ACUTE PAIN

This study tests whether a new pain scale that considers both pain level and ability to move can better guide when to give extra painkillers after surgery. About 76 adults having scheduled surgery will be randomly assigned to receive rescue pain medication based on either the sta…

This study tests two different numbing injections for people having single-level lower back surgery. The goal is to see which injection better controls pain and reduces the need for strong painkillers after the operation. About 70 adults aged 18 to 70 will take part.

This study compares two types of nerve blocks for pain after inguinal hernia surgery. The goal is to see which block provides longer pain relief and higher patient satisfaction. Sixty adults having elective surgery will be randomly assigned to receive either an anterior iliac blo…

This study looks at whether a rectus sheath block (a type of nerve block) can improve breathing and reduce pain after major upper abdominal surgery. Researchers will measure diaphragm movement and pain scores in 60 adults. The goal is to see if this technique helps patients recov…

This study tests whether adding a special laser treatment (called photobiomodulation) to standard care (rest, ice, compression, elevation, and exercise) can reduce pain from mild to moderate ankle sprains better than a fake laser treatment. About 108 adults with ankle sprain pain…

This study tests if giving magnesium sulfate through an IV can help manage pain in adults injured and admitted to the intensive care unit. The goal is to see if magnesium can reduce the need for strong painkillers like opioids. About 156 participants will receive either magnesium…

This study tests whether watching relaxing virtual reality (VR) scenes before egg retrieval can lower pain. One hundred women having elective egg freezing will either get standard care or standard care plus a VR relaxation session. Pain levels are measured with a simple 0-10 scal…

This study looks at whether a special numbing injection called the Twin Block can reduce jaw muscle pain and the need for opioid painkillers after wisdom tooth removal. About 48 healthy adults who have jaw pain the day after their surgery will receive either the Twin Block or a p…

This study tests whether a special numbing injection (temporo-masseteric nerve block) can reduce pain after wisdom tooth removal. Twenty adults having their lower wisdom teeth taken out under sedation will receive the injection and then report their pain levels and painkiller use…

This study tests whether listening to a short mindfulness audio while waiting for an orthopedic appointment can help reduce pain. About 400 adults will be randomly assigned to either the mindfulness audio or a standard injury management audio. The goal is to see if a simple, no-d…

This study tests a single dose of an experimental painkiller (LY4515100) in 212 people who have moderate-to-severe pain after having their wisdom teeth removed. Participants will be randomly assigned to receive either the drug or a placebo, and researchers will measure pain level…

This study tests whether using virtual reality (VR) can help reduce pain for adults with sickle cell disease who are in the emergency room for a painful crisis. Thirty participants will receive standard pain care plus either VR or a control activity. Researchers will compare pain…

This study looks at whether a single session of low-level laser therapy (LLLT) can immediately affect how much pain healthy adults can handle. About 52 people will get either real or fake laser treatment, and their pain threshold and tolerance will be measured with mild electrica…

This study tests whether a focused muscle contraction exercise program can improve body composition, physical abilities, and overall well-being in U.S. veterans who suffer from chronic pain, fatigue, or depression. Twenty-five veterans will complete 90 exercise sessions over 18 m…

This study tests two different ways to block pain after heart surgery through the breastbone. About 50 adults having planned heart surgery will receive either one type of nerve block or a combination of two others. The goal is to see which method provides better pain control and …

This study tests two different nerve block techniques to manage pain after lumbar spine surgery. Sixty adults undergoing single-level back surgery will receive either a standard or a modified block. Researchers will measure how much opioid pain medicine each group needs and how w…

This study compares two medications, dexmedetomidine and dexamethasone, added to a standard nerve block for upper arm surgery. The goal is to see which one helps the block work faster, last longer, and reduce the need for extra painkillers. About 44 adults aged 18-70 will take pa…

This study tests whether a very short (7-minute) mindfulness exercise can reduce pain and anxiety in adults undergoing kyphoplasty or radiofrequency ablation. About 80 participants will be randomly assigned to receive the mindfulness intervention or standard care. The goal is to …

This study compares two methods of giving a pain-relieving shot (TAP block) after a planned C-section: one guided by ultrasound and one done by the surgeon during the operation. Fifty women will take part to see which method works better and faster for controlling pain after surg…

This study tests a new drug that blocks a specific nerve channel (NaV1.8) to see how it affects different types of pain. Healthy volunteers receive tiny, safe doses of the drug into their skin and then undergo brief pain tests like heat, cold, and pressure. The goal is to underst…

This study uses a smartphone app called SOMA to track daily mood, pain, and activity in 800 people with acute or chronic pain, as well as healthy volunteers, over four months. The goal is to see if daily changes in these factors can predict whether acute pain becomes chronic, or …

This study involves about 60 caregivers and clinicians to check if new pain assessment tools are easy to understand and accurately capture pain in infants under 2 years old. Participants will be interviewed about the tools' instructions, questions, and response options. The goal …

This study looks at whether the intense pain people feel right before emergency surgery increases their risk of developing chronic pain that lasts for months. Researchers will follow about 700 adults having emergency orthopedic or abdominal surgery. They will measure pain levels …

This study is testing a non-invasive device called the AlgometRx Nociometer to see if it can measure pain in children and teens more objectively. Researchers will enroll 100 participants aged 6 to 21 who are having surgery or a bone marrow transplant. The device uses gentle elect…

This study looks at whether oxytocin, a natural hormone, can change how nerves send pain signals after a small area of skin is heated. Sixty healthy adults will receive either oxytocin or a placebo through an IV, and researchers will measure nerve activity and pain ratings. The g…

This study watches 1,000 surgery patients to see if things like worry about pain, sleep trouble, or anxiety change how well numbing medication (regional anesthesia) works. Researchers want to know if these factors affect pain levels and opioid use after surgery, and if they lead …