ASTHMA

This study tests a smartphone app called ASTHMAXcel Voice that helps adults with asthma track their symptoms and voice changes. About 200 English-speaking adults who use daily asthma medication will either use the app or receive usual care. The goal is to see if the app improves …

This study looks at whether giving families extra help from an asthma navigator after a child leaves the hospital can reduce asthma attacks and readmissions. About 340 children aged 4-12 who are hospitalized for asthma will take part. Half will get standard care, and half will ge…

This study tests whether using one inhaler (budesonide/formoterol) for both quick relief and daily control can reduce asthma attacks in children ages 6-18 in South Africa. About 1,038 kids with asthma will be split into two groups: one gets the single inhaler, the other gets sepa…

This study monitors the safety and effectiveness of the Enerzair inhaler in 600 adults with asthma over 24 weeks. It observes how well the drug controls asthma in everyday use, not in a controlled lab setting. The goal is to confirm the drug works safely outside of clinical trial…

This study looks at how well tezepelumab works for adults with chronic sinusitis and nasal polyps, with or without asthma. Researchers will track changes in nasal blockage and polyp size over a year. About 110 participants will be observed in real-world clinics, not in a lab.

This study is testing a mobile health program to help African American young adults (ages 18-30) better control their asthma. Participants will use a web-based app, have video meetings with an asthma nurse, receive text messages, and track physical activity. The goal is to see if…

This study enrolls 20 adults with moderate to severe asthma that is not well controlled. Participants will try two different triple-combination inhalers (Trimbow and Trelegy) in a crossover design to see which one improves lung ventilation more, using advanced MRI scans. The goal…

This study tests whether a triple-combination inhaler (FF/UMEC/VI) improves lung function more than a standard dual-combination inhaler (FF/VI) in teens aged 12–17 with asthma that is not well controlled by their current medication. About 292 participants will use the inhalers da…

This study tests a new inhaled drug called LQ036 for people whose asthma is not well controlled despite using standard inhalers. About 216 participants aged 12 to 75 will inhale the drug or a placebo daily for 24 weeks. The main goal is to see if LQ036 improves lung function and …

This study tests an experimental medicine called PF-07275315 for adults with moderate-to-severe asthma that is not well controlled by current treatments. About 252 participants will receive either the study drug or a placebo as injections over 12 weeks. The goal is to see if the …

This study tests an experimental oral medication, ENV-294, in 50 adults with moderate-to-severe asthma who already use standard inhalers. Participants take either the drug or a placebo once daily for 12 weeks. The goal is to see if the drug is safe and helps control asthma better…

This study compares a new asthma inhaler that uses a more environmentally friendly propellant to the current version. Researchers want to confirm both work equally well for people with mild to moderate asthma. About 780 adults will participate in this phase 2 trial.

This study tests whether an educational program called Asthma School can help adults with asthma better control their disease. Researchers will compare the number of asthma attacks, emergency room visits, and hospital stays over 12 months between those who attend the school and t…

This study tests a new drug called 610 in 480 Chinese adults with severe eosinophilic asthma. The goal is to see if it reduces the number of serious asthma attacks over one year. Participants will receive either the drug or a placebo, and researchers will track side effects and h…

This study tests a medicine called dupilumab in children aged 2 to under 6 years who have asthma or severe wheezing that is not well controlled with current treatments. The goal is to see if it can reduce serious asthma attacks and improve breathing over a year. About 90 children…

This study is testing whether adding an extra medication called glycopyrronium to standard asthma treatment can improve lung function in children aged 4 to under 12. About 69 children with asthma will receive two different doses of the drug or a placebo, in addition to their usua…

This study tests whether adults with sudden illnesses like infections, heart failure, or COPD can be safely treated at home instead of in a hospital. Researchers will compare costs, safety, and patient satisfaction between home and hospital care. The goal is to see if home treatm…

This study tests an investigational drug called tezepelumab in children aged 5 to 11 with severe asthma that is not well controlled by current treatments. The goal is to see if the drug can reduce serious asthma attacks and improve lung function. About 231 children will receive e…

This study tests whether escitalopram, an antidepressant, can reduce severe asthma attacks in adults with moderate to severe asthma who have had at least three flare-ups in the past year. Participants will take either escitalopram or a placebo for several months, and researchers …

This study tests whether a new inhaler (QMF149) works better than a standard one (budesonide) for children aged 6 to 12 with asthma. About 200 children will try each treatment for 12 weeks, and researchers will measure lung function and symptom control. The goal is to see if the …

This study tests two doses of an inhaled drug called glycopyrronium in 42 children aged 6 to 12 with moderate to severe asthma. The goal is to see how well it opens the airways and how safe it is compared to a placebo. Results will help develop a future combination inhaler for ch…

This study watches 200 adults with uncontrolled asthma who are already prescribed a triple inhaler (Trimbow). Researchers track symptom scores and medication adherence over 6 months to see how well the treatment works outside of a controlled trial. The goal is to understand real-…

This study looks at whether placing a temporary balloon in the stomach, along with diet and exercise, can improve asthma control in obese adults whose asthma is not well managed by inhalers. About 84 participants will be randomly assigned to get the balloon plus lifestyle changes…

This study tests an investigational drug called depemokimab in 150 adults with asthma that involves high levels of eosinophils (a type of white blood cell). The goal is to see if the drug can reduce mucus plugs and airway thickening in the lungs over 26 to 52 weeks. Participants …

This study tests a new drug called brenipatide in adults with moderate-to-severe asthma that is not well controlled by current treatments. About 531 participants will receive either brenipatide or a placebo for 52 weeks to see if it reduces asthma attacks and improves breathing. …

This study tests whether a combination inhaler (budesonide/albuterol) works better than a standard albuterol inhaler for teens aged 12 to 18 with asthma. About 440 participants will use the inhaler only when needed for 52 weeks. The goal is to see if the combo reduces the number …

This study looks at whether giving people with asthma a specific rescue inhaler (Airsupra) right in the emergency department can prevent future asthma attacks and improve control over the next 3 months. About 1,860 adults aged 18 to 55 who are being sent home from the ER with ste…

This study tests a program called BREATHE that helps Black adults with uncontrolled asthma work with their doctor to choose the best treatment. About 400 people from community health centers will take part. The goal is to see if this shared decision-making approach improves asthm…

This study compares two ways to reduce asthma attacks: using inhaled steroids as a rescue treatment (R-ICS) or taking azithromycin regularly. About 3,200 people with asthma aged 13-75 will be assigned to one or both treatments. The goal is to see which approach works best in ever…

This study tests an investigational drug called lunsekimig, given as a shot under the skin, in adults with mild-to-moderate asthma that is still hard to control. The goal is to see if adding this drug to standard treatment can reduce asthma attacks and improve breathing. About 1,…

This study tests a new medicine called SHR-1905 for people with severe asthma that is not controlled by current treatments. The goal is to see if it can reduce asthma attacks and improve lung function. About 408 adults will take part, receiving either the study drug or a placebo.…

This study tests whether semaglutide, a drug already approved for diabetes and weight loss, can improve asthma control in adults with obesity who still have symptoms despite using inhaled steroids. About 100 participants will receive either semaglutide or a placebo for up to 24 w…

This study looks at whether a smart inhaler cap and phone app can help adults with poorly controlled asthma use their inhaler correctly and take their medicine as prescribed. About 60 participants will use the smart system for one year while continuing their usual asthma treatmen…

This study tests whether metformin, a common diabetes medicine, can improve asthma control in overweight or obese adults whose asthma is not well managed by their current inhalers. About 100 participants will take metformin or a placebo for 24 weeks and have their asthma symptoms…

This study tests an investigational drug called tozorakimab in about 540 adults aged 18-75 whose asthma is not well controlled despite using medium-to-high dose inhaled steroids. Participants receive either tozorakimab or a placebo as a shot under the skin. The main goal is to se…

This study is testing whether dupilumab, an injectable medication, can improve how well the lungs clear mucus in people with moderate to severe asthma. About 30 adults will receive either dupilumab or a placebo for 12 weeks. The main goal is to see if the drug helps the lungs rem…

This study tests whether a digital inhaler (Whizz spacer) helps children aged 5-16 with asthma take their medication more consistently compared to a standard spacer. Researchers will also look for biomarkers in blood and breath to improve diagnosis and see how things like allerge…

This study looks at how well Airsupra works compared to albuterol for preventing serious asthma attacks in everyday life. Researchers will study about 4,000 people with asthma who use rescue inhalers. The goal is to see which medicine helps people have fewer severe asthma episode…

This study tests a drug called benralizumab in 200 children aged 6 to 17 with severe eosinophilic asthma that is not well controlled by current treatments. The goal is to see if the drug can reduce asthma attacks and improve daily symptoms. Participants will receive injections an…

This study tests a new inhaler (PT027) against a standard one (PT007) for Chinese adults with asthma. About 790 people who have had at least one severe asthma attack in the past year will use the inhaler as needed. The goal is to see if PT027 can delay or reduce severe asthma att…

This study tests a new inhaler that combines two common asthma medicines (fluticasone and albuterol) to see if it works better than each medicine alone or a placebo. About 724 people aged 12 and older with asthma will use the inhaler four times daily for four weeks. The goal is t…

This study is testing a device called fenoTRACK that measures a marker of lung inflammation (FeNO) in people with asthma. Researchers want to see if the device can accurately track changes in inflammation after steroid treatment in those with uncontrolled asthma, and how precise …

This study looks at whether two easy breathing tests (oscillometry and FeNO) done at a primary care clinic can correctly diagnose asthma and COPD, compared to the standard specialist evaluation. About 600 adults with symptoms like wheezing or shortness of breath will take these t…

This study aims to find people who have asthma or COPD but don't know it yet. Participants will take an online questionnaire to see if they are at risk. Those at risk will be randomly assigned to receive early diagnosis and treatment from their doctor or usual care. The goal is t…

This study looks at whether two easy, non-invasive tests—a breath test (FeNO) and a blood test—can accurately diagnose asthma in children aged 6 to 17. Currently, diagnosing asthma often requires a hospital-based breathing challenge test that is hard to access. The goal is to see…

This study tests whether a smartphone app (AWARE) can accurately detect and monitor lung diseases like asthma, COPD, and cystic fibrosis by analyzing breathing sounds. Researchers will enroll 800 people aged 8-70, including healthy volunteers and those with airway conditions. The…

This study looks at whether measuring inflammation in the breath and blood can help prioritize who gets asthma tests first. About 1,500 people aged 6 and older with suspected asthma will take a simple breath test and a blood test before their regular lung function tests. The goal…

This study is testing a small, wearable device called AeviceMD that listens to lung sounds to detect wheezing. Researchers want to see if the device can find wheezes as accurately as a doctor using a stethoscope. The study will include 160 people aged 3 and older who are having a…

This study is testing whether taking high-dose fish oil supplements during pregnancy can reduce the risk of asthma and persistent wheezing in children up to age 3. The researchers are recruiting 2,000 pregnant women in Denmark who have low blood levels of omega-3 fatty acids. Par…

This study tests whether giving pregnant women higher doses of vitamin D than currently recommended can prevent asthma and persistent wheezing in their children during the first three years of life. Researchers will enroll 2,000 pregnant women in Denmark and follow the children a…

This study compares two techniques—alternate nostril breathing and using an incentive spirometer—to see which better improves lung function in people with asthma. Researchers will measure how much air participants can exhale and their asthma control. The goal is to find a simple,…

This study is testing a serious video game designed to improve emotional well-being in teenagers aged 12 to 16, both with and without chronic conditions like type 1 diabetes, asthma, and allergies. The game uses artificial intelligence to personalize activities that build coping …

This study looks at whether using a CPAP machine at night can improve asthma control in adults with severe, hard-to-control asthma and obstructive sleep apnea. About 138 participants will use CPAP and be followed for changes in asthma symptoms and lung function. The goal is to se…

This study tests a device called the Lung Master to see if it can help people breathe better by increasing lung capacity. Researchers will measure lung function before and after one month of daily home use. The study is for adults aged 19-35 or over 65, including those with COPD …

This study looks at whether adding physical exercise to a restricted diet can improve lung function and weight in women who have both polycystic ovary syndrome (PCOS) and asthma. Researchers will measure breathing tests and body mass index in 40 obese women with these conditions.…

This study tests two types of exercise programs—energy conservation exercises and circuit training—in 32 adults with asthma. The goal is to see which approach better reduces shortness of breath, improves physical ability, and boosts quality of life. Participants will be assigned …

This early-stage study tests the safety of a new drug called AMG 691 in 124 healthy adults and people with mild-to-moderate asthma. Participants receive either the drug or a placebo to check for side effects and how the drug moves through the body. The goal is to see if the drug …

This study tests whether weekly phone calls with education, relaxation techniques, and motivational coaching can help anxious asthma patients stick to their daily inhaler medicine. About 216 adults with asthma and anxiety will be split into two groups: one gets the extra phone su…

This study tests whether a short questionnaire about asthma self-confidence can help teenagers manage their condition and improve their quality of life. About 98 teens aged 12-18 will either get a tailored doctor visit based on their answers or a standard check-up. After three mo…

This study looks at whether adding special breathing exercises (Buteyko or Pilates-style) to neck stretches can improve lung function and chest expansion in adults with well-controlled asthma who also have forward head posture. Twenty-two participants will be assigned to one of t…

This study tests an inhaled drug called ARO-RAGE in 36 adults with mild, allergen-triggered asthma. The goal is to see if it improves small airway function after breathing in an allergen. Participants will receive either the drug or a placebo and be monitored for lung function ch…

This study tests whether giving intravenous magnesium (IVMg) early to children aged 2-17 with severe asthma in the emergency room can reduce their breathing distress more than a placebo. About 192 children who still have moderate-to-severe symptoms after initial treatment will re…

This early-stage study tests the safety of a new drug called IBI3002 in adults with asthma. About 12 to 27 participants will receive either the drug or a placebo by injection over 12 weeks. The goal is to see if the drug is safe and how it behaves in the body, not yet to prove it…

This study looks at whether a new propellant (HFA-152a) in salbutamol inhalers works as well as the current one (HFA-134a) for people with mild asthma. About 84 adults aged 18-65 with mild asthma will take single doses of the inhaler and have their lung function measured. The goa…

This study tests a new education program to help adults with asthma manage their condition day-to-day. Researchers want to see if the program improves asthma control and quality of life, and if it's easy for nurses to deliver in primary care. About 40 adults with asthma will take…

This study tests a device that coaches people with COPD or asthma on proper inhaler technique. Researchers will enroll 140 adults who use specific inhalers. Participants will get training with the device or standard brief instruction, then return after 6 weeks to check their inha…

This study is observing 355 adults with asthma in China to learn more about their symptoms, treatments, and biological markers. The goal is to find different types of asthma that may need different treatments, helping doctors personalize care in the future. Participants will have…

This study looks at how the body's innate immune system—the part that causes inflammation—responds to certain environmental factors. Researchers want to understand if these responses can lead to chronic illnesses like asthma, heart disease, or cancer. Healthy volunteers aged 18 t…

This study follows 1,000 people with eczema and related allergies to learn why some get better while others don't. Researchers will collect health data and samples to find clues that predict remission. The goal is to develop better, personalized treatments for these chronic skin …

This study looks at how genes play a role in lung diseases like cystic fibrosis, asthma, and pulmonary fibrosis. Researchers will analyze DNA from up to 3,500 people with and without lung disease to find genetic differences. A small group may also get a low-dose CT scan to compar…

This study follows 400 adults aged 18–60 with moderate-to-severe asthma for up to 5 years. Researchers collect blood, urine, stool, dust, saliva, and lung samples at regular visits to see how bacteria and other environmental factors affect asthma symptoms and flare-ups. The goal …

This study aims to find out how many adults with mild-to-moderate asthma in Thailand achieve remission and what factors help. Researchers will ask participants about their symptoms, test their lung function, and take a blood sample. The study does not provide treatment but will h…

This study follows 500 adults with asthma in Hong Kong who are on strong daily medications (step 4 or 5 of GINA guidelines). Over two years, researchers will track how well their asthma is controlled and how often they have flare-ups or need hospital care. The goal is to gather l…

This study looks at whether a simple breathing test called impulse oscillometry (IOS) can help doctors monitor asthma better than standard tests. Researchers will follow 50 adults with asthma who are changing their daily medication. Participants will take breathing tests and fill…

This study looks at whether salbutamol, a common asthma medication, can improve exercise performance in non-asthmatic endurance athletes. Researchers will test if a select group of athletes with breathing limitations might benefit from the drug. The study involves 64 healthy, hig…

This study uses special lung scans to see how common asthma medications change airflow and blood flow in the lungs. Researchers will study 40 adults with asthma who already use daily inhaled steroids. The goal is to better understand how these drugs work, not to test a new treatm…

This study tracks 30 adults with asthma to see if daily changes in indoor and outdoor air pollution are linked to asthma attacks. Participants will have sensors placed in their homes to measure pollutants like fine particles and volatile organic compounds. The goal is to better u…

This study follows 6,000 children in Switzerland who have breathing issues like wheeze, cough, or asthma. Researchers collect information from doctor visits and family questionnaires to better understand these conditions. No experimental treatments are given—the goal is to learn …

This study tests whether computer-based tools in the emergency room can help doctors avoid prescribing antibiotics when they aren't needed for children with lung infections like pneumonia or bronchiolitis. About 2,800 children at three U.S. hospitals will take part. The goal is t…

This study looks at how airway inflammation from asthma might affect the brain and contribute to feelings of depression or anxiety. Researchers will monitor 50 adults with mild asthma through questionnaires, breathing tests, blood samples, and brain scans. The goal is to understa…

This study aims to better understand asthma and COPD by comparing immune and physical markers in 230 adults—both those with airway disease and healthy volunteers. Researchers will analyze blood and respiratory samples to identify distinct immune patterns. The goal is to improve k…

This study looks at 60 adults aged 35–75 with allergic or eosinophilic asthma to compare their breathing, symptoms, and frailty levels. Researchers want to see if these two asthma types differ in ways that could guide better rehabilitation. Participants will complete questionnair…

This study is testing two new types of lung MRI to see if they can better measure lung function in people with cystic fibrosis (CF) and asthma. Researchers will compare images from 30 participants (healthy volunteers and those with CF or asthma) to see if the scans can detect dif…

This study looks at how the body processes high doses of the steroid prednisolone in people with inflammatory conditions like thyroid eye disease, asthma, and vasculitis. Researchers will measure drug levels in the blood and urine to compare short-term and long-term use. The goal…

This study looks at whether tongue images and pulse wave data can help doctors better understand and monitor asthma in children. Researchers will collect these non-invasive measurements from 1,000 kids aged 5-18 during routine check-ups and compare them with standard lung functio…

This study looks at how mucus buildup in the airways affects people with asthma, COPD, and chronic cough. Researchers will use CT scans and breathing tests to compare mucus patterns in healthy volunteers and patients over two years. The goal is to find markers that help doctors c…

This study looks at why some people with asthma still have symptoms despite using inhalers. Researchers will use MRI and CT scans to see if blocked or narrow airways stop the medicine from reaching the lungs. They will test if oral medications work better for these patients. The …

This study looks at how certain cells in the airways cause inflammation in people with asthma. Researchers will expose participants to allergens like cat dander or dust mites to see which cells are recruited and how they contribute to asthma symptoms. The goal is to better unders…

This study is looking for specific chemicals (metabolites) in the blood and urine of children aged 12-17 with asthma. The goal is to find markers that could show when an asthma flare-up is happening. Participants continue their usual asthma treatment, and no new drugs are tested.

This study looks at how your genes and your environment (like pollution, diet, and lifestyle) work together to cause common diseases such as diabetes, heart disease, and asthma. Researchers will collect health information and DNA from 25,000 adults to better understand these link…

This study looks at the long-term health records of 3,500 asthma patients who took part in an earlier study. Researchers want to collect up to 10 years of medical data and a one-time questionnaire to better understand asthma risks, treatments, and how the disease changes over tim…

This study looks at cells from the airways of 24 adults—some with asthma, some without—to understand why mucus builds up in asthma. Researchers will compare gene activity in these cells using advanced sequencing. The goal is to learn more about asthma, not to test a new treatment…

This study looks at how genes are linked to different types and severities of asthma in Chinese people. Researchers will collect DNA from 2,000 asthma patients to find common genetic variations. The goal is to better understand why asthma varies so much between people, which coul…

This study looks at how asthma-related inflammation in the lungs might affect the brain and contribute to depression and anxiety. Researchers will compare brain scans, blood tests, and breathing tests between 100 adults with asthma and healthy volunteers. The goal is to understan…

This study aims to understand how two proteins, ezrin and Pip5k1α, behave in the airway muscles of people with asthma. Researchers will compare lung tissue samples from 120 adults with and without asthma. The goal is to find new targets for future asthma treatments.

This study is collecting information from 470 adults with chronic lung diseases like asthma, COPD, and cystic fibrosis, plus healthy volunteers. Researchers will analyze medical history, lung function, and lab tests to find distinct disease patterns. The goal is to better underst…

This study looks at how fungi in the environment (like mold in homes) affect people with asthma, allergic bronchopulmonary aspergillosis (ABPA), and bronchiectasis. Researchers will collect dust and sputum samples from 125 adults aged 18–80 and follow them for 6 months. The goal …

This study uses a harmless gas called hyperpolarized xenon during an MRI to take detailed pictures of lung function. Researchers will compare healthy volunteers and people with various lung diseases to see if this technique can better detect and measure lung problems. No treatmen…

This study tests a new wearable device called C-mo System that automatically detects and describes coughs. Researchers want to see if it can accurately count coughs, measure their intensity, and identify wheezing. About 300 people aged 2 and older with cough-related conditions wi…

This study follows 500 adults in Taiwan with severe asthma who are taking biologic medications. Researchers want to see how well these drugs work in everyday life, what factors predict better control, and whether switching biologics helps. The goal is to find the best treatment o…

This study looks at how tiny organisms in the airways (like bacteria and viruses) are linked to different types of asthma in adults. Researchers will collect samples from 140 adults with asthma to see which germs are present and how they relate to asthma severity and control. The…

This study looks at how the diaphragm, the main muscle used for breathing, works in people with lung diseases like asthma, COPD, fibrosis, and pulmonary hypertension. Researchers will measure diaphragm function and shortness of breath in 800 adults. The goal is to better understa…

This study will follow 2,500 people with asthma to learn more about their symptoms, treatments, and quality of life in real-world settings. Participants will complete surveys and lung function tests. The goal is to better understand how asthma affects people differently and how i…

This study looks at whether connecting youth (ages 12-25) to community programs rooted in Native Hawaiian values can improve their mental and physical health. About 100 participants from the Wai'anae area will take part in cultural activities and complete surveys over several mon…

This study is a global registry that collects health information from 500 adults with severe asthma. The goal is to track how patients respond to treatments and understand the disease better. The data will help researchers develop improved care and therapies for severe asthma.

This study looks back at medical records of 360 adults in Hong Kong with severe asthma who received biologic therapy. Researchers want to understand which biologics are used, how well they control asthma, and any side effects. The goal is to see if local practices match internati…

This study will check how many workers in an industrial zone in Thailand have asthma or COPD. About 310 adults will answer a questionnaire and take a breathing test. The goal is to find out how common these lung problems are in this group, not to test a treatment.

This study looks at the bacteria living in the airways of infants under 2 years old with severe asthma. Researchers want to understand how these bacteria differ from normal and how they relate to the immune system. The goal is to find new ways to treat severe asthma in babies. Th…