COGNITION

This study looks at whether eating peanuts every day can help people with prediabetes improve their blood sugar, heart health, thinking skills, and gut health. Researchers will enroll 72 adults aged 20-59 from diverse backgrounds. Participants will eat peanuts or avoid them for s…

This study looks at whether eating wild blueberries can improve heart health, thinking skills, and gut bacteria in Black and White adults aged 45-65 with high blood pressure. Participants will eat blueberries daily and have their blood pressure, artery stiffness, and cognitive fu…

This study is testing whether special reflective roof coatings can lower indoor temperatures and improve health in hot regions. About 3,200 people living in poor housing in Burkina Faso, Mexico, India, Niue, and Fiji will take part. Researchers will measure heart rate, blood suga…

This study looks at whether a freeze-dried wild blueberry powder can improve heart health, brain function, and gut bacteria in women with prediabetes. About 30 women aged 20-65 with prediabetes and overweight will take part. Researchers will measure blood sugar, blood pressure, a…

This study tests whether a safe, non-invasive brain stimulation device used at home for 6 months can improve thinking and walking in older adults (ages 65-90) who have mild memory concerns and slower walking speed, putting them at higher risk for dementia. Participants will use a…

This study tests a new exercise program for people with mild cognitive impairment, often an early sign of Alzheimer's. Participants will do exercises that combine physical and mental tasks, like walking while counting backwards, twice a week for three months. Researchers want to …

This study looks at whether eating nuts can help reduce symptoms of depression, anxiety, and stress, and improve memory and thinking skills in young adults. Researchers will enroll 135 university students aged 18 to 25 and measure changes in mood, cognitive function, and a brain-…

This study tests whether giving a daily prebiotic (a type of fiber) to 3-5 year olds with low fiber intake can improve their mood, sleep, thinking skills, and gut health. About 106 children will take either a prebiotic or a placebo for several weeks. Parents will report on their …

This study tests whether taking ETAS® daily for 12 weeks can improve memory, mood, and brain function in healthy adults aged 60 to 80 who have mild memory complaints. Participants will be randomly assigned to receive either ETAS® or a placebo, and will undergo memory tests, brain…

This study looks at whether a whey protein-enriched milk fat globule membrane supplement can improve heart and brain health after a high-fat meal. Sixteen postmenopausal women with overweight and moderate heart disease risk will attend two 8-hour visits, consuming either the supp…

This study tests whether a special type of lighting that changes throughout the day can improve sleep, daily rhythms, and well-being in frail older adults (65+) staying in the hospital. Researchers will measure changes in melatonin levels and sleep patterns. The goal is to help p…

This study tests whether a combined attention and thinking skills training program works as well when delivered via telehealth as it does in person. It includes 63 veterans with mild traumatic brain injury and PTSD who have trouble focusing. The goal is to improve their attention…

This study tests whether immersive virtual reality exercise can reduce pain, improve shoulder function, sleep, and thinking skills in people with mild to moderate frozen shoulder (grade 1-2). About 36 adults aged 18-64 who are new to physical therapy will use VR headsets to do ga…

This study tests whether a daily dietary supplement can improve memory, thinking, and emotional well-being in healthy adults aged 55 and older. Sixteen participants will take the supplement for 45 days and complete memory and mood tests at the start and end. The goal is to see if…

This study tests whether giving flumazenil before electroconvulsive therapy (ECT) can reduce memory and thinking side effects in hospitalized adults with depression. About 145 participants will either continue their usual sedative medication plus flumazenil, or stop sedatives bef…

This study tests whether a sport stacking program (fast cup stacking) can improve thinking, mood, and quality of life for people with mild dementia and their family caregivers. 144 pairs (person with dementia and caregiver) will either do the 18-week program or receive basic educ…

This study tests whether adding breathing exercises to balance training can improve thinking skills and prevent falls in healthy adults aged 65 and older. Forty participants will attend two weekly sessions for eight weeks, combining 30 minutes of balance exercises with 15 minutes…

This study looks at whether a single dose of a supplement containing American Ginseng can improve attention and brain function in healthy young adults aged 18 to 40. Participants will take the supplement and then complete memory and thinking tests over six hours, with blood sampl…

This study looks at whether taking the amino acid L-serine, alone or with strength training, can improve memory, thinking, and physical fitness in healthy adults aged 65 to 85. Over 48 weeks, participants will take either a placebo, L-serine, or L-serine plus strength training. T…

This study is testing whether a special nutrition shake given after surgery can help older adults (70+) regain physical and mental function faster. Half of the 100 participants will receive the shake daily for 30 days, while the other half will follow standard recovery advice. Th…

This study follows 874 children aged 3-5 in England to understand how using tablets and smartphones affects their thinking, learning, and health. Parents will install an app that tracks device use, while researchers measure skills like memory, language, and motor development. The…

This study is creating a large, diverse group of 1,000 older adults in Tennessee to help researchers better understand Alzheimer's disease. Participants, who may be healthy, have mild memory problems, or have Alzheimer's, will be followed yearly with tests like brain scans and bl…

This study looks at how a single dose of modafinil changes decision-making and brain activity in healthy adults. Researchers hope the results will improve understanding of psychosis spectrum disorders like schizophrenia. About 103 participants will take the drug, play computer br…

This study looks at whether low magnesium in the blood is linked to memory, word-finding, and other thinking problems after a stroke. Researchers will measure magnesium levels and thinking skills in 80 stroke patients over several weeks. The goal is to understand if magnesium def…

This study is watching 100 adults with treatment-resistant depression who are getting esketamine nasal spray as part of their regular care. Researchers want to see how well it works, who responds best, and how it affects daily life like work and social activities. They will also …

This study looks at how the antipsychotic medication haloperidol may block insulin action in the brain, which could explain why these drugs often cause weight gain and diabetes. Researchers will give healthy volunteers either haloperidol or a placebo and use brain scans to measur…

This study is testing whether a smartphone app can help firefighters improve their sleep, reduce stress, and boost thinking skills. About 50 firefighters will use the app and report how well it works. The goal is to see if the program is easy to use and helpful for real-life fire…

This pilot study tests whether shining a special near-infrared light on the head (called transcranial photobiomodulation, or tPBM) can improve blood flow and thinking in older adults. Thirty healthy volunteers aged 21-85 will receive either real or fake (sham) light sessions ever…

This study looks at how obstructive sleep apnea (OSA) affects thinking skills and empathy in children aged 3 to 12. Researchers will compare different treatments for mild OSA and track changes over one year. The goal is to understand how sleep problems impact brain development an…

This study looks at how healthy adults plan several steps ahead when making decisions. Volunteers will play a strategy game called Four-in-a-Row while researchers record their brain activity and eye movements. The goal is to understand which parts of the brain are involved in men…

This study tests whether a home-based mobile app can help 3-4 year olds who currently meet few or no daily movement, sleep, and screen-time guidelines. About 80 children will wear activity trackers, and parents will use the app for weekly lessons and goals. The goal is to see if …

This study looks at how chronic marijuana use changes brain inflammation and thinking abilities in people with HIV. Researchers will use brain scans and blood tests to measure brain health in 220 adults. The goal is to understand the effects, not to test a new treatment.

This study is for adults with depression who have recently attempted suicide. It tests a group program that teaches emotion regulation and values to improve daily functioning and prevent future suicide attempts. Researchers will also measure thinking skills, quality of life, and …