CORONARY ARTERY DISEASE

This study compares a new AI-driven method to the standard invasive method for deciding which heart arteries need stents. About 2100 adults with coronary artery disease will be randomly assigned to one of the two approaches. The goal is to see if the AI method is just as safe and…

This study tests a special balloon coated with medicine (Prevail DCB) to open blocked heart arteries. It is for people with coronary artery disease who have had a stent that narrowed again or have small artery blockages. The balloon delivers drug to prevent re-blockage without le…

This study compares two blood thinner combinations—aspirin plus prasugrel versus aspirin plus clopidogrel—in 3,500 adults with complex coronary artery disease who are getting stents. The goal is to see which combo better prevents major heart events like death, heart attack, or st…

This study tests whether ziltivekimab, an anti-inflammatory drug, can reduce fatty plaque buildup in the arteries of people who recently had a heart attack. About 332 participants will receive either ziltivekimab or a placebo, alongside standard care, for 15 months. Special imagi…

This study tests whether a drug-coated balloon can reduce fatty deposits in heart artery plaques more than standard medications alone. About 400 adults with acute coronary syndrome will be randomly assigned to receive either the balloon treatment during a planned heart procedure …

This study looks at two ways to reduce bleeding risk in people with coronary artery disease who have had a stent placed. Both methods involve changing their blood thinner medications. The goal is to see which approach works better at preventing blood clots while lowering the chan…

This study tests whether the drug colchicine, combined with a special surgical technique, can prevent atrial fibrillation (a type of irregular heartbeat) after coronary artery bypass surgery. Researchers will compare 70 patients receiving colchicine and the new technique to 70 pa…

This study tests whether a moderate-dose statin combined with ezetimibe works as well as a high-dose statin alone to stabilize fatty plaques in heart arteries. About 408 adults with coronary artery disease will receive one of the two treatments for 52 weeks. The goal is to see wh…

This study compares a new type of heart stent (XIENCE Skypoint) to other stents used to open blocked arteries in people with coronary artery disease. About 2000 adults receiving the new stent will be followed for 12 months to see if it reduces the risk of death, heart attack, or …

This study compares two procedures to treat hardened calcium deposits in heart arteries. 120 adults with severe coronary calcium will be randomly assigned to receive either a combination of two plaque-breaking techniques or one alone. The goal is to see which approach leads to be…

This study tests whether a lower dose of the blood thinner ticagrelor works better than the standard clopidogrel in stable heart disease patients who are at high risk of a heart attack during a stent procedure. About 50 adults will be enrolled and their blood's ability to clot wi…

This study looks at whether berberine, a natural compound, can help prevent blood clots in people who have had a heart stent placed. About 64 adults who are already taking aspirin and clopidogrel will receive different doses of berberine or continue their usual care. The goal is …

This study tests whether an inhaled medication called Aroxxen can protect the heart from injury during and after a common procedure to open blocked arteries (stent placement). About 180 adults with coronary artery disease will receive either Aroxxen or standard care. Researchers …

This study looks at people who have chest pain but no major blockages in their heart arteries. Researchers want to see if using an extra test during a heart catheterization can help doctors choose the right medicines to reduce pain and improve daily life. About 1,500 adults will …

This study looks at two common ways to restore blood flow to the heart in minority patients with blocked arteries: stenting (a less invasive procedure) and bypass surgery (open-heart surgery). Researchers want to see which approach leads to better survival and quality of life. Ab…

This study tests whether giving elderly patients with kidney disease a personalized amount of fluids, guided by a lung water monitor, can prevent acute kidney injury after a heart procedure called coronary angiography. About 320 participants aged 60 and older with chronic kidney …

This study looks at 2,000 people with chest pain and moderate coronary artery blockages seen on a CT scan. It compares an invasive approach (like stenting) with a non-invasive approach (medication and lifestyle changes) to see which leads to fewer heart attacks, deaths, or unplan…

This study compares a new dissolvable heart stent (Firesorb) to a standard metal stent in 2000 people with coronary artery disease. The dissolvable stent is designed to support the artery temporarily and then disappear, potentially reducing long-term risks. The goal is to see if …

This study looks at two ways to deliver cardiac rehabilitation—a program of exercise, education, and counseling for people with heart conditions. Some patients attend sessions in person, while others do them from home via telehealth. Researchers want to see if both methods are eq…

This study tests a device called Bioboosti that uses pulsed electromagnetic waves to see if it can improve blood flow to the heart in people with coronary artery disease. About 120 adults with known heart ischemia who cannot have standard procedures will receive the therapy. Rese…

This study tests a special balloon coated with medicine to open completely blocked heart arteries in 30 people with coronary artery disease. The balloon is used instead of a permanent stent. Doctors will use ultrasound and pressure measurements right after the procedure and again…

This study tests a new balloon device (Virtue SAB) that delivers a drug to prevent re-narrowing of heart arteries that have been previously stented. About 740 adults with one blocked stent will be randomly assigned to get either the new balloon or a standard drug-coated balloon. …

This study looks at whether a 12-week exercise program can improve artery health and reduce inflammation in people with coronary artery disease. Fifty patients aged 40-70 will exercise three times a week, and researchers will measure changes in artery thickness, blood vessel func…

This study tests a new way to treat a common heart problem where a stent (a small mesh tube) inside an artery becomes blocked again. It compares a shockwave-like technique called intravascular lithotripsy (IVL) with standard high-pressure balloons to reopen the stent. About 80 ad…

This study tests whether using just one blood thinner (single antiplatelet therapy) is safer and as effective as two blood thinners (dual antiplatelet therapy) in older adults or those at high risk of bleeding who have had a heart procedure with a drug-coated balloon. About 576 p…

This study is checking how safe and effective a device called Sequent Please Neo is for people with blocked heart arteries. About 2,000 patients who already got the device as part of their normal care will be followed. The main goal is to see how many have major heart problems li…

This study compares two types of drug-coated balloons used to open blocked heart arteries of medium-small size. About 140 adults with stable angina or stabilized heart attack symptoms will receive either a sirolimus-coated balloon or a paclitaxel-coated balloon. The main goal is …

This study tests a new ultrathin stent coated with a drug that slowly releases medication to keep arteries open. It is for 500 heart disease patients who also take blood thinners, which raises their bleeding risk. The stent uses a material that dissolves over time, allowing patie…

This study looks at whether it is safer to keep taking or temporarily stop blood thinners (DOACs) in people with atrial fibrillation and heart disease who need a heart procedure like angiography or stenting. About 1,270 adults will be randomly assigned to either continue or pause…

This study compares two strategies for deciding which narrowed heart arteries to treat with stents in high-risk patients. One strategy uses detailed imaging to look at plaque buildup and vulnerability, while the other uses blood flow measurements to find blockages that limit flow…

This study compares two methods—standard angiography and a more detailed pressure wire test (FFR)—to guide stent placement in people with severe narrowing of the left main heart artery. About 960 adults with chest pain or evidence of heart muscle strain will be randomly assigned …

This study tests a new type of heart stent made from magnesium that dissolves over time. It is designed for people with long blockages in their coronary arteries. The goal is to see if it is safe and effective at keeping arteries open and reducing heart-related problems. About 10…

This study looks at 600 women with coronary artery disease to compare two ways to restore blood flow to the heart: stenting (a less invasive procedure) and bypass surgery (an open-heart operation). The goal is to see which approach leads to better survival and quality of life. Pa…

This study is tracking 50,000 people with coronary artery disease who receive drug-eluting stents during routine care. The goal is to see how well these stents work and how safe they are in everyday practice. Researchers will monitor major heart problems like death, heart attack,…

This study tests whether adding a custom Chinese herbal medicine called Yiyang Huoluo Decoction to standard heart medications can improve symptoms and blood vessel health in older adults with coronary heart disease and atherosclerosis. Thirty participants aged 50–75 will be split…

This study tests whether a personalized risk score can help doctors decide how long patients should take two blood thinners after getting a heart stent. About 2,788 adults who had a stent placed will be assigned to either standard care or a tailored plan based on the algorithm. T…

This study tests a temporary heart pump called iVAC 2L in 100 people with severe coronary artery disease who need high-risk angioplasty. The pump helps keep blood flowing during the procedure, which may reduce the risk of death, heart attack, or stroke. The goal is to see if the …

This study compares two imaging methods to guide stent placement in people with hardened heart arteries. About 700 adults with heart disease will be randomly assigned to receive either a CT scan or the usual ultrasound-guided procedure. The goal is to see if CT guidance leads to …

This study looks at how well two types of heart stents (Synergy XD and Synergy Megatron) work in routine medical care for people with narrowed heart arteries. About 2000 adults receiving these stents will be followed to track rates of death, heart attack, or need for repeat proce…

This study aims to see if using tiny cameras inside the heart's arteries during stent placement leads to better outcomes for people with complex coronary artery disease. About 11,000 adults in the Netherlands who need a stent for a complicated blockage will be included. The goal …

This study compares a new temporary heart pump (Supira System) to a standard pump (Impella) in 358 people undergoing high-risk angioplasty. The goal is to see if the new pump is safer and just as effective at supporting the heart during the procedure. Participants must be stable …

This study tests whether a personalized antiplatelet therapy plan (shorter dual therapy followed by a single drug) is safer and just as effective as the standard approach for people with coronary artery disease who have received a stent guided by imaging. About 3,944 participants…

This study compares a new shockwave technique to standard balloon or cutting methods for treating severely hardened heart arteries. About 666 adults with coronary artery disease will take part. The goal is to see which approach is safer, more effective, and more cost-efficient fo…

This study compares two common heart procedures—bypass surgery (CABG) and stenting (PCI)—in 358 people with weak hearts (low pumping ability) and multiple blocked arteries. The goal is to see which approach leads to better survival, fewer heart problems, and improved quality of l…

This study looks at whether using two or more artery grafts during heart bypass surgery is better than using just one. Researchers want to see if multiple grafts lower the risk of death, stroke, heart attack, or needing another procedure. About 4,300 adults with coronary artery d…

This study tests whether adding evolocumab, a powerful cholesterol-lowering drug, to standard treatment can slow or stop the buildup of fatty plaque in heart arteries after a heart attack. About 233 adults aged 40-75 who recently had a heart attack and received a stent will be ra…

This study compares two types of heart bypass surgery in 2,300 women: using one artery (single arterial grafting) versus multiple arteries (multiple arterial grafting) to reroute blood around blocked heart vessels. The goal is to see which approach reduces the risk of heart attac…

This study tests a new, longer drug-coated stent (Orsiro Mission) for people with long blockages in their heart arteries. About 150 adults will receive the stent and be followed for up to 5 years to see if it safely keeps the artery open and reduces the risk of heart attacks or t…

This study is testing a special drug-coated stent (Supraflex) in 10,000 people with coronary artery disease who need a stent to open blocked heart arteries. The goal is to see if the stent is safe and works well in everyday medical practice. Participants will be followed to track…

This study compares two common heart procedures—bypass surgery (CABG) and stenting (PCI)—in 754 people with severe coronary artery disease and a weak heart pump. The goal is to see which approach better prevents death, stroke, heart attacks, or repeat procedures over 5 years. Par…

This study tests if a newer, gentler heart-lung machine (MiECC) causes fewer serious problems after heart surgery than the standard machine. About 1,300 adults having planned heart surgery will be randomly assigned to one of the two machines. The goal is to see if the newer machi…

This study looks at two ways to open completely blocked heart arteries: a drug-coated balloon and a drug-coated stent. About 200 adults with chronic total occlusion will be randomly assigned to one treatment. The goal is to see which method keeps the artery open longer and reduce…

This study tests whether indobufen (a newer blood thinner) works better and causes fewer bleeding problems than aspirin in people over 65 who have had a heart attack or unstable angina and received a stent. About 2,800 participants will take either indobufen plus ticagrelor or as…

This study tests whether adding a powerful cholesterol-lowering drug (PCSK9 inhibitor) to standard treatment can reduce heart attacks, strokes, and death in people with high-risk coronary plaques detected by CT scans. About 3,600 adults with at least one severely narrowed or high…

This study compares two types of drug-coated stents (small mesh tubes placed in heart arteries) in 2,100 people who have had a heart attack or unstable chest pain. The goal is to see which stent better prevents future heart problems, like heart attacks or the need for another pro…

This registry is following over 1,100 people with coronary artery disease who receive resorbable magnesium scaffolds to open blocked arteries. The goal is to see how well these temporary scaffolds work and if they are safe in everyday medical practice. Researchers will track hear…

This study tests a special tube (CardioGard Embolic Protection Cannula) used during high-risk heart valve surgery to catch debris and reduce the risk of stroke, kidney injury, and confusion after surgery. About 842 older adults (age 60+) having valve surgery will be randomly assi…

This study compares two methods to treat hardened (calcified) blockages in heart arteries that branch. About 200 adults will be randomly assigned to either standard balloon treatment or a special device called orbital atherectomy before getting a stent. The goal is to see which a…

This study compares two ways to treat blocked heart arteries: a drug-coated balloon (DCB) and a drug-eluting stent (DES). About 256 adults with at least one severely blocked artery will be enrolled. Researchers will use ultrasound to measure how much the artery narrows again afte…

This study compares two newer diabetes drugs, semaglutide and dapagliflozin, against the standard drug metformin in 300 adults with prediabetes and heart artery disease. The goal is to see which drug best slows or reverses plaque buildup in heart arteries over 24 months. Particip…

This study looks at using a drug-coated balloon to open small heart arteries in people with coronary artery disease who also have a high risk of bleeding. The goal is to see if the balloon works well and if patients can safely take blood thinners for only 7 days instead of longer…

This study tests a program to help low-income people with chronic conditions like diabetes and heart disease take their medications after leaving the hospital. The program provides free medications, delivers them to the bedside and home, and offers coaching to overcome barriers l…

This study compares a new stomach acid drug (tegoprazan) to a standard one (rabeprazole) in about 3,320 heart patients who take blood thinners and are at high risk for stomach bleeding or ulcers. The goal is to see if the new drug works as well as the standard one to prevent seri…

This study tests whether a drug-coated balloon or a drug-coated stent works better for treating hardened calcium deposits in heart arteries after using shockwave therapy to break them up. About 128 adults with coronary artery disease will be randomly assigned to one of the two tr…

This study looks at how well a drug-coated balloon works over time for people with coronary artery disease. Researchers will track 1,500 adults who receive this balloon treatment during angioplasty to see if it reduces the risk of death, heart attack, or the need for another proc…

This study tests whether dapagliflozin, a common diabetes medication, can slow or reverse plaque buildup in the heart arteries of people with type 2 diabetes. About 144 adults with stable heart disease will receive either the drug plus standard care or standard care alone for 18 …

This study tests whether colchicine, a safe anti-inflammatory drug used for centuries, can lower the risk of heart attack, stroke, or death in 700 heart disease patients undergoing major surgery. Participants have had prior heart procedures or significant artery blockages. The go…

This study compares two treatments for coronary artery disease in large heart arteries: a drug-coated balloon and a drug-eluting stent. About 94 adults with blocked arteries will be randomly assigned to one treatment. The main goal is to see how well the artery can relax and cont…

This study tests whether a combination of high-intensity statin and low-dose colchicine can slow or change the buildup of fatty plaque in the heart arteries of people with a high genetic risk for heart disease. Participants, aged 40-75, have early plaque but no symptoms. The goal…

This study tests whether a comprehensive treatment can reduce serious heart events in people with rapidly-progressive coronary artery disease driven by inflammation. Researchers will compare each participant's outcomes before and after treatment. The study enrolls 39 adults who h…

This study tests if a drug-coated balloon is better than a drug-coated stent for treating complex blockages in heart arteries. About 520 adults with coronary artery disease will be randomly assigned to one of the two treatments. The main goal is to see which approach reduces the …

This study compares two ways to treat long or widespread blockages in the heart's arteries. One method uses a temporary, dissolving scaffold plus drug-coated balloons, while the other uses permanent metal stents. The goal is to see if the newer, metal-free approach works as well …

This study is checking how safe and effective the Essential Pro device is for people with blocked heart arteries. About 100 patients who already received the device as part of their normal care will be followed. The main goal is to see if the device helps prevent serious heart pr…

This study tests if a new, easier-to-use pressure microcatheter works as well as the standard pressure wire for guiding treatment of narrowed heart arteries. About 2500 adults with stable coronary artery disease or recent non-emergency heart attack will be randomly assigned to on…

This study looks at whether a class of drugs called SGLT2 inhibitors can prevent acute kidney injury caused by contrast dye used during heart procedures like angiography or stenting. Researchers will analyze data from 4000 adults with coronary artery disease to see if those takin…

This study tests whether drug-coated balloons work as well as drug-eluting stents for people with blocked heart arteries at a fork (bifurcation). About 321 adults with stable or unstable heart disease will be randomly assigned to one of three treatments. The goal is to see which …

This study tests a special balloon coated with medicine to treat narrowed small arteries in the heart. About 960 adults with coronary artery disease will receive either this balloon or standard treatment. The goal is to see if the balloon safely opens the artery and reduces the n…

This study tests a new medicine called YN001 given through a vein to people with coronary atherosclerosis (plaque buildup in heart arteries). About 24 adults in Australia with at least one blocked artery will receive YN001 on top of standard care. Researchers will use CT scans to…

This study compares two blood thinners, prasugrel and ticagrelor, when taken alone after a heart stent procedure. It involves 48 adults with coronary artery disease who have been on dual therapy for at least 90 days. The goal is to see which single drug better prevents blood clot…

This pilot study tests whether canagliflozin, a diabetes medication, can reduce inflammation in the arteries of people with type 2 diabetes and stable coronary artery disease. About 16 participants will receive either the drug or a placebo for 6 months. The main goal is to measur…

This study looks at how well and how safely a special scaffold works to open blocked heart arteries in people with coronary artery disease. Over 1,100 adults who need at least one scaffold implant will be followed for at least a year. The goal is to track heart-related events lik…

This study tests whether a home monitoring program using text messages and a smartphone app can help people who just had a stent placed in their heart artery. About 200 patients will either get standard care or extra digital support, including blood pressure checks and health coa…

This study tests whether the blood thinner clopidogrel can prevent major heart problems like heart attacks and strokes in people who have early, non-blocking plaque in their heart arteries found on scans. About 11,000 adults aged 40 and older with this hidden condition will take …

This early-phase trial tests whether a drug called meplazumab can reduce inflammation and fatty buildup in the arteries of people with coronary artery disease. About 18 adults with stable chest pain and signs of artery inflammation will receive the drug or a placebo for several m…

This study tests whether giving the blood thinner cangrelor during a minimally invasive heart bypass procedure (MIDCAB) is safe and helps prevent blood clots. About 30 adults with coronary artery disease will receive cangrelor through a vein during surgery, and their results will…

This study tests whether a daily arm-cuff treatment (remote ischemic conditioning) plus mindfulness exercises can lower the risk of heart attacks, heart failure, and chest pain in 2,000 adults with coronary artery disease that wasn't fully fixed. Participants must have at least o…

This study is testing a long stent (a small mesh tube) to treat long blockages in the heart's arteries. The goal is to see if using one long stent is safe and works well for these difficult blockages. About 1,039 adults with coronary artery disease will take part. The main focus …

This study tests a special balloon coated with a drug (sirolimus) to open up small blood vessels in the heart that are narrowed by coronary artery disease. About 1,600 adults with chest pain or silent ischemia will be randomly assigned to receive this balloon or standard treatmen…

This study compares two strategies to reduce bleeding risk in people who take two blood thinners after having a stent placed in their heart. The goal is to see if lowering the dose of one drug works as well as switching to a different drug. About 78 adults who have had a stent wi…

This study looks for the best type and dose of a single blood thinner (P2Y12 inhibitor) for people who have had a heart stent placed. About 355 participants will try different doses to find the sweet spot that prevents blood clots without causing dangerous bleeding. The goal is t…

This study tests a new type of heart stent made from magnesium that slowly dissolves over time, compared to a permanent metal stent. The goal is to see if the dissolvable stent is safe and works as well for people with blocked heart arteries. About 1,859 adults with coronary arte…

This study is testing a medical device that uses gentle sound waves to break up hard calcium deposits inside heart arteries. The goal is to safely open severely hardened arteries so a stent can be placed more effectively. The study will enroll about 335 adults in the US with seve…

This study tests a new technology called 3DStent to see if it can accurately detect when a heart stent is not fully expanded after a procedure to open blocked arteries. Researchers will compare 3DStent results with standard ultrasound imaging in 200 adults with coronary artery di…

This study tests a new computer program that helps doctors diagnose blocked heart arteries more accurately using CT scans. The software combines several checks into one step, which may reduce the need for invasive procedures like heart catheterization. Researchers will look at pa…

This study tests whether artificial intelligence can automatically analyze ultrasound videos to detect coronary artery disease, a common heart condition. Researchers will enroll 1500 people with suspected heart disease who are already scheduled for a standard angiogram. The goal …

This study tests a new type of MRI that uses a safe, natural substance to measure how well the heart is producing energy. By looking at two simple molecules, the scan can tell which parts of the heart are still alive and working. The goal is to help doctors decide who will benefi…

This study looks at whether certain blood markers can tell if a person has significant blockages in their heart arteries, without needing a CT scan or invasive procedure. About 1000 adults with suspected coronary artery disease will have their blood tested and compared to CT scan…

This study tests the safety of a drug called regadenoson in children who need a heart stress MRI to check for reduced blood flow to the heart. The drug helps create better images during the scan. Researchers will monitor side effects and how the drug works in different age groups…

This study compares two non-invasive heart tests: a CT scan of the heart arteries and a stress ultrasound that also checks the neck arteries. The goal is to see which test better finds blockages and helps prevent heart attacks or other problems. About 2,000 people with suspected …

This study tests a new type of PET scan that uses a special form of water to see if it can accurately detect coronary artery disease. About 215 adults with suspected heart disease will receive two injections of this water tracer—one at rest and one during a stress test—and then h…

This study compares a new, personalized approach using an AI-powered CT scan to analyze plaque in the heart arteries against the usual care for people with suspected heart disease. The goal is to see if this method improves diagnostic accuracy, helps control risk factors like cho…

This study tests whether artificial intelligence (AI) can detect early signs of coronary artery disease (blocked heart arteries) using standard chest CT scans that don't require contrast dye. Researchers will analyze scans from about 1,600 people to see if the AI can accurately i…

This study looks at whether a new imaging technique called µQFR can accurately detect blocked blood flow in side branches of heart arteries after a single stent is placed. About 290 adults with coronary artery disease and complex artery branch points will be enrolled. The goal is…

This study tests whether taking Coenzyme Q10 and Glutathione before and after heart surgery can prevent acute kidney injury, a common complication. About 242 adults undergoing planned heart surgery with a heart-lung machine will receive either the supplements or a placebo. The go…

This study looks at whether a risk-based plan can prevent coronary artery disease in people who survived cancer. It includes 748 cancer survivors aged 40-70 who had chemotherapy or radiation more than 5 years ago. Researchers will assess heart disease risk and offer prevention st…

This study looks at 600 people who recently had a major heart attack and have multiple narrowed arteries. Doctors want to see if placing stents in unstable-looking plaques (that aren't severely blocking blood flow) plus standard medications is better than medications alone at pre…

This study tests whether an artificial intelligence (AI) tool can help doctors spot calcium buildup in the heart arteries from chest CT scans done for other reasons. The goal is to start or increase cholesterol-lowering medicine in people aged 40–75 who have no prior heart diseas…

This study tests whether placing stents in narrowed heart arteries improves quality of life for people with heart failure with preserved ejection fraction (HFpEF), a condition where the heart muscle is stiff. About 350 participants will be randomly assigned to receive either a re…

This study compares two breathing exercises—segmental breathing and active cycle breathing—to see which one better helps patients recover after open heart surgery. About 99 adults will be randomly assigned to one of these techniques or standard care. The goal is to improve oxygen…

This study tests whether a special camera inside the arteries (OCT) can help doctors place stents more precisely in people with stable angina. If the stent is perfectly placed, patients may be able to take blood thinners for a shorter time, lowering their risk of bleeding. About …

This study tests whether giving a numbing medicine (ropivacaine) through chest tubes after heart surgery helps patients recover better and feel less pain. About 116 adults having planned heart surgery will receive either the medicine or a placebo. The main goal is to see if this …

This study tests whether watching a short educational video before a planned heart procedure (called PCI) can help lower anxiety. About 144 adults will take part, with some watching the video and others receiving usual care. Anxiety levels are measured before and after using a st…

This study tests if a special thinner tube (6-French Glidesheath Slender) can make heart procedures safer and more effective for people with small blood vessels. About 594 adults with coronary artery disease will be randomly assigned to receive the procedure through a small wrist…

This study looks at 570 people with chronic coronary syndrome who have chest pain. They will get a special heart scan (PET scan) to check blood flow. Those with abnormal results are randomly assigned to either immediate heart catheterization or standard medication. The goal is to…

This study looks at 54 adults with coronary artery disease to see which of four treadmill tests best measures how much oxygen their bodies use during exercise. Researchers want to know if the best test differs between women and men. The goal is to improve exercise testing for peo…

This study follows 80 adults who had heart bypass surgery to see how developing pneumonia in the hospital affects their heart and lung health over the next year. Researchers will compare those who get pneumonia with those who don't, using blood tests, heart and lung function test…

This study looks at why some ICU patients bleed longer after a tube is removed from their leg artery following heart procedures. Researchers will track 157 adults to find factors that predict bleeding time and the need to lie flat for hours. The goal is to create a tool that help…

This study will test a new, high-speed CT scanner to see if it can measure heart artery plaque stiffness and blood flow without invasive procedures. About 500 adults with suspected or known coronary artery disease will get this scan, and results will be compared with standard tes…

This study looks at whether telling people they have a high genetic risk for heart disease motivates them to improve their heart health. Researchers will track 200 adults aged 40 to 75 who have a high genetic risk but no current heart disease. Half will learn their genetic risk a…

This study looks at why heart disease affects women differently than men, especially after menopause. Researchers will measure inflammation and hormone levels in 6,000 women with chest pain. The goal is to understand how hormones like estrogen influence heart disease risk and out…

This study looks at how a low dose of interleukin-2 (ld-IL-2) affects certain immune cells called regulatory T cells in heart tissue after a heart attack. Researchers will compare these cells in patients who receive ld-IL-2 versus those who do not, using advanced genetic analysis…

This study compares two methods to open completely blocked heart arteries: one going forward through the blockage and one going backward. It will measure how long each method takes, how often it works, and if it causes less heart damage. The study also tracks how stressed the doc…

This study compares two imaging methods—CT scans and intravascular ultrasound—to see how well they measure plaque buildup in heart arteries. About 250 adults with stable coronary artery disease will participate. The goal is to improve diagnosis, not to test a new treatment.

This study is re-examining 1,400 adults in Stockholm who were part of a larger national health study. Researchers are using advanced imaging, blood tests, and questionnaires to find new risk factors for heart disease, COPD, liver disease, and other conditions. The goal is to bett…

This study aims to create an artificial intelligence (AI) tool that can analyze heart CT scans to find dangerous plaque buildup that might cause a heart attack. Researchers will study 4,000 people with known or suspected coronary artery disease to see if the AI can better predict…

This study looks at whether a special CT scan (FFR CT) can accurately measure blood flow in heart arteries without needing a catheter procedure. Researchers will compare the CT results with the standard invasive test in 500 adults with suspected coronary artery disease. If the CT…

This study looks at how taking several different medicines at once affects the health of older adults with chronic conditions like heart disease, diabetes, and high blood pressure. Researchers will survey 2,000 people aged 65 and older in Shaanxi Province, China, over two years. …

This study tests a new device that collects blood directly from the coronary arteries of people with heart disease. The goal is to find specific molecules that show how the disease behaves, which could lead to more personalized treatments. About 300 adults scheduled for heart pro…

This study follows 4,000 people with coronary artery disease to see how detailed images taken from inside the heart's arteries can predict future heart attacks, need for repeat procedures, or death. Participants already had the imaging done as part of their care, and researchers …

This study is for 1,200 people with coronary artery disease who are starting a cardiac rehab program. Researchers will collect detailed health data, including fitness tests, activity trackers, and long-term heart monitoring, to understand what helps patients stick to a healthy li…

This study tests if giving heart medication based on a person's specific type of tiny blood vessel problem works better than standard care. About 180 people with chest pain and clear major arteries will be randomly assigned to either personalized or usual treatment. The main goal…

This study looks at the best way to check for blocked heart arteries in people with severe aortic stenosis who need a valve replacement (TAVI). Half will get the usual invasive artery X-ray, while the other half will have a non-invasive risk assessment. The goal is to see if skip…

This study follows 25,000 people with multivessel coronary artery disease to see how different treatments—medication, surgery, or stents—affect long-term health. Researchers will track serious events like heart attacks, strokes, and death. The goal is to learn which approach work…

This study looks at 180 non-diabetic adults with early coronary artery disease to see if a simple blood test called the triglyceride-glucose (TyG) index is linked to how many heart arteries are blocked. Participants will have their TyG index measured and compared to their angiogr…

This study tests whether doing several heart scans (blood flow, ultrasound, and CT) all in one day is faster and cheaper than the usual step-by-step approach for people with possible coronary artery disease. About 500 patients from Swedish primary care centers will be followed fo…

This study looks at whether tiny plastic particles (microplastics and nanoplastics) are present in the coronary blood of people with chronic coronary syndromes, a type of heart disease. Researchers will collect blood samples from 120 adults during a routine heart catheter procedu…

This study asks 600 people—heart patients who have had a stent procedure and healthcare providers—to rank the importance of different health events like heart attack, stroke, or bleeding. The goal is to understand if patients and doctors value these events differently, so future …

This study looks at how aging cells in blood vessels may make heart artery plaques more likely to rupture, causing heart attacks. Researchers will measure markers of cell aging in 300 people with different types of chest pain or coronary artery disease. No new treatment is tested…

This study is testing a new type of MRI scan that looks at how the heart uses energy. Researchers want to see if this scan can tell how much heart muscle is still healthy in people with severe heart disease. The study involves 15 people: 6 healthy volunteers and 9 patients with h…

This study tracks 120 adults with coronary artery disease that is linked to chronic inflammation but is not rapidly worsening. Researchers will collect medical history, current treatments, and watch for major heart events like heart attacks or need for procedures. The goal is to …

This study uses advanced CT scans to see how a short course of high-dose statins changes plaque buildup in the heart arteries. Researchers will follow 140 adults with mild heart disease for 24 months, comparing those on statins to those on a placebo. The goal is to understand who…

This study explores whether singing—alone or in a group—is a practical activity for older adults with coronary artery disease. Researchers want to see if people will stick with it and if it might lower heart disease risk. The study involves 32 participants and focuses on attendan…

This study follows 1,500 people who are having heart surgery or a less invasive valve replacement. Researchers want to find out what factors before the procedure might predict serious heart problems later, like heart failure, stroke, or death. No new treatment is being tested—the…

This study looks at two ways to treat people with chronic coronary syndrome, a condition where the heart gets less blood. One group gets a special CT scan to find blockages and then may have a procedure to open them, while the other group takes medication only. The goal is to see…

This study is testing new MRI techniques to see how the heart works during stress, like exercise or fluid changes. Researchers will scan healthy people and those with heart conditions to better understand heart function. The goal is to improve diagnosis and care for heart disease…

This study looks at why some people with heart disease get worse quickly due to inflammation. Researchers will compare 20 patients with inflammation-linked rapid coronary artery disease to 10 patients with typical disease. The goal is to find patterns in their health history, lab…

This study asks 600 heart patients and their doctors which treatment they prefer for blocked arteries: a permanent metal stent or a drug-coated balloon that dissolves over time. Researchers want to understand how much extra risk people are willing to accept to avoid having a meta…

This study looks at how fatty deposits (plaque) in heart arteries develop and change over time. Researchers will use special imaging to see the plaque and analyze blood cells at a detailed level. The goal is to find patterns that could help predict heart attacks or other heart pr…

This study looks at whether images from a standard heart X-ray (angiogram) can accurately diagnose disease in the tiny blood vessels of the heart, avoiding the need for a special wire. About 192 adults with chest pain or suspected heart disease will have their angiogram images ta…

This study looks at whether using a special heart CT scan (CCTA) to monitor high-risk patients after they've had a stent placed is better than usual follow-up care. About 3,500 adults with complex heart disease will be randomly assigned to one of the two strategies. The goal is t…

This study tests if wearable devices like smartwatches and blood pressure monitors can help track recovery in people who have been in the intensive care unit (ICU). Many patients face physical and mental challenges after an ICU stay. The study will give some participants wearable…

This study looks at four simple physical tests—like timed walks and sit-to-stand exercises—to see which one best measures how well patients recover after coronary artery bypass surgery. Researchers will test 150 adults aged 30-50 on days 3 and 5 after surgery. The goal is to find…

This study follows 30,000 people diagnosed with coronary artery disease to learn which factors affect long-term survival. Researchers will track deaths from any cause and from heart-related problems. The goal is to better understand how to predict and improve outcomes for heart p…

This study is watching and recording what happens when doctors use the wrist artery (radial or ulnar) for heart or blood vessel procedures. It will track problems like artery blockage, spasm, or bleeding in up to 20,000 adults. No new treatments are tested—the goal is to learn fr…

This study looks back at 5,000 adults who had heart or blood vessel surgery at UC Davis Medical Center. Researchers want to find out what factors affect recovery and survival after surgery. The goal is to learn how to improve care and reduce risks for future patients.

This study is a registry that collects information on the safety and effectiveness of Medtronic medical devices already on the market. It will include up to 100,000 people who have or will receive a Medtronic product. The goal is to monitor real-world performance and improve pati…

This study follows about 20,000 people with coronary artery disease who had a procedure to open blocked heart arteries guided by a special measurement called FFR. Researchers will track their health for two years to see how well the treated arteries hold up and what problems may …

This study looks at whether a special score, based on genetics and other factors, can identify which patients with stable coronary artery disease are at higher risk for a heart attack or heart injury during a planned stent procedure (PCI). The researchers will enroll 500 people a…

This study watches 130 adults having planned heart bypass surgery to see if giving back leftover blood from the heart-lung machine (using a saltwater "chase") lowers the need for donor blood transfusions in the first day after surgery. Researchers compare patients who get this bl…

This study looks at how calcium deposits in artery walls affect the healing of a heart stent after one month. About 40 people with coronary artery disease who need a stent will be enrolled. Doctors will use a special camera to compare stent healing over calcium spots versus areas…

This study follows 10,000 people with a severe blockage in the left main coronary artery to see how different treatments—medication, stents, or bypass surgery—work over many years in everyday medical practice. It aims to help doctors and patients choose the best approach by compa…

This study tests an online decision aid called 'My Heart Care and CKD' for people with both chronic kidney disease and heart disease. The tool helps patients and doctors understand the risks and benefits of heart procedures like angiograms or surgery, which can be riskier for kid…

This observational study aims to understand why some people tolerate ventricular tachycardia (a fast heart rhythm) better than others. Researchers will measure blood pressure and blood flow in the heart arteries of 70 participants who are already scheduled for a heart catheter pr…

This study tests a new online survey tool that lets patients with coronary artery disease report their symptoms and quality of life before doctor visits. The results are shared with their cardiologist to improve communication and care. About 200 patients and their doctors will tr…

This study looks at 1300 adults who had a heart procedure (PCI) and are at high risk for bleeding. Researchers will use artificial intelligence to find which blood-thinning medicines work best and for how long to prevent heart attacks and strokes while avoiding dangerous bleeds. …

This study watches how drug-coated balloons change blood vessels in people with coronary artery disease. Researchers will use CT scans to measure blood flow and plaque before and after the procedure. The goal is to see how these changes relate to patient outcomes. About 165 adult…

This study looks at tiny structures inside heart cells called mitochondria, which help produce energy. Researchers want to see if problems with these structures are linked to worse heart failure outcomes. About 45 to 60 people with heart failure and blocked arteries will give sma…

This study looks at whether telling people their genetic risk for heart disease (called a polygenic risk score) helps them lower their cholesterol and improve their heart health over one year. About 500 adults aged 30-75 who are not on cholesterol medication will be randomly assi…