403 in 52 adults with type 2 diabetes. The main goal is to see if it is safe and well-tolerated, and to measure how the body processes the drug. Researchers will also check if MK-1403 lowers a marker of inflammation (hsCRP) i…

This study looks at whether a class of diabetes drugs called GLP-1 receptor agonists can improve the way fat tissue works and help protect the kidneys in people with chronic kidney disease (CKD). Researchers will measure changes in fat around the kidneys and heart, as well as kid…

This study tests whether a continuous glucose monitor (CGM) helps older adults (60+) with type 2 diabetes who take pills but not insulin to better control their blood sugar. Participants will either wear a CGM every two months or use standard finger-stick monitoring for six month…

This study tests a new way to care for adults with type 2 diabetes at community health centers. It uses a team of providers and technology to help patients control their blood sugar. About 120,000 patients will take part over three years. The goal is to see if this approach lower…

This study tests whether adding vicadrostat to the standard drug empagliflozin can lower the chance of heart problems or death in adults with type 2 diabetes, high blood pressure, and existing heart disease. About 11,800 participants will take either the combination or a placebo …

This study looks at time-restricted eating (a form of intermittent fasting) to see if the timing of your daily eating window affects blood sugar control. Researchers will compare three different 9-hour eating windows in 120 adults with obesity who have or are at risk for type 2 d…

This study tests DiaMester, a Norwegian e-health program designed to help adults with type 2 diabetes manage their condition and lose weight. The goal is to see if significant weight loss can lead to diabetes remission. About 99 participants will be randomly assigned to different…

This study looks at whether using a continuous glucose monitor and a Fitbit can help people aged 55 and older with type 2 diabetes reduce sitting time and improve blood sugar control. Researchers will track how well participants respond to activity prompts and how often they wear…

This study compares having one laser treatment versus several sessions for a serious diabetic eye condition that can cause blindness. Researchers want to see which approach is safer and works better. The study will involve 40 adults with type 1 or type 2 diabetes who have this ey…

This study tests two experimental drugs, macupatide and eloralintide, alone or together, to help adults with obesity or overweight and type 2 diabetes lose weight. About 200 participants will take the drugs or a placebo for 48 weeks. The main goal is to see how much weight they l…

This study compares two drugs, choline fenofibrate and policosanol, in 56 Korean adults with type 2 diabetes and high cholesterol who have early signs of artery plaque. The goal is to see if choline fenofibrate can reduce plaque buildup in the carotid artery, measured by 3D ultra…

This study looks at whether adding omega-3 to a common statin (atorvastatin) can better reduce plaque buildup in the neck arteries of people with type 2 diabetes and high cholesterol. About 105 adults will be randomly assigned to get either atorvastatin plus omega-3 or atorvastat…

This study tests a new drug called LY3938577 against a standard insulin (degludec) in 100 people with type 2 diabetes who already use basal insulin. The goal is to see if the new drug can better control blood sugar levels over 26 weeks. Participants must have type 2 diabetes, use…

This study compares a smart insulin pump called the iLet Bionic Pancreas to usual care for adults with type 1 or type 2 diabetes who use insulin. About 240 participants will use the pump for 13 weeks or continue their regular treatment. The goal is to see if the pump improves blo…

This study looks at whether giving extra training to primary care doctors and nurses helps people with type 2 diabetes manage their blood sugar better. About 7,792 adults in Catalonia will take part. The training focuses on current diabetes care, and researchers will track blood …

This study looks at how different types of keto diets affect heart health and inflammation in adults who are overweight or have prediabetes or type 2 diabetes. Participants will follow either a keto diet with healthy canola oil, a traditional keto diet high in saturated fat, or a…

This study tests whether taking taurine, a common amino acid supplement, can improve blood sugar control, cholesterol levels, and inflammation in people with type 2 diabetes. Researchers will give taurine or a placebo to 94 adults with diabetes for 12 weeks and measure changes in…

This study tests whether adding a procedure that cuts the vagus nerve to standard gastric bypass surgery helps more people with type 2 diabetes achieve remission. About 40 adults with obesity and diabetes will be randomly assigned to receive either bypass alone or bypass plus the…

This study is testing a diabetes education program designed specifically for Arab Americans with type 2 diabetes. The program includes peer-led classes in Arabic and a 3-month text messaging service to help with self-care. Researchers want to see if this approach improves diabete…

This study looks at whether involving the whole family can help people with type 2 diabetes in rural Kentucky improve their eating and physical activity. About 75 participants will share their access to food and exercise options, then follow a 6-month nutrition and activity plan …

This study tests whether providing medically tailored meals along with intensive lifestyle coaching can help adults with HIV and type 2 diabetes or prediabetes better manage their weight and blood sugar. About 200 participants will be randomly assigned to receive either the meals…

This study looks at whether people with type 2 diabetes (who don't use insulin) can wear a continuous glucose monitor only two weeks each month instead of all the time, and still keep their blood sugar under control. About 150 adults will first wear the monitor full-time for 3 mo…

This study tests whether community health workers can help more women in urban Indian slums get tested for type 2 diabetes after having a baby. Women who had diabetes during pregnancy are at high risk, but many miss the recommended test. The trial will involve 330 women and use h…

This study tests whether using a mobile health app helps people with type 2 diabetes and obesity lose weight and control blood sugar better than standard programs. Thirty adults will track their weight daily and blood sugar before and after meals for six months. The goal is to se…

This study tests an oral drug called dapansutrile in 300 adults with type 2 diabetes. The drug targets inflammation, which may help control blood sugar and reduce diabetes-related complications. Participants will receive either the drug or a placebo to compare safety and effectiv…

This study tests the safety and effectiveness of tirzepatide in 344 Indian adults with type 2 diabetes or obesity. Participants receive the drug for 46 weeks. Researchers will track side effects, weight loss, and blood sugar control.

This study looks at whether a type of talk therapy for insomnia (CBT-I) can help lower blood sugar levels in people with prediabetes. About 300 adults with both prediabetes and insomnia will either get CBT-I or general health education. The goal is to see if improving sleep can r…

This study aims to improve long-term diabetes management by combining traditional Chinese medicine with Western medicine through a digital platform. Researchers will enroll 10,000 adults with type 2 diabetes and use an app, smart devices, and expert support to monitor blood sugar…

This study tests whether taking daily vitamin D3 or yeast beta-glucan (a type of fiber) supplements can improve blood sugar control and lower the 10-year risk of heart disease in people with type 2 diabetes. The trial will include 2,500 adults aged 40–79 and will last 5 years, wi…

This study is testing a new glucose sensor called the ROME GS System to see if it is safe and accurate for people with type 1 or type 2 diabetes. About 60 adults will wear the sensor for up to 90 days. Researchers will compare its readings to standard lab tests and track any side…

This study looks at whether drinking regular milk can lower the risk of type 2 diabetes in people with lactose intolerance who also have pre-diabetes. Researchers think milk might change gut bacteria in a helpful way. About 40 adults with a specific gene linked to lactose intoler…

This study compares two ways to prevent heart attacks and strokes in people with type 2 diabetes, prediabetes, or metabolic syndrome who have no known heart disease. One approach uses a detailed CT scan to stage artery plaque buildup, while the other relies on traditional risk fa…

This study compares two steroid injections for knee osteoarthritis in people with type 2 diabetes. It aims to see which one controls pain better while causing fewer blood sugar spikes. About 120 adults with diabetes and knee arthritis will receive either a long-acting or short-ac…

This study looks at whether a special way of talking between doctors and patients—called 'linguistic nudging'—can help people with type 2 diabetes make better decisions about their care and stick to their treatment plans. About 250 adults will be split into two groups: one where …

This early-stage study tests a new drug called LY4057996 in 124 healthy volunteers and people with type 1 or type 2 diabetes. The main goal is to see if the drug is safe and what side effects it may cause. Participants receive the drug as a shot under the skin or into a vein, and…

This study tests whether semaglutide, a drug used for diabetes, can help people with type 2 diabetes quit smoking when used with nicotine replacement therapy. About 100 adults in Ontario who smoke at least 5 cigarettes daily will participate. The main goal is to see if a larger s…

This study tests whether a short writing exercise, called self-affirmation, can help adults with type 2 diabetes feel less judged and more motivated to manage their health. About 150 participants will do the exercise before their regular checkups over a year. Researchers will tra…

This study tests whether a spinal cord stimulator can reduce severe leg pain in people with type 2 diabetes and peripheral artery disease. Fifteen adults who already have a permanent stimulator will receive two weeks of active stimulation and two weeks of a sham (inactive) treatm…

This study tests whether regular heat sessions at home can improve blood sugar control and blood vessel health in adults with type 2 diabetes. Over 12 weeks, 44 participants will use heat therapy and be monitored for changes in key markers like HbA1c and insulin resistance. The g…

This study tests whether a 12-week low-calorie diet can improve heart function and exercise ability in people with heart failure with preserved ejection fraction (HFpEF), obesity, and type 2 diabetes. About 63 adults will be randomly assigned to either the diet or standard care. …

This study looks at how social needs like food, housing, or transportation affect self-care and health in African American adults with diabetic kidney disease. Researchers will talk to 330 participants to understand barriers and then design a culturally tailored program to improv…

This study looks at how common memory problems are in people aged 65 and older with type 2 diabetes. It also tests whether a program that combines healthy habits, exercise, and mental activities can help prevent or slow down memory decline. The study involves 420 participants and…

This study looks at how Semaglutide, a drug that helps with weight loss and blood sugar control, affects the fat stored inside the heart and leg muscles of people with type 2 diabetes. Researchers will use special MRI scans to measure these fat changes in 60 adults aged 20-75 who…

This study follows 100 people with type 2 diabetes who have moderate to severe diabetic retinopathy, a condition that can lead to blindness. Researchers will use advanced eye scans and tests over two years to track tiny changes in blood vessels and retinal layers. The goal is to …

This study looks at kidney tissue from adults with diabetic kidney disease who are already having a biopsy or surgery. Researchers want to understand how SGLT2 inhibitors, a common diabetes medicine, change the kidney's molecular patterns. Participants donate a tissue slide, bloo…

This study looks at how a natural gut hormone called GIP affects bone breakdown and formation. Researchers will give 12 healthy adults GIP in two different ways—intermittent (8 hours daily) and continuous (24 hours daily)—for three days each. They will measure bone markers in blo…

This study is testing whether artificial intelligence can predict if someone will develop one of five common diseases: diabetes, heart disease, breast cancer, back pain, or arthritis. Researchers will collect health data from 1,000 adults aged 30 to 60, including medical records,…

This study aims to find new biological factors that lead to type 2 diabetes in people with severe obesity. Researchers will collect tissue samples (fat, muscle, liver, blood) during planned weight-loss surgery from 270 participants. They will compare three groups: those with diab…

This study looks at medical records of 400 adults aged 40-70 in Southeast Asia who were recently diagnosed with type 2 diabetes. The goal is to understand their heart disease risk factors, like blood pressure and cholesterol, at the time of diagnosis and during the first year. No…

This study from Stanford University aims to understand why people's blood sugar levels respond differently to the same foods. Researchers will use continuous glucose monitors (CGMs) in 100 healthy adults, people with prediabetes, and those with type 2 diabetes to track blood suga…

This study tests a new smartphone app and continuous glucose monitor for young people aged 16-24 who were diagnosed with type 2 diabetes before age 18. Participants wear a glucose monitor and Fitbit for 30 days, answer surveys about their health habits, and share feedback on the …

This study follows 1,250 adults at higher risk for pancreas cancer, including those with diabetes, pancreas cysts, or a family history. Researchers collect blood samples every six months to look for early markers of the disease. The goal is to make pancreas cancer easier to detec…

This study follows 600 adults with type 2 diabetes who do not yet have heart failure or dementia. Researchers will track their heart health, memory, and thinking skills over time. The goal is to find early warning signs so doctors can create personalized plans to prevent serious …

This study looks at why adults with diabetes find it hard to take their medicines as prescribed. Researchers will survey 220 patients to understand barriers like cost, family support, and communication with doctors. The goal is to find ways to help patients stick to their treatme…

This study aims to understand why some people are more likely to develop type 2 diabetes based on their genes. Researchers will compare how the body handles sugar and insulin in people with high versus low genetic risk. Participants are healthy volunteers aged 10 to 70 who have n…

This study looks at ways to help women aged 18-44 with type 2 diabetes learn more about their condition and how to manage it before getting pregnant. Researchers will compare two approaches to see which one improves blood sugar control and knowledge about reproductive risks. The …

This study looks at how bariatric surgery changes the way the body stores fat from food, which may quickly improve type 2 diabetes and heart health. Researchers will compare 40 people who have the surgery—some with diabetes and some without. The goal is to find out if better fat …

This study looks at how inflammation from conditions like type 2 diabetes, irritable bowel syndrome, and end-stage kidney disease might change the way the body processes certain drugs. Researchers will collect blood samples from 150 adults and children to measure inflammation mar…

This study looks at how well different forms and doses of aspirin work in people with type 2 diabetes. About 30 participants will first take a standard coated aspirin for a week. Those whose blood doesn't respond well will then try three other aspirin regimens to find which works…

This study follows 2,000 adults with type 2 diabetes to see how their eating habits, body composition, and grip strength change over time. Participants will have basic health checks like height, weight, and strength tests. The goal is to learn more about the disease, not to test …

This study is testing whether a smartphone app called Fabla-diabetesMM, which lets people record audio diaries, is easy and helpful for older adults with type 1 or 2 diabetes who also have other health conditions. Thirty participants will use the app and answer questions about th…